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1. 发明专利

GB8408611D0 LIGHTING APPARATUS 未知
公开(公告)号：GB8408611D0
公开(公告)日：1984-05-16
申请号：GB8408611
申请日：1984-04-04
申请人： MORGAN A M , GORDON FREEMAN R

2. 发明专利

GB9426353D0 Golf towel with protective cover 未知
公开(公告)号：GB9426353D0
公开(公告)日：1995-03-01
申请号：GB9426353
申请日：1994-12-29
申请人： GORDON FREEMAN RICHARD
IPC分类号： A47K10/02 , A63B47/04 , A63B55/00 , A63B57/00

3. 发明专利

CA231341A DEVICE FOR CLOSING AUTOMOBILE DOORS 未知
公开(公告)号：CA231341A
公开(公告)日：1923-05-29
申请号：CA231341D
申请人： MCEACHERN ANGUS , BALL GORDON FREEMAN
发明人： MCEACHERN ANGUS , BALL GORDON FREEMAN

4. 发明专利

GB2296432A Conical golf towel 未知
公开(公告)号：GB2296432A
公开(公告)日：1996-07-03
申请号：GB9426353
申请日：1994-12-29
申请人： GORDON FREEMAN RICHARD
发明人： GORDON-FREEMAN RICHARD
IPC分类号： A47K10/02 , A63B47/04 , A63B55/00 , A63B57/00 , A47K10/00
摘要： The towel is conical and fits inside a corresponding conical waterproof cover. Both towel and cover have matching holes for attachment to a golf bag.

5. 发明专利

GB8406266D0 BOARD GAME 未知
公开(公告)号：GB8406266D0
公开(公告)日：1984-04-11
申请号：GB8406266
申请日：1984-03-09
申请人： GORDON FREEMAN R

6. 发明授权

US07635757B2 B7-4 Antibodies and uses therefor 有权
标题翻译： B7-4抗体及其用途
公开(公告)号：US07635757B2
公开(公告)日：2009-12-22
申请号：US11340429
申请日：2006-01-26
申请人： Gordon Freeman , Vassiliki Boussiotis , Tatyana Chernova , Nelly Malenkovich
发明人： Gordon Freeman , Vassiliki Boussiotis , Tatyana Chernova , Nelly Malenkovich
IPC分类号： C07K16/00 , C07K16/28 , A61K39/395 , C12N5/10 , G01N33/53
CPC分类号： A61K45/06 , A61K39/00 , A61K2039/55516 , C07K14/70503 , C07K14/70532 , C07K16/2803 , C07K16/2827 , C07K2317/21 , C07K2317/24 , C07K2317/622 , C07K2319/30
摘要： The invention provides isolated nucleic acids molecules, designated B7-4 nucleic acid molecules, which encode novel B7-4 polypeptides. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing B7-4 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a B7-4 gene has been introduced or disrupted. The invention still further provides isolated B7-4 proteins, fusion proteins, antigenic peptides and anti-B7-4 antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供编码新的B7-4多肽的分离的核酸分子，命名为B7-4核酸分子。本发明还提供反义核酸分子，含有B7-4核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，以及引入或破坏了B7-4基因的非人转基因动物。本发明还进一步提供分离的B7-4蛋白，融合蛋白，抗原肽和抗B7-4抗体。还提供了利用本发明组合物的诊断，筛选和治疗方法。

7. 发明授权

US07432059B2 Methods of identifying compounds that upmodulate T cell activation in the presence of a PD-1 mediated signal 有权
标题翻译：识别在PD-1介导的信号存在下上调T细胞活化的化合物的方法
公开(公告)号：US07432059B2
公开(公告)日：2008-10-07
申请号：US09895837
申请日：2001-06-28
申请人： Gordon Freeman , Irene Chernova , Tatyana Chernova , Nelly Malenkovich , Clive Wood , Yvette Latchman , Arlene H. Sharpe
发明人： Gordon Freeman , Irene Chernova , Tatyana Chernova , Nelly Malenkovich , Clive Wood , Yvette Latchman , Arlene H. Sharpe
IPC分类号： G01N33/53
CPC分类号： G01N33/6854 , G01N33/5014 , G01N33/505 , G01N33/5052 , G01N33/573 , G01N2800/52
摘要： The invention provides isolated nucleic acids molecules, designated PD-L2 nucleic acid molecules, which encode novel B7-related molecules which are ligands for PD-1. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PD-L2 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a PD-L2 gene has been introduced or disrupted. The invention further provides isolated PD-L2 polypeptides, fusion proteins, antigenic peptides and anti-PD-L2 antibodies. The invention still further provides methods for promoting or inhibiting the interaction between PD-L2 and PD-1. The invention further provides methods of identifying compounds that upmodulate T cell activation in the presence of a PD-1-mediated signal. Diagnostic and treatment methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供分离的核酸分子，命名为PD-L2核酸分子，其编码作为PD-1配体的新型B7相关分子。本发明还提供了反义核酸分子，含有PD-L2核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，以及已导入或破坏了PD-L2基因的非人类转基因动物。本发明进一步提供分离的PD-L2多肽，融合蛋白，抗原肽和抗-PD-L2抗体。本发明还提供了促进或抑制PD-L2与PD-1之间相互作用的方法。本发明还提供鉴定在PD-1介导的信号存在下上调T细胞活化的化合物的方法。还提供了利用本发明组合物的诊断和治疗方法。

8. 发明申请

US20070202100A1 PD-1, a receptor for B7-4, and uses therefor 有权
标题翻译： PD-1，B7-4的受体，并用于此
公开(公告)号：US20070202100A1
公开(公告)日：2007-08-30
申请号：US11514328
申请日：2006-08-31
申请人： Clive Wood , Gordon Freeman
发明人： Clive Wood , Gordon Freeman
IPC分类号： A61K39/395 , A61K39/00 , G01N33/53
CPC分类号： C07K14/70532 , A61K38/00 , A61K39/00 , A61K39/395 , A61K45/06 , A61K2039/55516 , C07K14/70503 , C07K16/2803 , C07K16/2827 , C07K2317/21 , C07K2317/622 , C07K2317/73 , C07K2317/74 , C07K2317/76 , C07K2319/00 , C07K2319/30 , G01N2333/70503 , G01N2500/04 , A61K2300/00
摘要： The invention identifies PD-1 as a receptor for B7-4. B7-4 can inhibit immune cell activation upon binding to an inhibitory receptor on an immune cell. Accordingly, the invention provides agents for modulating PD-1, B7-4, and the interaction between B7-4 and PD-1 in order to modulate a costimulatory or an inhibitory signal in a immune cell resulting in modulation of the immune response.
摘要翻译：本发明将PD-1鉴定为B7-4的受体。 B7-4可以在结合免疫细胞上的抑制性受体时抑制免疫细胞活化。因此，本发明提供用于调节PD-1，B7-4以及B7-4和PD-1之间的相互作用的试剂，以调节免疫细胞中的共刺激或抑制性信号，从而导致免疫应答的调节。

9. 发明申请

US20070106070A1 Novel forms of T cell costimulatory molecules and uses therefor 失效
标题翻译：新型形式的T细胞共刺激分子及其用途
公开(公告)号：US20070106070A1
公开(公告)日：2007-05-10
申请号：US11589275
申请日：2006-10-26
申请人： Arlene Sharpe , Francescopaolo Borriello , Gordon Freeman , Lee Nadler
发明人： Arlene Sharpe , Francescopaolo Borriello , Gordon Freeman , Lee Nadler
IPC分类号： C07H21/04
CPC分类号： C07K14/70532 , A01K2217/05
摘要： Novel structural forms of T cell costimulatory molecules are described. These structural forms comprise a novel structural domain or have a structural domain deleted or added. The structural forms correspond to naturally-occurring alternatively spliced forms of T cell costimulatory molecules or variants thereof which can be produced by standard recombinant DNA techniques. In one embodiment, the T cell costimulatory molecule of the invention contains a novel cytoplasmic domain. In another embodiment, the T cell costimulatory molecule of the invention contains a novel signal peptide domain or has an immunoglobulin variable region-like domain deleted. The novel structural forms of T cell costimulatory molecules can be used to identify agents which stimulate the expression of alternative forms of costimulatory molecules and to identify components of the signal transduction pathway which results in costimulation of T cells.
摘要翻译：描述了T细胞共刺激分子的新型结构形式。这些结构形式包括一个新的结构域或者具有缺失或添加的结构域。结构形式对应于可以通过标准重组DNA技术产生的天然存在的可变剪接形式的T细胞共刺激分子或其变体。在一个实施方案中，本发明的T细胞共刺激分子含有新的细胞质结构域。在另一个实施方案中，本发明的T细胞共刺激分子含有新的信号肽结构域或具有免疫球蛋白可变区域结构域缺失。 T细胞共刺激分子的新型结构形式可用于鉴定刺激替代形式的共刺激分子表达的试剂，并鉴定导致T细胞共刺激的信号转导通路的成分。

10. 发明申请

US20060153841A1 B7-4 polypeptides and uses therefor 有权
公开(公告)号：US20060153841A1
公开(公告)日：2006-07-13
申请号：US11340429
申请日：2006-01-26
申请人： Gordon Freeman , Vassiliki Boussiotis , Tatyana Chernova , Nelly Malenkovich
发明人： Gordon Freeman , Vassiliki Boussiotis , Tatyana Chernova , Nelly Malenkovich
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： A61K45/06 , A61K39/00 , A61K2039/55516 , C07K14/70503 , C07K14/70532 , C07K16/2803 , C07K16/2827 , C07K2317/21 , C07K2317/24 , C07K2317/622 , C07K2319/30
摘要： The invention provides isolated nucleic acids molecules, designated B7-4 nucleic acid molecules, which encode novel B7-4 polypeptides. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing B7-4 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a B7-4 gene has been introduced or disrupted. The invention still further provides isolated B7-4 proteins, fusion proteins, antigenic peptides and anti-B7-4 antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.

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