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1. 发明申请

US20120108577A1 COMPOUNDS FOR THE TREATMENT OF MULTI-DRUG RESISTANT BACTERIAL INFECTIONS 审中-公开
标题翻译：用于治疗多药耐药性细菌感染的化合物
公开(公告)号：US20120108577A1
公开(公告)日：2012-05-03
申请号：US13348143
申请日：2012-01-11
申请人： Gloria Breault , Charles Joseph Eyermann , Bolin Geng , Marshall Morningstar , Folkert Reck
发明人： Gloria Breault , Charles Joseph Eyermann , Bolin Geng , Marshall Morningstar , Folkert Reck
IPC分类号： A61K31/436 , A61P31/04 , A61K31/538 , A61K31/4709 , A61K31/5415
CPC分类号： C07D401/06 , C07D401/14 , C07D403/06 , C07D405/06 , C07D413/06 , C07D491/04 , C07D513/04
摘要： The present invention relates to compounds that demonstrate antibacterial activity, processes for their preparation, pharmaceutical compositions containing them as the active ingredient, to their use as medicaments and to their use in the manufacture of medicaments for use in the treatment of bacterial infections in warm-blooded animals such as humans. In particular this invention relates to compounds useful for the treatment of bacterial infections in warm-blooded animals such as humans, more particularly to the use of these compounds in the manufacture of medicaments for use in the treatment of bacterial infections in warm-blooded animals such as humans.
摘要翻译：本发明涉及表现出抗菌活性的化合物，其制备方法，含有它们作为活性成分的药物组合物，它们作为药物的用途，以及它们在制备用于治疗温暖的细菌感染的药物中的用途，血液动物如人类。特别地，本发明涉及可用于治疗温血动物如人的细菌感染的化合物，更具体地涉及这些化合物在制备用于治疗温血动物细菌感染的药物中的用途，例如作为人类。

2. 发明申请

US20110092495A1 COMPOUNDS FOR THE TREATMENT OF MULTI-DRUG RESISTANT BACTERIAL INFECTIONS 失效
标题翻译：用于治疗多药耐药性细菌感染的化合物
公开(公告)号：US20110092495A1
公开(公告)日：2011-04-21
申请号：US12964366
申请日：2010-12-09
申请人： Gloria Breault , Charles Joseph Eyermann , Bolin Geng , Marshall Morningstar , Folkert Reck
发明人： Gloria Breault , Charles Joseph Eyermann , Bolin Geng , Marshall Morningstar , Folkert Reck
IPC分类号： A61K31/5383 , C07D471/04 , A61K31/4375 , C07D401/14 , A61K31/4709 , C07D498/04 , A61K31/4985 , A61P31/04
CPC分类号： C07D401/06 , C07D401/14 , C07D403/06 , C07D405/06 , C07D413/06 , C07D491/04 , C07D513/04
摘要： The present invention relates to compounds that demonstrate antibacterial activity, processes for their preparation, pharmaceutical compositions containing them as the active ingredient, to their use as medicaments and to their use in the manufacture of medicaments for use in the treatment of bacterial infections in warm-blooded animals such as humans. In particular this invention relates to compounds useful for the treatment of bacterial infections in warm-blooded animals such as humans, more particularly to the use of these compounds in the manufacture of medicaments for use in the treatment of bacterial infections in warm-blooded animals such as humans.
摘要翻译：本发明涉及表现出抗菌活性的化合物，其制备方法，含有它们作为活性成分的药物组合物，它们作为药物的用途，以及它们在制备用于治疗温暖的细菌感染的药物中的用途，血液动物如人类。特别地，本发明涉及可用于治疗温血动物如人的细菌感染的化合物，更具体地涉及这些化合物在制备用于治疗温血动物细菌感染的药物中的用途，例如作为人类

3. 发明申请

US20100152441A1 COMPOUNDS FOR THE TREATMENT OF MULTI-DRUG RESISTANT BACTERIAL INFECTIONS 有权
标题翻译：用于治疗多药耐药性细菌感染的化合物
公开(公告)号：US20100152441A1
公开(公告)日：2010-06-17
申请号：US11917394
申请日：2006-06-16
申请人： Gloria Breault , Charles Joseph Eyermann , Bolin Geng , Marshall Morningstar , Folkert Reck
发明人： Gloria Breault , Charles Joseph Eyermann , Bolin Geng , Marshall Morningstar , Folkert Reck
IPC分类号： C07D498/04
CPC分类号： C07D401/06 , C07D401/14 , C07D403/06 , C07D405/06 , C07D413/06 , C07D491/04 , C07D513/04
摘要： The present invention relates to compounds that demonstrate antibacterial activity, processes for their preparation, pharmaceutical compositions containing them as the active ingredient, to their use as medicaments and to their use in the manufacture of medicaments for use in the treatment of bacterial infections in warm-blooded animals such as humans. In particular this invention relates to compounds useful for the treatment of bacterial infections in warm-blooded animals such as humans, more particularly to the use of these compounds in the manufacture of medicaments for use in the treatment of bacterial infections in warm-blooded animals such as humans.
摘要翻译：本发明涉及表现出抗菌活性的化合物，其制备方法，含有它们作为活性成分的药物组合物，它们作为药物的用途，以及它们在制备用于治疗温暖的细菌感染的药物中的用途，血液动物如人类。特别地，本发明涉及可用于治疗温血动物如人的细菌感染的化合物，更具体地涉及这些化合物在制备用于治疗温血动物细菌感染的药物中的用途，例如作为人类

4. 发明授权

US07875715B2 Compounds for the treatment of multi-drug resistant bacterial infections 有权
标题翻译：用于治疗多重耐药细菌感染的化合物
公开(公告)号：US07875715B2
公开(公告)日：2011-01-25
申请号：US11917394
申请日：2006-06-16
申请人： Gloria Breault , Charles Joseph Eyermann , Bolin Geng , Marshall Morningstar , Folkert Reck
发明人： Gloria Breault , Charles Joseph Eyermann , Bolin Geng , Marshall Morningstar , Folkert Reck
IPC分类号： C07D498/04
CPC分类号： C07D401/06 , C07D401/14 , C07D403/06 , C07D405/06 , C07D413/06 , C07D491/04 , C07D513/04
摘要： The present invention relates to compounds that demonstrate antibacterial activity, processes for their preparation, pharmaceutical compositions containing them as the active ingredient, to their use as medicaments and to their use in the manufacture of medicaments for use in the treatment of bacterial infections in warm-blooded animals such as humans. In particular this invention relates to compounds useful for the treatment of bacterial infections in warm-blooded animals such as humans, more particularly to the use of these compounds in the manufacture of medicaments for use in the treatment of bacterial infections in warm-blooded animals such as humans.
摘要翻译：本发明涉及表现出抗菌活性的化合物，其制备方法，含有它们作为活性成分的药物组合物，它们作为药物的用途，以及它们在制备用于治疗温暖的细菌感染的药物中的用途，血液动物如人类。特别地，本发明涉及可用于治疗温血动物如人的细菌感染的化合物，更具体地涉及这些化合物在制备用于治疗温血动物细菌感染的药物中的用途，例如作为人类

5. 发明申请

US20060004033A1 Imidazolo-5-yl-2-anilino-pyrimidines as agents for the inhibition of the cell proliferation 审中-公开
标题翻译：咪唑并噻唑-5-基-2-苯胺基嘧啶作为抑制细胞增殖的试剂
公开(公告)号：US20060004033A1
公开(公告)日：2006-01-05
申请号：US11169197
申请日：2005-06-29
申请人： Gloria Breault , Nicholas Newcombe , Andrew Thomas
发明人： Gloria Breault , Nicholas Newcombe , Andrew Thomas
IPC分类号： A61K31/506 , C07D43/04
CPC分类号： C07D403/04 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14
摘要： Compounds of the formula (I): wherein R1, R2, R3, R4, R5, R6, p, q, and n are as defined within and a pharmaceutically acceptable salts and in vivo hydrolysable esters are described. Also described are processes for their preparation and their use as medicaments, particularly medicaments for producing a cell cycle inhibitory (anti-cell-proliferation) effect in a warm-blooded animal, such as man.
摘要翻译：式（I）化合物：其中R 1，R 2，R 3，R 4，R 4，R p，q和n如上所定义，并且描述了药学上可接受的盐和体内可水解的酯。还描述了它们的制备方法及其作为药物的用途，特别是用于在温血动物如人中产生细胞周期抑制（抗细胞增殖）作用的药物。

6. 发明申请

US20050090493A1 2,4-Diamino pyrimidine compounds having anti-cell proliferative activity 失效
标题翻译：具有抗细胞增殖活性的2,4-二氨基嘧啶化合物
公开(公告)号：US20050090493A1
公开(公告)日：2005-04-28
申请号：US10771118
申请日：2004-02-04
申请人： Gloria Breault , Janet Pease
发明人： Gloria Breault , Janet Pease
IPC分类号： C07D239/49 , A61K31/505 , A61K31/506 , A61K31/5355 , A61P9/00 , A61P9/10 , A61P13/12 , A61P17/06 , A61P19/00 , A61P27/02 , A61P29/00 , A61P35/00 , A61P37/00 , A61P43/00 , C07D239/48 , C07D403/12 , C07D413/02 , A61K31/5377 , C07D43/02
CPC分类号： C07D239/48
摘要： A pyrimidine derivative of formula (I) wherein, for example, R1 is hydrogen, (1-6C)alkyl, (3-5C)alkenyl or (3-5C)alkynyl; Q1 and Q2 are independently selected from phenyl, naphthyl, indanyl and 1,2,3,4-tetrahydronaphthyl; and one or both of Q1 and Q2 bears on any available carbon atom one substituent of formula (Ia) [provided that when present in Q1 the substituent of formula (Ia) is not adjacent to the —NH— link]; wherein, for example, X is CH2, O, S or NH; Y is H or as defined for Z; Z is OH, SH, NH2, (1-4C)alkoxy, (1-4C)alkylthio, —NH(1-4C)alkyl, —N[(1-4C)alkyl]2 or —NH—(3-8C)cycloalkyl; n is 1, 2 or 3; m is 1, 2 or 3; and Q1 and Q2 may optionally bear other substituents selected, for example, from halogeno, (1-6C)alkyl, cyano and (2-4C)alkenyl; or a pharmaceutically-acceptable salt or in-vivo-hydrolysable ester thereof; are useful as anti-cancer agents; and processes for heir manufacture and pharmaceutical compositions containing them are described.
摘要翻译：式（I）的嘧啶衍生物，其中例如R 1是氢，（1-6C）烷基，（3-5C）烯基或（3-5C）炔基; Q 1和Q 2个独立地选自苯基，萘基，茚满基和1,2,3,4-四氢萘基; 并且Q 1和Q 2中的一个或两个在任何可用的碳原子上具有式（Ia）的一个取代基[条件是当存在于Q 1中时，式（Ia）的取代基不与-NH-连接相邻]; 其中，例如，X是CH 2，O，S或NH; Y为H或Z定义; Z是OH，SH，NH 2，（1-4C）烷氧基，（1-4C）烷硫基，-NH（1-4C）烷基，-N [（1-4C）烷基] 或-NH-（3-8C）环烷基; n为1,2或3; m为1,2或3; 且Q 1和Q 2可任选地具有其它取代基，例如选自卤代，（1-6C）烷基，氰基和（2-4C）烯基; 或其药学上可接受的盐或体内可水解的酯; 可用作抗癌剂; 并描述了继承人制造的方法和含有它们的药物组合物。

7. 发明授权

US08124602B2 Compounds for the treatment of multi-drug resistant bacterial infections 失效
标题翻译：用于治疗多重耐药细菌感染的化合物
公开(公告)号：US08124602B2
公开(公告)日：2012-02-28
申请号：US12964366
申请日：2010-12-09
申请人： Gloria Breault , Charles Joseph Eyermann , Bolin Geng , Marshall Morningstar , Folkert Reck
发明人： Gloria Breault , Charles Joseph Eyermann , Bolin Geng , Marshall Morningstar , Folkert Reck
IPC分类号： A61K31/438 , A61K31/498 , C07D401/06 , C07D403/06
CPC分类号： C07D401/06 , C07D401/14 , C07D403/06 , C07D405/06 , C07D413/06 , C07D491/04 , C07D513/04
摘要： The present invention relates to compounds of Formula V(A): that demonstrate antibacterial activity, processes for their preparation, pharmaceutical compositions containing them as the active ingredient, to their use as medicaments and to their use in the manufacture of medicaments for use in the treatment of bacterial infections in warm-blooded animals such as humans. In particular this invention relates to compounds of Formula V(A) useful for the treatment of bacterial infections in warm-blooded animals such as humans, more particularly to the use of these compounds in the manufacture of medicaments for use in the treatment of bacterial infections in warm-blooded animals such as humans.
摘要翻译：本发明涉及式V（A）的化合物：其表现出抗菌活性，其制备方法，含有它们作为活性成分的药物组合物，其用作药物及其在制备药物中的用途治疗温血动物如人类的细菌感染。特别地，本发明涉及用于治疗温血动物如人的细菌感染的式V（A）化合物，更具体地说涉及这些化合物在制备用于治疗细菌感染的药物中的用途在温血动物如人类。

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