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1. 发明申请

US20140199272A1 AAV MEDIATED EXENDIN-4 GENE TRANSFER TO SALIVARY GLANDS TO PROTECT SUBJECTS FROM DIABETES OR OBESITY 有权
标题翻译： AAV介导的EXENDIN-4基因转移到唾液中，以保护患有糖尿病或肥胖症的受试者
公开(公告)号：US20140199272A1
公开(公告)日：2014-07-17
申请号：US14112790
申请日：2012-04-19
申请人： John A. Chiorini , Giovanni Di Pasquale , Edoardo Mannucci
发明人： John A. Chiorini , Giovanni Di Pasquale , Edoardo Mannucci
IPC分类号： A61K35/76
CPC分类号： A61K35/76 , A61K35/761 , A61K38/1703 , A61K48/005 , A61K48/0075 , C07H21/04 , C07K14/48 , C07K14/57563 , C07K14/605 , C07K2319/055 , C07K2319/50 , C12N7/00 , C12N15/86 , C12N2750/14143
摘要： The invention relates to a gene transfer-based method to protect a subject from diabetes or obesity. The method comprises administering to a salivary gland of the subject an AAV virion comprising an AAV vector that encodes an exendin-4 protein. Also provided are exendin-4 proteins and nucleic acid molecules that encode such exendin-4 proteins. Also provided are AAV vectors and AAV virions that encode an exendin-4 protein. One embodiment is an exendin-4 protein that is a fusion protein comprising an NGF secretory segment joined to the amino terminus of an exendin-4 protein domain.
摘要翻译：本发明涉及一种保护受试者免受糖尿病或肥胖症的基于基因转移的方法。该方法包括向受试者的唾液腺施用包含编码毒蜥外泌肽-4蛋白的AAV载体的AAV病毒体。还提供了毒蜥外泌肽-4蛋白和编码这种毒蜥外泌肽-4蛋白的核酸分子。还提供编码毒蜥外泌肽-4蛋白的AAV载体和AAV病毒体。一个实施方案是毒蜥外泌肽-4蛋白，其是包含与毒蜥外泌肽-4蛋白结构域的氨基末端连接的NGF分泌片段的融合蛋白。

2. 发明授权

US06983159B2 Optimum allocation of TMSI and P-TMSI in mobile communication systems 有权
标题翻译： TMSI和P-TMSI在移动通信系统中的最佳配置
公开(公告)号：US06983159B2
公开(公告)日：2006-01-03
申请号：US10020120
申请日：2001-12-18
申请人： Gianluca Giovanni Di Pasquale , Vatche Varvarian , Arndt Ritterbecks
发明人： Gianluca Giovanni Di Pasquale , Vatche Varvarian , Arndt Ritterbecks
IPC分类号： H04Q7/20
CPC分类号： H04W8/26
摘要： A TMSI, comprising a TMSI identification field and a TMSI generation field, is allocated to a mobile subscriber. For non-restart situations, this involves selecting an unused TMSI identification field value; determining an associated present TMSI generation field value; and performing a normal allocation adjustment to the present TMSI generation field value, thereby producing an adjusted TMSI generation field value. A complete TMSI is generated from the selected TMSI identification value and the adjusted TMSI generation field value. The complete TMSI is allocated to the mobile subscriber. For a normal release situation, the TMSI identification value is processed so that it will be considered unused, and a normal deallocation adjustment is performed to the adjusted TMSI generation field value. In some embodiments, the normal deallocation adjustment restores the TMSI generation field to its earlier value. In an abnormal release, the TMSI generation field value is left unchanged.
摘要翻译：包括TMSI识别字段和TMSI生成字段的TMSI被分配给移动用户。对于非重启情况，这涉及选择未使用的TMSI识别字段值; 确定相关联的当前TMSI生成场值; 对该TMSI生成区域值进行正常的分配调整，从而生成调整后的TMSI生成区域值。从所选择的TMSI识别值和调整后的TMSI生成字段值产生完整的TMSI。完整的TMSI被分配给移动用户。对于正常的释放情况，处理TMSI识别值，使其被认为是未使用的，并且对调整的TMSI生成字段值执行正常的解除分配调整。在一些实施例中，正常的释放调整将TMSI生成字段恢复到其较早的值。在异常释放中，TMSI生成域值保持不变。

3. 发明申请

US20120253018A1 Bovine Adeno-Associated Viral (BAAV) Vector and Uses Thereof 失效
标题翻译：牛腺相关病毒（BAAV）载体及其用途
公开(公告)号：US20120253018A1
公开(公告)日：2012-10-04
申请号：US13413321
申请日：2012-03-06
申请人： John A. Chiorini , Michael Schmidt , Ioannis Bossis , Giovanni Di Pasquale
发明人： John A. Chiorini , Michael Schmidt , Ioannis Bossis , Giovanni Di Pasquale
IPC分类号： C07K14/00 , C07K16/00 , C07H21/04
CPC分类号： C07K14/005 , A61K48/0075 , A61K48/0091 , C07K16/081 , C12N7/00 , C12N15/86 , C12N2750/14121 , C12N2750/14122 , C12N2750/14143 , G01N33/56983
摘要： The present invention provides a bovine adeno-associated virus (BAAV) virus and vectors and particles derived therefrom. In addition, the present invention provides methods of delivering a nucleic acid to a cell using the BAAV vectors and particles.
摘要翻译：本发明提供了牛腺相关病毒（BAAV）病毒及其衍生的载体和颗粒。此外，本发明提供了使用BAAV载体和颗粒将核酸递送至细胞的方法。

4. 发明授权

US09511103B2 AAV mediated exendin-4 gene transfer to salivary glands to protect subjects from diabetes or obesity 有权
标题翻译： AAV介导的毒蜥外泌肽-4基因转移到唾液腺，以保护受试者免受糖尿病或肥胖
公开(公告)号：US09511103B2
公开(公告)日：2016-12-06
申请号：US14112790
申请日：2012-04-19
申请人： John A. Chiorini , Giovanni Di Pasquale , Edoardo Mannucci
发明人： John A. Chiorini , Giovanni Di Pasquale , Edoardo Mannucci
IPC分类号： A61K31/70 , C12N15/00 , A61K48/00 , C07K14/00 , C07H21/04 , A61K35/761 , C07K14/48 , C07K14/575 , C07K14/605 , A61K38/17 , C12N15/86
CPC分类号： A61K35/76 , A61K35/761 , A61K38/1703 , A61K48/005 , A61K48/0075 , C07H21/04 , C07K14/48 , C07K14/57563 , C07K14/605 , C07K2319/055 , C07K2319/50 , C12N7/00 , C12N15/86 , C12N2750/14143
摘要： The invention relates to a gene transfer-based method to protect a subject from diabetes or obesity. The method comprises administering to a salivary gland of the subject an AAV virion comprising an AAV vector that encodes an exendin-4 protein. Also provided are exendin-4 proteins and nucleic acid molecules that encode such exendin-4 proteins. Also provided are AAV vectors and AAV virions that encode an exendin-4 protein. One embodiment is an exendin-4 protein that is a fusion protein comprising an NGF secretory segment joined to the amino terminus of an exendin-4 protein domain.
摘要翻译：本发明涉及一种保护受试者免受糖尿病或肥胖症的基于基因转移的方法。该方法包括向受试者的唾液腺施用包含编码毒蜥外泌肽-4蛋白的AAV载体的AAV病毒体。还提供了毒蜥外泌肽-4蛋白和编码这种毒蜥外泌肽-4蛋白的核酸分子。还提供编码毒蜥外泌肽-4蛋白的AAV载体和AAV病毒体。一个实施方案是毒蜥外泌肽-4蛋白，其是包含与毒蜥外泌肽-4蛋白结构域的氨基末端连接的NGF分泌片段的融合蛋白。

5. 发明申请

US20140088175A1 TRANSDUCTION OF CELLS BY ADENO-ASSOCIATED VIRUS VECTORS 审中-公开
标题翻译： ADENO相关病毒载体转染细胞
公开(公告)号：US20140088175A1
公开(公告)日：2014-03-27
申请号：US13416717
申请日：2012-03-09
申请人： John A. Chiorini , Giovanni Di Pasquale
发明人： John A. Chiorini , Giovanni Di Pasquale
IPC分类号： C12N15/86
CPC分类号： C12N15/86 , C07K14/005 , C12N7/00 , C12N2750/14121 , C12N2750/14122 , C12N2750/14143
摘要： The present invention provides methods of transcytosing barrier epithelial cells using adeno-associated virus-4 (AAV4), adeno-associated virus-5 (AAV5), adeno-associated virus-7 (AAV7), bovine adeno-associated virus (BAAV), and vectors and particles derived therefrom. In addition, the present invention provides methods of delivering a nucleic acid across the barrier epithelia using the AAV4, AAV5, AAV7, and BAAV vectors and particles.
摘要翻译：本发明提供了使用腺相关病毒-4（AAV4），腺相关病毒-5（AAV5），腺相关病毒-7（AAV7），牛腺相关病毒（BAAV），转移细胞转染屏障上皮细胞的方法，和衍生自其的载体和颗粒。此外，本发明提供使用AAV4，AAV5，AAV7和BAAV载体和颗粒递送核酸穿过屏障上皮的方法。

6. 发明申请

US20080188431A1 Transcytosis of Adeno-Associated Viruses 审中-公开
标题翻译：腺相关病毒的细胞因子
公开(公告)号：US20080188431A1
公开(公告)日：2008-08-07
申请号：US11574954
申请日：2005-09-08
申请人： John A. Chiorini , Giovanni Di Pasquale
发明人： John A. Chiorini , Giovanni Di Pasquale
IPC分类号： A61K48/00
CPC分类号： C12N15/86 , C07K14/005 , C12N7/00 , C12N2750/14121 , C12N2750/14122 , C12N2750/14143
摘要： The present invention provides methods of transcytosing barrier epithelial cells using adeno-associated virus-4 (AAV4), adeno-associated virus-5 (AAV5), adeno-associated virus-7 (AAV7), bovine adeno-associated virus (BAAV), and vectors and particles derived therefrom. In addition, the present invention provides methods of delivering a nucleic acid across the barrier epithelia using the AAV4, AAV5, AAV7, and BAAV vectors and particles.
摘要翻译：本发明提供了使用腺相关病毒-4（AAV4），腺相关病毒-5（AAV5），腺相关病毒-7（AAV7），牛腺相关病毒（BAAV），转移细胞转染屏障上皮细胞的方法，和衍生自其的载体和颗粒。此外，本发明提供使用AAV4，AAV5，AAV7和BAAV载体和颗粒递送核酸穿过屏障上皮的方法。

7. 发明授权

US08685722B2 Bovine adeno-associated viral (BAAV) vector and uses thereof 失效
标题翻译：牛腺相关病毒（BAAV）载体及其用途
公开(公告)号：US08685722B2
公开(公告)日：2014-04-01
申请号：US13413321
申请日：2012-03-06
申请人： John A. Chiorini , Michael Schmidt , Ioannis Bossis , Giovanni Di Pasquale
发明人： John A. Chiorini , Michael Schmidt , Ioannis Bossis , Giovanni Di Pasquale
IPC分类号： C12N15/86
CPC分类号： C07K14/005 , A61K48/0075 , A61K48/0091 , C07K16/081 , C12N7/00 , C12N15/86 , C12N2750/14121 , C12N2750/14122 , C12N2750/14143 , G01N33/56983
摘要： The present invention provides a bovine adeno-associated virus (BAAV) virus and vectors and particles derived therefrom. In addition, the present invention provides methods of delivering a nucleic acid to a cell using the BAAV vectors and particles.
摘要翻译：本发明提供了牛腺相关病毒（BAAV）病毒及其衍生的载体和颗粒。此外，本发明提供了使用BAAV载体和颗粒将核酸递送至细胞的方法。

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