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1. 发明申请

US20110263827A1 Dual Variable Domain Immunnoglobulins and Uses Thereof 审中-公开
标题翻译：双可变域免疫球蛋白及其用途
公开(公告)号：US20110263827A1
公开(公告)日：2011-10-27
申请号：US12771871
申请日：2010-04-30
申请人： Tariq Ghayur , Junjian Liu , Gillian A. Kingsbury , Edward B. Reilly , Susan E. Morgan-lappe
发明人： Tariq Ghayur , Junjian Liu , Gillian A. Kingsbury , Edward B. Reilly , Susan E. Morgan-lappe
IPC分类号： C07K16/22 , C07K16/00
CPC分类号： C07K16/2863 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K47/6879 , A61K2039/505 , C07K16/22 , C07K16/28 , C07K16/2809 , C07K16/40 , C07K16/468 , C07K2317/24 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/64 , C07K2317/76 , C07K2317/92 , C07K2319/00 , G01N33/74 , G01N2333/71 , Y02A50/386 , Y02A50/41 , Y02A50/412
摘要： The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
摘要翻译：本发明涉及工程化的多价和多特异性结合蛋白，制备方法，具体涉及用于预防，诊断和/或治疗疾病的用途。

2. 发明授权

US07972797B2 Compositions and methods for the diagnosis and treatment of immune disorders 有权
标题翻译：用于诊断和治疗免疫疾病的组合物和方法
公开(公告)号：US07972797B2
公开(公告)日：2011-07-05
申请号：US12284648
申请日：2008-09-24
申请人： Gillian A. Kingsbury , Kevin R. Leiby
发明人： Gillian A. Kingsbury , Kevin R. Leiby
IPC分类号： G01N33/53
CPC分类号： C07K16/24 , A61K38/00 , A61K2039/505 , C07K14/52 , C07K2317/21 , C07K2317/74 , C07K2317/92 , C07K2319/00 , C07K2319/30
摘要： The present invention relates to methods and compositions for the treatment and diagnosis of immune disorders, especially T helper lymphocyte-related disorders. In particular, the invention describes a gene known in the art, alternatively, as ST2, T1 and Fit-1, and referred to herein as the 103 gene. The 103 gene is disclosed herein to be differentially expressed in TH2 cells and not in TH1 cells. Further, the 103 gene product is demonstrated herein to be an important modulator of TH2 and TH2-like immune response both in vitro and in vivo. Thus, the 103 gene, its gene products and antibodies that specifically bind thereto can be used diagnostically or as targets for therapeutic intervention in the treatment of a variety of immune disorders.In this regard, the invention provides methods for the identification and therapeutic use of compounds for treatments of immune disorders, especially TH cell subpopulation-related disorders and including TH2 and TH2-like disorders (i.e., disorders associated with a TH2 or TH2-like mediated immune response) such as atopic conditions (e.g., allergy and asthma). Additionally, methods are provided for the diagnostic evaluation and prognosis of TH cell subpopulation related disorders, for the identification of subjects exhibiting a predisposition to such conditions, for monitoring patients undergoing clinical evaluation for the treatment of such disorders and for monitoring the efficacy of compounds used in clinical trials.
摘要翻译：本发明涉及用于治疗和诊断免疫疾病，特别是T辅助淋巴细胞相关疾病的方法和组合物。特别地，本发明描述了本领域已知的基因，或者作为ST2，T1和Fit-1，并且在本文中称为103基因。本文公开的103基因在TH2细胞中不差异表达，而不在TH1细胞中。此外，103基因产物在本文中被证明是体外和体内TH2和TH2样免疫应答的重要调节剂。因此，103基因，其基因产物和与其结合的抗体可以在诊断上用作治疗性干预的目标，用于治疗各种免疫疾病。在这方面，本发明提供了用于鉴定和治疗用于治疗免疫疾病，特别是TH细胞亚群相关病症并包括TH2和TH2样病症（即与TH2或TH2样介导的相关的病症）的化合物的方法免疫反应），如特应性病症（如过敏和哮喘）。另外，提供了用于TH细胞亚群相关疾病的诊断评价和预后的方法，用于鉴定表现出这种病症倾向的受试者，用于监测接受临床评估治疗这种病症的患者，并监测所用化合物的功效在临床试验中。

3. 发明授权

US09029508B2 Dual variable domain immunoglobulins and uses thereof 有权
标题翻译：双重可变结构域免疫球蛋白及其用途
公开(公告)号：US09029508B2
公开(公告)日：2015-05-12
申请号：US12431460
申请日：2009-04-28
申请人： Tariq Ghayur , Susan E. Morgan-Lappe , Edward B. Reilly , Gillian A. Kingsbury , Andrew Phillips , Jieyi Wang , Randy L. Bell , Suzanne M. Norvell , Yingchun Li , Junjian Liu , Hua Ying
发明人： Tariq Ghayur , Susan E. Morgan-Lappe , Edward B. Reilly , Gillian A. Kingsbury , Andrew Phillips , Jieyi Wang , Randy L. Bell , Suzanne M. Norvell , Yingchun Li , Junjian Liu , Hua Ying
IPC分类号： C07K16/00 , C12P21/08 , C07H21/04 , G01N33/53 , C12N15/09 , C12P21/04 , C12N5/02 , C12N5/06 , C12N1/20 , C12N15/00 , A61K39/395 , A61K39/40 , C07K16/46 , C07K16/22 , C07K16/28 , C07K16/32 , C07K1/00 , A61K39/00
CPC分类号： C07K16/468 , A61K39/39533 , A61K45/06 , A61K2039/505 , C07K16/22 , C07K16/28 , C07K16/2863 , C07K16/32 , C07K2317/31 , C07K2317/565 , C07K2317/64 , C07K2317/71 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92 , C07K2319/00 , G01N33/6872 , G01N33/74 , G01N2333/515 , G01N2333/705 , Y02A50/386 , Y02A50/41 , Y02A50/412 , Y02A50/58 , Y10S435/81
摘要： The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
摘要翻译：本发明涉及工程化的多价和多特异性结合蛋白，制备方法，具体涉及用于预防，诊断和/或治疗疾病的用途。

4. 发明申请

US20090304703A1 Compositions and methods for the diagnosis and treatment of immune disorders 有权
公开(公告)号：US20090304703A1
公开(公告)日：2009-12-10
申请号：US12284648
申请日：2008-09-24
申请人： Gillian A. Kingsbury , Kevin R. Leiby
发明人： Gillian A. Kingsbury , Kevin R. Leiby
IPC分类号： A61K39/395 , C12Q1/02 , G01N33/68 , A61P37/02
CPC分类号： C07K16/24 , A61K38/00 , A61K2039/505 , C07K14/52 , C07K2317/21 , C07K2317/74 , C07K2317/92 , C07K2319/00 , C07K2319/30
摘要： The present invention relates to methods and compositions for the treatment and diagnosis of immune disorders, especially T helper lymphocyte-related disorders. In particular, the invention describes a gene known in the art, alternatively, as ST2, T1 and Fit-1, and referred to herein as the 103 gene. The 103 gene is disclosed herein to be differentially expressed in TH2 cells and not in TH1 cells. Further, the 103 gene product is demonstrated herein to be an important modulator of TH2 and TH2-like immune response both in vitro and in vivo. Thus, the 103 gene, its gene products and antibodies that specifically bind thereto can be used diagnostically or as targets for therapeutic intervention in the treatment of a variety of immune disorders.In this regard, the invention provides methods for the identification and therapeutic use of compounds for treatments of immune disorders, especially TH cell subpopulation-related disorders and including TH2 and TH2-like disorders (i.e., disorders associated with a TH2 or TH2-like mediated immune response) such as atopic conditions (e.g., allergy and asthma). Additionally, methods are provided for the diagnostic evaluation and prognosis of TH cell subpopulation related disorders, for the identification of subjects exhibiting a predisposition to such conditions, for monitoring patients undergoing clinical evaluation for the treatment of such disorders and for monitoring the efficacy of compounds used in clinical trials.

5. 发明申请

US20150017168A1 DUAL VARIABLE DOMAIN IMMUNOGLOBULINS AND USES THEREOF 审中-公开
公开(公告)号：US20150017168A1
公开(公告)日：2015-01-15
申请号：US14332087
申请日：2014-07-15
申请人： Tariq Ghayur , Junjian Liu , Gillian A. Kingsbury , Edward B. Reilly , Susan E. Morgan-Lappe
发明人： Tariq Ghayur , Junjian Liu , Gillian A. Kingsbury , Edward B. Reilly , Susan E. Morgan-Lappe
IPC分类号： C07K16/28 , A61K45/06 , C07K16/22 , A61K47/48 , A61K39/395 , C07K16/40
CPC分类号： C07K16/2863 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K47/6879 , A61K2039/505 , C07K16/22 , C07K16/28 , C07K16/2809 , C07K16/40 , C07K16/468 , C07K2317/24 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/64 , C07K2317/76 , C07K2317/92 , C07K2319/00 , G01N33/74 , G01N2333/71 , Y02A50/386 , Y02A50/41 , Y02A50/412
摘要： The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.

6. 发明申请

US20100260668A1 Dual Variable Domain Immunoglobulins and Uses Thereof 审中-公开
标题翻译：双变量域免疫球蛋白及其用途
公开(公告)号：US20100260668A1
公开(公告)日：2010-10-14
申请号：US12605094
申请日：2009-10-23
申请人： Tariq Ghayur , Susan E. Morgan-lappe , Edward B. Reilly , Gillian A. Kingsbury , Andrew Phillips , Jieyi Wang , Randy L. Bell , Suzanne M. Norvell , Yingchun Li , Junjian Liu , Hua Ying , Zhihong Liu
发明人： Tariq Ghayur , Susan E. Morgan-lappe , Edward B. Reilly , Gillian A. Kingsbury , Andrew Phillips , Jieyi Wang , Randy L. Bell , Suzanne M. Norvell , Yingchun Li , Junjian Liu , Hua Ying , Zhihong Liu
IPC分类号： A61K51/10 , C07K16/46 , C07K16/32 , C07H21/04 , A61K39/395 , A61P29/00 , A61P21/02 , A61P25/20 , A61P17/06 , A61P19/02 , A61P1/00 , A61P11/00 , A61P1/16 , A61P25/28 , A61P15/00 , A61P3/10 , A61P35/00 , A61P37/06 , A61P9/00 , A61P7/00 , A61P17/00 , C12N15/63 , C12N1/21 , C12N1/11 , C12N5/10 , C12N1/15 , C12N1/19 , C12P21/00
CPC分类号： C07K16/22 , A61K2039/505 , C07K16/28 , C07K16/2863 , C07K16/32 , C07K16/468 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/00 , Y02A50/386 , Y02A50/41 , Y02A50/412 , Y02A50/58
摘要： The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
摘要翻译：本发明涉及工程化的多价和多特异性结合蛋白，制备方法，具体涉及用于预防，诊断和/或治疗疾病的用途。

7. 发明申请

US20100076178A1 Dual Variable Domain Immumoglobulins and Uses Thereof 有权
标题翻译：双变量域免疫球蛋白及其用途
公开(公告)号：US20100076178A1
公开(公告)日：2010-03-25
申请号：US12431460
申请日：2009-04-28
申请人： Tariq Ghayur , Susan E. Morgan-Lappe , Edward B. Reilly , Gillian A. Kingsbury , Andrew Phillips , Jieyi Wang , Randy L. Bell , Suzanne M. Norvell , Yingchun Li , Junjian Liu , Hua Ying
发明人： Tariq Ghayur , Susan E. Morgan-Lappe , Edward B. Reilly , Gillian A. Kingsbury , Andrew Phillips , Jieyi Wang , Randy L. Bell , Suzanne M. Norvell , Yingchun Li , Junjian Liu , Hua Ying
IPC分类号： C07K16/00
CPC分类号： C07K16/468 , A61K39/39533 , A61K45/06 , A61K2039/505 , C07K16/22 , C07K16/28 , C07K16/2863 , C07K16/32 , C07K2317/31 , C07K2317/565 , C07K2317/64 , C07K2317/71 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92 , C07K2319/00 , G01N33/6872 , G01N33/74 , G01N2333/515 , G01N2333/705 , Y02A50/386 , Y02A50/41 , Y02A50/412 , Y02A50/58 , Y10S435/81
摘要： The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
摘要翻译：本发明涉及工程化的多价和多特异性结合蛋白，制备方法，具体涉及用于预防，诊断和/或治疗疾病的用途。

8. 发明授权

US07452980B2 Compositions and methods for the diagnosis and treatment of immune disorders 失效
标题翻译：用于诊断和治疗免疫疾病的组合物和方法
公开(公告)号：US07452980B2
公开(公告)日：2008-11-18
申请号：US11599098
申请日：2006-11-14
申请人： Gillian A. Kingsbury , Kevin R. Leiby
发明人： Gillian A. Kingsbury , Kevin R. Leiby
IPC分类号： C07K16/00 , C12P21/08
CPC分类号： C07K16/24 , A61K38/00 , A61K2039/505 , C07K14/52 , C07K2317/21 , C07K2317/74 , C07K2317/92 , C07K2319/00 , C07K2319/30
摘要： The present invention relates to methods and compositions for the treatment and diagnosis of immune disorders, especially T helper lymphocyte-related disorders. In particular, the invention describes a gene known in the art, alternatively, as ST2, T1 and Fit-1, and referred to herein as the 103 gene. The 103 gene is disclosed herein to be differentially expressed in TH2 cells and not in TH1 cells. Further, the 103 gene product is demonstrated herein to be an important modulator of TH2 and TH2-like immune response both in vitro and in vivo. Thus, the 103 gene, its gene products and antibodies that specifically bind thereto can be used diagnostically or as targets for therapeutic intervention in the treatment of a variety of immune disorders.In this regard, the invention provides methods for the identification and therapeutic use of compounds for treatments of immune disorders, especially TH cell subpopulation-related disorders and including TH2 and TH2-like disorders (i.e., disorders associated with a TH2 or TH2-like mediated immune response) such as atopic conditions (e.g., allergy and asthma). Additionally, methods are provided for the diagnostic evaluation and prognosis of TH cell subpopulation related disorders, for the identification of subjects exhibiting a predisposition to such conditions, for monitoring patients undergoing clinical evaluation for the treatment of such disorders and for monitoring the efficacy of compounds used in clinical trials.
摘要翻译：本发明涉及用于治疗和诊断免疫疾病，特别是T辅助淋巴细胞相关疾病的方法和组合物。特别地，本发明描述了本领域已知的基因，或者作为ST2，T1和Fit-1，并且在本文中称为103基因。本文公开的103基因在TH2细胞中不差异表达，而不在TH1细胞中。此外，103基因产物在本文中被证明是体外和体内TH2和TH2样免疫应答的重要调节剂。因此，103基因，其基因产物和与其结合的抗体可以在诊断上用作治疗性干预的目标，用于治疗各种免疫疾病。在这方面，本发明提供了用于鉴定和治疗用于治疗免疫疾病，特别是TH细胞亚群相关病症并包括TH2和TH2样病症（即与TH2或TH2样介导的相关的病症）的化合物的方法免疫反应），如特应性病症（如过敏和哮喘）。另外，提供了用于TH细胞亚群相关疾病的诊断评价和预后的方法，用于鉴定表现出这种病症倾向的受试者，用于监测接受临床评估治疗这种病症的患者，并监测所用化合物的功效在临床试验中。

9. 发明授权

US08444987B2 Compositions and methods for the diagnosis and treatment of immune disorders 有权
公开(公告)号：US08444987B2
公开(公告)日：2013-05-21
申请号：US13116108
申请日：2011-05-26
申请人： Gillian A. Kingsbury , Kevin R. Leiby
发明人： Gillian A. Kingsbury , Kevin R. Leiby
IPC分类号： A61K39/395
CPC分类号： C07K16/24 , A61K38/00 , A61K2039/505 , C07K14/52 , C07K2317/21 , C07K2317/74 , C07K2317/92 , C07K2319/00 , C07K2319/30
摘要： The present invention relates to methods and compositions for the treatment and diagnosis of immune disorders, especially T helper lymphocyte-related disorders. In particular, the invention describes a gene known in the art, alternatively, as ST2, T1 and Fit-1, and referred to herein as the 103 gene. The 103 gene is disclosed herein to be differentially expressed in TH2 cells and not in TH1 cells. Further, the 103 gene product is demonstrated herein to be an important modulator of TH2 and TH2-like immune response both in vitro and in vivo. Thus, the 103 gene, its gene products and antibodies that specifically bind thereto can be used diagnostically or as targets for therapeutic intervention in the treatment of a variety of immune disorders.In this regard, the invention provides methods for the identification and therapeutic use of compounds for treatments of immune disorders, especially TH cell subpopulation-related disorders and including TH2 and TH2-like disorders (i.e., disorders associated with a TH2 or TH2-like mediated immune response) such as atopic conditions (e.g., allergy and asthma). Additionally, methods are provided for the diagnostic evaluation and prognosis of TH cell subpopulation related disorders, for the identification of subjects exhibiting a predisposition to such conditions, for monitoring patients undergoing clinical evaluation for the treatment of such disorders and for monitoring the efficacy of compounds used in clinical trials.

10. 发明申请

US20120148573A1 COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF IMMUNE DISORDERS 有权
标题翻译：用于诊断和治疗免疫缺陷病的组合物和方法
公开(公告)号：US20120148573A1
公开(公告)日：2012-06-14
申请号：US13116108
申请日：2011-05-26
申请人： Gillian A. Kingsbury , Kevin R. Leiby
发明人： Gillian A. Kingsbury , Kevin R. Leiby
IPC分类号： A61K39/395 , A61P11/06 , A61P37/08 , A61P37/00
CPC分类号： C07K16/24 , A61K38/00 , A61K2039/505 , C07K14/52 , C07K2317/21 , C07K2317/74 , C07K2317/92 , C07K2319/00 , C07K2319/30
摘要： The present invention relates to methods and compositions for the treatment and diagnosis of immune disorders, especially T helper lymphocyte-related disorders. In particular, the invention describes a gene known in the art, alternatively, as ST2, T1 and Fit-1, and referred to herein as the 103 gene. The 103 gene is disclosed herein to be differentially expressed in TH2 cells and not in TH1 cells. Further, the 103 gene product is demonstrated herein to be an important modulator of TH2 and TH2-like immune response both in vitro and in vivo. Thus, the 103 gene, its gene products and antibodies that specifically bind thereto can be used diagnostically or as targets for therapeutic intervention in the treatment of a variety of immune disorders.In this regard, the invention provides methods for the identification and therapeutic use of compounds for treatments of immune disorders, especially TH cell subpopulation-related disorders and including TH2 and TH2-like disorders (i.e., disorders associated with a TH2 or TH2-like mediated immune response) such as atopic conditions (e.g., allergy and asthma). Additionally, methods are provided for the diagnostic evaluation and prognosis of TH cell subpopulation related disorders, for the identification of subjects exhibiting a predisposition to such conditions, for monitoring patients undergoing clinical evaluation for the treatment of such disorders and for monitoring the efficacy of compounds used in clinical trials.
摘要翻译：本发明涉及用于治疗和诊断免疫疾病，特别是T辅助淋巴细胞相关疾病的方法和组合物。特别地，本发明描述了本领域已知的基因，或者作为ST2，T1和Fit-1，并且在本文中称为103基因。本文公开的103基因在TH2细胞中不差异表达，而不在TH1细胞中。此外，103基因产物在本文中被证明是体外和体内TH2和TH2样免疫应答的重要调节剂。因此，103基因，其基因产物和与其结合的抗体可以在诊断上用作治疗性干预的目标，用于治疗各种免疫疾病。在这方面，本发明提供了用于鉴定和治疗用于治疗免疫疾病，特别是TH细胞亚群相关病症并包括TH2和TH2样病症（即与TH2或TH2样介导的相关的病症）的化合物的方法免疫反应），如特应性病症（如过敏和哮喘）。另外，提供了用于TH细胞亚群相关疾病的诊断评价和预后的方法，用于鉴定表现出这种病症倾向的受试者，用于监测接受临床评估治疗这种病症的患者，并监测所用化合物的功效在临床试验中。

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