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1. 发明授权

US09551701B2 Method for detecting analyte in a bodily fluid, and dressing for implementing such a method 有权
标题翻译：用于检测体液中的分析物的方法，以及用于实施这种方法的敷料
公开(公告)号：US09551701B2
公开(公告)日：2017-01-24
申请号：US13520078
申请日：2010-12-29
申请人： Gilles Marchand , Pierre Marcoux
发明人： Gilles Marchand , Pierre Marcoux
IPC分类号： G01N33/00 , G01N33/50 , A61B5/00 , A61L15/56 , A61F13/02 , A61F13/00
CPC分类号： G01N33/5088 , A61B5/00 , A61F13/0213 , A61F13/0226 , A61F13/0273 , A61F2013/00429 , A61F2013/00846 , A61F2013/00965 , A61L15/56
摘要： A method for detecting an analyte in a bodily fluid includes placing the detector in contact with at least one metabolite resulting from the metabolism or degradation of the analyte. The contact between the detector and the metabolite produces an optically detectable signal. The detection method includes the detection of the metabolite only in gas form, said metabolite in gas form coming from the evaporation of at least a part of said metabolite. The detection is also carried out without contact between the bodily fluid and the detector. A dressing for implementing the detection method is also described.
摘要翻译：用于检测体液中的分析物的方法包括使检测器与由分析物的代谢或降解导致的至少一种代谢物接触。检测器和代谢物之间的接触产生可光学检测的信号。检测方法包括仅以气体形式检测代谢物，所述代谢物以气体形式来自至少一部分所述代谢物的蒸发。检测也可以在体液和检测器之间没有接触的情况下进行。还描述了用于实现检测方法的敷料。

2. 发明申请

US20140046076A1 Surface Functionalization of a Substrate in an Ionic Liquid Medium 审中-公开
标题翻译：离子液体介质中底物的表面官能化
公开(公告)号：US20140046076A1
公开(公告)日：2014-02-13
申请号：US14003195
申请日：2012-03-02
申请人： Gilles Marchand , Antoine Hoang , Olivier Zaouak , Carole Sauer
发明人： Gilles Marchand , Antoine Hoang , Olivier Zaouak , Carole Sauer
IPC分类号： B05D1/00
CPC分类号： B05D1/00 , B01J20/286 , B01J20/3204 , B01J20/3208 , B01J20/3217 , B01J20/3248 , B01J20/3257 , B05D1/185 , B05D2201/02 , B05D2202/00 , B05D2203/30 , B05D2350/10 , B82Y30/00 , B82Y40/00
摘要： The present invention relates to a process that is useful for surface functionalization of a substrate comprising at least one hydroxyl function, in which one or more point regions of said surface are brought into contact with an ionic liquid matrix containing at least one reactive molecule, as it is known, that carries at least one reactive function, under conditions that are suitable for the creation of a covalent bond between said reactive function of the molecule and a hydroxyl function of said surface.
摘要翻译：本发明涉及一种可用于包含至少一个羟基官能团的基材的表面官能化的方法，其中所述表面的一个或多个点区域与含有至少一个反应性分子的离子液体基质接触，作为在适于在所述分子的反应性功能和所述表面的羟基官能团之间产生共价键的条件下，已知其具有至少一个反应性官能团。

3. 发明授权

US08192980B2 Microreactor, process for the preparation thereof, and process for carrying out a biochemical or biological reaction 有权
标题翻译：微反应器，其制备方法以及进行生物化学或生物反应的方法
公开(公告)号：US08192980B2
公开(公告)日：2012-06-05
申请号：US10514066
申请日：2003-05-16
申请人： Philippe Combette , Olivier Constantin , Françoise Vinet , Gilles Marchand
发明人： Philippe Combette , Olivier Constantin , Françoise Vinet , Gilles Marchand
IPC分类号： C12M1/34 , C12M3/00
CPC分类号： B01J19/0093 , B01J2219/00783 , B01J2219/00828 , B01J2219/00889 , B01L3/5027 , B01L2200/12 , B01L2300/0636 , B01L2300/0864 , B01L2400/049 , G01N30/6095
摘要： A microreactor is shown having an inlet or feed channel, an inlet or feed zone for a flow of fluid, a reaction zone, an outlet zone and an outlet or evacuation channel, the zones and channels being in fluid communication, and at least one compound such as an enzyme capable of producing a biological or biochemical reaction with at least one constituent of the flow of fluid, the compound being attached to the surfaces of the inlet zone, reaction zone, and outlet zone.
摘要翻译：示出了微反应器具有入口或进料通道，用于流体流动的入口或进料区域，反应区域，出口区域和出口或排出通道，所述区域和通道是流体连通的，以及至少一种化合物例如能够与流体流动的至少一种成分产生生物或生物化学反应的酶，所述化合物附着到入口区域，反应区域和出口区域的表面。

4. 发明申请

US20070207055A1 Operating Device Comprising A Localized Zone For The Capture Of A Drop A Liquid Of Interest 审中-公开
标题翻译：操作装置包含一个本地化区域，用于捕获一滴液体
公开(公告)号：US20070207055A1
公开(公告)日：2007-09-06
申请号：US10576345
申请日：2003-10-21
申请人： Gilles Marchand , Cyril Delattre , Patrick Pouteau , Patrice Caillat
发明人： Gilles Marchand , Cyril Delattre , Patrick Pouteau , Patrice Caillat
IPC分类号： G01N21/00
CPC分类号： B01L3/502792 , B01J2219/00317 , B01J2219/00527 , B01J2219/00596 , B01J2219/0065 , B01J2219/00653 , B01J2219/00722 , B01J2219/00725 , B01J2219/00743 , B01L3/502707 , B01L3/50273 , B01L3/5085 , B01L3/5088 , B01L2300/0636 , B01L2300/0645 , B01L2300/0816 , B01L2300/0819 , B01L2300/0877 , B01L2300/089 , B01L2400/0487 , C40B40/06 , C40B40/10 , C40B60/14
摘要： The present invention relates to an operating device characterized in that it comprises an active surface that is substantially non-wetting with respect to a liquid of interest; at least one zone for the localized capture of a drop of said liquid formed on said active surface; at least one operating zone arranged with a capture zone in such a way that the operating zone is at least partially covered by the drop of the liquid when said drop is captured by said capture zone; and means for leaving a drop of said liquid on said capture zone. This device makes it possible in particular to form high-density arrays of drops of said liquid on a surface, with the aim in particular of carrying out chemical and/or biochemical reactions and/or of analysing the liquid of interest in each drop. It finds, for example, an application in biological chips.
摘要翻译：本发明涉及一种操作装置，其特征在于其包括相对于感兴趣的液体基本上不润湿的活性表面; 用于局部捕获形成在所述活性表面上的一滴所述液体的至少一个区域; 所述至少一个操作区域布置有捕获区域，使得当所述液滴被所述捕获区域捕获时，所述操作区域至少部分地被所述液滴所覆盖; 以及用于在所述捕获区上留下一滴所述液体的装置。该装置特别可以在表面上形成所述液体的高密度液滴阵列，其目的是特别是进行化学和/或生物化学反应和/或分析每一滴中感兴趣的液体。例如，它发现生物芯片中的应用。

5. 发明申请

US20060051858A1 Microreactor, method for preparing same, and method for producing a biochemical or biological reaction 有权
标题翻译：微反应器，其制备方法以及生物化学或生物反应的生产方法
公开(公告)号：US20060051858A1
公开(公告)日：2006-03-09
申请号：US10514066
申请日：2003-05-16
申请人： Philippe Combette , Olivier Constantin , Francoise Vinet , Gilles Marchand
发明人： Philippe Combette , Olivier Constantin , Francoise Vinet , Gilles Marchand
IPC分类号： C12M1/14 , B01J19/00
CPC分类号： B01J19/0093 , B01J2219/00783 , B01J2219/00828 , B01J2219/00889 , B01L3/5027 , B01L2200/12 , B01L2300/0636 , B01L2300/0864 , B01L2400/049 , G01N30/6095
摘要： Microreactor comprising an inlet or feed channel, an inlet or feed zone (1) for a flow of fluid, a reaction zone (2), an outlet zone (3) and an outlet or evacuation channel, said zones (1, 2, 3) and channels (46, 48) being in fluid communication, and at least one compound such as an enzyme capable of producing a biological or biochemical reaction with at least one constituent of said flow of fluid, said compound being attached to the surfaces of said inlet zone (1), reaction zone (2), and outlet zone (3).
摘要翻译：微反应器包括入口或进料通道，用于流体流动的入口或进料区（1），反应区（2），出口区（3）和出口或抽空通道，所述区（1,2,3））和通道（46,48）处于流体连通，以及至少一种化合物，例如能够与所述流体流的至少一种成分产生生物或生物化学反应的酶，所述化合物附着到所述入口区（1），反应区（2）和出口区（3）。

6. 发明授权

US08864967B2 Device for moving and treating volumes of liquid 有权
标题翻译：用于移动和处理液体体积的装置
公开(公告)号：US08864967B2
公开(公告)日：2014-10-21
申请号：US11631389
申请日：2005-06-30
申请人： Gilles Marchand , Yves Fouillet , Philippe Clementz
发明人： Gilles Marchand , Yves Fouillet , Philippe Clementz
IPC分类号： B01D59/42 , F04B19/00 , B01L3/00
CPC分类号： B01L3/502792 , B01L3/5025 , B01L2300/0645 , B01L2300/0816 , B01L2300/089 , B01L2300/165 , B01L2300/1816 , B01L2300/1827 , B01L2400/0427 , F04B19/006 , Y10T137/206 , Y10T137/2185
摘要： A device for displacing a small volume of liquid under the effect of an electric control, including a first substrate with a hydrophobic surface provided with a first electrical conductor, a second electrical conductor positioned facing the first conductor, and a third conductor, forming with the second conductor, a mechanism for analyzing or heating a volume of liquid.
摘要翻译：一种用于在电控制的作用下移动小体积的液体的装置，包括具有设置有第一电导体的疏水表面的第一基板，面对第一导体的第二电导体和与第一导体成形的第三导体第二导体，用于分析或加热一定体积的液体的机构。

7. 发明授权

US08758576B2 Device and methods for coupling/uncoupling a target or an object present in a sample 失效
标题翻译：用于耦合/解耦样品中存在的目标或物体的装置和方法
公开(公告)号：US08758576B2
公开(公告)日：2014-06-24
申请号：US10555099
申请日：2004-05-17
申请人： Celine Escoffier , Gilles Marchand , Frederic Revol-Cavalier , Francoise Vinet
发明人： Celine Escoffier , Gilles Marchand , Frederic Revol-Cavalier , Francoise Vinet
IPC分类号： C25D17/00
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00497 , B01J2219/00527 , B01J2219/00574 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/0063 , B01J2219/00635 , B01J2219/00637 , B01J2219/00677 , B01J2219/00713 , B01J2219/00722 , B01J2219/00725 , B01J2219/0074 , B01J2219/00743 , C12Q1/6825 , C40B40/06 , C40B40/10 , G01N33/5438 , C12Q2527/119
摘要： The device of the invention comprises a support having a surface comprising an attachment zone (Z) capable of being functionalized with a probe (A) capable of binding, according to the pH and reversibly, to a target (B) so as to attach it; a working electrode (WE) and a counterelectrode (CE) for this working electrode, arranged on the support in the vicinity of the attachment zone; and means for applying a given electric current or a given potential to said working electrode so as to cause, when said attachment zone and said electrodes are immersed in an aqueous solution, a local variation in pH in the region of said attachment zone.The method for attaching and/or detaching a target or an object according to the invention uses this device, the attachment and/or the detachment being electrochemically controlled with the working electrode.
摘要翻译：本发明的装置包括具有表面的支撑体，该表面包括能够用能够根据pH并可逆地结合到目标物（B）的探针（A）进行功能化的附着区域（Z），以便附着 ; 用于该工作电极的工作电极（WE）和反电极（CE），布置在安装区附近的支撑件上; 以及用于将给定电流或给定电位施加到所述工作电极的装置，以便当所述附着区域和所述电极浸入水溶液中时，在所述附着区域的区域中导致pH的局部变化。根据本发明的用于附接和/或拆卸目标或物体的方法使用该装置，附接和/或拆卸由工作电极进行电化学控制。

8. 发明授权

US08298399B2 Method, device and system for the microanalysis of ions 失效
标题翻译：用于离子微量分析的方法，装置和系统
公开(公告)号：US08298399B2
公开(公告)日：2012-10-30
申请号：US12302947
申请日：2007-05-24
申请人： Gilles Marchand
发明人： Gilles Marchand
IPC分类号： G01N27/49
CPC分类号： G01N33/1813 , G01N27/48 , G01N33/182
摘要： A method of microanalyzing ions, which includes: placing in a cavity having an internal volume, a volume of an ionic liquid that is smaller than the internal volume; placing in the cavity a solution containing the ions that are to be analyzed, a solvent of the solution and the ionic liquid being selected so as to be immiscible and so as to enable the ions to be transferred from the solution to the ionic liquid; and detecting a presence of the ions in the ionic liquid with an analyzer that analyzes at least one of cations or anions of the ions in the ionic liquid, in a free state or in a complexed state, the analyzer being in contact with the ionic liquid.
摘要翻译：一种微量分析离子的方法，其包括：将具有内部体积的空腔放置成小于内部体积的体积的离子液体; 将包含要分析的离子的溶液置于空腔中，溶液和离子液体的溶剂被选择为不混溶，以使离子能够从溶液转移到离子液体中; 并且利用分析仪检测离子液体中离子的存在，所述分析仪分析离子液体中的离子的阳离子或阴离子中的至少一种，处于游离状态或复合状态，分析仪与离子液体接触。

9. 发明申请

US20120171682A1 METHOD FOR DETECTING, IDENTIFYING AND/OR QUANTIFYING CARBON NANOTUBES 审中-公开
标题翻译：检测，鉴定和/或定量碳纳米管的方法
公开(公告)号：US20120171682A1
公开(公告)日：2012-07-05
申请号：US13255387
申请日：2010-03-08
申请人： Gilles Marchand , Dorothee Jary , Pierre Puget , Francois Tardif
发明人： Gilles Marchand , Dorothee Jary , Pierre Puget , Francois Tardif
IPC分类号： C12Q1/68 , B82Y35/00
CPC分类号： C12Q1/6844 , C12Q2563/185 , C12Q2563/155
摘要： The present invention relates to a method and a kit for detecting, optionally identifying and optionally quantifying at least one carbon nanotube possibly included in a sample, including the steps consisting in: (a) subjecting said sample to conditions enabling the amplification of a nucleotide sequence using primers capable of amplifying said nucleotide sequence, the possibly included carbon nanotube having been functionalized by said nucleotide sequence prior to step (a), and (b) detecting, optionally identifying and optionally quantifying the amplification product possibly obtained after step (a).
摘要翻译：本发明涉及用于检测任选地鉴定和任选定量可能包含在样品中的至少一种碳纳米管的方法和试剂盒，其包括以下步骤：（a）使所述样品经受能够扩增核苷酸序列的条件使用能够扩增所述核苷酸序列的引物，可能包括的在步骤（a）之前由所述核苷酸序列官能化的碳纳米管，和（b）检测任选地鉴定和任选定量可能在步骤（a）之后获得的扩增产物。

10. 发明申请

US20110033996A1 METHOD FOR PRODUCING A CONDUCTIVE NANOPARTICLE MEMORY DEVICE 失效
标题翻译：制造导电纳米材料存储器件的方法
公开(公告)号：US20110033996A1
公开(公告)日：2011-02-10
申请号：US12727593
申请日：2010-03-19
申请人： Simon DELEONIBUS , Jean-Marie Basset , Paul Campbell , Thibaut Gutel , Paul-Henri Haumesser , Gilles Marchand , Catherine Santini
发明人： Simon DELEONIBUS , Jean-Marie Basset , Paul Campbell , Thibaut Gutel , Paul-Henri Haumesser , Gilles Marchand , Catherine Santini
IPC分类号： H01L21/336 , B82Y30/00
CPC分类号： H01L29/66833 , B82Y10/00 , B82Y40/00 , H01L21/28273 , H01L27/11563 , H01L29/42332 , H01L29/513 , H01L29/66545 , H01L29/66825 , H01L29/7881 , Y10S977/773
摘要： A method for producing a memory device with nanoparticles, comprising the steps of: a) forming, in a semi-conductor substrate, source and drain regions, and at least one first dielectric on a zone of the substrate arranged between the source and drain regions and intended to form a channel of the memory device, b) deposition of an ionic liquid, comprising nanoparticles of an electrically conductive material in suspension, covering the first dielectric, c) formation of a deposition of nanoparticles on the first dielectric, d) removal of the remaining ionic liquid, e) forming a second dielectric and a control gate on at least one part of the deposition of nanoparticles.
摘要翻译：一种制备具有纳米颗粒的存储器件的方法，包括以下步骤：a）在半导体衬底中形成源极和漏极区域，以及在衬底上的至少一个第一电介质，所述第一电介质布置在源极和漏极区域之间并且旨在形成存储器件的通道，b）沉积离子液体，其包含悬浮液中的导电材料的纳米颗粒，覆盖第一电介质，c）在第一电介质上形成纳米颗粒的沉积，d）去除的剩余离子液体，e）在纳米颗粒沉积的至少一部分上形成第二电介质和控制栅极。

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