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1. 发明申请

US20090184001A1 Sensor Apparatus for an Electrochemical Measuring Device and Method for Carrying Out Electrochemical Measurements 有权
标题翻译：用于电化学测量装置的传感器装置和用于进行电化学测量的方法
公开(公告)号：US20090184001A1
公开(公告)日：2009-07-23
申请号：US12278672
申请日：2007-02-06
申请人： Gerd-Uwe Flechsig , Jan Gimsa , Peter Gründler , Harald Grabow
发明人： Gerd-Uwe Flechsig , Jan Gimsa , Peter Gründler , Harald Grabow
IPC分类号： G01N27/26
CPC分类号： G01N27/286 , G01N27/3275
摘要： A sensor apparatus for an electrochemical measuring device. The apparatus has at least one electrode, which can be heated using a heating current in the form of an alternating current, and a first and a second connection for the supply line for the heating current. The electrochemical measuring device is connected to the electrode by a third connection. In this case, the apparatus has the third connection connected to the electrode by a bridge circuit, which is also connected to the first and second connections. There also is provided a method for carrying out electrochemical measurements at elevated temperature. The sensor apparatus and the method for carrying out electrochemical measurements enable electrochemical measurements with little interference and directly heated electrodes in conjunction with a simplified design of the electrodes.
摘要翻译：一种用于电化学测量装置的传感器装置。该装置具有至少一个电极，其可以使用交流电形式的加热电流加热，以及用于加热电流的供应管线的第一和第二连接。电化学测量装置通过第三连接连接到电极。在这种情况下，该装置具有通过桥接电路连接到电极的第三连接，桥接电路也连接到第一和第二连接。还提供了一种用于在升高的温度下进行电化学测量的方法。用于进行电化学测量的传感器装置和方法使电化学测量具有很少的干扰和直接加热的电极以及电极的简化设计。

2. 发明授权

US09823215B2 Electrochemical sensor 有权
公开(公告)号：US09823215B2
公开(公告)日：2017-11-21
申请号：US14236997
申请日：2012-08-01
申请人： Gerd-Uwe Flechsig , Anne Walter , Martin Jacobsen
发明人： Gerd-Uwe Flechsig , Anne Walter , Martin Jacobsen
IPC分类号： G01N27/327
CPC分类号： G01N27/3275 , G01N27/3276
摘要： This invention relates to an electrochemical sensor (1), comprising a base element (3), which is made of electrically insulating material and has a planar surface (9), and a pair of conductors (5), which are attached to said planar surface (9) of the base element (3), wherein the two conductors (5) of the pair are connected by at least one wire-shaped electrochemical working electrode (7). The invention further related to a sensor array (21), which has several previously described sensors (1), and to a method for coating a working electrode (7) of the previously described sensor (1).

3. 发明授权

US08216446B1 Method for labelling and analysing nucleic acids 有权
标题翻译：标记和分析核酸的方法
公开(公告)号：US08216446B1
公开(公告)日：2012-07-10
申请号：US11990666
申请日：2006-08-17
申请人： Gerd-Uwe Flechsig , Thomas Reske
发明人： Gerd-Uwe Flechsig , Thomas Reske
IPC分类号： C12Q1/68 , G01N27/327
CPC分类号： C12Q1/6837 , C12Q1/6825 , C12Q2563/113 , C12Q2525/204
摘要： The invention relates to a method of labelling and analysing nucleic acids. More specifically, the invention relates to a method of analysing nucleic acids, which comprises contacting the nucleic acids to be detected, which are in the form of single-stranded nucleic acid strands partially (i.e. over a part of the total length of the nucleic acid strands) hybridized with protective strands, with substances which specifically react with nucleobases of the single-stranded sections of the nucleic acid strands, and which are capable of subsequently participating in a reversible redox reaction in electroanalytical processes known to the skilled worker.
摘要翻译：本发明涉及一种标记和分析核酸的方法。更具体地，本发明涉及一种分析核酸的方法，其包括将待检测的核酸部分地（即在核酸的总长度的一部分上）处于单链核酸链的形式与保护性链相互杂交的物质，其与与核酸链的单链切片的核碱基特异性反应的物质，并且能够随后在本技术人员已知的电分析过程中参与可逆的氧化还原反应。

4. 发明申请

US20080269066A1 Method and Array for the Replication and Analysis of Nucleic Acids 有权
标题翻译：用于复制和分析核酸的方法和阵列
公开(公告)号：US20080269066A1
公开(公告)日：2008-10-30
申请号：US11884066
申请日：2006-02-10
申请人： Gerd-Uwe Flechsig , Joerg Peter
发明人： Gerd-Uwe Flechsig , Joerg Peter
IPC分类号： C40B30/04 , C40B60/12
CPC分类号： C12Q1/6837
摘要： The invention includes a method and array for replicating and analyzing one or a plurality of different target sequences in nucleic acid samples. The different reactions for replicating the target sequences occur simultaneously on an array with selectively heatable array elements with their reaction surfaces, some of which have been modified differently, and in the sample solution disposed thereabove. The target sequences are analyzed using molecular detection on reaction surfaces of said array that have been modified with probe strands. The target strands are replicated and analyzed simultaneously, successively, or alternately.
摘要翻译：本发明包括用于复制和分析核酸样品中一种或多种不同靶序列的方法和阵列。用于复制靶序列的不同反应同时存在于具有选择性可加热的阵列元件的阵列上，其反应表面，其中一些已经被不同地修改，并且在设置在其上的样品溶液中。使用已经用探针链修饰的所述阵列的反应表面上的分子检测分析靶序列。目标链被同时，连续地或交替地复制和分析。

5. 发明授权

US08211291B2 Sensor apparatus for an electrochemical measuring device and method for carrying out electrochemical measurements 有权
标题翻译：用于电化学测量装置的传感器装置和用于进行电化学测量的方法
公开(公告)号：US08211291B2
公开(公告)日：2012-07-03
申请号：US12278672
申请日：2007-02-06
申请人： Gerd-Uwe Flechsig , Jan Gimsa , Peter Gründler , Harald Grabow
发明人： Gerd-Uwe Flechsig , Jan Gimsa , Peter Gründler , Harald Grabow
IPC分类号： G01F1/64 , G01N17/00 , G01N27/26
CPC分类号： G01N27/286 , G01N27/3275
摘要： A sensor apparatus for an electrochemical measuring device. The apparatus has at least one electrode, which can be heated using a heating current in the form of an alternating current, and a first and a second connection for the supply line for the heating current. The electrochemical measuring device is connected to the electrode by a third connection. In this case, the apparatus has the third connection connected to the electrode by a bridge circuit, which is also connected to the first and second connections. There also is provided a method for carrying out electrochemical measurements at elevated temperature. The sensor apparatus and the method for carrying out electrochemical measurements enable electrochemical measurements with little interference and directly heated electrodes in conjunction with a simplified design of the electrodes.
摘要翻译：一种用于电化学测量装置的传感器装置。该装置具有至少一个电极，其可以使用交流电形式的加热电流加热，以及用于加热电流的供应管线的第一和第二连接。电化学测量装置通过第三连接连接到电极。在这种情况下，该装置具有通过桥接电路连接到电极的第三连接，桥接电路也连接到第一和第二连接。还提供了一种用于在升高的温度下进行电化学测量的方法。用于进行电化学测量的传感器装置和方法使得电化学测量具有很少的干扰和直接加热的电极以及电极的简化设计。

6. 发明授权

US09273348B2 Method and array for the replication and analysis of nucleic acids 有权
标题翻译：用于核酸复制和分析的方法和阵列
公开(公告)号：US09273348B2
公开(公告)日：2016-03-01
申请号：US11884066
申请日：2006-02-10
申请人： Gerd-Uwe Flechsig , Joerg Peter
发明人： Gerd-Uwe Flechsig , Joerg Peter
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6837
摘要： The invention includes a method and array for replicating and analyzing one or a plurality of different target sequences in nucleic acid samples. The different reactions for replicating the target sequences occur simultaneously on an array with selectively heatable array elements with their reaction surfaces, some of which have been modified differently, and in the sample solution disposed thereabove. The target sequences are analyzed using molecular detection on reaction surfaces of said array that have been modified with probe strands. The target strands are replicated and analyzed simultaneously, successively, or alternately.
摘要翻译：本发明包括用于复制和分析核酸样品中一种或多种不同靶序列的方法和阵列。用于复制靶序列的不同反应同时存在于具有选择性可加热的阵列元件的阵列上，其反应表面，其中一些已经被不同地修改，并且在设置在其上的样品溶液中。使用已经用探针链修饰的所述阵列的反应表面上的分子检测分析靶序列。目标链被同时，连续地或交替地复制和分析。

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