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1. 发明授权

US4918025A Self contained immunoassay element 失效
标题翻译：自含免疫测定元素
公开(公告)号：US4918025A
公开(公告)日：1990-04-17
申请号：US21136
申请日：1987-03-03
申请人： Gerd Grenner
发明人： Gerd Grenner
IPC分类号： G01N33/543 , B01L3/00 , G01N33/52 , G01N33/53
CPC分类号： B01L3/50273 , B01L3/5027 , G01N33/528 , G01N33/5302 , B01L2200/0605 , B01L2300/0681 , B01L2300/069 , B01L2300/0816 , B01L2400/0406 , B01L2400/0481 , B01L3/502715 , Y10S436/807
摘要： An element for analysis of a liquid sample including a capillary containing a fixed reagent in fluid communication with reagent reservoirs and a waste liquid reservoir. A sample introducing means is provided which permits analyte in a sample to interact with the fixed reagent. A labelled reagent is provided which interacts with either the fixed reagent or the analyte in a manner which permits detection of the concentration of analyte in the sample. The capillary, reagent reservoirs, waste liquid reservoir and the sample introducing means are arranged within a common housing so that reagent waste liquid need not be removed from the element.

2. 发明授权

US4906439A Biological diagnostic device and method of use 失效
标题翻译：生物诊断装置及使用方法
公开(公告)号：US4906439A
公开(公告)日：1990-03-06
申请号：US133071
申请日：1987-12-21
申请人： Gerd Grenner
发明人： Gerd Grenner
IPC分类号： G01N33/52 , G01N33/53 , G01N33/543 , G01N33/552
CPC分类号： B01L3/502707 , B01L3/50273 , G01N33/525 , G01N33/5302 , G01N33/54386 , G01N33/552 , Y10S435/805 , Y10T436/25125 , Y10T436/25375 , Y10T436/2575
摘要： A biological diagnostic device and process for efficiently and accurately analyzing a sample of a biological fluid for in analyte of interest. The device, which is a preferred embodiment utilized for the analysis of whole blood samples, comprises a diagnostic test element and a sample application unit comprising a fluid delivery element and means for providing sample fluid to the fluid delivery element. The fluid delivery element comprises a layer having a plurality of grooves, or channels, in the surface thereof which is adjacent the test element. The fluid which is provided to the grooves is subsequently delivered to the test element.
摘要翻译：一种用于有效和准确地分析感兴趣的分析物中生物流体样品的生物诊断装置和方法。用于分析全血样品的优选实施方案的装置包括诊断测试元件和包括流体输送元件的样品施用单元和用于将样品流体提供给流体输送元件的装置。流体输送元件包括在其与测试元件相邻的表面中具有多个凹槽或通道的层。随后将提供给凹槽的流体输送到测试元件。

3. 发明授权

US5147609A Assay element 失效
标题翻译：测量元件
公开(公告)号：US5147609A
公开(公告)日：1992-09-15
申请号：US354026
申请日：1989-05-19
申请人： Gerd Grenner
发明人： Gerd Grenner
IPC分类号： B01L99/00 , B01L3/00 , G01N33/543 , G01N37/00
CPC分类号： B01L3/5023 , G01N33/54366 , B01L2200/027 , B01L2300/0825 , B01L2400/0406 , Y10S435/97 , Y10S436/808
摘要： There is described an assay element suitable for use in an automated analytical test instrument for assaying a fluid sample. The element includes a thin porous member possessing a high degree of capillarity such as a fibrous mesh pad supported within a guide defined by surfaces contiguous the porous member. The dimensions of the porous member and its degree of capillarity are such as to provide for capillary transport of fluid through the member. A fluid dispenser and a fluid collecting chamber are disposed contiguous to opposed ends of the porous member. The fluid dispenser is formed as a well with a port at the bottom of the well, the port being contiguous the porous member and having a ridge extending along a perimeter of the port. The ridge protrudes into the porous member a distance sufficient for entraining fluid present in the well to propagate within the member rather than along an interface between a surface of the member and guide surfaces which hold it in place. Reservoirs may also be provided in the housing for storing reagents, mixing fluids and diluting samples so as to provide a self contained assay element. Optionally, and preferably, there may be an opening in the housing to provide fluid access directly to the central area of the porous member.
摘要翻译：描述了适合用于测定流体样品的自动分析测试仪器中的测定元件。元件包括具有高毛细管度的薄多孔构件，例如支撑在由邻近多孔构件的表面限定的引导件内的纤维网垫。多孔构件的尺寸和毛细管的程度是为了提供流体通过构件的毛细管输送。流体分配器和流体收集室设置成与多孔构件的相对端邻接。流体分配器形成为具有在井的底部的端口的井，该端口邻接多孔构件并且具有沿着端口的周边延伸的脊。脊突出到多孔构件中足以使存在于井中的流体夹带在构件内传播的距离，而不是沿着构件的表面和将其保持在适当位置的引导表面之间的界面。还可以在壳体中设置储存器以存储试剂，混合流体和稀释样品，以提供自包含的测定元件。可选地，并且优选地，壳体中可以具有开口以提供流体直接通向多孔构件的中心区域。

4. 再颁专利

USRE38688E1 Sheet-like diagnostic device 有权
标题翻译：片状诊断装置
公开(公告)号：USRE38688E1
公开(公告)日：2005-01-18
申请号：US09820974
申请日：2001-03-30
申请人： Heinz-Jürgen Friesen , Gerd Grenner , Hans-Erwin Pauly , Helmut Kohl , Klaus Habenstein , Joseph Stärk
发明人： Heinz-Jürgen Friesen , Gerd Grenner , Hans-Erwin Pauly , Helmut Kohl , Klaus Habenstein , Joseph Stärk
IPC分类号： A61K39/00 , C12Q1/00 , G01N33/52 , G01N33/543 , G01N33/558
CPC分类号： G01N33/521 , G01N33/525 , G01N33/54366 , G01N33/558 , Y10S435/805 , Y10S435/81 , Y10S435/962 , Y10S435/97 , Y10S436/81
摘要： A solid diagnostic device for the quantitative determination of substances of biological affinity in biological fluids is described. A process is also described in which the biological fluid is brought into contact with a specific functional sector of the device, the fluid migrates through several functional sectors situated beside one another and containing suitable reagent components, and one or more substances of biological affinity are detected in such functional sectors which contain, for each substance to be detected, at least one combination partner of biological affinity, attached to a solid phase.

5. 再颁专利

USRE37437E1 Sheet-like diagnostic device 失效
标题翻译：片状诊断装置
公开(公告)号：USRE37437E1
公开(公告)日：2001-11-06
申请号：US08544579
申请日：1995-10-18
申请人： Heinz-Jürgen Friesen , Gerd Grenner , Hans-Erwin Pauly , Helmut Kohl , Klaus Habenstein , Joseph Stärk
发明人： Heinz-Jürgen Friesen , Gerd Grenner , Hans-Erwin Pauly , Helmut Kohl , Klaus Habenstein , Joseph Stärk
IPC分类号： G01N33558
CPC分类号： G01N33/521 , G01N33/525 , G01N33/54366 , G01N33/558 , Y10S435/805 , Y10S435/81 , Y10S435/962 , Y10S435/97 , Y10S436/81
摘要： A solid diagnostic device for the quantitative determination of substances of biological affinity in biological fluids is described. A process is also described in which the biological fluid is brought into contact with a specific functional sector of the device, the fluid migrates through several functional sectors situated beside one another and containing suitable reagent components, and one or more substances of biological affinity are detected in such functional sectors which contain, for each substance to be detected, at least one combination partner of biological affinity, attached to a solid phase.
摘要翻译：描述了用于定量测定生物流体中生物亲和力物质的固体诊断装置。还描述了一种方法，其中使生物流体与装置的特定功能部分接触，流体通过位于彼此旁边并包含合适的试剂组分的几个功能部分迁移，并且检测到一种或多种生物亲和力的物质在这样的功能部门中，对于每种待检测的物质，其包含附着于固相的至少一种生物亲和力的组合配偶体。

6. 发明授权

US5336621A Divalent hapten derivatives 失效
标题翻译：二价半抗原衍生物
公开(公告)号：US5336621A
公开(公告)日：1994-08-09
申请号：US211940
申请日：1988-06-27
申请人： Kathleen J. Primes , Gerald F. Sigler , Gerd Grenner , Wolfgang Kapmeyer
发明人： Kathleen J. Primes , Gerald F. Sigler , Gerd Grenner , Wolfgang Kapmeyer
IPC分类号： G01N33/531 , G01N33/543 , G01N33/78 , G01N33/94 , G01N33/546
CPC分类号： G01N33/531 , G01N33/536 , G01N33/543 , G01N33/54313 , G01N33/78 , G01N33/94 , Y10S436/815 , Y10S436/816 , Y10S436/822 , Y10S436/823
摘要： Divalent hapten derivatives wherein two hapten moieties are connected by means of a bifunctional spacer wherein the derivative has the formulaA--X--Awhere A is a bonded hapten moiety and X is a bifunctional spacer having the formula(B).sub.m --Y--(CH.sub.2).sub.n --Z--(CH.sub.2).sub.n --Y--(B).sub.mwhere m is independently 0 or 1, B is (CH.sub.2).sub.n', wherein n' is an integer from 1 to 4, or CO(CH.sub.2).sub.n", wherein n" is an integer from 2 or 4; Y is independently --CONH--, --NHCO--, --OOC, --COO--, --O--, --S--, or --NR--, wherein R is hydrogen or alkyl; n is an integer from 1 to 10; and Z is an organic moiety containing at least one hydrophilic atom, useful for the determination of haptens by immunochemical techniques are disclosed.
摘要翻译：二价半抗原衍生物，其中两个半抗原部分通过双官能间隔基连接，其中衍生物具有式AXA，其中A是键合半抗原部分，X是具有式（B）的双官能间隔基mY-（CH2）nZ-（CH2 ）nY-（B）m其中m独立地为0或1，B为（CH 2）n'，其中n'为1至4的整数，或CO（CH 2）n“，其中n”为整数从2或4; Y独立地为-CONH-，-NHCO-，-OOC，-COO - ， - O - ， - S - 或-NR-，其中R为氢或烷基; n是1至10的整数; 并且Z是含有至少一个亲水性原子的有机部分，其用于通过免疫化学技术测定半抗原。

7. 发明授权

US5051237A Liquid transport system 失效
标题翻译：液体输送系统
公开(公告)号：US5051237A
公开(公告)日：1991-09-24
申请号：US210732
申请日：1988-06-23
申请人： Gerd Grenner , Shai Inbar , Ernest W. Long
发明人： Gerd Grenner , Shai Inbar , Ernest W. Long
IPC分类号： G01N33/49 , B01L3/00 , G01N1/00 , G01N1/12 , G01N33/52 , G01N33/543 , G01N33/58
CPC分类号： G01N33/525 , B01L3/502746 , B01L2300/0816 , B01L2300/089 , B01L2400/0406 , B01L2400/0688 , B01L2400/086
摘要： A liquid transport system provides controlled flow of liquid in a liquid flow zone between two surfaces wherein one surface includes a plurality of projections, or raised areas, arranged substantially throughout the surface in the liquid flow zone and an aperture for allowing the introduction of liquid between the two surfaces. In a preferred embodiment the projections on the first surface are arranged in parallel spaced rows and parallel spaced columns. The second surface may be one surface of a layer of a diagnostic assay element.

8. 发明授权

US4861711A Sheet-like diagnostic device 失效
标题翻译：片状诊断装置
公开(公告)号：US4861711A
公开(公告)日：1989-08-29
申请号：US808563
申请日：1985-12-13
申请人： Heinz-Jurgen Friesen , Gerd Grenner , Hans-Erwin Pauly , Helmut Kohl , Klaus Habenstein , Joseph Stark
发明人： Heinz-Jurgen Friesen , Gerd Grenner , Hans-Erwin Pauly , Helmut Kohl , Klaus Habenstein , Joseph Stark
IPC分类号： A61K39/00 , C12Q1/00 , G01N33/52 , G01N33/543 , G01N33/558
CPC分类号： G01N33/521 , G01N33/525 , G01N33/54366 , G01N33/558 , Y10S435/805 , Y10S435/81 , Y10S435/962 , Y10S435/97 , Y10S436/81
摘要： A solid diagnostic device for the quantitative determination of substances of biological affinity in biological fluids is described. A process is also described in which the biological fluid is brought into contact with a specific functional sector of the device, the fluid migrates through several functional sectors situated beside one another and containing suitable reagent components, and one or more substances of biological affinity are detected in such functional sectors which contain, for each substance to be detected, at least one combination partner of biological affinity, attached to a solid phase.
摘要翻译：描述了用于定量测定生物流体中生物亲和力物质的固体诊断装置。还描述了一种方法，其中使生物流体与装置的特定功能部分接触，流体通过位于彼此旁边并包含合适的试剂组分的几个功能部分迁移，并且检测到一种或多种生物亲和力的物质在这样的功能部门中，对于每种待检测的物质，其包含附着于固相的至少一种生物亲和力的组合配偶体。

9. 发明授权

US4760142A Divalent hapten derivatives 失效
标题翻译：二价半抗原衍生物
公开(公告)号：US4760142A
公开(公告)日：1988-07-26
申请号：US69747
申请日：1987-07-06
申请人： Kathleen J. Primes , Gerald F. Sigler , Gerd Grenner , Wolfgang Kapmeyer
发明人： Kathleen J. Primes , Gerald F. Sigler , Gerd Grenner , Wolfgang Kapmeyer
IPC分类号： G01N33/531 , G01N33/543 , G01N33/78 , G01N33/94 , C07D239/72
CPC分类号： G01N33/531 , G01N33/536 , G01N33/543 , G01N33/54313 , G01N33/78 , G01N33/94 , Y10S436/815 , Y10S436/816 , Y10S436/822 , Y10S436/823
摘要： Divalent hapten derivatives wherein two hapten moieties are connected by means of a bifunctional spacer wherein the derivative has the formulaA--X--Awhere A is a bonded hapten moiety and X is a bifunctional spacer having the formula(B).sub.m --Y--(CH.sub.2).sub.n --Z--(CH.sub.2).sub.n --Y--(B).sub.mwhere m is independently 0 or 1, B is (CH.sub.2).sub.n', wherein n' is an integer from 1 to 4, or CO(CH.sub.2).sub.n", wherein n" is an integer from 2 to 4; Y is independently --CONH--, NHCO--, OOC--, --COO--, --O--, --S--, or --NR--, wherein R is hydrogen or alkyl; n is an integer from 1 to 10; and Z is an organic moiety containing at least one hydrophilic atom are disclosed.
摘要翻译：二价半抗原衍生物，其中两个半抗原部分通过双官能间隔基连接，其中衍生物具有式AXA，其中A是键合半抗原部分，X是具有式（B）的双官能间隔基mY-（CH2）nZ-（CH2 ）nY-（B）m其中m独立地为0或1，B为（CH 2）n'，其中n'为1至4的整数，或CO（CH 2）n“，其中n”为整数从2到4; Y独立地是-CONH-，NHCO-，OOC-，-COO-，-O - ， - S - 或-NR-，其中R是氢或烷基; n是1至10的整数; 并且Z是含有至少一个亲水性原子的有机部分。

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