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1. 发明授权

US5391770A Process for preparing ascorbic acid 失效
标题翻译：抗坏血酸的制备方法
公开(公告)号：US5391770A
公开(公告)日：1995-02-21
申请号：US171988
申请日：1993-12-23
申请人： Isidore Le Fur , Jean-Paul Richard , Gerard Wolff
发明人： Isidore Le Fur , Jean-Paul Richard , Gerard Wolff
IPC分类号： C07D307/62
CPC分类号： C07D307/62
摘要： Process for preparing pure ascorbic acid from 2-keto-L-gulonic acid or its sodium salt, by carrying out the following successive steps:esterification of 2-keto-L-gulonic acid or its sodium saltlactonization to sodium ascorbateoptional separation of the sodium ascorbatedisplacement of the ascorbic acid from its saltseparation of the sodium sulphateseparation and purification of the ascorbic acid from its methanolic or aqueous-methanolic solution.
摘要翻译：通过进行以下连续步骤从2-酮-L-古洛糖酸或其钠盐制备纯抗坏血酸的方法：将2-酮-L-古洛糖酸或其钠盐内酯化酯化为抗坏血酸钠任选分离抗坏血酸钠从硫酸钠的盐分离中分离并从其甲醇或含水甲醇溶液中纯化抗坏血酸。

2. 发明授权

US4291032A Thiazolo(3,2-C)benzoxazine derivatives 失效
标题翻译：噻唑（3,2-C）苯并恶嗪衍生物
公开(公告)号：US4291032A
公开(公告)日：1981-09-22
申请号：US192988
申请日：1980-10-02
申请人： Christian Berger , Daniel Farge , Claude Moutonnier , Gerard Wolff
发明人： Christian Berger , Daniel Farge , Claude Moutonnier , Gerard Wolff
IPC分类号： A61K31/4188 , A61K31/535 , A61K31/5365 , A61P25/04 , A61P29/00 , C07D513/04
CPC分类号： C07D513/04
摘要： New thiazolo[3,2-c]-1,3-benzoxazine derivatives of the general formula (I), in which X is oxygen or sulfur, R.sub.1 and R.sub.2, which are identical or different, are hydrogen or halogen atoms or alkyl, alkoxy, alkylthio or trifluoromethyl radicals, in the 7-, 8-, 9- or 10-position, and R.sub.3 is a hydrogen atom or a carboxyl radical, their salts, if appropriate, their preparation and the medicaments in which they are present.These new derivatives are particularly useful as analgesic agents. ##STR1##
摘要翻译：其中X是氧或硫的通式（I）的新的噻唑并[3,2-c] -1,3-苯并恶嗪衍生物，相同或不同的R 1和R 2是氢或卤素原子或烷基，烷氧基，烷硫基或三氟甲基，在7-，8-，9-或10-位，R3是氢原子或羧基，它们的盐，如果合适，它们的制备和它们存在的药物。这些新衍生物作为止痛剂特别有用。（一）

3. 发明授权

US4178290A Dithiinoacetic acid and its preparation 失效
标题翻译：二硫乙酸及其制备方法
公开(公告)号：US4178290A
公开(公告)日：1979-12-11
申请号：US913088
申请日：1978-06-06
申请人： Christian Berger , Dominique Deprez , Daniel Farge , Claude Moutonnier , Gerard Wolff
发明人： Christian Berger , Dominique Deprez , Daniel Farge , Claude Moutonnier , Gerard Wolff
IPC分类号： C07D339/08 , C07D498/10 , C07D501/22
CPC分类号： C07D339/08
摘要： .alpha.-Amino(1,3-dithiin-5-yl)-acetic acid in the D-, L-, or D,L-form and in which the amino radical is free or protected by tert.-butoxycarbonyl or 2,2,2-trichloroethoxycarbonyl is a useful intermediate in the preparation of cephalosporins having valuable antibacterial activity.
摘要翻译： D-，L-或D，L-型的α-氨基（1,3-二噻吩-5-基） - 乙酸，其中氨基自由或被叔丁氧羰基或2,2 ，2-三氯乙氧基羰基是制备具有有价值的抗菌活性的头孢菌素的有用中间体。

4. 发明授权

US4849417A Acetylsalicylic acid derivative and pharmaceutical composition thereof 失效
标题翻译：乙酰水杨酸衍生物及其药物组合物
公开(公告)号：US4849417A
公开(公告)日：1989-07-18
申请号：US155057
申请日：1988-02-11
申请人： Claude Bertrand , Gerard Wolff
发明人： Claude Bertrand , Gerard Wolff
IPC分类号： A61K31/17 , A61K31/60 , A61P25/04 , A61P29/00 , C07C67/00 , C07C67/52 , C07C69/157 , C07C69/86 , C07C239/00 , C07C275/02
CPC分类号： C07C69/157
摘要： The hydrated complex of magnesium acetylsalicylate and urea of formula ##STR1## possesses exceptional analgesic and antipyretic properties. It may be crystallized from a solution obtained by reacting acetylsalicylic acid with magnesium carbonate in the presence of urea.
摘要翻译：乙酰水杨酸镁和式（Ⅰ）的脲水合物具有特殊的止痛和解热特性。可以在尿素存在下使乙酰水杨酸与碳酸镁反应得到的溶液结晶。

5. 发明授权

US4764637A Hydrated magnesium acetylsalicylate/urea complex preparation 失效
标题翻译：水合乙酰水杨酸镁/尿素复合物制剂
公开(公告)号：US4764637A
公开(公告)日：1988-08-16
申请号：US853434
申请日：1986-04-18
申请人： Claude Bertrand , Gerard Wolff
发明人： Claude Bertrand , Gerard Wolff
IPC分类号： A61K31/17 , A61K31/60 , A61P25/04 , A61P29/00 , C07C67/00 , C07C67/52 , C07C69/157 , C07C69/86 , C07C239/00 , C07C275/02
CPC分类号： C07C69/157
摘要： The hydrated complex of magnesium acetylsalicylate and urea of formula ##STR1## possesses exceptional analgesic and antipyretic properties. It may be crystallized from a solution obtained by reacting acetylsalicylic acid with magnesium carbonate in the presence of urea.
摘要翻译：乙酰水杨酸镁和式（Ⅰ）的脲水合物具有特殊的止痛和解热特性。可以在尿素存在下使乙酰水杨酸与碳酸镁反应得到的溶液结晶。

6. 发明授权

US4520193A Cephalosporin derivatives 失效
标题翻译：头孢菌素衍生物
公开(公告)号：US4520193A
公开(公告)日：1985-05-28
申请号：US322961
申请日：1981-11-19
申请人： Christian Berger , Daniel Farge , Claude Moutonnier , Gerard Wolff
发明人： Christian Berger , Daniel Farge , Claude Moutonnier , Gerard Wolff
IPC分类号： A61K31/545 , A61K31/546 , A61P31/04 , C07D501/20 , C07D501/24 , C07D501/38
CPC分类号： C07D501/24
摘要： The invention provides new cephalosporin derivatives of the general formula, ##STR1## which are in the form of a bicyclooct-2-ene or bicyclooct-3-ene, in which formula R.sub.1 is a radical of the general formula ##STR2## [in which R.sub.5 is hydrogen, alkyl, vinyl, cyanomethyl, protected carboxyalkyl or a protective radical and R.sub.6 is a protective radical] or an amino-protecting radical, R.sub.2 is an acid-protecting radical and R.degree. represents various organic radicals, or alternatively R.sub.1 is an amino-protecting radical or various acyl radicals, R.sub.2 is a protective radical and R.degree. represents various organic radicals, and R.sub.3 and R.sub.4 are alkyl radicals optionally substituted by alkoxy or dialkylamino, or phenyl radicals, or --NR.sub.3 R.sub.4 forms a heterocyclic ring. These products are intermediates for the synthesis of cephalosporins having antibacterial activity.
摘要翻译：本发明提供了通式为（IMA）（I）的新型头孢菌素衍生物，其为双环-2-烯或双环辛-3-烯的形式，其中式R1为通式为“IMAGE” （II）[其中R5为氢，烷基，乙烯基，氰基甲基，被保护的羧基烷基或保护基，R6为保护基]或氨基保护基，R2为酸保护基，R DEG为各种有机基团或者R 1为氨基保护基或各种酰基，R 2为保护基，R≠表示各种有机基团，R 3和R 4为任选被烷氧基或二烷基氨基取代的烷基或苯基或-NR 3 R 4形式杂环。这些产品是合成具有抗菌活性的头孢菌素的中间体。

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