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1. 发明授权

US5955293A Assays for shiga toxin and shiga-like toxins 失效
标题翻译：测定志贺毒素和志贺样毒素
公开(公告)号：US5955293A
公开(公告)日：1999-09-21
申请号：US243539
申请日：1994-05-16
申请人： Gerald T. Keusch , Arthur Donohue-Rolfe , David W. K. Acheson
发明人： Gerald T. Keusch , Arthur Donohue-Rolfe , David W. K. Acheson
IPC分类号： C07K16/12 , G01N33/569 , G01N33/53 , C07K16/00
CPC分类号： G01N33/56916 , C07K16/1228 , G01N2333/25 , Y10S435/975
摘要： The present invention relates to a substantially pure antigenic peptide or protein related to Shiga toxin, Shiga-like toxin I, Shiga-like toxin II or a variant of Shiga-like toxin II, and to a vaccine formulation containing such a peptide or protein useful in treating a disease associated with the toxin. Also disclosed is a method for treating a disorder associated with the expression of Shiga toxin or a Shiga-like toxin using an effective amounts of the P1 glycoprotein. Antibodies may be generated to Shiga-like toxin II of the present invention that cross-react with Shiga toxin and Shiga-like toxin I. Also disclosed are methods for removing Shiga toxin or a Shiga-like toxin from a sample such as a body fluid using the antibody or the P1 glycoprotein. Also provided are methods and kits for detecting disorders associated with the expression of Shiga toxins and Shiga-like toxins I and II involving the detection of the toxins.
摘要翻译：本发明涉及与志贺毒素，志贺样毒素I，志贺样毒素II或志贺样毒素II的变体相关的基本上纯的抗原肽或蛋白质，以及含有此类肽或蛋白质的疫苗制剂治疗与毒素相关的疾病。还公开了使用有效量的P1糖蛋白治疗与志贺毒素或志贺样毒素的表达相关的病症的方法。可以产生与志贺毒素和志贺样毒素I交叉反应的本发明的志贺样毒素II的抗体。还公开了从样品例如体液中除去志贺毒素或志贺样毒素的方法使用抗体或P1糖蛋白。还提供了用于检测与涉及检测毒素的志贺毒素和志贺样毒素I和II的表达相关的病症的方法和试剂盒。

2. 发明授权

US5204097A Shiga toxin B chain polypeptides and vaccine thereto 失效
标题翻译：志贺毒素B链多肽及其疫苗
公开(公告)号：US5204097A
公开(公告)日：1993-04-20
申请号：US364506
申请日：1989-06-09
申请人： Ruth Arnon , Ilana Harari , Gerald T. Keusch , Arthur Donohue-Rolfe
发明人： Ruth Arnon , Ilana Harari , Gerald T. Keusch , Arthur Donohue-Rolfe
IPC分类号： A61K39/00 , C07K14/25
CPC分类号： C07K14/25 , A61K39/00 , Y10S530/825
摘要： The invention relates to a number of synthetic polypeptides which correspond to a part of the sequences of the Shiga B peptide chain. More specifically, the invention relates to polypeptides corresponding to the residues 5 to 18, 7 to 26, 13 to 26, and 19 to 29 of said B chain. The invention further relates to the conjugates of each of these with a suitable carrier and to polymers of each or these obtained by polymerization with a suitable polymerization agent: these can be used as effective vaccines which afford protection against Shiga toxin. Anti-peptide anti-sera are effective in neutralizing to a large extent the biological activity of Shiga toxin.
摘要翻译：本发明涉及许多对应于志贺B肽链的一部分序列的合成多肽。更具体地，本发明涉及对应于所述B链的残基5至18,7至26,13至26和19至29的多肽。本发明还涉及其中每一种与合适的载体的缀合物以及通过与合适的聚合剂聚合获得的各种或这些聚合物的聚合物：它们可以用作提供针对志贺毒素的有效疫苗。抗肽抗血清在很大程度上有效地中和志贺毒素的生物活性。

3. 发明授权

US5800821A Bacterial spores as a heat stable vaccine delivery system 失效
标题翻译：细菌孢子作为热稳定的疫苗输送系统
公开(公告)号：US5800821A
公开(公告)日：1998-09-01
申请号：US402347
申请日：1995-03-10
申请人： David W. K. Acheson , Abraham L. Sonenshein , Gerald T. Keusch
发明人： David W. K. Acheson , Abraham L. Sonenshein , Gerald T. Keusch
IPC分类号： A61K39/00 , C07K14/24 , C07K14/245 , A61K39/02
CPC分类号： C07K14/24 , C07K14/245 , A61K39/00
摘要： A method of stimulating a vertebrate animal to produce an immune response to at least one antigen is described. The method includes genetically engineering a bacterial cell with DNA encoding at least one antigen and inducing the bacterial cell to sporulate, then orally administering the bacterial spores to an animal. The bacterial spores germinate in the gastrointestinal tract of the animal and express the antigen so that it comes into contact with the animal's immune system and elicits an immune response.
摘要翻译：描述了刺激脊椎动物以产生对至少一种抗原的免疫应答的方法。该方法包括用编码至少一种抗原的DNA将细菌细胞遗传工程化，诱导细菌细胞进行孢子形成，然后将细菌孢子口服给动物。细菌孢子在动物的胃肠道中发芽，并表达抗原，使其与动物的免疫系统接触并引发免疫应答。

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