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1. 发明申请

US20070168001A1 Remotely RF powered conformable thermal applicators 有权
标题翻译：远程射频功率一致的热敷设器
公开(公告)号：US20070168001A1
公开(公告)日：2007-07-19
申请号：US11601083
申请日：2006-11-16
申请人： Xiao-Dong Xiang , Gang Wang , Haitao Yang , Jonathan Melman , Gerald Dionne
发明人： Xiao-Dong Xiang , Gang Wang , Haitao Yang , Jonathan Melman , Gerald Dionne
IPC分类号： A61F2/00
CPC分类号： A61N1/406 , A61K41/0052 , A61K49/1818
摘要： Embodiments of the present invention are generally related to apparatus and methodology of thermal applicators in cancer therapy. In particular, the present embodiments are directed to a technique called “nanoparticle ferromagnetic resonance heating,” where ferromagnetic resonance heating in addition to an RF hyperthermia treatment is used to cause cell apoptosis and necrosis. An apparatus for carrying out a ferromagnetic resonance heating treatment of a tumor, comprises a volume concentration of super paramagnetic particles contained within the interior of the tumor, the concentration ranging from about 0.1 to about 1 percent; a magnetic field source configured to deliver a gradient DC magnetic field to the region of the tumor; and an energy source configured to deliver to the tumor an RF field at a frequency ranging from about 100 to 200 MHz. The apparatus of claim 1, wherein the super paramagnetic particles are selected from the group consisting of maghemite (γ-Fe2O3) based compounds, and yttrium iron garnet (Y3Fe5O12) based compounds.
摘要翻译：本发明的实施例通常涉及癌症治疗中的热敷装置的装置和方法。特别地，本实施例涉及一种称为“纳米颗粒铁磁共振加热”的技术，其中使用除RF热疗处理之外的铁磁共振加热以引起细胞凋亡和坏死。用于进行肿瘤的铁磁共振加热处理的装置包括包含在肿瘤内部的超顺磁性颗粒的体积浓度，其浓度范围为约0.1％至约1％; 磁场源，被配置为向所述肿瘤的区域递送梯度DC磁场; 以及能量源，其被配置为以大约100至200MHz的频率向所述肿瘤递送RF场。 2.根据权利要求1所述的设备，其中所述超顺磁性颗粒选自由以下物质组成的组：基于磁赤铁矿（γ-Fe 2 O 3 O 3）的化合物和钇铁石榴石（Y 3 5 12 12）基的化合物。

2. 发明申请

US20070048870A1 Endohedral fullerenes as spin labels and MRI contrast agents 审中-公开
标题翻译：内含富勒烯作为自旋标记物和MRI造影剂
公开(公告)号：US20070048870A1
公开(公告)日：2007-03-01
申请号：US11351312
申请日：2006-02-08
申请人： Xiao Xiang , Haitao Yang , Gerald Dionne
发明人： Xiao Xiang , Haitao Yang , Gerald Dionne
IPC分类号： G01N37/00
CPC分类号： B82Y5/00 , A61K49/189 , Y10T436/13
摘要： This invention pertains to the discovery that certain endohedral fullerenes are functional paramagnetic materials exhibiting increased relaxation times. These endohedral fullerenes provide improved labels for use in electron spin resonance (ESR) detection systems.
摘要翻译：本发明涉及某些内消旋富勒烯是表现出增加的松弛时间的功能顺磁材料的发现。这些内嵌的富勒烯提供了用于电子自旋共振（ESR）检测系统的改进的标记。

3. 发明申请

US20050118102A1 Spin resonance heating and/or imaging in medical applications 审中-公开
标题翻译：在医疗应用中旋转共振加热和/或成像
公开(公告)号：US20050118102A1
公开(公告)日：2005-06-02
申请号：US10835247
申请日：2004-04-28
申请人： Xiao Xiang , Gang Wang , Haitao Yang , Gerald Dionne , Ted Sun
发明人： Xiao Xiang , Gang Wang , Haitao Yang , Gerald Dionne , Ted Sun
IPC分类号： A61K41/00 , A61K47/48 , A61K49/00
CPC分类号： B82Y5/00 , A61K41/0052 , A61K47/6923 , A61K47/6929
摘要： This invention pertains to the use of spin resonance absorption heating as a therapeutic treatment method. It was a surprising discovery that electron spin resonance absorption of superparamagnetic (SPM) nanoparticles can be used as a heating method, more preferably as an in vivo heating method that can be utilized in a variety of therapeutic contexts.
摘要翻译：本发明涉及使用自旋共振吸收加热作为治疗方法。令人惊讶的发现是，超顺磁（SPM）纳米颗粒的电子自旋共振吸收可以用作加热方法，更优选作为可用于各种治疗情境的体内加热方法。

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