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1. 发明申请

US20080306282A1 Novel Forms of [R-(R*,R*)]-2-(4-Fluorophenyl)-Beta,Delta-Dihydroxy-5-(1-Methylethyl)-3-Phenyl-4-[(Phenylamino)Carbonyl]-1H-Pyrrole-1-HeptanoicAcid Calcium Salt (2:1) 有权
标题翻译： [R-（R *，R *）] -2-（4-氟苯基） - 二，三羟甲基 - 二羟基-5-（1-甲基乙基）-3-苯基-4 - [（苯基氨基）羰基] 1H-吡咯-1-庚酸钙盐（2:1）
公开(公告)号：US20080306282A1
公开(公告)日：2008-12-11
申请号：US11572333
申请日：2005-07-11
申请人： Joseph F. Krzyzaniak , George M. Laurence , Aeri Park , Kevin J. Quackenbush , Marie L. Reynolds , Peter R. Rose , Timothy A. Woods
发明人： Joseph F. Krzyzaniak , George M. Laurence , Aeri Park , Kevin J. Quackenbush , Marie L. Reynolds , Peter R. Rose , Timothy A. Woods
IPC分类号： C07D207/34
CPC分类号： C07D207/34
摘要： Novel forms of [R—(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid hemi calcium salt designated Form XX, Form XXI, Form XXII, Form XXIII, Form XXIV, Form XXV, Form XXVI, Form XXVII, Form XXVIII, Form XXIX, and Form XXX, characterized by their X-ray powder diffraction, solid-state NMR, and/or Raman spectroscopy are described, as well as methods for the preparation and pharmaceutical composition of the same, which are useful as agents for treating hyperlipidemia, hypercholesterolemia, osteoporosis, benign prostatic hyperplasia (BPH) and Alzheimer's disease.
摘要翻译： [R-（R *，R *）] -2-（4-氟苯基） - ，δ-二羟基-5-（1-甲基乙基）-3-苯基-4 - [（苯基氨基）羰基] 指定为XX型，XXI型，XXII型，XXIII型，XXIV型，XXV型，XXVI型，XXVII型，XXVIII型，XXX型和XXX型的1H-吡咯-1-庚酸半钙盐，其特征在于它们的X 描述了射线粉末衍射，固体NMR和/或拉曼光谱，以及其制备方法和药物组合物，其可用作治疗高脂血症，高胆固醇血症，骨质疏松症，良性前列腺增生症（BPH ）和阿尔茨海默病。

2. 发明申请

US20110301358A1 Novel Forms of [R-(R*,R*)]-2-(4-fluorophenyl)-beta,delta-Dihydroxy-5-(1-Methylethyl)-3-Phenyl-4-[(Phenylmino)Carbonyl]-1H-Pyrrole-1-Heptanoic Acid Calcium Salt (2:1) 有权
标题翻译： [R-（R *，R *）] -2-（4-氟苯基） - ，δ-二羟基-5-（1-甲基乙基）-3-苯基-4 - [（苯基）羰基] - 1H-吡咯-1-庚酸钙盐（2:1）
公开(公告)号：US20110301358A1
公开(公告)日：2011-12-08
申请号：US13214559
申请日：2011-08-22
申请人： Joseph F. Krzyzaniak , George M. Laurence , Aeri Park , Kevin J. Quackenbush , Marie L. Reynolds , Peter R. Rose , Timothy A. Woods
发明人： Joseph F. Krzyzaniak , George M. Laurence , Aeri Park , Kevin J. Quackenbush , Marie L. Reynolds , Peter R. Rose , Timothy A. Woods
IPC分类号： C07D207/34
CPC分类号： C07D207/34
摘要： Novel forms of [R—(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid hemi calcium salt designated Form XX, Form XXI, Form XXII, Form XXIII, Form XXIV, Form XXVV, Form XXVI, Form XXVII, Form XXVIII, Form XXIX, and Form XXX, characterized by their X-ray powder diffraction, solid-state NMR, and/or Raman spectroscopy are described, as well as methods for the preparation and pharmaceutical composition of the same, which are useful as agents for treating hyperlipidemia, hypercholesterolemia, osteoporosis, benign prostatic hyperplasia (BPII) and Alzheimer's disease.
摘要翻译： [R-（R *，R *）] - 2-（4-氟苯基） - ，β-二羟基-5-（1-甲基乙基）-3-苯基-4 - [（苯基氨基）羰基] 指定为XX型，XXI型，XXII型，XXIII型，XXIV型，XXVV型，XXVI型，XXVII型，XXVIII型，XXIX型和XXX型的1H-吡咯-1-庚酸半钙盐，本发明描述了X射线粉末衍射，固体NMR和/或拉曼光谱，以及其制备方法和药物组合物，其可用作治疗高脂血症，高胆固醇血症，骨质疏松症，良性前列腺增生症 BPII）和阿尔茨海默病。

3. 发明授权

US06483581B1 Raman system for rapid sample indentification 失效
标题翻译：拉曼系统快速样品识别
公开(公告)号：US06483581B1
公开(公告)日：2002-11-19
申请号：US09446673
申请日：1999-12-22
申请人： Dor Ben-Amotz , Yanan Jiang , Edward R. Grant , Ken Haber , George M. Laurence, Jr.
发明人： Dor Ben-Amotz , Yanan Jiang , Edward R. Grant , Ken Haber , George M. Laurence, Jr.
IPC分类号： G01J344
CPC分类号： G01N21/65 , G01J3/02 , G01J3/0218 , G01J3/0272 , G01J3/0289 , G01J3/0291 , G01J3/44 , G01N21/85 , G01N2021/656
摘要： A hand-held material identification apparatus 10 uses a spectrograph and detector array detecting a Raman spectrum produced by a sample illuminated by a laser source to recognize a variety of materials with a command to recognition time cycle of about one second or less. The width of the spectrum detected by each detector in the array is less than ¼th the excitation source wavelength deviation to permit smoothing of the spectrum detected by the discrete spectral elements to eliminate pixel noise without loss of Raman spectral information. The Raman spectra are produced by materials illuminated by an inexpensive near-infrared multimode laser operated in a pulse mode to deliver between 0.05 and 0.5 joules of photon energy, with the Raman spectra being detected before any significant heating of the sample occurs. The identification apparatus 10 qualitatively determines the chemical composition of reinforced and unreinforced copolymers and composites such as ABS, polypropylene, talc-filled polypropylene, polycarbonate, PMMA, polyethylene, and PVC, from samples of different colors and textures with a high degree of success without the need for special positioning or sample preparation.
摘要翻译：手持材料识别装置10使用检测由激光源照射的样品产生的拉曼光谱的光谱仪和检测器阵列，以识别大约1秒以下的识别时间周期的指令来识别各种材料。由阵列中的每个检测器检测到的光谱的宽度小于激发源波长偏差的1/4，以允许平滑由离散光谱元素检测的光谱，以消除像素噪声而不损耗拉曼光谱信息。拉曼光谱由以脉冲模式操作的便宜的近红外多模激光器照射的材料产生，以传递0.05至0.5焦耳的光子能量，在样品发生任何显着加热之前，检测拉曼光谱。识别装置10从不同颜色和纹理的样品定性地确定增强和非增强共聚物和复合材料如ABS，聚丙烯，填充滑石的聚丙烯，聚碳酸酯，PMMA，聚乙烯和PVC的化学组成，而没有需要特殊定位或样品制备。

4. 发明授权

US08026376B2 Forms of [R-(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoicacid calcium salt (2:1) 有权
标题翻译： [R-（R *，R *）] -2-（4-氟苯基） - ，δ-二羟基-5-（1-甲基乙基）-3-苯基-4 - [（苯基氨基）羰基] 1H-吡咯-1-庚酸钙盐（2:1）
公开(公告)号：US08026376B2
公开(公告)日：2011-09-27
申请号：US11572333
申请日：2005-07-11
申请人： Joseph F. Krzyzaniak , George M. Laurence , Aeri Park , Kevin J. Quackenbush , Marie L. Reynolds , Peter R. Rose , Timothy A. Woods
发明人： Joseph F. Krzyzaniak , George M. Laurence , Aeri Park , Kevin J. Quackenbush , Marie L. Reynolds , Peter R. Rose , Timothy A. Woods
IPC分类号： C07D207/34
CPC分类号： C07D207/34
摘要： Novel forms of [R-(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4 -[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid hemi calcium salt designated Form XX, Form XXI, Form XXII, Form XXIII, Form XXIV, Form XXV, Form XXVI, Form XXVII, Form XXVIII, Form XXIX, and Form XXX, characterized by their X-ray powder diffraction, solid-state NMR, and/or Raman spectroscopy are described, as well as methods for the preparation and pharmaceutical composition of the same, which are useful as agents for treating hyperlipidemia, hypercholesterolemia, osteoporosis, benign prostatic hyperplasia (BPH) and Alzheimer's disease.
摘要翻译： [R-（R *，R *）] - 2-（4-氟苯基） - ，β-二羟基-5-（1-甲基乙基）-3-苯基-4 - [（苯基氨基）羰基] 表示XX型，XXI型，XXIV型，XXV型，XXVI型，XXVII型，XXVIII型，XXIX型和XXX型的1H-吡咯-1-庚酸半钙盐，其特征在于它们本发明描述了X射线粉末衍射，固体NMR和/或拉曼光谱，以及其制备方法和药物组合物，其可用作治疗高脂血症，高胆固醇血症，骨质疏松症，良性前列腺增生症 BPH）和阿尔茨海默病。

5. 发明授权

US07132017B2 Low-pressure cleaning system using high velocity high volume air 失效
标题翻译：低压清洗系统采用高速大容量空气
公开(公告)号：US07132017B2
公开(公告)日：2006-11-07
申请号：US10645445
申请日：2003-08-21
申请人： George M. Laurence
发明人： George M. Laurence
IPC分类号： B08B9/00
CPC分类号： F28G9/00 , B08B3/02 , B08B5/02 , F24F2221/225
摘要： A method for cleaning a heat exchanging coil in an air conditioning unit using a low-pressure cleaning system to remove foreign particles that have accumulated on the heat exchanging coil. The low-pressure cleaning system discharges air at a low pressure, high velocity, and a high volume in order to clean the heat exchanging coil. Further, the low-pressure cleaning system can inject a substance into the discharge air flow to aid in cleaning the heat exchanging coil.
摘要翻译：一种使用低压清洁系统清洁空调单元中的热交换盘管的方法，以去除积聚在热交换盘管上的异物。低压清洁系统以低压，高速度和高体积排出空气，以清洁热交换盘管。此外，低压清洁系统可以将物质注入排出空气流中以帮助清洁热交换盘管。

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