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1. 发明申请

US20130316374A1 BREAST CANCER DIAGNOSTICS 审中-公开
标题翻译：乳腺癌诊断
公开(公告)号：US20130316374A1
公开(公告)日：2013-11-28
申请号：US13825502
申请日：2011-09-22
申请人： Josef Penninger , Daniel Schramek , Georg Schett , Martin Widschwendter , Ian J. Jacobs , Usha Menon
发明人： Josef Penninger , Daniel Schramek , Georg Schett , Martin Widschwendter , Ian J. Jacobs , Usha Menon
IPC分类号： G01N33/68
CPC分类号： G01N33/57415 , G01N33/6893 , G01N2333/70575 , G01N2800/50 , G01N2800/56
摘要： The present invention relates to methods and means for detecting cancer or of predicting a patient developing cancer or of determining the rate of progression of cancer in a patient suffering from cancer, comprising determining RANKL activity and/or the amount of OPG in a sample of said patient.
摘要翻译：本发明涉及用于检测癌症或预测患有癌症的患者或确定患有癌症的患者的癌症进展速率的方法和手段，包括确定所述癌症的样品中的RANKL活性和/或OPG的量患者。

2. 发明申请

US20090098536A1 Method for subgroup analysis in subjects having or being suspected of having inflammatory disease, use of anti-p38MAPK antibodies, kits and their use 审中-公开
标题翻译：具有或怀疑患有炎性疾病的受试者的亚组分析方法，使用抗p38MAPK抗体，试剂盒及其用途
公开(公告)号：US20090098536A1
公开(公告)日：2009-04-16
申请号：US11871565
申请日：2007-10-12
申请人： Georg Schett , Wolfgang Albrecht , Stefan Laufer
发明人： Georg Schett , Wolfgang Albrecht , Stefan Laufer
IPC分类号： C12Q1/68 , C12Q1/02 , G01N33/53
CPC分类号： G01N33/564 , C12Q1/6883 , C12Q2600/106 , C12Q2600/112 , C12Q2600/158 , G01N33/5088 , G01N2800/24 , G01N2800/52 , G01N2800/56
摘要： The present invention relates to a method of determining whether a subject having or suspected of having inflammatory disease may potentially benefit from treatment with a p38 mitogen-activated protein kinase (p38MAPK) inhibitor, which method comprises (I) obtaining an inflammatory tissue sample from the subject; and (II) determining whether p38MAPK, in particular p38MAPKα, is expressed in the tissue sample. The present invention further relates to the use of an antibody against the p38MAPK protein for determining whether a subject having or suspected of having inflammatory disease may benefit from treatment with a p38 mitogen-activated protein kinase (p38MAPK) inhibitor; kits for determining from an inflammatory tissue sample whether a subject having or suspected of having inflammatory disease may benefit from treatment with a p38 mitogen-activated protein kinase (p38MAPK) inhibitor; and to the corresponding use of said kit.
摘要翻译：本发明涉及一种确定具有或怀疑具有炎症性疾病的受试者是否可能受益于用p38丝裂原活化蛋白激酶（p38MAPK）抑制剂治疗的方法，该方法包括（I）获得来自学科; 和（II）确定p38MAPK，特别是p38MAPKα是否在组织样品中表达。本发明还涉及针对p38MAPK蛋白的抗体用于确定具有或怀疑具有炎性疾病的受试者是否可受益于用p38丝裂原活化蛋白激酶（p38MAPK）抑制剂的治疗; 用于从炎性组织样品测定具有或怀疑具有炎性疾病的受试者的试剂盒可以受益于用p38丝裂原活化蛋白激酶（p38MAPK）抑制剂的治疗; 以及所述试剂盒的相应使用。

3. 发明授权

US5353186A Reactor switch 失效
标题翻译：电抗器开关
公开(公告)号：US5353186A
公开(公告)日：1994-10-04
申请号：US30575
申请日：1993-03-12
申请人： Erich Ruoss , Georg Schett
发明人： Erich Ruoss , Georg Schett
IPC分类号： H01H33/16 , H01H33/59 , H02J3/18
CPC分类号： H02J3/1828 , H01H33/161 , H01H33/59 , Y02E40/30
摘要： The reactor switch is provided for switching on and off a reactor (2) in a multiphase electrical high-voltage network. It has switch poles (3) which are arranged phase-by-phase between the reactor (2) and a part of the network containing, a high-voltage line (1). These switch poles (3) in each case contain at least two series-connected switching chambers (11, 12; 13, 14) in parallel with which at least two series-connected varistors (15, 16; 18, 19) are connected. This reactor switch is intended to be capable of disconnecting short-circuits occurring between the reactor switch and the reactor (2) without problems. This is achieved in that the at least two varistors (15, 16, 17, 18, 19) and the at least two switching chambers (11, 12; 13, 14) are connected together in the form of a network on which the high-voltage network acts in terms of current and voltage and in which, in the event of restriking of some (11, 12) of the at least two switching chambers, the energy which is supplied to those varistors (17, 18, 19) which are connected in parallel with the switching chambers (13, 14) which are free of restrikes is less than in the case of a reactor switch having a network which is acted on in a corresponding manner, but in which each of the at least two switching chambers is bridged by at least one of the at least two varistors.
摘要翻译：电抗器开关用于在多相电气高压网络中接通和关闭电抗器（2）。它具有在反应器（2）和包含高压线（1）的网络的一部分之间相位布置的开关极（3）。这些开关极（3）在每种情况下都包含至少两个串联连接的开关室（11,12; 13,14）并联连接至少两个串联连接的变阻器（15,16; 18,19）。该电抗器开关旨在能够在不存在问题的情况下断开在电抗器开关和电抗器（2）之间发生的短路。这是通过以网络的形式将至少两个变阻器（15,16,17,18,19）和至少两个开关室（11,12; 13,14）连接在一起的，其中高 - 电压网络根据电流和电压起作用，并且在所述至少两个开关室的一些（11,12）的再起弧的情况下，提供给所述压敏电阻器（17,18,19）的能量与不具有重新起动的开关室（13,14）并联连接的电抗器小于在具有以相应方式作用的网络的电抗器开关的情况下，但是其中至少两个开关室由至少两个变阻器中的至少一个桥接。

4. 发明授权

US5796060A Gas insulated switchgear with grounding and disconnecting switches 失效
公开(公告)号：US5796060A
公开(公告)日：1998-08-18
申请号：US596746
申请日：1996-02-05
申请人： Dieter Fuchsle , Peter Hogg , Lothar Mantel , Georg Schett
发明人： Dieter Fuchsle , Peter Hogg , Lothar Mantel , Georg Schett
IPC分类号： H02B13/02 , H01H31/00 , H02B13/035 , H01H33/59 , H02B5/06
CPC分类号： H02B13/035 , H01H31/003
摘要： A switching apparatus includes a grounded, insulating gas-filled housing, the housing having a housing wall, and a power circuit-breaker disposed in the housing. The apparatus further includes a current connection for a first busbar, a current connection for a second busbar, and a current connection for a load outgoer. The apparatus further includes a grounding switch disposed in the housing, the grounding switch being connected between the power circuit-breaker and the current connection for the load outgoer, and a busbar disconnector, the busbar disconnector being connected between the current connection of the first busbar and the power circuit-breaker and between the current connection of the second busbar and the power circuit-breaker. An outwardly extended, first tubular flange arrangement is attached over a first opening in the housing wall, and an outwardly extended, second tubular flange arrangement is attached over a second opening in the housing wall. A first outdoor bushing is provided, the first outdoor bushing being fastened to the first tubular flange attachment, the current connection for the first busbar extending through the first outdoor bushing. A second outdoor bushing is provided, the second outdoor bushing being fastened to the second tubular flange attachment, the current connection for the second busbar extending through the second outdoor bushing. The busbar disconnector is movable between at least three positions, the busbar disconnector having a first and a second fixed contact and a movable contact arrangement, the movable contact arrangement interacting with the first and second fixed contacts and being electrically conductively connected to the power circuit-breaker, the first fixed contact defining an end of the current connection of the first busbar and being disposed in the housing, and the second fixed contact defining an end of the current connection of the second busbar and being disposed in the housing.

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