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1. 发明授权

US09205255B2 Implantable pulse generator systems and methods for providing functional and/or therapeutic stimulation of muscles and/or nerves and/or central nervous system tissue 有权
标题翻译：用于提供对肌肉和/或神经和/或中枢神经系统组织的功能和/或治疗刺激的可植入脉冲发生器系统和方法
公开(公告)号：US09205255B2
公开(公告)日：2015-12-08
申请号：US11517170
申请日：2006-09-07
申请人： Robert B. Strother , Geoffrey B. Thrope
发明人： Robert B. Strother , Geoffrey B. Thrope
IPC分类号： A61N1/378 , A61N1/36 , A61N1/372 , A61N1/375 , A61N1/05
CPC分类号： A61N1/36007 , A61N1/05 , A61N1/0551 , A61N1/3605 , A61N1/36071 , A61N1/37229 , A61N1/37252 , A61N1/375 , A61N1/3754 , A61N1/3758 , A61N1/3787
摘要： Improved assemblies, systems, and methods provide a stimulation system for prosthetic or therapeutic stimulation of muscles, nerves, or central nervous system tissue, or any combination. The stimulation system includes a pulse generator including a housing sized and configured for implantation in subcutaneous tissue, circuitry carried within the housing, the circuitry operable for generating electrical stimulation pulses, and a rechargeable battery coupled to the circuitry and carried within the housing, the rechargeable battery including a battery capacity. The circuitry is adapted to suspend the generation of electrical stimulation pulses at a first remaining battery capacity, and the circuitry is adapted to enter a dormant mode at a second remaining battery capacity. The first battery remaining capacity may be greater than or equal to the second remaining battery capacity. At the second remaining battery capacity, only a safety margin battery capacity remains.
摘要翻译：改进的装配，系统和方法提供用于肌肉，神经或中枢神经系统组织或任何组合的假体或治疗刺激的刺激系统。所述刺激系统包括脉冲发生器，所述脉冲发生器包括尺寸和构造用于植入皮下组织的壳体，所述壳体内承载的电路，可操作以产生电刺激脉冲的电路，以及耦合到所述电路并在所述壳体内承载的可充电电池，电池包括电池容量。电路适于暂停在第一剩余电池容量下的电刺激脉冲的产生，并且电路适于以第二剩余电池容量进入休眠模式。第一电池剩余容量可以大于或等于第二剩余电池容量。在第二个剩余电池容量下，仅剩下一个安全边际电池容量。

2. 发明授权

US08649870B2 Systems and methods including lead and electrode structures sized and configured for implantation in adipose tissue 有权
标题翻译：包括铅和电极结构的系统和方法的尺寸和构造用于植入脂肪组织
公开(公告)号：US08649870B2
公开(公告)日：2014-02-11
申请号：US11980989
申请日：2007-10-31
申请人： Joseph J. Mrva , Robert B. Strother , Geoffrey B. Thrope , Julie H. Grill , Maria E. Bennett
发明人： Joseph J. Mrva , Robert B. Strother , Geoffrey B. Thrope , Julie H. Grill , Maria E. Bennett
IPC分类号： A61N1/36
CPC分类号： A61N1/36007 , A61N1/05 , A61N1/0524 , A61N1/0551 , A61N1/0558 , A61N1/372
摘要： A stimulation electrode assembly comprises an elongated lead sized and configured to be implanted within an adipose tissue region. The lead includes an electrically conductive portion to apply electrical stimulation to nerve or muscle in the adipose tissue region and at least one expandable anchoring structure deployable from the lead to engage adipose tissue and resist dislodgment and/or migration of the electrically conductive portion within the adipose tissue region.
摘要翻译：刺激电极组件包括细长的引线，其尺寸和构造被植入脂肪组织区域内。引线包括导电部分，以对脂肪组织区域中的神经或肌肉施加电刺激，以及至少一个可展开的锚定结构，其可从引导部分展开以接合脂肪组织并抵抗脂肪内的导电部分的移动和/或迁移组织区域。

3. 发明授权

US08165692B2 Implantable pulse generator power management 有权
标题翻译：可植入脉冲发生器电源管理
公开(公告)号：US08165692B2
公开(公告)日：2012-04-24
申请号：US11824892
申请日：2007-07-03
申请人： Robert B Strother , Joseph J Mrva , Geoffrey B Thrope
发明人： Robert B Strother , Joseph J Mrva , Geoffrey B Thrope
IPC分类号： A61N1/08 , A61B19/00
CPC分类号： A61N1/37276 , A61N1/36003 , A61N1/36071 , A61N1/37223 , Y10S128/903 , Y10S128/904
摘要： Improved assemblies, systems, and methods provide an implantable pulse generator for prosthetic or therapeutic stimulation of muscles, nerves, or central nervous system tissue, or any combination thereof. The implantable pulse generator is sized and configured to be implanted subcutaneously in a tissue region. The implantable pulse generator includes an electrically conductive case of a laser welded titanium material. Control circuitry is located within the case. The control circuitry includes a rechargeable power source, a receive coil for receiving an RF magnetic field to recharge the power source, and a microcontroller for control of the implantable pulse generator. The improved assemblies, systems, and methods also provide a stimulation system for prosthetic or therapeutic stimulation of muscles, nerves, or central nervous system tissue, or any combination thereof. The stimulation system provides at least one electrically conductive surface, a lead connected to the electrically conductive surface, and an implantable pulse generator electrically connected to the lead.
摘要翻译：改进的组件，系统和方法提供了用于假体或治疗性刺激肌肉，神经或中枢神经系统组织的植入式脉冲发生器或其任何组合。可植入脉冲发生器的尺寸和构造被皮下植入组织区域。可植入脉冲发生器包括激光焊接钛材料的导电壳体。控制电路位于外壳内。控制电路包括可充电电源，用于接收RF磁场以对电源再充电的接收线圈，以及用于控制可植入脉冲发生器的微控制器。改进的组合件，系统和方法还提供用于肌肉，神经或中枢神经系统组织或其任何组合的假体或治疗刺激的刺激系统。刺激系统提供至少一个导电表面，连接到导电表面的引线以及电连接到引线的可植入脉冲发生器。

4. 发明申请

US20110144468A1 SYSTEMS AND METHODS OF NEUROMODULATION STIMULATION FOR THE RESTORATION OF SEXUAL FUNCTION 有权
标题翻译：用于恢复性功能的神经调节刺激的系统和方法
公开(公告)号：US20110144468A1
公开(公告)日：2011-06-16
申请号：US13031482
申请日：2011-02-21
申请人： Joseph W. Boggs , Robert B. Strother , Joseph J. Mrva , Geoffrey B. Thrope
发明人： Joseph W. Boggs , Robert B. Strother , Joseph J. Mrva , Geoffrey B. Thrope
IPC分类号： A61B5/05 , A61N1/36
CPC分类号： A61N1/05 , A61M2205/054 , A61M2210/1067 , A61M2210/1089 , A61N1/0512 , A61N1/0524 , A61N1/36007 , A61N1/36107
摘要： Systems and methods use an external and/or implantable pulse generator system for neuromodulation stimulation to treat sexual dysfunction by the unilateral or bilateral stimulation of a target nerve A and/or a target nerve B using one or more leads and electrodes implanted in tissue in the pelvic region. The electrical stimulation waveform may be conveyed to the target nerve A electrode for a first predetermined amount of time, and conveyed to the target nerve B electrode for a second predetermined amount of time.
摘要翻译：系统和方法使用外部和/或可植入的脉冲发生器系统进行神经调节刺激，以通过使用植入组织中的一个或多个引线和电极单目或双侧刺激靶神经A和/或靶神经B来治疗性功能障碍骨盆部位。电刺激波形可以以第一预定量的时间传送到目标神经A电极，并且传送到目标神经B电极第二预定时间量。

5. 发明申请

US20100298920A1 Devices, Systems, and methods employing a molded nerve cuff electrode 审中-公开
标题翻译：使用模制神经袖口电极的装置，系统和方法
公开(公告)号：US20100298920A1
公开(公告)日：2010-11-25
申请号：US12804984
申请日：2010-08-03
申请人： Joseph J. Mrva , James Coburn , Robert B. Strother , Geoffrey B. Thrope
发明人： Joseph J. Mrva , James Coburn , Robert B. Strother , Geoffrey B. Thrope
IPC分类号： A61N1/05
CPC分类号： A61N1/0556
摘要： Devices, systems, and methods for recording, and/or stimulation, and/or blocking of a nerve make use of a molded cuff electrode. An electrically conductive surface is coupled to an inside surface of the elastic body of the cuff. The elastic body of the cuff is formed from a substantially homogeneous material, and the electrically conductive surface and the body assume a coiled configuration in the natural state of the cuff. An applicator tool having a body and a slider are used to implant the cuff electrode about a nerve.
摘要翻译：用于记录和/或刺激和/或阻断神经的装置，系统和方法利用模压的袖带电极。导电表面联接到袖带的弹性体的内表面。袖带的弹性体由基本均匀的材料形成，并且导电表面和本体在袖带的自然状态下呈现卷曲构型。使用具有主体和滑块的涂抹器工具将袖带电极植入在神经周围。

6. 发明授权

US07813809B2 Implantable pulse generator for providing functional and/or therapeutic stimulation of muscles and/or nerves and/or central nervous system tissue 有权
标题翻译：用于提供肌肉和/或神经和/或中枢神经系统组织的功能和/或治疗刺激的植入式脉冲发生器
公开(公告)号：US07813809B2
公开(公告)日：2010-10-12
申请号：US11150535
申请日：2005-06-10
申请人： Robert B. Strother , Joseph J. Mrva , Geoffrey B. Thrope
发明人： Robert B. Strother , Joseph J. Mrva , Geoffrey B. Thrope
IPC分类号： A61N1/08 , A61B19/00
CPC分类号： A61N1/37235 , A61B5/0031 , A61B5/0488 , A61B5/7232 , A61B2560/0209 , A61N1/36003 , A61N1/37247 , Y10S128/903 , Y10S128/904
摘要： An implantable pulse generator for prosthetic or therapeutic stimulation of muscles, nerves, or central nervous system tissue, or any combination is sized and configured to be implanted in subcutaneous tissue. The implantable pulse generator includes an electrically conductive laser welded titanium case. Control circuitry is located within the case, and includes a primary cell or rechargeable power source, a receive coil for receiving an RF magnetic field to recharge the rechargeable power source, non-inductive wireless telemetry circuitry, and a microcontroller for control of the implantable pulse generator. A stimulation system for prosthetic or therapeutic stimulation of muscles, nerves, or central nervous system tissue, or any combination comprises at least one electrically conductive surface, a lead connected to the electrically conductive surface, and an implantable pulse generator electrically connected to the lead.
摘要翻译：用于假体或治疗性刺激肌肉，神经或中枢神经系统组织或任何组合的可植入脉冲发生器的大小和构造被植入皮下组织。可植入脉冲发生器包括导电激光焊接钛壳。控制电路位于壳体内，并且包括主电池或可充电电源，用于接收RF磁场以对可再充电电源进行再充电的接收线圈，非感性无线遥测电路和用于控制可植入脉冲的微控制器发电机。用于对肌肉，神经或中枢神经系统组织或任何组合的假体或治疗刺激的刺激系统包括至少一个导电表面，连接到导电表面的引线和电连接到引线的可植入脉冲发生器。

7. 发明授权

US07761167B2 Systems and methods for clinician control of stimulation systems 有权
标题翻译：刺激系统临床医生控制系统和方法
公开(公告)号：US07761167B2
公开(公告)日：2010-07-20
申请号：US11541890
申请日：2006-10-02
申请人： Maria E. Bennett , Kenneth P. Rundle , Stuart F. Rubin , James Coburn , Danny R. Pack , Robert B. Strother , Geoffrey B. Thrope , Joseph J. Mrva
发明人： Maria E. Bennett , Kenneth P. Rundle , Stuart F. Rubin , James Coburn , Danny R. Pack , Robert B. Strother , Geoffrey B. Thrope , Joseph J. Mrva
IPC分类号： A61N1/00
CPC分类号： A61N1/37217 , A61N1/37247
摘要： Systems and methods for programming and logging medical device and patient data are provided. The systems include a handheld device, which is capable of communicating with a medical device, and a base station, which provides connectivity for the handheld device to accomplish various functions such as recharging, programming, data back-up and data entry. The methods comprise the steps of detecting a medical device, obtaining and recording information from the medical device. Additionally, medical device parameters may be modified and the recorded information may be archived for future reference.
摘要翻译：提供了用于编程和记录医疗设备和患者数据的系统和方法。该系统包括能够与医疗设备进行通信的手持设备以及为手持设备提供连接以完成各种功能（例如充电，编程，数据备份和数据输入）的基站。所述方法包括检测医疗装置，从医疗装置获取和记录信息的步骤。此外，医疗设备参数可以被修改，并且记录的信息可以存档以备将来参考。

8. 发明申请

US20100100158A1 Percutaneous electrode assemblies, systems, and methods for providing highly selective functional or therapeutic neuromuscular stimulation 审中-公开
标题翻译：用于提供高选择性功能或治疗性神经肌肉刺激的经皮电极组件，系统和方法
公开(公告)号：US20100100158A1
公开(公告)日：2010-04-22
申请号：US12653528
申请日：2009-12-15
申请人： Geoffrey B. Thrope , Robert B. Strother , Joseph J. Mrva
发明人： Geoffrey B. Thrope , Robert B. Strother , Joseph J. Mrva
IPC分类号： A61N1/05 , A61N1/378
CPC分类号： A61N1/32 , A61N1/0551 , Y10S128/907
摘要： Percutaneous electrode assemblies, systems, and methods make possible the providing of short-term therapy or diagnostic testing by providing electrical connections between muscles or nerves inside the body and stimulus generators or recording instruments carried outside the body. The percutaneous electrodes include a flexible body having an electrically conductive region, a tissue penetrating region, and a percutaneous lead electrically coupled to the electrically conductive region. An anchoring element is positioned on the flexible body to resist movement of the electrically conductive region within tissue. An introducer is sized and configured to receive the flexible body and shield the anchoring element from contact with tissue while the electrically conductive region is placed to a desired position within tissue, and accommodates advancement of the anchoring element beyond the interior lumen for contact with tissue to resist movement of the electrically conductive region placed in the desired position.
摘要翻译：经皮电极组件，系统和方法可以通过在体内的肌肉或神经之间提供短期治疗或诊断测试，以及在体外携带的刺激发生器或记录仪器。经皮电极包括具有导电区域，组织穿透区域和电耦合到导电区域的经皮引线的柔性体。锚定元件定位在柔性体上以抵抗组织内导电区域的移动。导引器的尺寸和构造被设计成接收柔性体并且屏蔽锚固元件免受与组织的接触，同时将导电区域放置在组织内的期望位置，并且容纳锚定元件超出内腔以与组织接触阻止放置在所需位置的导电区域的移动。

9. 外观设计

USD559987S1 Implantable pulse generator 有权
标题翻译：可植入脉冲发生器
公开(公告)号：USD559987S1
公开(公告)日：2008-01-15
申请号：US29231490
申请日：2005-06-06
申请人： Robert B. Strother , Joseph J. Mrva , Geoffrey B. Thrope
设计人： Robert B. Strother , Joseph J. Mrva , Geoffrey B. Thrope

10. 发明授权

US08467875B2 Stimulation of dorsal genital nerves to treat urologic dysfunctions 有权
标题翻译：刺激背部生殖器神经来治疗泌尿功能障碍
公开(公告)号：US08467875B2
公开(公告)日：2013-06-18
申请号：US11729333
申请日：2007-03-28
申请人： Maria E Bennett , Julie Grill , Tina E Lechman , Joseph J Mrva , Jonathan L Sakai , Robert B Strother , Geoffrey B Thrope , Therese M Zmina
发明人： Maria E Bennett , Julie Grill , Tina E Lechman , Joseph J Mrva , Jonathan L Sakai , Robert B Strother , Geoffrey B Thrope , Therese M Zmina
IPC分类号： A61N1/36
CPC分类号： A61N1/36007 , A61N1/0524 , A61N1/0551 , A61N1/0558 , A61N1/36014 , A61N1/36107 , A61N1/37211
摘要： Systems and methods treat urologic dysfunctions by implanting a lead and electrode in a tissue region affecting urologic function, and implanting a pulse generator in an anterior pelvic region remote from the electrode. Bilateral stimulation of the left and/or right branches of the dorsal genital nerves using a single lead implanted in adipose or other tissue in the region at or near the pubic symphysis is able to treat urinary incontinence.
摘要翻译：系统和方法通过将铅和电极植入影响泌尿功能的组织区域中并将脉冲发生器植入远离电极的前盆腔区域来治疗泌尿系统功能障碍。使用植入在耻骨联合处或附近的区域中的脂肪或其他组织中的单个引线对背生殖神经的左侧和/或右侧分支的双侧刺激能够治疗尿失禁。

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