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1. 发明申请

US20190255528A1 CELL SEPARATION CHIP AND SYSTEM 审中-公开
公开(公告)号：US20190255528A1
公开(公告)日：2019-08-22
申请号：US15999665
申请日：2016-12-29
申请人： Genobio, Inc.
发明人： Jea Ku LEE , Ju Hyun HWANG , Sung-Hoon PARK , Jong Jin JO
IPC分类号： B01L3/00 , G01N35/08 , G01N33/574
摘要： The present invention relates to a system and method for cell separation. The system includes: a cartridge having a polygonal shape in cross section and including an injection part, a separation chip separating a flow channel of a sample injected through the injection part, and a discharge part; and a base plate coupled to the cartridge through its upper surface and including a magnetic chip for cancer cell capture, liquid sensors, and valves. The method includes: coupling a cut plane of one side of the cell separation cartridge to one side of the base plate; engaging a recess formed at the other end of the cell separation cartridge with a pin formed at the other end of the base plate; fixing holes of the separation chip of the cell separation cartridge and holes of the magnetic chip of the base plate using a fixing member to match the holes of the separation chip of the cell separation cartridge and the holes of the magnetic chip of the base plate; and determining whether a pattern of the separation chip of the cell separation cartridge matches a pattern of the magnetic chip of the base plate.

2. 发明公开

US20240116050A1 MICROFLUIDIC BUBBLE TRAP 审中-公开
公开(公告)号：US20240116050A1
公开(公告)日：2024-04-11
申请号：US17928490
申请日：2022-10-17
申请人： GENOBIO, INC.
发明人： Ju Hyun HWANG
IPC分类号： B01L3/00
CPC分类号： B01L3/502723 , B01L2200/0684 , B01L2300/0663 , B01L2300/0681 , B01L2300/0832 , B01L2400/0655
摘要： The present disclosure relates to a microfluidic bubble trap for blocking or removing bubbles introduced inside a chip in the process of sensing, a separation, a measurement, an incubation, and an analysis based on the microfluidic technology and preventing a flow of fluid in a channel from being hindered or preventing bubbles from occupying the fluid, so that the functional efficiency in an operation such as a sample analysis, a sample separation, a measurement, and the like may be significantly improved.
The present disclosure provides a microfluidic bubble trap including a trap body for separating bubbles and the microfluid is introduced therethrough; a microfluid inlet connected in a first direction of the trap body and supplying the microfluid; and a microfluid outlet installed through an upper portion of the trap body and an end of a channel is disposed in a lower portion of the microfluid inlet.

3. 发明公开

US20240116052A1 DISPOSABLE SEPARATION CHIP 审中-公开
公开(公告)号：US20240116052A1
公开(公告)日：2024-04-11
申请号：US17928272
申请日：2022-10-17
申请人： GENOBIO, INC.
发明人： Ju Hyun HWANG
IPC分类号： B01L3/00
CPC分类号： B01L3/502761 , B01L2200/0668 , B01L2200/0684 , B01L2200/16 , B01L2300/0654 , B01L2300/0681 , B01L2300/0819 , B01L2300/0858 , B01L2300/0864 , B01L2300/088 , B01L2400/043
摘要： The present invention relates to a disposable separation chip used when separating magnetic beads present in a mixed solution using magnetic force.
The present invention provides disposable separation chip including a lower chip on which a wire pattern having a parabolic shape from one side to another side thereof is formed; and a separation chip separable from the lower chip, wherein the separation chip includes: an upper plate on which a coupling portion coupled to a tubing is formed; and a first member disposed under the upper plate and coupled to a lower surface of the upper plate, wherein the coupling portion is integrally produced with the upper plate wherein it is formed through the upper surface and the lower surface of the upper plate to be connected to a channel.

4. 发明授权

US10758906B2 Cell separation chip and system 有权
公开(公告)号：US10758906B2
公开(公告)日：2020-09-01
申请号：US15999665
申请日：2016-12-29
申请人： GENOBIO, INC.
发明人： Jea Ku Lee , Ju Hyun Hwang , Sung Hoon Park , Jong Jin Jo
IPC分类号： B01L3/00 , G01N33/574 , G01N35/08 , G01N35/00
摘要： The present invention relates to a system and method for cell separation. The system includes: a cartridge having a polygonal shape in cross section and including an injection part, a separation chip separating a flow channel of a sample injected through the injection part, and a discharge part; and a base plate coupled to the cartridge through its upper surface and including a magnetic chip for cancer cell capture, liquid sensors, and valves. The method includes: coupling a cut plane of one side of the cell separation cartridge to one side of the base plate; engaging a recess formed at the other end of the cell separation cartridge with a pin formed at the other end of the base plate; fixing holes of the separation chip of the cell separation cartridge and holes of the magnetic chip of the base plate using a fixing member to match the holes of the separation chip of the cell separation cartridge and the holes of the magnetic chip of the base plate; and determining whether a pattern of the separation chip of the cell separation cartridge matches a pattern of the magnetic chip of the base plate.

5. 发明公开

EP4400845A1 DISPOSABLE SEPARATION CHIP 审中-公开
公开(公告)号：EP4400845A1
公开(公告)日：2024-07-17
申请号：EP22883907.2
申请日：2022-10-17
申请人： Genobio, Inc.
发明人： HWANG, Ju Hyun
IPC分类号： G01N35/00 , G01N35/08 , B01L3/00
CPC分类号： G01N35/00 , G01N35/08 , B01L3/502761 , B01L2200/065220130101 , B01L2200/068420130101 , B01L2200/1620130101 , B01L2300/065420130101 , B01L2300/068120130101 , B01L2200/02720130101 , B01L2300/064520130101 , B01L3/502776 , B01L2300/088720130101
摘要： The present invention relates to a disposable separation chip used when separating magnetic beads present in a mixed solution using magnetic force.
The present invention provides disposable separation chip including a lower chip on which a wire pattern having a parabolic shape from one side to another side thereof is formed; and a separation chip separable from the lower chip, wherein the separation chip includes: an upper plate on which a coupling portion coupled to a tubing is formed; and a first member disposed under the upper plate and coupled to a lower surface of the upper plate, wherein the coupling portion is integrally produced with the upper plate wherein it is formed through the upper surface and the lower surface of the upper plate to be connected to a channel.

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