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1. 发明专利

JP2015023832A 飲料水有权
标题翻译：饮用水
公开(公告)号：JP2015023832A
公开(公告)日：2015-02-05
申请号：JP2013155645
申请日：2013-07-26
申请人：克史小早川 , Katsushi Kobayakawa , 克史小早川 , 源一郎杣 , Genichiro Soma , 源一郎杣 , 有限会社バイオメディカルリサーチグループ , Bio Medical Research Group:Kk , 自然免疫応用技研株式会社 , Shizen Meneki Oyo Giken Kk
发明人： KOBAYAKAWA KATSUSHI , SOMA GENICHIRO , KAWACHI CHIE , INAGAWA HIROYUKI
IPC分类号： A23K1/18 , A23K1/16 , A23L2/52 , A61K31/739 , A61P37/04
摘要：【課題】動物の自然免疫機能を活性化し、かつ、動物に好まれる飲料水を提供すること。【解決手段】パントエア・アグロメランス由来のリポ多糖が0.08μg/ml以上0.8μg/ml以下配合されている飲料水。この飲料水は動物に好んで飲用されるため、ペットやヒトの健康を継続的に安定して維持することができる。【選択図】図1
摘要翻译：要解决的问题：提供激活动物的天然免疫功能的饮用水，并且也被动物所喜爱。解决方案：本发明涉及一种饮用水，其中来自成团泛菌的脂多糖的量为0.08μg/ ml以上0.8μg/ ml以下。饮用水被动物喜欢喝醉，因此可以持续稳定地保持宠物和人的健康。

2. 发明专利

JP2009232793A Feed additive, feed, method for producing the feed additive and the feed, death-preventive agent, and breeding method 有权
标题翻译：饲料添加剂，饲料，生产饲料添加剂和饲料的方法，死亡预防剂和育种方法
公开(公告)号：JP2009232793A
公开(公告)日：2009-10-15
申请号：JP2008085057
申请日：2008-03-27
申请人： Bio Medical Research Group:Kk , Kawasaki Seiyaku Kk , Shizen Meneki Oyo Giken Kk , Genichiro Soma , 川崎製薬株式会社 , 有限会社バイオメディカルリサーチグループ , 源一郎杣 , 自然免疫応用技研株式会社
发明人： INAGAWA HIROYUKI , KAWACHI CHIE , SOMA GENICHIRO , NISHIZAWA TAKASHI , NAKATSUKA YOSHIHARU , FUKUDA KOHEI
IPC分类号： A23K1/18 , A23K1/16
CPC分类号： Y02A40/818
摘要： PROBLEM TO BE SOLVED: To provide safe feed additive to grow shellfish and fish with an extremely small amount of which immune function inherent in livestock, the shellfish or the fish is accurately activated to prevent infection disease, and which has no problem in public health sanitation such as medical drug residue; to provide a method for producing feed to which the feed additive is added; and to provide additive, prepared mix, supplement and various kinds of feed to each of which wheat fermented extract effective on prevention against allergy disease, self immune disease, life-style disease, functional abnormality as a result of advanced age, malignant neoplasm or the like, is added. SOLUTION: The method for producing feed and additive having immunostimulatory effect and infectious disease-protective effect includes addition of the wheat fermented extract and bacillus fungi. The additive, the prepared mix and the feed are provided by the method. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：为了提供安全的饲料添加剂，生产贝类和鱼类，其中极少量的家畜固有的免疫功能，贝类或鱼类被精确地活化，以防止感染疾病，而且没有问题公共卫生卫生如药物残留; 提供添加饲料添加剂的饲料的制造方法; 并为每种小麦发酵提取物提供添加剂，制备的混合物，补充剂和各种饲料，其有效预防过敏疾病，自身免疫疾病，生活方式疾病，由于晚期，恶性肿瘤或喜欢，被添加。解决方案：具有免疫刺激作用和感染性疾病保护作用的饲料和添加剂的生产方法包括加入小麦发酵提取物和芽孢杆菌真菌。通过该方法提供添加剂，制备的混合物和进料。版权所有（C）2010，JPO＆INPIT

3. 发明专利

JPS6127923A Preparation of human tumor necrosis factor 失效
标题翻译：人肿瘤坏死因子的制备
公开(公告)号：JPS6127923A
公开(公告)日：1986-02-07
申请号：JP14672384
申请日：1984-07-17
申请人： Denichi Mizuno , Genichiro Soma
发明人： SOMA GENICHIRO , KITAHARA NAMIKO , KATANAGA TETSUYA , YAMAZAKI MASATOSHI , ABE SHIGERU , MIZUNO DENICHI , MURATA MASAHIRO , ANDO TOSHIO
IPC分类号： A61K38/16 , A61K35/12 , A61P35/00 , C12P21/00 , C12R1/91
摘要： PURPOSE: The titled factor is prepared by culturing a human malignant monocytic cell in the presence of a differentiation-inducing substance, or by differentiating a human malignant monocytic cell with a differentiation-inducing substance, and culturing the cell in the presence of an extracorporeal stimulation substance.
CONSTITUTION: A human tumor necrosis factor can be prepared either by culturing a malignant human monocytic cell (e.g. human proosseous leukemia cell, human chronic myelocytic leukemia cell, etc.) in the presence of a differentiation-inducing substance (e.g. hemin, actinomycin D, hexamethyleneaclacinomycin A, teleocidin, etc.) or by differentiating a malignant human monocytic cell with a differentiation-inducing substance, and culturing the cell in the presence of an extracorporeal stimulation substance (e.g. lipopolysaccharoid, various lectins, vitamin A, etc.). The medium for the above cultivation is preferably Rosewell. Park.Memorial.Institute 1640 medium.
COPYRIGHT: (C)1986,JPO&Japio
摘要翻译：目的：通过在分化诱导物质的存在下培养人类恶性单核细胞，或通过将人恶性单核细胞与分化诱导物质分化，并在体外刺激存在下培养细胞来制备标题因子物质。构成：人体肿瘤坏死因子可以通过在分化诱导物质（例如血红素，放线菌素D等）存在下培养恶性人单核细胞（例如人类前体白血病细胞，人慢性骨髓性白血病细胞等）六亚甲基青霉素A，铁杆菌素等）或通过将恶性人单核细胞与分化诱导物质分化，并在体外刺激物质（例如脂多糖，各种凝集素，维生素A等）存在下培养细胞。用于上述培养的培养基优选为Rosewell。公园。学院1640培养基。

4. 发明专利

JP2013255469A Sorghum fermented extract 有权
标题翻译： SORGHUM FERMENTED EXTRACT
公开(公告)号：JP2013255469A
公开(公告)日：2013-12-26
申请号：JP2012134318
申请日：2012-06-13
申请人： Genichiro Soma , 源一郎杣 , Bio Medical Research Group:Kk , 有限会社バイオメディカルリサーチグループ
发明人： SOMA GENICHIRO , KAWACHI CHIE , INAGAWA HIROYUKI , NISHIZAWA TAKASHI
IPC分类号： C12N1/20 , A23K1/16 , A23L1/30 , A61K8/99 , A61K35/74 , A61P3/04 , A61P15/00 , A61P17/02 , A61P25/28 , A61P31/04 , A61P35/00 , A61P37/08 , A61P43/00 , A61Q19/00 , C12P1/04 , C12R1/01
摘要： PROBLEM TO BE SOLVED: To eliminate a possibility of causing an allergy concerning a glycolipid material that excels in immunostimulation power.SOLUTION: Sorghum known as wheat alternative grain is used instead of wheat although wheat considered as a specified allergic substance has been used in a conventional method for producing a glycolipid material. A material without the anxiety of causing an allergy can therby be provided while maintaining the immunostimmulation action of the glycolipid material as it is.
摘要翻译：要解决的问题：消除引起对免疫刺激能力优异的糖脂材料的过敏的可能性。解决方案：使用称为小麦替代谷物的高粱代替小麦，尽管被认为是特定的过敏物质的小麦已经用于常规生产糖脂材料的方法可以在保持糖脂材料的免疫刺激作用的同时提供不引起过敏焦虑的物质。

5. 发明专利

JP2013180963A Crushed material of acetobacter and its formulation 审中-公开
标题翻译： ACETOBACTER及其配方的粉碎材料
公开(公告)号：JP2013180963A
公开(公告)日：2013-09-12
申请号：JP2012044885
申请日：2012-02-29
申请人： Genichiro Soma , 源一郎杣 , Toyo Hakko:Kk , 株式会社東洋発酵
发明人： INAGAWA HIROYUKI , KAWACHI CHIE , SOMA GENICHIRO
IPC分类号： A61K35/74 , A23K1/16 , A23K1/18 , A23L1/28 , A61K8/99 , A61P37/08 , A61Q19/10 , C12N1/20
摘要： PROBLEM TO BE SOLVED: To provide a crushed material of acetobacter which is inexpensive and has practicality as a natural immunity activator derived from acetobacter having an infection controlling effect and a growth promoting effect, and its formulation and drug.SOLUTION: A crushed material of acetobacter obtained by culturing acetobacter and subjecting the acetobacter to physical, chemical or biological crushing treatment has an effect of inhibiting occurrence of pollinosis. As the acetobacter, the genus Acetobacter, the genus Gluconobacter, the genus Saccaribacter, the genus Asaia, the genus Suwaminasania, the genus Kozakia, the genus Neoasaia, the genus Acidomonas, the genus Gluconacetobacter and the genus Guranulibacter are preferably used.
摘要翻译：要解决的问题：提供廉价的具有感染控制效果和生长促进作用的醋杆菌的天然免疫活化剂的实用性的醋杆菌粉碎物及其制剂和药物。解决方案：将醋酸杆菌粉碎的材料通过培养乙酸杆菌获得并对乙酸杆菌进行物理，化学或生物破碎处理获得抑制花粉症发生的效果。作为醋杆菌，优选使用醋杆菌属，醋杆菌属，阿尔卡氏菌属，亚ia属，苏瓦曼菌属，科扎卡氏菌属，新氏菌属，单胞菌属，葡萄糖酸杆菌属和古兰菌属属。

6. 发明专利

JP2010241945A Lipopolysaccharide, rice fermentation extract, and rice fermentation extract composition 有权
标题翻译：油菜籽，发酵提取物和米饭发酵提取物组合物
公开(公告)号：JP2010241945A
公开(公告)日：2010-10-28
申请号：JP2009091637
申请日：2009-04-05
申请人： Bio Medical Research Group:Kk , Shizen Meneki Oyo Giken Kk , Genichiro Soma , 有限会社バイオメディカルリサーチグループ , 源一郎杣 , 自然免疫応用技研株式会社
发明人： INAGAWA HIROYUKI , KAWACHI CHIE , SOMA GENICHIRO
IPC分类号： C08B37/00 , A23K1/00 , A23K1/16 , A23L1/30 , A61K31/715 , A61K36/00 , A61K36/899 , A61P1/04 , A61P3/06 , A61P3/10 , A61P17/02 , A61P25/04 , A61P25/36 , A61P31/12 , A61P31/22 , A61P33/02 , A61P35/00 , A61P37/08 , C05F11/00 , C05F11/08
摘要： PROBLEM TO BE SOLVED: To provide an excellent lipopolysaccharide having a property different from that of the conventional lipopolysaccharide of Pantoea agglomerans of wheat, to provide an extract containing the lipopolysaccharide, and to provide the application product thereof. SOLUTION: The lipopolysaccharide is obtained from a Gram-negative bacterium living together with a rice plant. The lipopolysaccharide has high Limulus activity, low molecular weight of a subband, a different saccharide chain structure, different lipid A structure, different protain content, saccharide content, nucleic acid content and Limulus active substance content as compared with the conventional lipopolysaccharide of Pantoea agglomerans of wheat and has high preventive effect. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：待解决的问题：提供与常规的小麦泛菌脂多糖的性质不同的优异的脂多糖，以提供含有脂多糖的提取物，并提供其应用产物。解决方案：脂多糖从与水稻植物一起生长的革兰氏阴性细菌获得。脂多糖具有较高的鲎活性，低分子量的子带，不同的糖链结构，不同的脂质A结构，不同的成分含量，糖含量，核酸含量和鲎活性物质含量，与传统的泛菌泛素小麦具有较高的预防效果。版权所有（C）2011，JPO＆INPIT

7. 发明专利

JP2008183011A Method for fermentation and cultivation, fermented plant extract, fermented plant extract powder and composition of fermented plant extract 有权
标题翻译：发酵和培养方法，发酵植物提取物，发酵植物提取物粉末和发酵植物提取物的组合物
公开(公告)号：JP2008183011A
公开(公告)日：2008-08-14
申请号：JP2008042509
申请日：2008-02-25
申请人： Bio Medical Research Group:Kk , Genichiro Soma , 有限会社バイオメディカルリサーチグループ , 源一郎杣
发明人： SOMA GENICHIRO , KAWACHI CHIE , INAGAWA HIROYUKI , NISHIZAWA TAKASHI , TAKAHASHI YUKINORI
IPC分类号： C12N1/20 , A23K1/00 , A23K1/14 , A23L1/105 , A23L1/20 , A23L1/29 , A23L1/30 , A61K8/97 , A61K35/74 , A61K36/00 , A61K36/02 , A61K36/03 , A61K36/48 , A61K36/88 , A61K36/899 , A61P17/00 , A61P25/04 , A61P31/00 , A61P31/22 , A61P37/04 , A61P37/08 , A61P43/00 , A61Q19/00 , A61Q19/10 , C07G99/00 , C12R1/01
CPC分类号： C12N1/20 , A23L7/104 , A23L11/09 , A23L33/105 , A23V2002/00 , A61K36/03 , A61K36/48 , A61K36/88 , A61K36/899 , C12P1/04 , C12P19/04 , Y02P60/877 , A23V2200/324 , A23V2250/21
摘要： PROBLEM TO BE SOLVED: To provide a method for safely and inexpensively producing a fermented plant extract containing an immunopotentiator at a high concentration. SOLUTION: A plant material such as wheat flour is fermented using Pantoea agglomerans which is a gram-negative bacterium living in a symbiotic relation with a plant such as wheat or apple. Thus, the immunopotentiation action of the plant can be extremely enhanced. Moreover, such a product has a high safety because of being free from contamination with animal-origin impurities. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：待解决的问题：提供一种安全廉价地生产含有高浓度免疫增强剂的发酵植物提取物的方法。解决方案：使用Pantoea成团发酵诸如小麦粉的植物材料，其是与植物如小麦或苹果生物共生关系的革兰氏阴性细菌。因此，可以极大地提高植物的免疫增强作用。此外，这种产品由于没有动物源杂质的污染而具有高安全性。版权所有（C）2008，JPO＆INPIT

8. 发明专利

JP2007202562A Fermentation and culture method, fermented plant extract, fermented plant extract powder and composition containing fermented plant extract 有权
标题翻译：发酵和培养方法，发酵植物提取物，发酵植物提取物和包含发酵植物提取物的组合物
公开(公告)号：JP2007202562A
公开(公告)日：2007-08-16
申请号：JP2007050166
申请日：2007-02-28
申请人： Bio Medical Research Group:Kk , Genichiro Soma , 有限会社バイオメディカルリサーチグループ , 源一郎杣
发明人： SOMA GENICHIRO , KAWACHI CHIE , INAGAWA HIROYUKI , NISHIZAWA TAKASHI , TAKAHASHI YUKINORI
IPC分类号： C12N1/20 , A23K1/00 , A23L1/105 , A23L1/20 , A23L1/29 , A23L1/30 , A61K8/97 , A61K36/00 , A61K36/02 , A61K36/03 , A61K36/48 , A61K36/88 , A61K36/899 , A61P37/02 , A61P37/04 , A61P43/00 , A61Q19/00 , A61Q19/10 , C07G99/00
CPC分类号： C12N1/20 , A23L7/104 , A23L11/09 , A23L33/105 , A23V2002/00 , A61K36/03 , A61K36/48 , A61K36/88 , A61K36/899 , C12P1/04 , C12P19/04 , Y02P60/877 , A23V2200/324 , A23V2250/21
摘要： PROBLEM TO BE SOLVED: To provide a process for safely and less expensively producing a fermented plant extract containing an immunopotentiator at high concentration. SOLUTION: A plant material such as wheat flour is fermented by using Pantoea agglomerans which is a gram-negative bacterium living in a symbiotic relation with a plant such as wheat or apple. Thus, the immunopotentiation action of the plant can be extremely enhanced. Moreover, such a product has a high safety because of being free from contamination with animal-origin impurities. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供一种安全且低成本地生产含有高浓度免疫增强剂的发酵植物提取物的方法。解决方案：通过使用与植物如小麦或苹果生活在共生关系中的革兰阴性细菌泛菌成分，发酵诸如小麦粉的植物材料。因此，可以极大地提高植物的免疫增强作用。此外，这种产品由于没有动物源杂质的污染而具有高安全性。版权所有（C）2007，JPO＆INPIT

9. 发明专利

JP2006131623A Medicinal agent 有权
标题翻译：医药代理
公开(公告)号：JP2006131623A
公开(公告)日：2006-05-25
申请号：JP2005292596
申请日：2005-10-05
申请人： Genichiro Soma , 源一郎杣
发明人： TAKIGUCHI KUNIO , INAGAWA HIROYUKI , KAWACHI CHIE , NISHIZAWA TAKASHI , SOMA GENICHIRO
IPC分类号： A61K35/74 , A61P1/00 , A61P1/04 , A61P3/06 , A61P3/10 , A61P17/00 , A61P17/04 , A61P21/00 , A61P25/04 , A61P29/00 , A61P35/00 , A61P37/02 , C12N15/09
摘要： PROBLEM TO BE SOLVED: To provide a safe antiallergic therapeutic agent containing Posterisan and Eksalb and being a medicine or a medicinal agent using killed organism of gram-negative bacterium or gram-positive bacterium alone or in mixed state, because it is thought that new treating method for autoimmune diseases can be provided when macrophage activation is safely induced and IL-12 or the like can be produced, though an autoimmune disease such as atopic dermatitis, asthma or cancer is intractable and a therapeutic medicine effective for these diseases scarcely exists, while posterisan is a therapeutic medicine for hemorrhoids in which infection-protecting action and wound healing action are clinically recognized and generally used and active ingredient of the agent is killed organism liquid of Escherichia coli and it is suggested that the active ingredient safely induces macrophage activation, though the treating mechanism is not clear.
SOLUTION: The agent having effect on atopic dermatitis model mouse is obtained by percutaneously using the suspension of Escherichia coli contained in posterisan.
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：为了提供含有Posterisan和Eksalb的安全的抗过敏治疗剂，并且是单独或混合使用革兰氏阴性细菌或革兰氏阳性菌的杀死生物体的药物或药剂，因为认为当安全诱导巨噬细胞活化时可以提供自身免疫性疾病的新的治疗方法，尽管自身免疫性疾病如特应性皮炎，哮喘或癌症是难治性的，并且对这些疾病有效的治疗药物几乎不能产生IL-12等存在，而后嗣是痔疮的治疗药物，其中感染保护作用和伤口愈合作用在临床上被认可和普遍使用，该药剂的活性成分是大肠杆菌的杀死生物体液体，并且建议活性成分安全地诱导巨噬细胞激活，虽然治疗机制不明确。解决方案：通过经皮使用包含在前列腺素中的大肠杆菌的悬浮液获得对特应性皮炎模型小鼠具有作用的药剂。版权所有（C）2006，JPO＆NCIPI

10. 发明专利

JP2005132795A Anti-malignant gliomatous agent and anti-malignant gliomatous agent for animal 审中-公开
标题翻译：抗恶性胶质细胞剂和抗恶性胶质瘤药物
公开(公告)号：JP2005132795A
公开(公告)日：2005-05-26
申请号：JP2003372659
申请日：2003-10-31
申请人： Genichiro Soma , 源一郎杣
发明人： INAGAWA HIROYUKI , KAWACHI CHIE , SOMA GENICHIRO
IPC分类号： A61K38/00 , A61P35/00 , C07K14/525
CPC分类号： C07K14/525 , A61K38/00
摘要： PROBLEM TO BE SOLVED: To obtain a new anti-malignant gliomatous agent and an anti-malignant gliomatous agent for animals.
SOLUTION: The anti-malignant gliomatous agent comprises (a) a polypeptide composed of an amino acid sequence described in a sequence No.1 or 2 or (b) a polypeptide composed of an amino acid sequence in which a plurality of amino acids are deleted, substituted or added from/for/to the amino acid sequence described in the sequence No.1 or 2 and having anti-malignant gliomatous action or a mixture of the polypeptide (a) with the polypeptide (b).
COPYRIGHT: (C)2005,JPO&NCIPI

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