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1. 发明专利

AU2002314747B2 Novel endophytic fungi and methods of use 未知
公开(公告)号：AU2002314747B2
公开(公告)日：2008-06-19
申请号：AU2002314747
申请日：2002-04-11
申请人： GARY STROBEL
发明人： MANKER DENISE CAROL , STROBEL GARY A
IPC分类号： C12Q1/04 , A01N63/02 , A01N63/04 , A61L2/16 , B09C1/02 , B09C1/08 , B09C1/10 , C02F11/00 , C02F11/02 , C12N1/14 , C12N15/01 , C12P1/02
摘要： This invention provides a novel endophytic fungus, Muscodor, that produces a mixture of volatile antibiotics with activity on specific plant pathogens, bacteria, nematodes and insects. Also provided is a method for treating or protecting plants, soil and seeds from microbial infections comprising applying an effective amount of a volatile antibiotic producing Muscodor sp. The invention also relates to fungicidal, bactericidal, insecticidal and nematicidal compositions comprising this novel Muscodor strain and the antibiotics and metabolites produced by this strain either alone, or in combination with other chemical and biological pesticides. Also provided is a method for identifying and isolating related gas producing fungi.

2. 发明专利

CR8236A COMPOSICIONES RELACIONADOS CON UN NOVEDOSO HONGO ENDOFITO Y SUS METODOS DE USO 未知
公开(公告)号：CR8236A
公开(公告)日：2007-01-17
申请号：CR8236
申请日：2006-02-16
申请人： GARY STROBEL
发明人： GARY A STROBEL , DENISE C MANKER , JULIEN MERCIER , JORGE JIMENEZ , JIAN-ER JOHN LIN , JONATHAN THURSTON , BARRY KERSTING
IPC分类号： A01N31/02 , A01N37/02 , A01N63/04 , A61K20060101 , C12N1/14
摘要： La invencion provee composiciones pesticidas eficientes relacionadas con un novedoso hongo endofito llamado Muscodor. Especificamente la invencion se relaciona con formulaciones comercialmente utiles de Muscodor y metodos para preparar tales formulaciones. Tambien provee varias mezclas sinteticas de pesticidas de compuestos organicos volatiles aislables de Muscodor crecido sobre distintos substratos. Asimismo provee metodos para inhibir el crecimiento de organismos, tales como microbios, insectos y nematodos, en exponer tales organismos o sus habitats a las composiciones Muscodor antes- mencionadas.

3. 发明专利

CR7111A HONGOS ENDOFITOS NOVEDOSOS Y METODOS DE UTILIZACION 未知
公开(公告)号：CR7111A
公开(公告)日：2004-03-24
申请号：CR7111
申请日：2003-10-15
申请人： GARY STROBEL
发明人： GARY STROBEL , DENISE CAROL MANKER
IPC分类号： C12Q1/04 , A01N3/02 , A01N63/02 , A01N63/04 , A61L2/16 , B09C1/02 , B09C1/08 , B09C1/10 , C02F11/00 , C02F11/02 , C12N1/14 , C12N15/01 , C12P1/02
摘要： La invencion proporciona un hongo endofito novedoso, Muscodor, que produce una mezcla de antibioticos volatiles con actividad sobre patogenos especificos de las plantas, bacterias, nematodos e insectos. Tambiien se proporciona un metodo para el tratamiento o proteccion de plantas, suelo, y semillas de infecciones microbianas que incluye la aplicacion de una cantidad efectiva de un muscodor sp.

4. 发明授权

US08093024B2 Endophytic fungi and methods of use 有权
标题翻译：内生真菌及其使用方法
公开(公告)号：US08093024B2
公开(公告)日：2012-01-10
申请号：US12786434
申请日：2010-05-25
申请人： Gary Strobel , Denise C. Manker , Julien Mercier
发明人： Gary Strobel , Denise C. Manker , Julien Mercier
IPC分类号： C12P3/00 , A01N63/00
CPC分类号： A01N63/02 , A01N63/04 , C12N1/14 , Y02E50/17 , Y02E50/343
摘要： This invention provides a novel endophytic fungus, Muscodor, that produces a mixture of volatile antibiotics with activity on specific plant pathogens, bacteria, nematodes and insects. Also provided is a method for treating or protecting plants, soil and seeds from microbial infections comprising applying an effective amount of a volatile antibiotic producing Muscodor sp. The invention also relates to fungicidal, bactericidal, insecticidal and nematicidal compositions comprising this novel Muscodor strain and the antibiotics and metabolites produced by this strain either alone, or in combination with other chemical and biological pesticides. Also provided is a method for identifying and isolating related gas producing fungi.
摘要翻译：本发明提供了一种新颖的内生真菌Muscodor，其产生具有对特定植物病原体，细菌，线虫和昆虫的活性的挥发性抗生素的混合物。还提供了一种治疗或保护植物，土壤和种子免受微生物感染的方法，包括施用有效量的挥发性抗生素产生的Muscodor sp。本发明还涉及杀真菌，杀菌，杀虫剂和杀线虫剂组合物，其包含该新颖的Muscodor菌株以及该菌株单独或与其它化学和生物农药组合产生的抗生素和代谢物。还提供了鉴定和分离相关产气真菌的方法。

5. 发明申请

US20100285543A1 Novel Endophytic Fungi And Methods Of Use 有权
标题翻译：新颖的内生真菌和使用方法
公开(公告)号：US20100285543A1
公开(公告)日：2010-11-11
申请号：US12786434
申请日：2010-05-25
申请人： Gary Strobel , Denise C. Manker , Julien Mercier
发明人： Gary Strobel , Denise C. Manker , Julien Mercier
IPC分类号： C12P5/00 , C12P5/02 , C12P7/28 , C12P7/62 , C12P7/06 , C12P7/16 , C12P17/04
CPC分类号： A01N63/02 , A01N63/04 , C12N1/14 , Y02E50/17 , Y02E50/343
摘要： This invention provides a novel endophytic fungus, Muscodor, that produces a mixture of volatile antibiotics with activity on specific plant pathogens, bacteria, nematodes and insects. Also provided is a method for treating or protecting plants, soil and seeds from microbial infections comprising applying an effective amount of a volatile antibiotic producing Muscodor sp. The invention also relates to fungicidal, bactericidal, insecticidal and nematicidal compositions comprising this novel Muscodor strain and the antibiotics and metabolites produced by this strain either alone, or in combination with other chemical and biological pesticides. Also provided is a method for identifying and isolating related gas producing fungi.
摘要翻译：本发明提供了一种新颖的内生真菌Muscodor，其产生具有对特定植物病原体，细菌，线虫和昆虫的活性的挥发性抗生素的混合物。还提供了一种治疗或保护植物，土壤和种子免受微生物感染的方法，包括施用有效量的挥发性抗生素产生的Muscodor sp。本发明还涉及杀真菌，杀菌，杀虫剂和杀线虫剂组合物，其包含该新颖的Muscodor菌株以及该菌株单独或与其它化学和生物农药组合产生的抗生素和代谢物。还提供了鉴定和分离相关产气真菌的方法。

6. 发明授权

US07267975B2 Methods and compositions relating to insect repellents from a novel endophytic fungus 失效
标题翻译：与新生内生真菌的驱虫剂相关的方法和组合物
公开(公告)号：US07267975B2
公开(公告)日：2007-09-11
申请号：US10687546
申请日：2003-10-15
申请人： Gary Strobel , Bryn Daisy
发明人： Gary Strobel , Bryn Daisy
IPC分类号： A01N25/00 , A01N63/00 , A01N63/04 , A01N65/00 , C12N1/00 , C12P1/02 , C12P7/00 , C07C409/44
CPC分类号： C12R1/645 , A01N63/04 , C12P5/005 , Y10S435/911
摘要： The present invention relates to the discovery of a novel endophytic fungus, Muscodor vitigenus, from the liana, Paullinia paullinioides. This fungus produces naphthalene under certain cultural conditions that has chromatographic and mass spectral properties that are identical to authentic naphthalene. In a preferred embodiment, the naphthalene in the gas phase of M. vitigenus is useful in the repellency of unwanted insect pests. The unique biological activity of the novel endophyte suggests a wide range of potential practical applications, particularly in the area of insect repellents, insecticides, antimicrobials, anthelmintics and vermicides.
摘要翻译：本发明涉及一种新颖的内生真菌，来自木犀草的保护性痢疾杆菌（Paillinia paullinioides）。这种真菌在某些文化条件下产生萘，其色谱和质谱光谱性质与真正的萘相同。在优选的实施方案中，维生素M.的气相中的萘可用于不期望的害虫的排斥。新型内生真菌的独特生物活性表明广泛的潜在实际应用，特别是在驱虫剂，杀虫剂，抗微生物剂，驱肠虫剂和杀真菌剂方面。

7. 发明授权

US07192939B2 Pestalotiopsis microsporia isolates and compounds derived therefrom 失效
标题翻译：小孢子菌（Pestalotiopsis microsporia）分离株及其衍生物
公开(公告)号：US07192939B2
公开(公告)日：2007-03-20
申请号：US10356320
申请日：2003-01-30
申请人： Gary Strobel , Eugene Ford , James K. Harper
发明人： Gary Strobel , Eugene Ford , James K. Harper
IPC分类号： A01N57/00 , C07D305/12 , C07D307/93
CPC分类号： C07D307/87 , A61K31/343 , C07D307/88 , C12P17/04 , C12R1/645 , Y02A50/492
摘要： The present invention relates to the novel isolated 12–30 strain of Pestalotiopsis microspora capable of producing novel antioxidant and antimycotic agents. The present invention also relates to the novel isolated 3,5,7 trisubstituted isobenzofuranone and derivatives thereof, methods of isolating the novel isobenzofuranone from cultures P. microspora 12–30, and to novel uses of the compound as an antioxidant and antimycotic agent. The present invention further relates to a novel 1,5,7 trisubstituted 1,3-dihydroisobenzofuran and derivatives thereof, methods of isolating this novel compound from cultures of Pestalotiopsis microspora 12–30, and to uses thereof.
摘要翻译：本发明涉及能够生产新型抗氧化剂和抗真菌剂的新型分离的Pestalotiopsis microspora的12-30菌株。本发明还涉及新型分离的3,5,7三取代异苯并呋喃酮及其衍生物，从培养物微孢子菌属12-30中分离出新的异苯并呋喃酮的方法，以及该化合物作为抗氧化剂和抗真菌剂的新用途。本发明还涉及一种新的1,5,7三取代1,3-二氢异苯并呋喃及其衍生物，其从Pestalotiopsis microspora 12-30的培养物中分离出该新化合物的方法及其应用。

8. 发明申请

US20060127346A1 Application of volatile antibiotics and non-volatile inhibitors from muscodor spp. to control harmful microbes in human and animal wastes 审中-公开
公开(公告)号：US20060127346A1
公开(公告)日：2006-06-15
申请号：US11344768
申请日：2006-02-01
申请人： Gary Strobel , David Ezra
发明人： Gary Strobel , David Ezra
IPC分类号： A61L9/015 , A61K35/74
CPC分类号： A01N63/04 , A01N63/02 , C12N1/14
摘要： This invention relates to the discovery of a novel endophytic fungus, Muscodor albus, which produces volatile antibiotics that have been shown to be effective in the treatment of human and animal waste products. Through experimentation, this invention confirms that Muscodor albus can be used in disposable bags in connection with portable toilets to solve the problem of degradation of waste products in situations where humans are removed from sanitary facilities. This invention includes the discovery of non-volatile inhibitors that are also produced by Muscodor albus and that are similarly effective in treating human and animal wastes. This invention covers a unique and novel method for preparing Muscodor albus for commercial use in the treatment of human and animal wastes, which involves infesting barley seeds with Muscodor albus and then storing them under conditions that will allow the fungus to remain viable for up to nine months.

9. 发明申请

US20050260182A1 Coronamycins 失效
标题翻译：冠心病
公开(公告)号：US20050260182A1
公开(公告)日：2005-11-24
申请号：US11064486
申请日：2005-02-24
申请人： Gary Strobel , Debbie Yaver , Uvidelio Castillo , David Ezra
发明人： Gary Strobel , Debbie Yaver , Uvidelio Castillo , David Ezra
IPC分类号： A01N63/00 , A01N63/02 , A61K38/00 , A61K38/54 , C07K14/36 , C12N1/20 , C12N9/99 , C12P21/00 , C12R1/465
CPC分类号： C12R1/465 , A01N63/00 , A01N63/02 , A61K38/00 , C07K14/36 , C12P21/00
摘要： The present invention relates to isolated strains of a Streptomyces spp. which are endophytes of dicotyledonous plants and to methods for selecting such strains. The present invention also relates to a biologically active compound called coronamycin obtained from endophytic Streptomycetes isolated from higher plants. The present invention further relates to compositions of such compounds and to methods of protecting plants against attack by a plant pathogen and methods of inhibiting bacterial growth, fungal growth, viral infection, growth of parasitic organisms, and cancer cell growth with such compositions.
摘要翻译：本发明涉及链霉菌属（Streptomyces spp。）的分离菌株。其是双子叶植物的内生真菌和选择这些菌株的方法。本发明还涉及从高等植物分离的内生菌链球菌获得的称为冠状病毒的生物活性化合物。本发明进一步涉及这些化合物的组合物以及保护植物免受植物病原体攻击的方法以及用这些组合物抑制细菌生长，真菌生长，病毒感染，寄生生物生长和癌细胞生长的方法。

10. 发明申请

US20060127347A1 Application of volatile antibiotics and non-volatile inhibitors from muscodor spp. to control harmful microbes in human and animal wastes 审中-公开
标题翻译：挥发性抗生素和非挥发性抑制剂的应用。控制人体和动物废物中的有害微生物
公开(公告)号：US20060127347A1
公开(公告)日：2006-06-15
申请号：US11344769
申请日：2006-02-01
申请人： Gary Strobel , David Ezra
发明人： Gary Strobel , David Ezra
IPC分类号： A61L9/015 , A61K35/74
CPC分类号： A01N63/04 , A01N63/02 , C12N1/14
摘要： This invention relates to the discovery of a novel endophytic fungus, Muscodor albus, which produces volatile antibiotics that have been shown to be effective in the treatment of human and animal waste products. Through experimentation, this invention confirms that Muscodor albus can be used in disposable bags in connection with portable toilets to solve the problem of degradation of waste products in situations where humans are removed from sanitary facilities. This invention includes the discovery of non-volatile inhibitors that are also produced by Muscodor albus and that are similarly effective in treating human and animal wastes. This invention covers a unique and novel method for preparing Muscodor albus for commercial use in the treatment of human and animal wastes, which involves infesting barley seeds with Muscodor albus and then storing them under conditions that will allow the fungus to remain viable for up to nine months.
摘要翻译：本发明涉及一种新颖的内生真菌Muscodor albus的发现，它产生已被证明在人和动物废物处理方面有效的挥发性抗生素。通过实验，本发明证实了Muscodor albus可以用于与便携式厕所相关的一次性袋中，以解决在人类从卫生设施中移除的情况下废物降解的问题。本发明包括还发现也由Muscodor albus生产并且类似地有效治疗人和动物废物的非挥发性抑制剂。本发明涵盖了用于制备用于人和动物废物的商业用途的Muscodor albus的独特和新颖的方法，其涉及用Muscodor albus侵染大麦种子，然后在允许真菌保持最多9种条件的条件下储存几个月。

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