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1. 发明专利

JP2007167855A Centrifugal separator 有权
标题翻译：离心分离器
公开(公告)号：JP2007167855A
公开(公告)日：2007-07-05
申请号：JP2007057440
申请日：2007-03-07
申请人： Gambro Inc , ガンブロ、インコーポレイテッド
发明人： HLAVINKA DENNIS , FELT THOMAS J
IPC分类号： B04B5/04 , G01N33/48 , A61M1/02 , A61M1/36 , G01N1/10 , G01N1/28
CPC分类号： A61M1/3693 , A61M1/3696 , A61M2202/0427 , B04B5/0442 , B04B2005/045 , B04B2005/0471
摘要： PROBLEM TO BE SOLVED: To provide a centrifugal separator, which can substantially eliminate one or more of restrictions and disadvantages involved in the conventional related technique, and to provide a centrifugal separation method. SOLUTION: A first outlet port 56, a second outlet port 58, a third outlet port 60, and an interfacial control outlet port 61 are positioned at various radial positions for removing materials of which the density is varied on a rotor 12. The second outlet port 58 is disposed more distant from a rotating axial line A-A than the first outlet port 56, the third outlet port 60, and the interfacial control outlet port 61. A component H having higher density such as blood red cells is separated from a separation vessel 28. The third outlet port 60 is disposed near the rotating axial line A-A as compared with the first outlet port 56, the second outlet port 58, and the interfacial control unit 61, and the minimum-density component separated within the separation vessel 28, for example, plasma, is removed. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供一种离心分离器，其基本上可以消除常规相关技术中涉及的一个或多个限制和缺点，并提供离心分离方法。解决方案：第一出口端口56，第二出口端口58，第三出口端口60和界面控制出口端口61定位在各种径向位置，用于移除在转子12上密度变化的材料。第二出口58布置成比第一出口56，第三出口60和界面控制出口61更远离旋转轴线AA。具有较高密度的组分H如血红细胞从分离容器28.与第一出口56，第二出口58和界面控制单元61相比，第三出口60设置在旋转轴线AA附近，并且在分离期间分离的最小密度分量容器28例如等离子体被去除。版权所有（C）2007，JPO＆INPIT

2. 发明专利

JP2005161093A Method and apparatus for controlling concentration in living body and tubing system 有权
标题翻译：用于控制生活体系和管道系统浓度的方法和装置
公开(公告)号：JP2005161093A
公开(公告)日：2005-06-23
申请号：JP2005052412
申请日：2005-02-28
申请人： Gambro Inc , ガンブロ、インコーポレイテッド
发明人： LANGLEY ROBERT W , WAEG GEERT VAN , DUMONT LARRY JOE
IPC分类号： A61M1/30 , A61M1/34 , A61M1/36
CPC分类号： A61M1/3672 , A61M1/30 , A61M1/303 , A61M1/34 , A61M1/36 , A61M1/3693 , A61M1/3696 , A61M2205/3334
摘要： PROBLEM TO BE SOLVED: To prevent coagulation in extracorporeal blood and activation of a blood platelet.
SOLUTION: This apparatus includes a means for predicting a minimum extracorporeal anticoagulant level capable of existing in an extracorporeal tubing set, and a means for determining how an anticoagulant flow is slowly changed with the lapse of time so that an anticoagulant in the extracorporeal tubing set is maintained above the predicted minimum extracorporeal anticoagulant level.
COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：防止体外血液凝血和血小板活化。解决方案：该装置包括用于预测能够存在于体外管组中的最小体外抗凝血水平的装置，以及用于确定抗凝血流如何随着时间的推移而缓慢变化的手段，使得体外抗凝血剂油管套保持在预计的最低体外抗凝血水平之上。版权所有（C）2005，JPO＆NCIPI

3. 发明专利

JP2007209768A Method for separating fluid component 有权
标题翻译：分离流体组分的方法
公开(公告)号：JP2007209768A
公开(公告)日：2007-08-23
申请号：JP2007057445
申请日：2007-03-07
申请人： Gambro Inc , ガンブロ、インコーポレイテッド
发明人： HLAVINKA DENNIS , FELT THOMAS J
IPC分类号： A61M1/02 , G01N33/48 , A61M1/36 , B04B5/04 , G01N1/10 , G01N1/28
CPC分类号： A61M1/3693 , A61M1/3696 , A61M2202/0427 , B04B5/0442 , B04B2005/045 , B04B2005/0471
摘要： PROBLEM TO BE SOLVED: To provide a method for separating fluid components substantially removing one or more of restrictions and faults of conventional related arts. SOLUTION: A method is provided for reducing the aggregation of platelets of blood components under separation. This method includes that the blood components are introduced in a rotating separation vessel to layer the blood components in the separation vessel and form a radial external layer containing red blood cells, an intermediate layer containing at least the platelets, and a radial internal layer containing low-density substances. The radial external layer containing the red blood cells is retained between the intermediate layer and a radial external wall and/or the radial internal layer containing the low-density substances is retained between the intermediate layer and a radial internal wall of the separation vessel for substantially limiting contact between the platelets and at least one of the radial internal wall and the external wall of the separation vessel. This constitution can reduce the aggregation of the platelets. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供一种用于分离基本上去除传统相关技术的一个或多个限制和故障的流体组分的方法。解决方案：提供一种减少分离时血液成分血小板聚集的方法。该方法包括将血液成分引入旋转分离容器中以分层分离容器中的血液成分，形成含有红细胞的径向外层，至少含有血小板的中间层，以及含有低血压的径向内层密度物质。含有红细胞的径向外层保留在中间层和径向外壁之间，和/或包含低密度物质的径向内层保留在分离容器的中间层和径向内壁之间，基本上限制血小板与分离容器的径向内壁和外壁中的至少一个之间的接触。这种构成可以减少血小板聚集。版权所有（C）2007，JPO＆INPIT

4. 发明专利

JP2007105489A Technique for priming and recirculating fluid through dialysis machine 有权
标题翻译：通过DIALYSIS机器预处理和再循环流体的技术
公开(公告)号：JP2007105489A
公开(公告)日：2007-04-26
申请号：JP2006333948
申请日：2006-12-12
申请人： Gambro Inc , ガンブロ、インコーポレイテッド
发明人： BRUGGER JAMES , HENDRICKSON DAN LEE , HOVLAND ROY SVEN
IPC分类号： A61M1/14 , A61M1/36 , A61M39/10
CPC分类号： A61M1/3643 , A61M1/3644 , A61M1/3646 , A61M1/3647 , A61M39/10 , A61M2205/123
摘要： PROBLEM TO BE SOLVED: To provide a method for automatically priming and recirculating sterile fluid through an extracorporeal circuit of a dialysis machine having a blood pump, a dialyzer, and a blood tubing set including an arterial line for drawing blood from a patient and a venous line for returning the blood to the patient.
SOLUTION: The dialysis machine selectively opens and closes clamps 40 and 72 on the arterial and venous lines 36 and 77 and further operates a waste valve leading to a waste drain 86. A connector attaches both the arterial and venous lines 33 and 66 to the waste valve during a priming procedure. The dialysis machine automatically operates the blood pump 34, the clamps 40 and 72 and the waste valve to flush the dialyzer 54 and the blood tubing set with the sterile fluid, direct the used fluid down the waste drain 86, and recirculate additional sterile fluid through the extracorporeal circuit.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供一种用于通过具有血泵，透析器和血液管组的透析机的体外循环自动引发和再循环无菌液体的方法，所述血液泵，透析器和血管组包括用于从患者抽取血液的动脉线以及用于将血液返回到患者的静脉线。解决方案：透析机选择性地打开和关闭动脉和静脉线36和77上的夹具40和72，并进一步操作导致废液排放口86的废气阀。连接器将动脉和静脉管路33和66两者相连在启动过程中到废气阀。透析机自动操作血液泵34，夹具40和72以及废气阀以冲洗透析器54和用无菌流体组合的血液管路，将废液排出废液排放口86，并将另外的无菌流体再循环通过体外电路。版权所有（C）2007，JPO＆INPIT

5. 发明专利

JP2006273868A Method and apparatus for inactivation of biological contaminant using photosensitizer 有权
标题翻译：使用光敏剂灭活生物污染物的方法和装置
公开(公告)号：JP2006273868A
公开(公告)日：2006-10-12
申请号：JP2006182909
申请日：2006-07-03
申请人： Gambro Inc , ガンブロ、インコーポレイテッド
发明人： GOODRICH JR RAYMOND PAUL , CORBIN III FRANK , WOOD JR EDWARD C , HLAVINKA DENNIS
IPC分类号： A61K35/14 , A61L2/02 , A61L20060101 , A61L2/00 , A61L2/08 , A61L2/10 , A61L2/16 , A61L2/23 , A61M1/36
CPC分类号： A61L2/08 , A61L2/0011 , A61L2/0047 , A61L2/0052 , A61L2/0082 , A61L2/10 , A61L2/23 , A61L2202/22 , A61M1/3683 , C12N7/04
摘要： PROBLEM TO BE SOLVED: To provide a method which does not need the removal of a remaining reagent after light irradiation in a process of preparing a blood product or the like. SOLUTION: A method is provided for the inactivation of microorganisms or leukocytes which may be in a collected fluid by treatment of the fluid. The method includes (a) a step of adding an effective amount of endogenous alloxazine or basically endogenous alloxazine derivative as a photosensitizer for inactivation to the above fluid and (b) a step of exposing the fluid of step (a) to an ultraviolet light, a visible light or a mixture thereof, to thoroughly or partially prevent the replication of the above microorganisms or the leukocytes, and does not include (c) a step of removing the endogenous alloxazine or the basically endogenous alloxazine derivative, after inactivation of the microorganisms or the leukocytes. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供在制备血液制品等的过程中在光照射后不需要除去剩余试剂的方法。解决方案：提供了通过处理流体来灭活可能在收集的流体中的微生物或白细胞的方法。该方法包括（a）将有效量的内源性环氮嗪或基本上内源的环氮嗪衍生物作为光敏剂加入到上述流体失活的步骤和（b）将步骤（a）的流体暴露于紫外线的步骤，可见光或其混合物，以彻底或部分地防止上述微生物或白细胞的复制，并且不包括（c）在灭活微生物之后除去内源性环氮嗪或基本上内源性的环氮嗪衍生物的步骤，或白细胞。版权所有（C）2007，JPO＆INPIT

6. 发明专利

JP2006136747A Extracorporeal blood processing method and apparatus 有权
标题翻译：超声波血液加工方法和装置
公开(公告)号：JP2006136747A
公开(公告)日：2006-06-01
申请号：JP2006031786
申请日：2006-02-09
申请人： Gambro Inc , ガンブロ、インコーポレイテッド
发明人： BAINBRIDGE MARLENE ADELE , BILODEAU LEON E , BLAKESLEE JEFFREY J , BREIERTON MARK J , CORBIN FRANK III , CRUZ EDWARD V , DOLECEK VICTOR D , GARRISON DENISE C , GORDON TIMOTHY M , HEMPSTEAD RUSSEL , HOARD DAVID W , HOLMES BRIAN M , KAPPUS JOHN J , LANGLEY ROBERT W , MENHENNETT THOMAS L , MUDLOFF FREDERICK S , MURRAY RICHARD E , SHOULDICE DAVID R , STEEL CHAD C , TOAVS COY , WAHL TERRY R
IPC分类号： A61M1/02
摘要： PROBLEM TO BE SOLVED: To provide a blood component removing system to make a blood manipuulation chamber be easily set on a channel combined to a centrifugal separator rotor. SOLUTION: A blood processing channel (208) equipped on a channel housing (204) connected to a centrifugal rotor (568) of a blood component removing system (2) includes a first cell separation stage (312) with blood inlets (224, 388) and RBC outlets (276, 516) and at least one other stage (316). The ratio of a volume of the at least one other stage (316) of the channel (208) to a volume of the first separation stage (312) is to be smaller than the ratio of desired hematocrit of liquid to be removed through the RBC outlets (272, 516) to desired hematocrit of liquid to be guided through the blood inlets (224, 388), lower than 1/2. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供一种血液成分去除系统，以使血液操作室容易地设置在与离心分离器转子组合的通道上。解决方案：配备在与血液成分去除系统（2）的离心转子（568）连接的通道壳体（204）上的血液处理通道（208）包括具有血液入口的第一细胞分离级（312） 224,388）和RBC出口（276,516）和至少一个其他阶段（316）。通道（208）的至少一个其他阶段（316）的体积与第一分离阶段（312）的体积的比例应小于通过RBC去除的液体的期望血细胞比容的比例出口（272,516），其通过血液入口（224,388）引导的液体的期望血细胞比容小于1/2。版权所有（C）2006，JPO＆NCIPI

7. 发明专利

JP2006124405A Aqueous solution of platelet additive 有权
标题翻译：钢板添加剂的水溶液
公开(公告)号：JP2006124405A
公开(公告)日：2006-05-18
申请号：JP2006033243
申请日：2006-02-10
申请人： Gambro Inc , ガンブロ、インコーポレイテッド
发明人： GOODRICH JR RAYMOND PAUL , CORBIN III FRANK , WOOD JR EDWARD C , HLAVINKA DENNIS
IPC分类号： A61K35/14 , A61L2/02 , A61L20060101 , A61L2/00 , A61L2/08 , A61L2/10 , A61L2/16 , A61L2/23 , A61M1/36 , A61P7/00
CPC分类号： A61L2/08 , A61L2/0011 , A61L2/0047 , A61L2/0052 , A61L2/0082 , A61L2/10 , A61L2/23 , A61L2202/22 , A61M1/3683 , C12N7/04
摘要： PROBLEM TO BE SOLVED: To provide an aqueous solution of a platelet additive, useful as a carrier of a platelet concentrate, and prolonging its storage life. SOLUTION: The aqueous solution of the platelet additive contains an endogenous photosensitizer selected from endogenous alloxazines, vitamin Ks and vitamin L. Preferably, the solution contains physiological saline solution, a buffer and sodium gluconate besides them, and has about pH 7.0-7.4. The photosensitizer is preferably the endogenous alloxazines, more preferably 7,8-dimethyl-10-ribitylisoalloxazine. The concentration of the photosensitizer is preferably about 10-100 μM. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供可用作血小板浓缩物的载体的血小板添加剂的水溶液，并延长其储存寿命。解决方案：血小板添加剂的水溶液含有选自内源性环氧烷，维生素K和维生素L的内源性光敏剂。优选地，该溶液含有生理盐水溶液，缓冲液和除了它们之外的葡萄糖酸钠，并且具有约pH 7.0- 7.4。光敏剂优选为内源性环氧烷，更优选为7,8-二甲基-10-核糖基咪唑并。光敏剂的浓度优选为约10-100μM。版权所有（C）2006，JPO＆NCIPI

8. 发明专利

JP2004033721A Device, system, and method for separating fluid using fluid pressure driving/balancing structure 审中-公开
公开(公告)号：JP2004033721A
公开(公告)日：2004-02-05
申请号：JP2002232145
申请日：2002-07-04
申请人： Gambro Inc , ガンブロインコーポレーテッド
发明人： HLAVINKA DENNIS J , FELT THOMAS J
IPC分类号： A61M1/02 , B04B5/00
摘要： PROBLEM TO BE SOLVED: To provide a centrifugal fluid separating system used for centrifugally separating a composite fluid into components. SOLUTION: The centrifugal fluid separating system includes at least one centrifugal rotor having a composite housing area, a plurality of fluid flow passages, and two or more separated recovering areas 43 and 44 demarcated in the flow passages. The composite fluid to be separated is sent to a fluid housing area 42, reaches a substantially annular peripheral fluid separating flow passage 50 from the area 42 through a flowing-in passage, and is separated into components by a centrifugal force. The separated components respectively enter into the separated component recovering areas 43 and 44 respectively through first and second separated fluid flowing-out passages 53 and 54. The passages 53 and 54 respectively have first and second heights and the heights are set to have such a correlation that substantially balances the fluid pressures of the separated components flowing through the passages 53 and 54. This pressure balance controls the boundary face between the fluid components separated from each other in the peripheral fluid separating flow passage 50. COPYRIGHT: (C)2004,JPO

9. 发明专利

TW590780B 含核黃素之添加溶液有权
简体标题：含核黄素之添加溶液
公开(公告)号：TW590780B
公开(公告)日：2004-06-11
申请号：TW090112943
申请日：2001-05-29
申请人：甘比羅股份有限公司 GAMBRO, INC.
发明人：賴瑞.杜蒙特 DUMONT, LARRY JOE , 雷門.古德瑞奇 GOODRICH, RAYMOND PAUL
IPC分类号： A61L
CPC分类号： A61L2/084 , A61K41/0019 , A61L2/0011 , A61L2/0082 , A61L2/0088 , A61L2/08 , A61L2/10 , A61L2202/22 , A61M1/0213 , A61M1/3681 , A61M1/3683 , A61M1/3693 , A61M2205/123
摘要：本發明提出一種使流體中或表面上之微生物滅能之方法及裝置。該流體以含有血液或血液製品且包括生物活性蛋白質為佳。較佳方法係包括添加有效、無毒性之量的內源感光劑於流體中，使該流體曝照足以活化該內源感光劑之光輻射，以使微生物滅能。其他流體，包括果汁、水等，亦可藉此等方法去除污染物，食品表面、動物屍體、創傷、食品製備表面及浸浴及洗滌容器表面亦可。咯及K－與L－維生素係為較佳之感光劑。亦提供流通式系統及裝置與分批式方法以使用感光劑以去除該流體之污染物。
简体摘要：本发明提出一种使流体中或表面上之微生物灭能之方法及设备。该流体以含有血液或血液制品且包括生物活性蛋白质为佳。较佳方法系包括添加有效、无毒性之量的内源感光剂于流体中，使该流体曝照足以活化该内源感光剂之光辐射，以使微生物灭能。其他流体，包括果汁、水等，亦可借此等方法去除污染物，食品表面、动物尸体、创伤、食品制备表面及浸浴及洗涤容器表面亦可。咯及K－与L－维生素系为较佳之感光剂。亦提供流通式系统及设备与分批式方法以使用感光剂以去除该流体之污染物。

10. 发明申请

US20040104182A1 Methods and apparatuses for blood component separation 有权
标题翻译：血液成分分离方法和装置
公开(公告)号：US20040104182A1
公开(公告)日：2004-06-03
申请号：US10648559
申请日：2003-08-25
申请人： Gambro, Inc.
发明人： Brian M. Holmes , Johan-Petter Hagstrom , Per-Olov Lundberg , Geert Van Waeg , Peter Nordgren
IPC分类号： B04B001/00
CPC分类号： B04B13/00 , A61M1/0209 , A61M1/0218 , A61M1/025 , A61M1/26 , A61M1/262 , A61M1/3633 , A61M1/3639 , A61M1/3641 , A61M1/3693 , A61M1/3696 , A61M1/3698 , A61M2205/331 , B04B5/0428 , B04B5/0442 , B04B2005/045 , B04B2005/0478 , B04B2013/006
摘要： A system for separating a composite fluid into component parts thereof, including: a centrifuge having a rotor with a separation space and at least two valve members disposed thereon and a container set having a separation container adapted to be disposed in the separation space of the rotor and first and second collection containers connected to the separation container by a first and a second tubes. The tubes are adapted to be disposed in operative relationship with the valve members so that flow through the tubes may be controlled thereby. Three components of the composite fluid may be separated therefrom by the present system and two components may be moved to the collection containers. The container set may further include a third collection container connected to the separation container by a tube, and a third component may thus be moved to this third container.
摘要翻译：一种将复合流体分离成其组成部分的系统，包括：具有分离空间的转子和设置在其上的至少两个阀构件的离心机和具有适于设置在转子的分离空间中的分离容器的容器组以及通过第一和第二管连接到分离容器的第一和第二收集容器。管适于与阀构件成可操作的关系，从而可以控制通过管的流动。复合流体的三个组分可以通过本系统与其分离，并且两个组分可以移动到收集容器中。容器组还可以包括通过管连接到分离容器的第三收集容器，并且因此第三组分可以移动到第三容器。

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