专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2010141406A2 AMINO PYRIMIDINE ANTICANCER COMPOUNDS 审中-公开
标题翻译：氨基吡啶类化合物
公开(公告)号：WO2010141406A2
公开(公告)日：2010-12-09
申请号：PCT/US2010036808
申请日：2010-06-01
申请人： OSI PHARM INC , APPARI RAMA DEVI , CHEN XIN , CHILUKURI RAMESH , CREW ANDREW P , DONG HANQING , FERRARO CATERINA , FOREMAN KENNETH , GUPTA RAMESH C , LI AN-HU , SHERMAN DAN , STOLZ KATHRYN M , VOLK BRIAN , ZAHLER ROBERT
发明人： APPARI RAMA DEVI , CHEN XIN , CHILUKURI RAMESH , CREW ANDREW P , DONG HANQING , FERRARO CATERINA , FOREMAN KENNETH , GUPTA RAMESH C , LI AN-HU , SHERMAN DAN , STOLZ KATHRYN M , VOLK BRIAN , ZAHLER ROBERT
IPC分类号： C07D401/12 , A61K31/497 , A61P35/00 , C07D403/12 , C07D403/14
CPC分类号： C07F9/65583 , A61K31/497 , C07D401/12 , C07D403/12 , C07D403/14 , C07F9/65122 , C07F9/6544
摘要： Compounds of Formula (1), as shown below and defined herein: and pharmaceutically acceptable salts, synthesis, intermediates, formulations, and methods of disease treatment therewith, including cancers mediated at least in part by FAK.
摘要翻译：式（1）的化合物，如下文所定义：和其药学上可接受的盐，合成，中间体，制剂及其治疗方法，包括至少部分由FAK介导的癌症。

2. 发明申请

WO02056837A3 INHIBITION OF PROTEIN-PHOSPHATASES FOR THE TREATMENT OF HEART FAILURE 审中-公开
标题翻译：用于治疗心力衰竭的蛋白质磷酸酶的抑制
公开(公告)号：WO02056837A3
公开(公告)日：2003-03-06
申请号：PCT/US0200957
申请日：2002-01-15
申请人： FORD HENRY HEALTH SYSTEM , GUPTA RAMESH C , SABBAH HANI N
发明人： GUPTA RAMESH C , SABBAH HANI N
IPC分类号： A61K38/00 , A61K38/17 , A61P9/10 , C07K14/47 , C12N15/57 , C12P21/08 , C12N9/16 , A61K38/46 , A61K39/00 , C07K1/00
CPC分类号： A61K38/1709 , A61K38/005 , C07K14/4703
摘要： There is provided a method for treating an individual with cardiovascular disease, including the step of administering a therapeutically effective amount of protein phosphatase inhibitor and analogues thereof, to the individual after the onset of cardiac ischemia. Also provided is a method of treating an individual with cardiovascular disease by selectively inhibiting protein phosphatase activity in the heart. A composition for the treatment of heart failure, the composition including an inhibitor of PP1 and a pharmaceutically acceptable carrier is also provided. There is provided a sequence encoding inhibitor-2.
摘要翻译：提供了治疗患有心血管疾病的个体的方法，包括在心脏缺血发作后向个体施用治疗有效量的蛋白质磷酸酶抑制剂及其类似物的步骤。还提供了通过选择性抑制心脏中的蛋白磷酸酶活性来治疗患有心血管疾病的个体的方法。还提供了用于治疗心力衰竭的组合物，包含PP1抑制剂和药学上可接受的载体的组合物。提供了编码抑制剂-2的序列。

3. 发明申请

WO02056837A9 INHIBITION OF PROTEIN-PHOSPHATASES FOR THE TREATMENT OF HEART FAILURE 审中-公开
标题翻译：抑制蛋白磷酸酶治疗心力衰竭
公开(公告)号：WO02056837A9
公开(公告)日：2002-11-28
申请号：PCT/US0200957
申请日：2002-01-15
申请人： FORD HENRY HEALTH SYSTEM , GUPTA RAMESH C , SABBAH HANI N
发明人： GUPTA RAMESH C , SABBAH HANI N
IPC分类号： A61K38/00 , A61K38/17 , A61P9/10 , C07K14/47 , C12N15/57 , C12P21/08 , A61K
CPC分类号： A61K38/1709 , A61K38/005 , C07K14/4703
摘要： There is provided a method for treating an individual with cardiovascular disease, including the step of administering a therapeutically effective amount of protein phosphatase inhibitor and analogues thereof, to the individual after the onset of cardiac ischemia. Also provided is a method of treating an individual with cardiovascular disease by selectively inhibiting protein phosphatase activity in the heart. A composition for the treatment of heart failure, the composition including an inhibitor of PP1 and a pharmaceutically acceptable carrier is also provided. There is provided a sequence encoding inhibitor-2.
摘要翻译：提供了治疗心血管疾病个体的方法，包括在心脏局部缺血发作后向个体施用治疗有效量的蛋白磷酸酶抑制剂及其类似物的步骤。还提供了通过选择性抑制心脏中的蛋白磷酸酶活性来治疗患有心血管疾病的个体的方法。还提供了用于治疗心力衰竭的组合物，所述组合物包含PP1抑制剂和药学上可接受的载体。提供了编码抑制剂-2的序列。

4. 发明申请

WO2010141406A3 AMINO PYRIMIDINE ANTICANCER COMPOUNDS 审中-公开
公开(公告)号：WO2010141406A3
公开(公告)日：2010-12-09
申请号：PCT/US2010/036808
申请日：2010-06-01
申请人： OSI PHARMACEUTICALS, INC. , APPARI, Rama, Devi , CHEN, Xin , CHILUKURI, Ramesh , CREW, Andrew, P. , DONG, Hanqing , FERRARO, Caterina , FOREMAN, Kenneth , GUPTA, Ramesh, C. , LI, An-hu , SHERMAN, Dan , STOLZ, Kathryn, M. , VOLK, Brian , ZAHLER, Robert
发明人： APPARI, Rama, Devi , CHEN, Xin , CHILUKURI, Ramesh , CREW, Andrew, P. , DONG, Hanqing , FERRARO, Caterina , FOREMAN, Kenneth , GUPTA, Ramesh, C. , LI, An-hu , SHERMAN, Dan , STOLZ, Kathryn, M. , VOLK, Brian , ZAHLER, Robert
IPC分类号： C07D401/12 , C07D403/12 , C07D403/14 , A61P35/00 , A61K31/497
摘要： Compounds of Formula (1), as shown below and defined herein: and pharmaceutically acceptable salts, synthesis, intermediates, formulations, and methods of disease treatment therewith, including cancers mediated at least in part by FAK.

5. 发明申请

WO2009114525A1 METHODS AND COMPOSITIONS FOR CONTROLLED DELIVERY OF PHYTOCHEMICAL AGENTS 审中-公开
标题翻译：用于控制输送生物化学剂的方法和组合物
公开(公告)号：WO2009114525A1
公开(公告)日：2009-09-17
申请号：PCT/US2009/036663
申请日：2009-03-10
申请人： UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. , GUPTA, Ramesh, C. , VADHANAM, Manicka, V.
发明人： GUPTA, Ramesh, C. , VADHANAM, Manicka, V.
IPC分类号： A01N65/00 , A61K35/12 , A61K31/55
CPC分类号： A61M31/00 , A61K9/0024 , A61K9/0036 , A61K9/204 , A61K9/205 , A61K31/01 , A61K31/05 , A61K31/121 , A61K31/366 , A61K31/404 , A61K31/497
摘要： The presently-disclosed subject matter provides compositions and methods for treating a cancer by providing a composition comprising a biocompatible polymeric matrix incorporating an effective amount of a phytochemical agent, a combination of phytochemical agents, or a phytochemical agent and a chemotherapeutic agent. Further, provided is a device for uterine cervical insertion for local delivery.
摘要翻译：目前公开的主题提供了通过提供包含有效量的植物化学试剂，植物化学试剂或植物化学试剂和化学治疗剂的组合的生物相容性聚合物基质的组合物来治疗癌症的组合物和方法。此外，提供了用于子宫颈插入用于局部递送的装置。

6. 发明申请

WO2015127118A1 METHOD FOR ISOLATION OF BULK ANTHOCYANIDINS AND OTHER BIOACTIVES 审中-公开
标题翻译：分离大肠杆菌和其他生物活性的方法
公开(公告)号：WO2015127118A1
公开(公告)日：2015-08-27
申请号：PCT/US2015/016678
申请日：2015-02-19
申请人： GUPTA, Ramesh, C.
发明人： GUPTA, Ramesh, C.
IPC分类号： C07D311/62 , C07D311/76 , A61K36/45 , C07H17/06
CPC分类号： C07D311/76 , A23L5/43 , C07D311/62
摘要： This invention describes a simple, rapid and cost-effective method to isolate bulk quantities of relatively pure and enriched anthocyanidins and other plant bioactives. The method is based on the principle of solubility. Some bioactives (anthocyanidins) were extracted in an aqueous solvent, transferred to a non-aqueous solvent and finally insolubilized by adding a miscible solvent in which the bioactive was insoluble. Thus, anthocyanidins were isolated from anthocyanin-enriched berries or non-enriched, dark-colored fruits, vegetables and grains by extraction of anthocyanins, acid hydrolysis, and extraction of the resulting anthocyanidins, followed by their insolubilization (precipitation). Some bioactives (hydrophobic and hydrophilic) were extracted in a solvent with high solubility and then directly insolubilized by adding a miscible solvent in which the bioactive was insoluble, for example, withaferin A from enriched Withania somnifera and punicalagins from enriched punica extract.
摘要翻译：本发明描述了分离大量相对纯的和富集的花青素和其它植物生物活性物的简单，快速和成本有效的方法。该方法是基于溶解度的原理。一些生物活性物质（花色素苷）在水性溶剂中提取，转移到非水溶剂中，最后通过加入其中生物活性不溶性的混溶溶剂而不溶解。因此，通过提取花青素，酸水解和提取所得花青素，然后使其不溶（沉淀），从花青素浓缩的浆果或非浓缩的深色水果，蔬菜和谷物中分离出花青素。一些生物活性物质（疏水性和亲水性）在高溶解度的溶剂中提取，然后通过加入其中生物活性不溶性的可混溶溶剂直接不溶，例如来自富集的有色金属藻的嗜铬蛋白A和来自浓缩的竹提提液的刺梧桐木。

7. 发明申请

WO2015073802A1 PROTEIN PHOSPHATASE INHIBITORS THAT CROSS THE BLOOD BRAIN BARRIER 审中-公开
标题翻译：蛋白磷酸酶抑制剂跨越血脑屏障
公开(公告)号：WO2015073802A1
公开(公告)日：2015-05-21
申请号：PCT/US2014/065669
申请日：2014-11-14
申请人： LIXTE BIOTECHNOLOGY, INC. , KOVACH, John, S. , JOHNSON, Francis , SAMUDRALA, Ramakrishna , GUPTA, Ramesh, C.
发明人： KOVACH, John, S. , JOHNSON, Francis , SAMUDRALA, Ramakrishna , GUPTA, Ramesh, C.
IPC分类号： A61K31/496 , A61P35/00 , C07D493/08
CPC分类号： C07D493/08 , A61K31/4178 , A61K31/4433 , A61K31/496 , A61K45/06 , C07F9/6561 , A61K2300/00
摘要： The present invention provides a method for in vivo delivery of endothal to a target cell in a subject, the method comprising administering to the subject a compound having the structure: Formula (I).
摘要翻译：本发明提供了一种用于体内递送受试者的靶细胞的内给体的方法，所述方法包括向受试者施用具有以下结构的化合物：式（I）。

8. 发明申请

WO2011100502A8 7-AMINOFUROPYRIDINE DERIVATIVES 审中-公开
标题翻译： 7-氨基脲衍生物
公开(公告)号：WO2011100502A8
公开(公告)日：2011-09-22
申请号：PCT/US2011024449
申请日：2011-02-11
申请人： OSI PHARMACEUTICALS LLC , HORNBERGER KEITH R , BERGER DAN M , CHEN XIN , CREW ANDREW P , DONG HANQING , KLEINBERG ANDREW , LI AN-HU , MA LIFU , MULVIHILL MARK J , PANICKER BIJOY , SIU KAM W , STEINIG ARNO G , TARRANT JAMES G , WANG JING , WENG QINGHUA , SANGEM RAJARAM , GUPTA RAMESH C
发明人： HORNBERGER KEITH R , BERGER DAN M , CHEN XIN , CREW ANDREW P , DONG HANQING , KLEINBERG ANDREW , LI AN-HU , MA LIFU , MULVIHILL MARK J , PANICKER BIJOY , SIU KAM W , STEINIG ARNO G , TARRANT JAMES G , WANG JING , WENG QINGHUA , SANGEM RAJARAM , GUPTA RAMESH C
IPC分类号： C07D491/048 , A61K31/4355 , A61P35/00
CPC分类号： C07D491/048
摘要： Compounds of Formula (1), as shown below and defined herein: pharmaceutically acceptable salts thereof, synthesis, intermediates, formulations, and methods of disease treatment therewith, including treatment of cancers, such as tumors driven at least in part by TAK1 or for which an appropriate TAK1 inhibitor is effective. This Abstract is not limiting of the invention.
摘要翻译：式（1）的化合物，如下文所定义：其药学上可接受的盐，合成，中间体，制剂及其治疗方法，包括治疗癌症，例如至少部分由TAK1驱动的肿瘤，或其中适当的TAK1抑制剂是有效的。本发明并不限于本发明。

9. 发明申请

WO2011109593A1 SUBSTITUTED-5-AMINOPYRROLO/PYRAZOLOPYRIDINES 审中-公开
标题翻译：取代的-5-氨基吡咯并/吡唑并吡啶
公开(公告)号：WO2011109593A1
公开(公告)日：2011-09-09
申请号：PCT/US2011/026984
申请日：2011-03-03
申请人： OSI PHARMACEUTICALS, LLC , AN-HU, Li , GUPTA, Ramesh, C. , MULVIHILL, Mark, J. , RAI, Anand, Narain , WANG, Jing
发明人： AN-HU, Li , GUPTA, Ramesh, C. , MULVIHILL, Mark, J. , RAI, Anand, Narain , WANG, Jing
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
CPC分类号： C07D471/04
摘要： Compounds of Formula I, as shown below and defined herein: pharmaceutically acceptable salts, synthesis, intermediates, formulations, and methods of disease treatment therewith, including cancers mediated at least in part by RON and/or MET.
摘要翻译：式I的化合物，如下文所示和本文定义：药学上可接受的盐，合成，中间体，制剂及其治疗方法，包括至少部分由RON和/或MET介导的癌症。

10. 发明申请

WO2011100502A1 7-AMINOFUROPYRIDINE DERIVATIVES 审中-公开
标题翻译： 7-氨基脲衍生物
公开(公告)号：WO2011100502A1
公开(公告)日：2011-08-18
申请号：PCT/US2011/024449
申请日：2011-02-11
申请人： OSI PHARMACEUTICALS, LLC , HOMBERGER, Keith, R. , BERGER, Dan, M. , CHEN, Xin , CREW, Andrew, P. , DONG, Hanqing , KLEINBERG, Andrew , LI, An-Hu , MA, Lifu , MULVIHILL, Mark, J. , PANICKER, Bijoy , SIU, Kam, W. , STEINIG, Arno, G. , TARRANT, James, G. , WANG, Jing , WENG, Qinghua , SANGEM, Rajaram , GUPTA, Ramesh, C.
发明人： HOMBERGER, Keith, R. , BERGER, Dan, M. , CHEN, Xin , CREW, Andrew, P. , DONG, Hanqing , KLEINBERG, Andrew , LI, An-Hu , MA, Lifu , MULVIHILL, Mark, J. , PANICKER, Bijoy , SIU, Kam, W. , STEINIG, Arno, G. , TARRANT, James, G. , WANG, Jing , WENG, Qinghua , SANGEM, Rajaram , GUPTA, Ramesh, C.
IPC分类号： C07D491/048 , A61K31/4355 , A61P35/00
CPC分类号： C07D491/048
摘要： Compounds of Formula 1, as shown below and defined herein: pharmaceutically acceptable salts thereof, synthesis, intermediates, formulations, and methods of disease treatment therewith, including treatment of cancers, such as tumors driven at least in part by TAK1 or for which an appropriate TAK1 inhibitor is effective. This Abstract is not limiting of the invention.
摘要翻译：式1的化合物，如下文所定义：其药学上可接受的盐，合成，中间体，制剂及其治疗方法，包括治疗癌症，例如至少部分由TAK1驱动的肿瘤，或适合于 TAK1抑制剂有效。本发明并不限于本发明。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式