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1. 发明申请

WO2004051274A1 AHEMICALLY AMPLIFIED ELECTROCHEMICAL DETECTION OF AFFINITY REACTION 审中-公开
标题翻译：重要的放大电化学检测活性反应
公开(公告)号：WO2004051274A1
公开(公告)日：2004-06-17
申请号：PCT/CN2003/000329
申请日：2003-05-06
申请人： CAPITAL BIOCHIP COMPANY, LTD. , TSINGHUA UNIVERSITY , GUO, Lianghong , LI, Yuanguang , WANG, Na , WANG, Fuquan , YANG, Xiqiang , CHENG, Jing
发明人： GUO, Lianghong , LI, Yuanguang , WANG, Na , WANG, Fuquan , YANG, Xiqiang , CHENG, Jing
IPC分类号： G01N33/543
CPC分类号： G01N33/5438 , C12Q1/6825 , G01N27/3277 , G01N33/58 , G01N2458/30
摘要： This invention relates generally to the field of electrochemistry. In particular, the invention provides a method for assaying an analyte, using, inter alia , a reactant capable of binding and/or reacting with an analyte to be analyzed on an oxide electrode and a reducing agent not capable of being oxidized directly by said electrode to generate reduced electrochemically active molecule that participates in oxidation-reduction reactions repeatedly to generate an amplified electrochemical signal to determine presence and/or amount of said analyte in said sample.
摘要翻译：本发明一般涉及电化学领域。特别地，本发明提供了一种用于分析分析物的方法，特别是使用能够在氧化物电极和不能被所述电极直接氧化的还原剂上结合和/或反应待分析物的反应物以产生重复参与氧化还原反应的还原电化学活性分子以产生放大的电化学信号以确定所述样品中所述分析物的存在和/或量。

2. 发明申请

WO2004046721A1 APPARATUSES AND METHODS FOR ASSAYING ANALYTES USING PHOTOELECTROCHEMICAL LABELS 审中-公开
标题翻译：使用光电化学标签测定分析仪的装置和方法
公开(公告)号：WO2004046721A1
公开(公告)日：2004-06-03
申请号：PCT/CN2003/000327
申请日：2003-05-06
申请人： CAPITAL BIOCHIP COMPANY, LTD. , TSINGHUA UNIVERSITY , GUO, Lianghong , DONG, Dong , ZHENG, Dong , WANG, Fuquan , YANG, Xiqiang , CHENG, Jing
发明人： GUO, Lianghong , DONG, Dong , ZHENG, Dong , WANG, Fuquan , YANG, Xiqiang , CHENG, Jing
IPC分类号： G01N33/543
CPC分类号： G01N33/582 , C12Q1/6816 , G01N2458/30 , C12Q2563/113 , C12Q2523/313
摘要： The present invention provides apparatus, kits and methods for assaying analytes using photoelectrochemical molecules as labels. Specifically, the present invention provides a method for assaying an analyte, comprising: a) contacting a sample suspected of containing an analyte with a reactant capable of binding and/or reacting with the analyte under suitable conditions to allow binding of analyte, if present in the sample, to the reactant; and b) assessing binding and/or reacting between the analyte and the reactant to determine presence and/or amount of analyte in the sample, wherein the reactant, analyte, or additional reactant or additional analyte or analyte analog is labeled with a photoelectrochemically active molecule. The assessing step also comprises converting the photoelectrochemically active molecule with light to an excited state in the presence of an electrode, and assessing an electric current generated by an electron transfer between the excited photoelectrochemically active molecule and the electrode.
摘要翻译：本发明提供了使用光电化学分子作为标记来测定分析物的装置，试剂盒和方法。具体地，本发明提供了一种用于分析分析物的方法，其包括：a）在合适的条件下将疑似含有分析物的样品与能够与分析物结合和/或反应的反应物接触，以使分析物（如果存在于样品，反应物; 和b）评估分析物和反应物之间的结合和/或反应以确定样品中分析物的存在和/或量，其中反应物，分析物或附加反应物或其他分析物或分析物类似物用光电化学活性分子标记。评估步骤还包括在存在电极的情况下将光电化学活性分子与光转化为激发态，并评估由激发的光电化学活性分子和电极之间的电子转移产生的电流。

3. 发明申请

WO2005015213A1 FLUORESCENT MAGNETIC NANOPARTICLES AND PROCESS OF PREPARATION 审中-公开
标题翻译：荧光磁性纳米粒子及其制备方法
公开(公告)号：WO2005015213A1
公开(公告)日：2005-02-17
申请号：PCT/CN2003/000666
申请日：2003-08-13
申请人： TSINGHUA UNIVERSITY , CAPITAL BIOCHIP COMPANY LTD. , LU, Huachang , YI, Guangshun , CHEN, Depu , GUO, Lianghong , CHENG, Jing
发明人： LU, Huachang , YI, Guangshun , CHEN, Depu , GUO, Lianghong , CHENG, Jing
IPC分类号： G01N33/533
CPC分类号： B82Y15/00 , G01N33/54326 , G01N33/588 , Y10T428/2991
摘要： This invention provides nanometer-sized fluorescent magnetic particles and processes of making them. The nanoparticle has a core particle comprising a magnetic material and a fluorescent material, and the particle size is less than about 1 micrometer. The nanoparticles can be coated with an inorganic or organic layer and can be surface-modified. The nanoparticles can be used in many biological assays.
摘要翻译：本发明提供纳米级荧光磁性颗粒及其制备方法。纳米颗粒具有包含磁性材料和荧光材料的核心颗粒，并且其粒径小于约1微米。纳米颗粒可以用无机或有机层涂覆并且可以进行表面改性。纳米颗粒可用于许多生物测定。

4. 发明申请

WO2003087259A1 NANOMETER-SIZED UP-CONVERTING PHOSPHOR FLUORIDE PARTICLES AND PROCESS OF PREPARATION 审中-公开
标题翻译：纳米尺寸上转换磷光体颗粒及其制备方法
公开(公告)号：WO2003087259A1
公开(公告)日：2003-10-23
申请号：PCT/CN2003/000268
申请日：2003-04-15
申请人： TSINGHUA UNIVERSITY , CAPITAL BIOCHIP COMPANY, LTD. , YI, Guangshun , SUN, Baoquan , CHEN, Depu , ZHOU, Yuxiang , CHENG, Jing , YANG, Wenjun , GE, Yue , GUO, Lianghong
发明人： YI, Guangshun , SUN, Baoquan , CHEN, Depu , ZHOU, Yuxiang , CHENG, Jing , YANG, Wenjun , GE, Yue , GUO, Lianghong
IPC分类号： C09K11/77
CPC分类号： C09K11/7772 , C09K11/7773 , Y10S977/83 , Y10S977/834
摘要： Nanometer-scaled up-converting fluoride phosphor particles and processes of making them are disclosed. In the process, an aqueous solution consisting of soluble salts of rare-earth metal ions at a molar ratio of (yttrium, lanthanum or gadolinium): ytterbium:(erbium, holmium, terbium or thulium) = (70-90):(0-29):(0.001-15) is mixed a rare-earth metal chelator and a soluble fluoride salt to form precipitates, which are then annealed at an elevated temperature to produce nanometer-scaled up-converting fluoride phosphor particles. The particle size is between 35nm and 200nm, and can be controlled by the amount of the metal chelator added to the solution. The nanometer-sized particle is applicable to many biological assays.
摘要翻译：公开了纳米级上转换氟化物荧光体颗粒及其制备方法。在该方法中，以（钇，镧或钆）的摩尔比形成的稀土金属离子的可溶性盐：镱（铒，钬，铽或ium）=（70-90）：（0） -29）:( 0.001-15）混合稀土金属螯合剂和可溶性氟化物盐形成析出物，然后在升高的温度下退火，生成纳米级的上转换氟化物荧光体颗粒。粒径介于35nm和200nm之间，可以通过添加到溶液中的金属螯合剂的量来控制。纳米级粒子适用于许多生物测定。

5. 发明申请

WO2006007766A1 A CALIBRATION SLIDE FOR FLUORESCENCE DETECTION INSTRUMENTS AND PROCESS OF PREPARATION 审中-公开
标题翻译：用于荧光检测仪器的校准幻灯片及其制备方法
公开(公告)号：WO2006007766A1
公开(公告)日：2006-01-26
申请号：PCT/CN2004/001328
申请日：2004-11-22
申请人： CAPITALBIO CORPORATION , TSINGHUA UNIVERSITY , GE, Yue , YANG, Wenjun , ZHAO, Shuying , GUO, Lianghong , CHENG, Jing
发明人： GE, Yue , YANG, Wenjun , ZHAO, Shuying , GUO, Lianghong , CHENG, Jing
IPC分类号： G01N21/64
CPC分类号： G01N21/6452 , G01N21/278 , Y10T436/255
摘要： The present invention relates to calibration slides for fluorescence detection instruments and processing method of making them. The aim of this invention is to disclose calibration slides with high photostability and long lifetime for fluorescence detection instruments. The calibration slides are fabricated by patterning calibration spot arrays of modified inorganic phosphors on the glass slide. The process for producing a calibration slide comprises the following procedure: 1) Dispersing the inorganic phosphors of rare-earth doped complex in water; 2) Patterning the affay of the above suspension on the glass slide. The calibration slides in the present invention employ a very stable fluorescing material that is insensitive to photobleaching, has long lifetime and stability under mild storage condition. The calibration slides in the present invention can be used to calibrate and test for some fluorescence instruments, i.e. microarray scanner, fluorescent microscopy, fluorescence spectrometer, fluorescent multiwell-plate reader.
摘要翻译：本发明涉及用于荧光检测仪器的校准载片及其制作方法。本发明的目的是公开具有高荧光检测仪器的高光稳定性和长寿命的校准载玻片。通过在玻璃载片上图案化修饰的无机磷光体的校准点阵列来制造校准载玻片。制备校准载玻片的方法包括以下步骤：1）将稀土掺杂络合物的无机磷光体分散在水中; 2）将上述悬浮液的印刷图案化在玻璃载玻片上。本发明中的校准载玻片使用对光漂白不敏感的非常稳定的荧光材料，在温和储存条件下具有长寿命和稳定性。本发明中的校准载玻片可用于校准和测试一些荧光仪器，即微阵列扫描仪，荧光显微镜，荧光光谱仪，荧光多孔板读数器。

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