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1. 发明授权

US09982026B2 Compositions and methods for assessing and treating adrenal diseases and disorders 有权
公开(公告)号：US09982026B2
公开(公告)日：2018-05-29
申请号：US13978098
申请日：2012-01-04
申请人： Richard P. Lifton , Bixiao Zhao , Murim Choi , Goran Akerstrom , Gunnar Westin , Peyman Bjorklund , Per Hellman
发明人： Richard P. Lifton , Bixiao Zhao , Murim Choi , Goran Akerstrom , Gunnar Westin , Peyman Bjorklund , Per Hellman
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/02 , C07H21/04 , C07K14/435 , C07K14/705 , A61K49/06 , A61K51/00 , G01N33/68
CPC分类号： C07K14/435 , A61K49/06 , A61K51/00 , C07K14/705 , C12Q1/686 , C12Q1/6883 , C12Q1/6886 , C12Q2600/156 , G01N33/6893
摘要： The present invention relates to the discovery that mutations in KCNJ5 are associated with adrenal diseases and disorders. The invention includes compositions and methods for the assessment, characterization and treatment of adrenal diseases and disorders, based upon the presence or absence of a KCNJ5 mutation that is associated with an adrenal disease or disorder.

2. 发明申请

US20120282451A1 PIEZOELECTRIC FILM 审中-公开
公开(公告)号：US20120282451A1
公开(公告)日：2012-11-08
申请号：US13547867
申请日：2012-07-12
申请人： Tom ERIKSSON , Kenth NILSSON , Anna-Karin JOHANSSON , Karin LJUNGSTRÖM , Koroush LASHGARI , Annika POHL , Gunnar WESTIN
发明人： Tom ERIKSSON , Kenth NILSSON , Anna-Karin JOHANSSON , Karin LJUNGSTRÖM , Koroush LASHGARI , Annika POHL , Gunnar WESTIN
IPC分类号： H01L41/18 , B32B15/04
CPC分类号： C04B35/495 , A61N1/056 , A61N1/0565 , A61N1/36542 , A61N1/36564 , C01G33/00 , C01G33/006 , C01P2002/72 , C01P2002/77 , C01P2002/82 , C01P2002/88 , C01P2004/03 , C04B35/624 , C04B35/62645 , C04B35/62675 , C04B2235/3201 , C04B2235/3251 , C04B2235/3255 , C04B2235/441 , C04B2235/6562 , C04B2235/768 , C04B2235/80 , C23C18/1216 , C23C18/1225 , C23C18/1254 , C23C18/1283 , H01L41/1873 , H01L41/318
摘要： A method for producing a biocompatible material of the formula NaxKyNbO3, 0≦x≦0.8, 0.2≦y≦1, x+y=1 includes the steps of a) providing a Na-precursor and a K-precursor for NaxKyNbO3, b) mixing the precursors in solution wherein said precursors first react to form a sol and thereafter a gel, c) heat treating the gel to obtain an oxide of the material NaxKyNbO3, 0≦x≦0.8, 0.2≦y≦1, x+y=1. The material can be produced as a film, and the material or film can be provided on the exterior surface of a medical implant that will come into contact with body tissue and/or body fluids upon implantation thereof.

3. 发明申请

US20120289807A1 PIEZOELECTRIC FILM 审中-公开
公开(公告)号：US20120289807A1
公开(公告)日：2012-11-15
申请号：US13547894
申请日：2012-07-12
申请人： Tom ERIKSSON , Kenth NILSSON , Anna-Karin JOHANSSON , Karin LUNGSTRÖM , Koroush LASHGARI , Annika POHL , Gunnar WESTIN
发明人： Tom ERIKSSON , Kenth NILSSON , Anna-Karin JOHANSSON , Karin LUNGSTRÖM , Koroush LASHGARI , Annika POHL , Gunnar WESTIN
IPC分类号： A61B5/04 , A61N1/05
CPC分类号： C04B35/495 , A61N1/056 , A61N1/0565 , A61N1/36542 , A61N1/36564 , C01G33/00 , C01G33/006 , C01P2002/72 , C01P2002/77 , C01P2002/82 , C01P2002/88 , C01P2004/03 , C04B35/624 , C04B35/62645 , C04B35/62675 , C04B2235/3201 , C04B2235/3251 , C04B2235/3255 , C04B2235/441 , C04B2235/6562 , C04B2235/768 , C04B2235/80 , C23C18/1216 , C23C18/1225 , C23C18/1254 , C23C18/1283 , H01L41/1873 , H01L41/318
摘要： A method for producing a biocompatible material of the formula NaxKyNbO3, 0≦x≦0.8, 0.2≦y≦1, x+y=1 includes the steps of a) providing a Na-precursor and a K-precursor for NaxKyNbO3, b) mixing the precursors in solution wherein said precursors first react to form a sol and thereafter a gel, c) heat treating the gel to obtain an oxide of the material NaxKyNbO3, 0≦x≦0.8, 0.2≦y≦1, x+y=1. The material can be produced as a film, and the material or film can be provided on the exterior surface of a medical implant that will come into contact with body tissue and/or body fluids upon implantation thereof.

4. 发明授权

US08246929B2 Synthesis of sodium potassium niobate by sol-gel 有权
标题翻译：通过溶胶 - 凝胶合成铌酸钠钠
公开(公告)号：US08246929B2
公开(公告)日：2012-08-21
申请号：US11920380
申请日：2005-05-31
申请人： Tom Eriksson , Kenth Nilsson , Anna-Karin Johansson , Karin Ljungström , Koroush Lashgari , Annika Pohl , Gunnar Westin
发明人： Tom Eriksson , Kenth Nilsson , Anna-Karin Johansson , Karin Ljungström , Koroush Lashgari , Annika Pohl , Gunnar Westin
IPC分类号： C04B35/00
CPC分类号： C04B35/495 , A61N1/056 , A61N1/0565 , A61N1/36542 , A61N1/36564 , C01G33/00 , C01G33/006 , C01P2002/72 , C01P2002/77 , C01P2002/82 , C01P2002/88 , C01P2004/03 , C04B35/624 , C04B35/62645 , C04B35/62675 , C04B2235/3201 , C04B2235/3251 , C04B2235/3255 , C04B2235/441 , C04B2235/6562 , C04B2235/768 , C04B2235/80 , C23C18/1216 , C23C18/1225 , C23C18/1254 , C23C18/1283 , H01L41/1873 , H01L41/318
摘要： A method for producing a biocompatible material of the formula NaxKyNbO3, 0≦x≦0.8, 0.2≦y≦1, x+y=1 includes the steps of a) providing a Na-precursor and a K-precursor for NaxKyNbO3, b) mixing the precursors in solution wherein said precursors first react to form a sol and thereafter a gel, c) heat treating the gel to obtain an oxide of the material NaxKyNbO3, 0≦x≦0.8, 0.2≦y≦1, x+y=1. The material can be produced as a film, and the material or film can be provided on the exterior surface of a medical implant that will come into contact with body tissue and/or body fluids upon implantation thereof.
摘要翻译：一种制备式NaxKyNbO3,0和nlE; x和nlE; 0.8,0.2＆nlE; y＆nlE; 1，x + y = 1的生物相容性材料的方法包括以下步骤：a）提供NaxKyNbO3的Na前体和K-前体，b 将前体混合在溶液中，其中所述前体首先反应形成溶胶，然后进行凝胶，c）热处理该凝胶以获得材料NaxKyNbO3,0和nlE; x和nlE; 0.8,0.2和nlE; y和nlE; 1，x + y = 1。该材料可以作为膜制造，并且材料或膜可以设置在将在其植入时将与身体组织和/或体液接触的医用植入物的外表面上。

5. 发明申请

US20100227187A1 COMPOSITE MATERIALS AND METHOD OF ITS MANUFACTURE 有权
标题翻译：复合材料及其制造方法
公开(公告)号：US20100227187A1
公开(公告)日：2010-09-09
申请号：US12785092
申请日：2010-05-21
申请人： GUNNAR WESTIN , Annika Pohl , Asa Ekstrand
发明人： GUNNAR WESTIN , Annika Pohl , Asa Ekstrand
IPC分类号： C04B35/00 , H01F1/01 , C04B35/10 , B32B5/16 , B32B15/04 , B32B15/20 , B32B18/00 , B32B15/02
CPC分类号： C04B35/117 , B01J23/755 , B01J35/0013 , B82Y30/00 , C04B35/6264 , C04B35/6265 , C04B2235/3279 , C04B2235/3281 , C04B2235/405 , C04B2235/407 , C04B2235/441 , C04B2235/443 , C04B2235/449 , C04B2235/5288 , C04B2235/80 , C22C1/1026 , C23C18/1216 , C23C24/08 , C23C26/00 , C23C30/00 , F24S70/10 , Y02E10/40 , Y10T428/12056 , Y10T428/12181 , Y10T428/25
摘要： A novel solution route has been developed that after heat-treatment to 500-600° C. under inert atmosphere, yields highly porous composites of nano-sized metal (Ni) particle inclusions in ceramics (Al2O3). Metal loadings could be made from 95% Ni. The metal inclusion sizes in the Ni—Al2O3 system with the 10 atom % Ni sample were 4-7 nm, while for the 75 atom % Ni sample they were 5-8 nm. It was shown that the 10 atom % Ni sample could be used as a catalyst for the conversion of CO2 and CH4 in the temperature range 550-700° C., while higher temperatures led to growth of the Ni particles and carbon poisoning over time. The solution routes could also be deposited as thin dense films containing
摘要翻译：已经开发了一种新颖的解决方案，在惰性气氛下热处理至500-600℃后，在陶瓷（Al2O3）中产生纳米尺寸金属（Ni）颗粒夹杂物的高度多孔复合材料。金属负载量可以由<1％至> 95％的Ni制成。具有10原子％Ni样品的Ni-Al 2 O 3体系中的金属夹杂物尺寸为4-7nm，而对于75原子％的Ni样品，其为5-8nm。已经表明，10原子％Ni样品可用作在550-700℃的温度范围内转化CO 2和CH 4的催化剂，而较高的温度导致Ni颗粒的生长和随时间的碳中毒。溶液路径也可以沉积为含有<10nm Ni颗粒的薄致密膜。沉积在铝基板上的这种具有高Ni-粒子载量的膜已经显示出非常好的太阳能吸热能力，并为碳管生长提供了良好的底物。

6. 发明授权

US6033735A Method of coating cutting inserts 失效
标题翻译：切削刀片涂层方法
公开(公告)号：US6033735A
公开(公告)日：2000-03-07
申请号：US849770
申请日：1997-09-18
申请人： Stefan Ederyd , Enrico Galli , Mats Nygren , Gunnar Westin , Asa Ekstrand
发明人： Stefan Ederyd , Enrico Galli , Mats Nygren , Gunnar Westin , Asa Ekstrand
IPC分类号： C04B41/88 , C23C18/08 , C23C18/12 , B05D3/02 , B05D3/04
CPC分类号： C23C18/08
摘要： There is disclosed a method of coating cemented carbide inserts at least partly with a layer of at least one iron group metal. When inserts coated with such a layer are brazed to a tool holder, a joint with improved strength is obtained. According to the present method, one or more metal salts of at least one iron group metal containing organic groups are dissolved and complex bound in at least one polar solvent with at least one complex former comprising functional groups in the form of OH or NR.sub.3 (R.dbd.H or alkyl). A soluble carbon source is added to the solution which is subsequently at least partly applied to the cemented carbide inserts by dipping, spraying or painting. The inserts are dried and heat treated in an inert and/or reducing atmosphere. As a result, cemented carbide inserts are obtained at least partly coated with a layer of an iron group metal.
摘要翻译： PCT No.PCT / SE95 / 01586 Sec。 371日期：1997年9月18日 102（e）日期1997年9月18日PCT 1995年12月27日PCT PCT。公开号WO96 / 21051 日期1996年7月11日公开了至少部分地具有至少一种铁族金属层的硬质合金刀片涂覆的方法。当涂覆有这种层的插入件钎焊到工具保持器时，获得具有改善的强度的接头。根据本方法，将至少一种含有铁基金属的有机基团的一种或多种金属盐溶解并且在至少一种极性溶剂中与至少一种包含OH或NR 3（R = H或烷基）。向溶液中加入可溶性碳源，其随后通过浸渍，喷涂或喷涂至少部分地施加到硬质合金刀片上。将刀片干燥并在惰性和/或还原气氛中热处理。结果，获得至少部分地涂覆有铁族金属层的硬质合金刀片。

7. 发明授权

US5887242A Method of making metal composite materials 失效
标题翻译：制作金属复合材料的方法
公开(公告)号：US5887242A
公开(公告)日：1999-03-23
申请号：US721766
申请日：1996-09-25
申请人： Mats Nygren , Gunnar Westin , .ANG.sa Ekstrand
发明人： Mats Nygren , Gunnar Westin , .ANG.sa Ekstrand
IPC分类号： B22F1/02 , B22F9/30 , C22C1/05 , B22F3/12
CPC分类号： B22F9/30 , B22F1/025 , C22C1/051
摘要： A method of making a hard constituent powder coated with at least one iron group metal, Me, by dissolving and complex binding at least one of Me.sub.n (NO.sub.3).sub.m and Me.sub.n (SO.sub.4).sub.m and other similar Me.sub.n --X.sub.m compounds containing X-groups with low or no carbon content, preferably Me-nitrates, solely or together with one or more metal salts of at least one iron group metal containing organic groups in at least one polar solvent with at least one complex former comprising functional groups in the form of OH or NR.sub.3, (R=H or alkyl). Hard constituent powder is added to the solution. The solvent is evaporated and remaining powder is heat treated in an inert and/or reducing atmosphere. As a result, coated hard constituent powder is obtained which after addition of a pressing agent can be compacted and sintered according to standard practice.
摘要翻译：通过溶解和复合结合Men（NO 3）m和Men（SO 4）m和其它类似的含有X基团的Men-Xm化合物的至少一种，制备涂覆有至少一种铁族金属Me的硬组分粉末的方法具有低或不含碳量，优选Me-硝酸盐，单独或与一种或多种至少一种在至少一种极性溶剂中含有有机基团的铁基金属的金属盐与至少一种包含以下形式的官能团的络合物 OH或NR 3，（R = H或烷基）。将硬组分粉末加入溶液中。蒸发溶剂，剩余的粉末在惰性和/或还原气氛中进行热处理。结果，得到涂布的硬质组分粉末，其可以按照标准实践将加压剂加入并烧结。

8. 发明授权

US5505902A Method of making metal composite materials 失效
标题翻译：制作金属复合材料的方法
公开(公告)号：US5505902A
公开(公告)日：1996-04-09
申请号：US412945
申请日：1995-03-29
申请人： Udo Fischer , Mats Waldenstrom , Stefan Ederyd , Mats Nygren , Gunnar Westin , Asa Ekstrand
发明人： Udo Fischer , Mats Waldenstrom , Stefan Ederyd , Mats Nygren , Gunnar Westin , Asa Ekstrand
IPC分类号： B22F9/22 , B22F1/02 , B22F9/24 , C22C1/05 , C22C29/00 , C22C29/08 , B22F7/00
CPC分类号： C22C1/051 , C22C29/08 , B22F2999/00 , Y10T428/12181
摘要： A method wherein one or more metal salts of at least one iron group metal containing organic groups are dissolved and complex bound in at least one polar solvent with at least one complex former comprising functional groups in the form of OH or NR.sub.3, (RH.dbd.H or alkyl). Hard constituent powder and, optionally, a soluble carbon source are added to the solution. The solvent is evaporated and the remaining powder is heat treated in an inert and/or reducing atmosphere. As a result, coated hard constituent powder is obtained which after addition of a pressing agent can be compacted and sintered according to standard practice to a body containing hard constituents in a binder phase.
摘要翻译：一种方法，其中至少一种含有铁基金属的有机基团的一种或多种金属盐溶解并且在至少一种极性溶剂中与至少一种包含OH或NR 3形式的官能团的复合物（RH = H 或烷基）。将硬组分粉末和任选的可溶性碳源加入到溶液中。蒸发溶剂，剩余的粉末在惰性和/或还原气氛中进行热处理。结果，可以得到涂布的硬质成分粉末，其可以在加入压制剂之后按照标准做法压实和烧结至包含粘结相中的硬组分的物体。

9. 发明申请

US20080227734A1 Mutant Lrp5/6 Wnt-Signaling Receptors in Cancer Diagnosis, Prognosis, and Treatment 审中-公开
标题翻译：突变Lrp5 / 6 Wnt信号传导受体在癌症诊断，预后和治疗
公开(公告)号：US20080227734A1
公开(公告)日：2008-09-18
申请号：US10580487
申请日：2004-11-24
申请人： Gunnar Westin , Peyman Bjorklund , Goran Akerstrom
发明人： Gunnar Westin , Peyman Bjorklund , Goran Akerstrom
IPC分类号： A61K31/70 , C07H21/04 , C07K14/00 , C12N5/06 , A01K67/027 , A61P43/00 , C12Q1/68 , G01N33/574 , C40B30/06
CPC分类号： G01N33/574 , A01K2217/05 , C07K14/705 , G01N33/5011 , G01N33/57407 , G01N2800/046 , G01N2800/52
摘要： A novel mutant form of lrp5 and lrp6 genes, the mutant LRP5 and LRP6 receptor proteins expressed therefrom, and a cell line which expresses the mutant LRP5 and/or LRP6 receptor proteins. Methods of diagnosing, prognosing and treating LRP5 related diseases, specifically hyperthyroidism and parathyroid tumors, and kits suitable for rapid on-site testing. Finally, methods of screening for agents capable of modulating the mutant LRP5 or LRP6 receptor proteins and pharmaceutical compositions comprising the selected agents.
摘要翻译： lrp5和lrp6基因的新突变形式，由其表达的突变体LRP5和LRP6受体蛋白，以及表达突变型LRP5和/或LRP6受体蛋白的细胞系。诊断，预后和治疗LRP5相关疾病，特别是甲状旁腺功能亢进肿瘤的方法，以及适用于快速现场检测的试剂盒。最后，筛选能够调节突变型LRP5或LRP6受体蛋白的试剂的方法和包含所选试剂的药物组合物。

10. 发明授权

US08372469B2 Method for producing a piezoelectric film 有权
标题翻译：压电膜的制造方法
公开(公告)号：US08372469B2
公开(公告)日：2013-02-12
申请号：US13547841
申请日：2012-07-12
申请人： Tom Eriksson , Kenth Nilsson , Anna-Karin Johansson , Karin Lungstrom , Koroush Lashgari , Annika Pohl , Gunnar Westin
发明人： Tom Eriksson , Kenth Nilsson , Anna-Karin Johansson , Karin Lungstrom , Koroush Lashgari , Annika Pohl , Gunnar Westin
IPC分类号： B32B17/00
CPC分类号： C04B35/495 , A61N1/056 , A61N1/0565 , A61N1/36542 , A61N1/36564 , C01G33/00 , C01G33/006 , C01P2002/72 , C01P2002/77 , C01P2002/82 , C01P2002/88 , C01P2004/03 , C04B35/624 , C04B35/62645 , C04B35/62675 , C04B2235/3201 , C04B2235/3251 , C04B2235/3255 , C04B2235/441 , C04B2235/6562 , C04B2235/768 , C04B2235/80 , C23C18/1216 , C23C18/1225 , C23C18/1254 , C23C18/1283 , H01L41/1873 , H01L41/318
摘要： A method for producing a biocompatible material of the formula NaxKyNbO3, 0≦x≦0.8, 0.2≦y≦1, x+y=1 includes the steps of a) providing a Na-precursor and a K-precursor for NaxKyNbO3, b) mixing the precursors in solution wherein said precursors first react to form a sol and thereafter a gel, c) heat treating the gel to obtain an oxide of the material NaxKyNbO3, 0≦x≦0.8, 0.2≦y≦1, x+y=1. The material can be produced as a film, and the material or film can be provided on the exterior surface of a medical implant that will come into contact with body tissue and/or body fluids upon implantation thereof.
摘要翻译：一种制备式NaxKyNbO3,0和nlE; x和nlE; 0.8,0.2＆nlE; y＆nlE; 1，x + y = 1的生物相容性材料的方法包括以下步骤：a）提供NaxKyNbO3的Na前体和K-前体，b 将前体混合在溶液中，其中所述前体首先反应形成溶胶，然后进行凝胶，c）热处理该凝胶以获得材料NaxKyNbO3,0和nlE; x和nlE; 0.8,0.2和nlE; y和nlE; 1，x + y = 1。该材料可以作为膜制造，并且材料或膜可以设置在将在其植入时将与身体组织和/或体液接触的医用植入物的外表面上。

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