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1. 发明申请

WO2011106877A1 DERIVATIZED HYPERBRANCHED POLYGLYCEROLS 审中-公开
标题翻译：衍生的高分子聚合物
公开(公告)号：WO2011106877A1
公开(公告)日：2011-09-09
申请号：PCT/CA2011/000225
申请日：2011-03-01
申请人： THE UNIVERSITY OF BRITISH COLUMBIA , CENTRE FOR DRUG RESEARCH AND DEVELOPMENT , BURT, Helen , BROOKS, Donald , KIZHAKKEDATHU, Jayachandran , LIGGINS, Richard , GUAN, Dechi , YE, Lucy , MUGABE, Clement , SO, Alan , GLEAVE, Martin , JACKSON, John, K.
发明人： BURT, Helen , BROOKS, Donald , KIZHAKKEDATHU, Jayachandran , LIGGINS, Richard , GUAN, Dechi , YE, Lucy , MUGABE, Clement , SO, Alan , GLEAVE, Martin , JACKSON, John, K.
IPC分类号： C08G65/329 , A61K47/34 , A61K47/48 , C08G65/22
CPC分类号： A61K47/10 , A61K9/0034 , A61K9/006 , A61K9/5146 , A61K31/337 , A61K31/407 , A61K33/24 , A61K47/34 , A61K47/60 , C08G65/33306 , C08G65/33337 , C08G65/34 , C08G65/48 , C08G83/005 , C08G83/006 , C08G2650/54
摘要： Herein are provided derivatized hyperbranched polyglycerols ("dHPGs"). The dHPG comprises a core comprising a hyperbranched polyglycerol derivatized with C 1 C 20 alkyl chains and a shell comprising at least one hydrophilic substituent bound to hydroxyl groups of the core, wherein the hyperbranched polyglycerol comprises from about 1 to about 200 moles of the at least one hydrophilic substituent. The dHPGs are for use as agents for the delivery of a drug or other biologically active moiety to the urinary tract, the digestive tract, the airways, the vaginal cavity and cervix and the peritoneal cavity to treat indications such as cancer, which may be useful in the treatment of or the manufacture of a medicament, in the preparation, of a pharmaceutical composition for the treatment of cancer, as a pre-treatment or co- treatment to improve drug uptake in a tissue. Furthermore, there are provided methods of making dHPGs.
摘要翻译：本文提供衍生的超支化聚甘油（“dHPG”）。 dHPG包含核心，其包含用C1C20烷基链衍生的超支化聚甘油和包含至少一个与核心羟基结合的亲水取代基的壳，其中超支化聚甘油包含约1至约200摩尔的至少一个亲水取代基。 dHPG用作将药物或其他生物活性部分递送至尿路，消化道，气道，阴道腔和子宫颈以及腹膜腔以治疗诸如癌症的适应症的药剂，其可能是有用的在制备中用于治疗癌症的药物组合物的治疗或制造中，作为用于改善组织中药物吸收的预处理或共同处理。此外，还提供了制备dHPG的方法。

2. 发明申请

WO2004060424A2 SILK STENT GRAFTS 审中-公开
标题翻译：丝绸礼服
公开(公告)号：WO2004060424A2
公开(公告)日：2004-07-22
申请号：PCT/US2003/041494
申请日：2003-12-29
申请人： ANGIOTECH INTERNATIONAL GMBH , GRAVETT, David, M. , SIGNORE, Pierre , WANG, Kaiyue , TOLEIKIS, Philip, M. , GUAN, Dechi , HU, Zengxuan , MAITI, Arpita
发明人： GRAVETT, David, M. , SIGNORE, Pierre , WANG, Kaiyue , TOLEIKIS, Philip, M. , GUAN, Dechi , HU, Zengxuan , MAITI, Arpita
IPC分类号： A61L27/00
CPC分类号： A61F2/07 , A61F2/89 , A61F2002/065 , A61F2002/075 , A61L31/005 , A61L31/14 , A61L31/16 , A61L2300/25 , A61L2300/252 , A61L2300/258 , A61L2300/412 , A61L2300/414 , A61L2300/426 , A61L2300/432 , A61L2300/434 , A61L2300/602
摘要： Silk-containing stent grafts are provided comprising an endoluminal stent and a graft, wherein the silk is induces the in vivo adhesion of the stent graft to vessel walls, or, otherwise induces or accelerates an in vivo fibrotic reaction causing said stent graft to adhere to vessel wall. Also provided are methods for making and using such stent grafts.
摘要翻译：提供含有丝素的支架移植物，其包括腔内支架和移植物，其中所述丝诱导所述支架移植物体内粘附于血管壁，或者诱导或加速体内纤维化反应，导致所述支架移植物附着于血管壁。还提供了制造和使用这种支架移植物的方法。

3. 发明申请

WO2005051316A3 POLYMER COMPOSITIONS AND METHODS FOR THEIR USE 审中-公开
标题翻译：聚合物组合物及其使用方法
公开(公告)号：WO2005051316A3
公开(公告)日：2010-01-28
申请号：PCT/US2004039491
申请日：2004-11-22
申请人： ANGIOTECH INT AG , HUNTER WILLIAM L , GRAVETT DAVID M , TOLEIKIS PHILIP M , MAITI ARPITA , LIGGINS RICHARD T , TAKACS-COX ANIKO , AVELAR RUI , LOSS TROY A E , GUAN DECHI , WANG KAIYUE
发明人： HUNTER WILLIAM L , GRAVETT DAVID M , TOLEIKIS PHILIP M , MAITI ARPITA , LIGGINS RICHARD T , TAKACS-COX ANIKO , AVELAR RUI , LOSS TROY A E , GUAN DECHI
IPC分类号： A61F2/02 , A61L31/10 , A61L31/16
CPC分类号： A61L31/10 , A61L31/16 , A61L2300/404 , A61L2300/416
摘要： Compositions comprising anti-fibrotic agent(s) and/or polymeric compositions can be used in various medical applications including the prevention of surgical adhesions, treatment of inflammatory arthritis, treatment of scars and keloids, the treatment of vascular disease, and the prevention of cartilage loss.
摘要翻译：包含抗纤维化剂和/或聚合物组合物的组合物可用于各种医学应用，包括预防手术粘连，治疗炎性关节炎，治疗瘢痕和瘢痕疙瘩，治疗血管疾病和预防软骨失利。

4. 发明申请

WO2005044142A3 INTRAVASCULAR DEVICES AND FIBROSIS-INDUCING AGENTS 审中-公开
标题翻译：血管内装置和纤维化诱导剂
公开(公告)号：WO2005044142A3
公开(公告)日：2005-12-29
申请号：PCT/US2004038246
申请日：2004-11-10
申请人： ANGIOTECH INT AG , HUNTER WILLIAM L , GRAVETT DAVID M , TOLEIKIS PHILIP M , MAITI ARPITA , SIGNORE PIERRE E , LIGGINS RICHARD T , GUAN DECHI
发明人： HUNTER WILLIAM L , GRAVETT DAVID M , TOLEIKIS PHILIP M , MAITI ARPITA , SIGNORE PIERRE E , LIGGINS RICHARD T , GUAN DECHI
IPC分类号： A61B17/00 , A61B17/11 , A61B17/12 , A61F2/00 , A61F2/86 , A61F13/00 , A61K38/48 , A61L27/00 , A61L27/54 , A61L31/00 , A61L31/16 , A61M29/00 , A61M31/00 , A61M1/00 , A61F2/06
CPC分类号： A61B17/12172 , A61B17/00491 , A61B17/11 , A61B17/12022 , A61B17/12045 , A61B17/12136 , A61B17/1215 , A61B17/12177 , A61B17/12186 , A61B17/1219 , A61B2017/00004 , A61F2/86 , A61F2250/0067 , A61L31/16 , A61L2300/412
摘要： Intravascular devices (e.g., stents, stent grafts, covered stents, aneurysm coils, embolic agents and drug delivery catheters and balloons) are used in combination with fibrosing agents in order to induce fibrosis that may otherwise not occur when the implant is placed within an animal or to promote fibrosis betweent the devices and the host tissues. Compositions and methods are described for use in the treatment of aneurysms and unstable arterial (vulnerable) plaque.
摘要翻译：血管内装置（例如，支架，支架移植物，覆盖支架，动脉瘤线圈，栓塞剂和药物输送导管和球囊）与纤维化剂组合使用以诱导纤维化，否则当将植入物置于动物内时可能不会发生纤维化或促进装置与宿主组织之间的纤维化。描述了用于治疗动脉瘤和不稳定动脉（易损）斑块的组合物和方法。

5. 发明申请

WO2004060424A3 SILK-CONTAINING STENT GRAFT 审中-公开
标题翻译：含SILK的STENT GRAFT
公开(公告)号：WO2004060424A3
公开(公告)日：2004-12-09
申请号：PCT/US0341494
申请日：2003-12-29
申请人： ANGIOTECH INT AG , GRAVETT DAVID M , SIGNORE PIERRE , WANG KAIYUE , TOLEIKIS PHILIP M , GUAN DECHI , HU ZENGXUAN , MAITI ARPITA
发明人： GRAVETT DAVID M , SIGNORE PIERRE , WANG KAIYUE , TOLEIKIS PHILIP M , GUAN DECHI , HU ZENGXUAN , MAITI ARPITA
IPC分类号： A61F2/06 , A61L27/36 , A61L27/50 , A61L27/54 , A61L27/14 , A61L31/16
CPC分类号： A61F2/07 , A61F2/89 , A61F2002/065 , A61F2002/075 , A61L31/005 , A61L31/14 , A61L31/16 , A61L2300/25 , A61L2300/252 , A61L2300/258 , A61L2300/412 , A61L2300/414 , A61L2300/426 , A61L2300/432 , A61L2300/434 , A61L2300/602
摘要： Silk-containing stent grafts are provided comprising an endoluminal stent and a graft, wherein the silk is induces the in vivo adhesion of the stent graft to vessel walls, or, otherwise induces or accelerates an in vivo fibrotic reaction causing said stent graft to adhere to vessel wall. Also provided are methods for making and using such stent grafts.
摘要翻译：提供含有丝素的支架移植物，其包括腔内支架和移植物，其中所述丝诱导所述支架移植物体内粘附于血管壁，或者诱导或加速体内纤维化反应，导致所述支架移植物附着于血管壁。还提供了制造和使用这种支架移植物的方法。

6. 发明申请

WO2002072150A3 MICELLAR DRUG DELIVERY VEHICLES AND USES THEREOF 审中-公开
公开(公告)号：WO2002072150A3
公开(公告)日：2002-09-19
申请号：PCT/CA2002/000326
申请日：2002-03-13
申请人： ANGIOTECH PHARMACEUTICALS INC. , LIGGINS, Richard , MURPHY, Larry , GUAN, Dechi
发明人： LIGGINS, Richard , MURPHY, Larry , GUAN, Dechi
IPC分类号： A61K47/48
摘要： Anhydrous formulations are formed of a diblock copolymer (X-Y) having a hydrophilic bloc X comprising residues of monomer x, and a hydrophobic block Y comprising residues of monomer y; an additive selected from a polymer and an organic solvent, where the solvent is water-miscible and biocompatible, and the polymer is hydrophobic or hydrophilic and comprises residues of monomers x and/or y, the polymer optionally having a molecular weight that is less than the molecular weight of the diblock copolymer; and a drug. Upon admixture with water, the anhydrous formulations form drug delivery vehicles, preferably in micellar form. The inclusion of polymer and/or organic solvent provides for the formation of micelles at an enhanced rate, and/or provides the formation of micelles having an enhanced ability to incorporate drug(s), and/or provides the formation of micelles having advantageous physical characteristics, e.g. , advantageous viscosity and/or melting point.

7. 发明申请

WO2008033533A2 COMPOSITE DRUG DELIVERY SYSTEM 审中-公开
标题翻译：复合药物输送系统
公开(公告)号：WO2008033533A2
公开(公告)日：2008-03-20
申请号：PCT/US2007/020059
申请日：2007-09-14
申请人： ANGIOTECH PHARMACEUTICALS, INC. , GRAVETT, David, M. , SHALABY, Shalaby, W. , GUAN, Dechi , TOLEIKIS, Philip, M. , MURPHY, Larry , THURMOND, Kenneth, Bruce, II
发明人： GRAVETT, David, M. , SHALABY, Shalaby, W. , GUAN, Dechi , TOLEIKIS, Philip, M. , MURPHY, Larry , THURMOND, Kenneth, Bruce, II
IPC分类号： A61L31/14 , A61L31/16
CPC分类号： A61L31/16 , A61L31/10 , A61L2300/602 , C08L67/00
摘要： A present invention provides composite drug delivery systems and methods for maintaining or improving a integrity of body passageways (i.e., for example, blood vessels) following surgery, such as at a graft site, or injury. Delivery systems including one or more bioactive agents and a polymer matrix, reinforced by a fibrous construct are described. The fibrous constructs provide a predictable rate of degradation and therapeutic agent release based upon surface area and density relationships. Representative examples of bioactive agents include microtubule stabilizing agents ( i.e. , for example, paclitaxel), anti-angiogenic factors, inhibitors of smooth muscle cell growth or proliferation, non-steroidal anti-inflammatory drugs, and some factors useful preventing and/or reducing a proliferative biological response that may obstruct or hinder a optimal functioning of a passageway or cavity.
摘要翻译：本发明提供复合药物递送系统和用于维持或改善手术后的身体通道（例如，血管）的完整性的复合药物递送系统和方法，例如在移植部位或损伤。描述了包括由纤维结构增强的一种或多种生物活性剂和聚合物基质的递送系统。基于表面积和密度关系，纤维结构提供可预测的降解速率和治疗剂释放速率。生物活性剂的代表性实例包括微管稳定剂（例如紫杉醇），抗血管生成因子，平滑肌细胞生长或增殖抑制剂，非甾体抗炎药物和一些可用于预防和/或减少可能阻碍或阻碍通道或腔的最佳功能的增殖性生物反应。

8. 发明申请

WO2007019439A3 BLOCK COPOLYMER COMPOSITIONS AND USES THEREOF 审中-公开
标题翻译：嵌段共聚物组合物及其用途
公开(公告)号：WO2007019439A3
公开(公告)日：2007-05-03
申请号：PCT/US2006030715
申请日：2006-08-04
申请人： ANGIOTECH INT AG , ANGIOTECH PHARM INC , LIGGINS RICHARD T , TAKACS-COX ANIKO , GRAVETT DAVID M , GUAN DECHI , LOSS TROY A E , LIU MUXIN
发明人： LIGGINS RICHARD T , TAKACS-COX ANIKO , GRAVETT DAVID M , GUAN DECHI , LOSS TROY A E , LIU MUXIN
IPC分类号： A61K31/00
CPC分类号： A61K9/0024 , A61K9/0014 , A61K9/0019 , A61K9/06 , A61K9/1075 , A61K31/787 , A61K45/06 , A61K47/34 , A61K2300/00
摘要： The present invention describes compositions, devices, and methods for the production, use and administration of the composition having a non-thermoreversible block copolymer composition.
摘要翻译：本发明描述了具有非热可逆嵌段共聚物组合物的组合物的制备，使用和给药的组合物，装置和方法。

9. 发明申请

WO2007019439A2 BLOCK COPOLYMER COMPOSITIONS AND USES THEREOF 审中-公开
标题翻译：嵌段共聚物组合物及其用途
公开(公告)号：WO2007019439A2
公开(公告)日：2007-02-15
申请号：PCT/US2006/030715
申请日：2006-08-04
申请人： ANGIOTECH INTERNATIONAL AG , ANGIOTECH PHARMACEUTICALS, INC. US , LIGGINS, Richard, T. , TAKACS-COX, Aniko , GRAVETT, David, M. , GUAN, Dechi , LOSS, Troy, A., E. , LIU, Muxin
发明人： LIGGINS, Richard, T. , TAKACS-COX, Aniko , GRAVETT, David, M. , GUAN, Dechi , LOSS, Troy, A., E. , LIU, Muxin
IPC分类号： A61K31/787
CPC分类号： A61K9/0024 , A61K9/0014 , A61K9/0019 , A61K9/06 , A61K9/1075 , A61K31/787 , A61K45/06 , A61K47/34 , A61K2300/00
摘要： The present invention describes compositions, devices, and methods for the production, use and administration of the composition having a non-thermoreversible block copolymer composition.
摘要翻译：本发明描述了用于生产，使用和施用具有非热可逆性嵌段共聚物组合物的组合物的组合物，装置和方法。

10. 发明申请

WO02072150A2 MICELLAR DRUG DELIVERY VEHICLES AND PRECURSORS THERETO AND USES THEREOF 审中-公开
标题翻译： MICELLAR DRUG交付车辆及其前身及其使用
公开(公告)号：WO02072150A2
公开(公告)日：2002-09-19
申请号：PCT/CA0200326
申请日：2002-03-13
申请人： ANGIOTECH PHARM INC , LIGGINS RICHARD , MURPHY LARRY , GUAN DECHI
发明人： LIGGINS RICHARD , MURPHY LARRY , GUAN DECHI
IPC分类号： A61K9/22 , A61K47/48
CPC分类号： A61K47/6907
摘要： Anhydrous formulations are formed of a diblock copolymer (X-Y) having a hydrophilic bloc X comprising residues of monomer x, and a hydrophobic block Y comprising residues of monomer y; an additive selected from a polymer and an organic solvent, where the solvent is water-miscible and biocompatible, and the polymer is hydrophobic or hydrophilic and comprises residues of monomers x and/or y, the polymer optionally having a molecular weight that is less than the molecular weight of the diblock copolymer; and a drug. Upon admixture with water, the anhydrous formulations form drug delivery vehicles, preferably in micellar form. The inclusion of polymer and/or organic solvent provides for the formation of micelles at an enhanced rate, and/or provides the formation of micelles having an enhanced ability to incorporate drug(s), and/or provides the formation of micelles having advantageous physical characteristics, e.g. , advantageous viscosity and/or melting point.
摘要翻译：无水制剂由具有包含单体x的残基的亲水性团块X和包含单体y残基的疏水性嵌段Y的二嵌段共聚物（X-Y）形成; 选自聚合物和有机溶剂的添加剂，其中溶剂是水可混溶和生物相容的，并且聚合物是疏水的或亲水的，并且包含单体x和/或y的残基，所述聚合物任选地具有小于二嵌段共聚物的分子量; 和一种药物。在与水混合时，无水制剂形成药物递送载体，优选以胶束形式存在。包含聚合物和/或有机溶剂提供以增强的速率形成胶束，和/或提供具有增强的引入药物的能力的胶束的形成和/或提供具有有利物理性质的胶束的形成特征，例如，有利的粘度和/或熔点。

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