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    • 1. 发明申请
    • PARTICLES, METHOD OF PREPARING SAID PARTICLES AND USES THEREOF
    • 颗粒,制备该颗粒的方法及其用途
    • WO1993006921A1
    • 1993-04-15
    • PCT/SE1992000692
    • 1992-10-02
    • GS BIOCHEM ABLANDH, TomasLARSSONS, Kåre
    • GS BIOCHEM AB
    • B01J13/00
    • B01J13/00A61K9/1274B01J13/02
    • Particles, especially colloidal particles, comprising an interior phase of a non-lamellar reversed cubic, intermediate or hexagonal liquid crystalline phase, or a homogeneous L3 phase, and a surface phase of a lamellar crystalline or liquid crystalline phase, or an L3 phase. A method of preparing such particles by creating a local dispersible phase, within the homogeneous phase, preferably by means of a fragmentation agent, and fragmentating the homogeneous phase so as to form said surface phase. Several medical as well as non-medical uses of the particles referred to, e.g. as an antigen-presenting system, as a delivery system for anticancer, antifungal and antimicrobial drugs, and as carriers of nucleic acids or nucleotides.
    • 颗粒,特别是胶体颗粒,其包含非层状反相立方晶体,中间或六方晶相结晶的内相,或均相L3相,以及层状结晶或液晶相或L3相的表面相。 通过在均相中产生局部可分散相,优选通过破碎剂制备此类颗粒并破坏均相以形成所述表面相的方法。 涉及的颗粒的几种医学和非医学用途,例如, 作为抗原呈递系统,作为抗癌,抗真菌和抗微生物药物的递送系统,以及核酸或核苷酸的载体。