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1. 发明公开

EP0130750A1 Lift brake control method and apparatus 失效
标题翻译： Verfahren und Vorrichtung zur Steuerung einer Aufzugbremse。
公开(公告)号：EP0130750A1
公开(公告)日：1985-01-09
申请号：EP84304233.4
申请日：1984-06-22
申请人： Grossi, Alfredo , Grossi, Ricardo
发明人： Grossi, Alfredo , Grossi, Ricardo
IPC分类号： B66B1/32
CPC分类号： B66B1/285 , B66B1/32
摘要： The invention controls the braking of a lift (35), stopping it exactly at a selected floor stop level (23) independently of initial speed (34) and load conditions, optimizing travel time and security. Braking is activated at a preestablished distance (34) from the floor level (23) when the lift cabin (35) trips a reference sensor (39, 41). From there on, the real time speed (V) of the lift is compared with a theoretical value to generate a signal controlling the braking power of the reversed driver-motor (47). The theoretical value is determined exclusively from a preset table (45) on the basis of the remaining distance (D) to the floor level (23), unlike some prior art system which use time for the control variable. The remaining distance (D) and real time speed data (V) are obtained from a single transducer consisting of a perforated disc (55) coupled to the motor (46) shaft and a optoelectronic circuit (59) which emits a pulse for each unitary distance (D) travelled by the lift (35).
摘要翻译：本发明控制升降机（35）的制动，与初始速度（34）和负载条件无关地精确地停在选定的地板停止水平（23），优化行驶时间和安全性。当提升舱（35）跳闸参考传感器（39,41）时，制动在与地板水平面（23）的预定距离（34）下被激活。从那里，升降机的实时速度（V）与理论值进行比较，以产生控制反向驱动器电动机（47）的制动功率的信号。与使用时间为控制变量的现有技术系统不同，理论值仅基于预设表（45），基于剩余距离（D）到楼层（23）而确定。剩余的距离（D）和实时速度数据（V）从单个换能器获得，该单个换能器由耦合到马达（46）轴的多孔盘（55）和发射每个单位的脉冲的光电子回路（59）组成电梯行驶距离（D）（35）。

2. 发明申请

WO2010027404A2 STABLE SOLID FORMULATION OF THERAPEUTIC POLYPEPTIDES SUITABLE FOR ORAL ADMINISTRATION 审中-公开
标题翻译：适用于口腔管理的治疗性多肽的稳定配方
公开(公告)号：WO2010027404A2
公开(公告)日：2010-03-11
申请号：PCT/US2009/004676
申请日：2009-08-14
申请人： IRONWOOD PHARMACEUTICALS, INC. , FRETZEN, Angelika , WITOWSKI, Steven , GROSSI, Alfredo , ZHAO, Hong
发明人： FRETZEN, Angelika , WITOWSKI, Steven , GROSSI, Alfredo , ZHAO, Hong
IPC分类号： A61K38/17 , A61K9/14
CPC分类号： A61K9/1611 , A61K9/1617 , A61K9/1623 , A61K9/1635 , A61K9/205 , A61K9/2054 , A61K9/485 , A61K9/4858 , A61K9/4866 , A61K9/5078 , A61K38/00 , A61K47/18 , A61K47/36 , A61K47/38
摘要： Solid, stable formulations of therapeutic polypeptide suitable for oral administration are described herein as are methods for preparing such formulations. The therapeutic polypeptide formulations described herein are stable and have a sufficient shelf life for manufacturing, storing and distributing the drug.
摘要翻译：适用于口服给药的治疗性多肽的固体稳定制剂在本文中描述为制备这些制剂的方法。本文所述的治疗性多肽制剂是稳定的并且具有用于制造，储存和分配药物的足够的保质期。

3. 发明申请

WO2011017502A3 LINACLOTIDE-CONTAINING FORMULATIONS FOR ORAL ADMINISTRATION 审中-公开
标题翻译：用于口腔管理的含LINACLOTIDE的制剂
公开(公告)号：WO2011017502A3
公开(公告)日：2011-05-19
申请号：PCT/US2010044522
申请日：2010-08-05
申请人： IRONWOOD PHARMACEUTICALS INC , FRETZEN ANGELIKA , WITOWSKI STEVEN , GROSSI ALFREDO , ZHAO HONG , DEDHIYA MAHENDRA , MO YUN , FOREST LAB HOLDINGS LTD
发明人： FRETZEN ANGELIKA , WITOWSKI STEVEN , GROSSI ALFREDO , ZHAO HONG , DEDHIYA MAHENDRA , MO YUN
IPC分类号： A61K38/00 , A61K9/16 , A61K9/20 , A61K9/48 , A61K9/50
CPC分类号： A61K9/50 , A61K9/1611 , A61K9/1617 , A61K9/1623 , A61K9/205 , A61K9/2054 , A61K9/485 , A61K9/4858 , A61K9/4866 , A61K9/5078 , A61K38/10 , A61K38/12 , A61K47/02 , A61K47/183 , A61K47/36 , B65D81/26 , G01N30/02 , G01N2030/027
摘要： The present invention relates to stable compositions comprising imaciotide, as well as to various methods and processes for the preparation and use of the compositions.
摘要翻译：本发明涉及包含伊马替尼的稳定组合物，以及用于制备和使用组合物的各种方法和方法。

4. 发明申请

WO2010027404A3 STABLE FORMULATION COMPRISING THERAPEUTIC POLYPEPTIDES FOR ORAL ADMINISTRATION 审中-公开
标题翻译：包含用于口服管理的治疗性多糖的稳定配方
公开(公告)号：WO2010027404A3
公开(公告)日：2010-07-01
申请号：PCT/US2009004676
申请日：2009-08-14
申请人： IRONWOOD PHARMACEUTICALS INC , FRETZEN ANGELIKA , WITOWSKI STEVEN , GROSSI ALFREDO , ZHAO HONG
发明人： FRETZEN ANGELIKA , WITOWSKI STEVEN , GROSSI ALFREDO , ZHAO HONG
IPC分类号： A61K9/16 , A61K9/20 , A61K9/48 , A61K9/50 , A61K38/00
CPC分类号： A61K9/1611 , A61K9/1617 , A61K9/1623 , A61K9/1635 , A61K9/205 , A61K9/2054 , A61K9/485 , A61K9/4858 , A61K9/4866 , A61K9/5078 , A61K38/00 , A61K47/18 , A61K47/36 , A61K47/38
摘要： Solid, stable formulations of therapeutic polypeptide suitable for oral administration are described herein as are methods for preparing such formulations. The therapeutic polypeptide formulations described herein are stable and have a sufficient shelf life for manufacturing, storing and distributing the drug.
摘要翻译：适用于口服给药的治疗性多肽的固体稳定制剂在本文中描述为制备这些制剂的方法。本文所述的治疗性多肽制剂是稳定的并且具有用于制造，储存和分配药物的足够的保质期。

5. 发明申请

WO2010019239A2 PHARMACEUTICAL COMPOSITION AND ADMINISTRATIONS THEREOF 审中-公开
标题翻译：药物组合物及其药理学
公开(公告)号：WO2010019239A2
公开(公告)日：2010-02-18
申请号：PCT/US2009/004629
申请日：2009-08-13
申请人： VERTEX PHARMACEUTICALS INCORPORATED , ROWE, William , HURTER, Patricia , YOUNG, Christopher , DINEHART, Kirk , VERWIJS, Marinus, Jacobus , OVERHOFF, Kirk , GROOTENHUIS, Peter, D., J. , BOTFIELD, Martyn , GROSSI, Alfredo
发明人： ROWE, William , HURTER, Patricia , YOUNG, Christopher , DINEHART, Kirk , VERWIJS, Marinus, Jacobus , OVERHOFF, Kirk , GROOTENHUIS, Peter, D., J. , BOTFIELD, Martyn , GROSSI, Alfredo
IPC分类号： A61K47/32
CPC分类号： A61K9/1652 , A61K9/1635 , A61K9/2054 , A61K9/282 , A61K31/47
摘要： The present invention relates to pharmaceutical compositions comprising a solid dispersion of N-[2,4-Bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline- 3-carboxamide, methods of manufacturing pharmaceutical compositions of the present invention, and methods of administering pharmaceutical compositions of the present invention.
摘要翻译：本发明涉及包含N- [2,4-双（1,1-二甲基乙基）-5-羟基苯基] -1,4-二氢-4-氧代喹啉-3-甲酰胺的固体分散体的药物组合物，制造方法本发明的药物组合物和本发明的药物组合物的给药方法。

6. 发明申请

WO2011017502A9 FORMULATIONS COMPRISING LINACLOTIDE 审中-公开
公开(公告)号：WO2011017502A9
公开(公告)日：2011-02-10
申请号：PCT/US2010/044522
申请日：2010-08-05
申请人： IRONWOOD PHARMACEUTICALS, INC. , FRETZEN, Angelika , WITOWSKI, Steven , GROSSI, Alfredo , ZHAO, Hong , DEDHIYA, Mahendra , MO, Yun , FOREST LABORATORIES HOLDINGS LIMITED
发明人： FRETZEN, Angelika , WITOWSKI, Steven , GROSSI, Alfredo , ZHAO, Hong , DEDHIYA, Mahendra , MO, Yun
IPC分类号： A61K38/10 , A61P1/00
摘要： The present invention relates to stable compositions comprising imaciotide, as well as to various methods and processes for the preparation and use of the compositions.

7. 发明申请

WO2011017502A2 FORMULATIONS COMPRISING LINACLOTIDE 审中-公开
标题翻译：包含LINACLOTIDE的配方
公开(公告)号：WO2011017502A2
公开(公告)日：2011-02-10
申请号：PCT/US2010044522
申请日：2010-08-05
申请人： IRONWOOD PHARMACEUTICALS INC , FRETZEN ANGELIKA , WITOWSKI STEVEN , GROSSI ALFREDO , ZHAO HONG , DEDHIYA MAHENDRA , MO YUN , FOREST LAB HOLDINGS LTD
发明人： FRETZEN ANGELIKA , WITOWSKI STEVEN , GROSSI ALFREDO , ZHAO HONG , DEDHIYA MAHENDRA , MO YUN
IPC分类号： A61K38/10 , A61P1/00
CPC分类号： A61K9/50 , A61K9/1611 , A61K9/1617 , A61K9/1623 , A61K9/205 , A61K9/2054 , A61K9/485 , A61K9/4858 , A61K9/4866 , A61K9/5078 , A61K38/10 , A61K38/12 , A61K47/02 , A61K47/183 , A61K47/36 , B65D81/26 , G01N30/02 , G01N2030/027
摘要： The present invention relates to stable compositions comprising imaciotide, as well as to various methods and processes for the preparation and use of the compositions.
摘要翻译：本发明涉及包含伊马替尼的稳定组合物，以及用于制备和使用组合物的各种方法和方法。

8. 发明申请

WO2010019266A2 STABLE SOLID FORMULATION OF A GC-C RECEPTOR AGONIST POLYPEPTIDE SUITABLE FOR ORAL ADMINISTRATION 审中-公开
标题翻译：适用于口服管理的GC-C受体激动剂聚合物的稳定配制
公开(公告)号：WO2010019266A2
公开(公告)日：2010-02-18
申请号：PCT/US2009/004675
申请日：2009-08-14
申请人： IRONWOOD PHARMACEUTICALS, INC. , FOREST LABORATORIES INC. , FRETZEN, Angelika , WITOWSKI, Steven , GROSSI, Alfredo , ZHAO, Hong , DEDHIYA, Mahendra , MO, Yun
发明人： FRETZEN, Angelika , WITOWSKI, Steven , GROSSI, Alfredo , ZHAO, Hong , DEDHIYA, Mahendra , MO, Yun
IPC分类号： A61K38/10 , A61P1/00
CPC分类号： A61J3/00 , A61K9/1611 , A61K9/1617 , A61K9/1623 , A61K9/1635 , A61K9/167 , A61K9/205 , A61K9/2054 , A61K9/485 , A61K9/4858 , A61K9/4866 , A61K9/5078 , A61K38/10
摘要： Solid, stable formulations of linaclotide suitable for oral administration are described herein as are methods for preparing such formulations. The formulations described herein contain a polypeptide consisting of the amino acid sequence Cys Cys GIu Tyr Cys Cys Asn Pro Ala Cys Thr GIy Cys Tyr ("linaclotide") or a pharmaceutically acceptable salt thereof. The linaclotide formulations described herein are stable and have a sufficient shelf life for manufacturing, storing and distributing the drug.
摘要翻译：适用于口服给药的利那洛肽的固体，稳定制剂在本文中描述为制备这些制剂的方法。本文描述的制剂含有由氨基酸序列Cys Cys GluTyr Cys Cys Asn Pro Ala Cys Thr Gly Cys Tyr（“linaclotide”）或其药学上可接受的盐组成的多肽。本文所述的利那洛肽制剂是稳定的并且具有用于制造，储存和分配药物的足够的保质期。

9. 发明申请

WO2011019819A1 ORALLY DISINTEGRATING COMPOSITIONS OF LINACLOTIDE 审中-公开
标题翻译：木质素的ORALLY DISINTEGRATING COMPOSITION OF LINACLOTIDE
公开(公告)号：WO2011019819A1
公开(公告)日：2011-02-17
申请号：PCT/US2010/045174
申请日：2010-08-11
申请人： FOREST LABORATORIES HOLDINGS LIMITED , MO, Yun , DEDHIYA, Mahendra , CHHETTRY, Anil , FRETZEN, Angelika , IRONWOOD PHARMACEUTICALS, INC. , WITOWSKI, Steven , GROSSI, Alfredo , ZHAO, Hong
发明人： MO, Yun , DEDHIYA, Mahendra , CHHETTRY, Anil , FRETZEN, Angelika , WITOWSKI, Steven , GROSSI, Alfredo , ZHAO, Hong
IPC分类号： A61K9/00 , A61K38/10
CPC分类号： A61K38/10 , A61K9/0056 , A61K9/2009 , A61K9/2013 , A61K9/2027 , A61K9/7007 , A61K47/02 , A61K47/183 , A61K47/32 , C07K7/08
摘要： The present invention relates to orally disintegrating or dissolving pharmaceutical compositions comprising linaclotide or pharmaceutically acceptable salts thereof, as well to various methods and processes for the preparation and use of the compositions.
摘要翻译：本发明涉及口服崩解或溶解包含利那洛肽或其药学上可接受的盐的药物组合物，以及用于制备和使用组合物的各种方法和方法。

10. 发明申请

WO2011019413A1 PHARMACEUTICAL COMPOSITION AND ADMINISTRATIONS THEREOF 审中-公开
标题翻译：药物组合物及其药理学
公开(公告)号：WO2011019413A1
公开(公告)日：2011-02-17
申请号：PCT/US2010/024609
申请日：2010-02-18
申请人： VERTEX PHARMACEUTICALS INCORPORATED , ROWE, William , HURTER, Patricia , YOUNG, Christopher, R. , DINEHART, Kirk , VERWIJS, Marinus, Jacobus , OVERHOFF, Kirk , GROOTENHUIS, Peter, D. J. , BOTFIELD, Martyn , GROSSI, Alfredo , ZLOKARNIK, Gregor , VAN GOOR, Fredrick F.
发明人： ROWE, William , HURTER, Patricia , YOUNG, Christopher, R. , DINEHART, Kirk , VERWIJS, Marinus, Jacobus , OVERHOFF, Kirk , GROOTENHUIS, Peter, D. J. , BOTFIELD, Martyn , GROSSI, Alfredo , ZLOKARNIK, Gregor , VAN GOOR, Fredrick F.
IPC分类号： A61K9/14 , A61K31/47 , A61P19/10 , A61P19/00 , A61P43/00
CPC分类号： A61K31/47 , A61K9/0053 , A61K9/1635 , A61K9/1652 , A61K9/2009 , A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K9/28 , A61K9/282 , A61K9/284 , A61K31/44 , A61K2300/00
摘要： The present invention relates to pharmaceutical compositions comprising a solid dispersion of N-[2,4-Bis( 1, 1 -dimethylethyl)-5-hydroxyphenyl]- 1,4-dihydro-4-oxoquinoline-3-carboxamide, methods of manufacturing pharmaceutical compositions of the present invention, and methods of administering pharmaceutical compositions of the present invention.
摘要翻译：本发明涉及包含N- [2,4-双（1,1-二甲基乙基）-5-羟基苯基] -1,4-二氢-4-氧代喹啉-3-甲酰胺的固体分散体的药物组合物，制造方法本发明的药物组合物和本发明的药物组合物的给药方法。

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