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1. 发明申请

WO2006072601A2 THERAPEUTIC USE OF GROWTH FACTORS, NsG29 AND NsG31 审中-公开
标题翻译： NsG29和NsG31的生长因子的治疗用途
公开(公告)号：WO2006072601A2
公开(公告)日：2006-07-13
申请号：PCT/EP2006000178
申请日：2006-01-09
申请人： NSGENE AS , PETERSEN THOMAS NORDAHL , BLOM NIKOLAJ , GROENBORG METTE , KUSK PHILIP , BRUNAK SOEREN , JOHANSEN TEIT E , WAHLBERG LARS U
发明人： PETERSEN THOMAS NORDAHL , BLOM NIKOLAJ , GROENBORG METTE , KUSK PHILIP , BRUNAK SOEREN , JOHANSEN TEIT E , WAHLBERG LARS U
IPC分类号： C12N15/12 , C07K14/47 , C07K16/18 , C12N15/63
CPC分类号： C07K14/48
摘要： The present invention relates to the field of therapeutic use of proteins, genes and cells, in particular to the therapy based on secreted therapeutic proteins, NsG29 and NsG31. NsG29 and NsG31 are members of a newly identified family of growth factors with a specific cystein pattern and characterised by expression in the nevous system. The secreted growth factors have potential for the treatment of disorders of the nervous system. The invention also relates to bioactive NsG29 and NsG31 polypeptide fragments and the corresponding encoding DNA sequences.
摘要翻译：本发明涉及蛋白质，基因和细胞的治疗用途领域，特别涉及基于分泌的治疗性蛋白NsG29和NsG31的治疗。 NsG29和NsG31是新鉴定的具有特定半胱氨酸模式的生长因子家族的成员，并且其特征在于在神经系统中表达。分泌的生长因子具有治疗神经系统疾病的潜力。本发明还涉及生物活性NsG29和NsG31多肽片段和相应的编码DNA序列。

2. 发明申请

WO2006013462A3 GROWTH FACTORS NSG28, NSG30, AND NSG32 审中-公开
标题翻译：生长因子NSG28，NSG30和NSG32
公开(公告)号：WO2006013462A3
公开(公告)日：2006-12-28
申请号：PCT/IB2005002490
申请日：2005-08-01
申请人： NSGENE AS , PETERSEN THOMAS NORDAHL , WAHLBERG LARS , BRUNAK SOEREN , JOHANSEN TEIT E , BLOM NIKOLAJ , GROENBORG METTE , KUSK PHILIP
发明人： PETERSEN THOMAS NORDAHL , WAHLBERG LARS , BRUNAK SOEREN , JOHANSEN TEIT E , BLOM NIKOLAJ , GROENBORG METTE , KUSK PHILIP
IPC分类号： C07K14/475 , A61K38/18 , C12N15/12
CPC分类号： C07K14/475 , A61K38/00
摘要： Disclosed are NsG28, NsG30, NsG32 polypeptides, nucleic acids encoding NsG28, NsG30, NsG32 polypeptides, and antibodies that bind to NsG28, NsG30, NsG32 polypeptides as well as methods of making and using the same.
摘要翻译：公开了NsG28，NsG30，NsG32多肽，编码NsG28，NsG30，NsG32多肽的核酸，以及与NsG28，NsG30，NsG32多肽结合的抗体以及制备和使用它们的方法。

3. 发明申请

WO2005095450A3 THERAPEUTIC USE OF A GROWTH FACTOR, NSG33 审中-公开
标题翻译： NSG33的生长因子的治疗用途
公开(公告)号：WO2005095450A3
公开(公告)日：2006-01-05
申请号：PCT/EP2005051431
申请日：2005-03-30
申请人： NSGENE AS , GROENBORG METTE , KUSK PHILIP , BLOM NIKOLAJ , PETERSEN THOMAS NORDAHL , JOHANSEN TEIT E , BRUNAK SOEREN , WAHLBERG LARS
发明人： GROENBORG METTE , KUSK PHILIP , BLOM NIKOLAJ , PETERSEN THOMAS NORDAHL , JOHANSEN TEIT E , BRUNAK SOEREN , WAHLBERG LARS
IPC分类号： A61K31/7088 , A61K31/713 , A61K38/18 , C07K14/475
CPC分类号： C07K14/475 , A01K67/027 , A01K2207/05 , A01K2207/20 , A01K2227/105 , A01K2267/0356 , A61K38/00 , A61K38/17 , A61K38/185 , C12N2799/027
摘要： The present invention relates to the field of therapeutic use of proteins, genes and cells. More specifically the invention relates to therapy based on the biological function of a secreted therapeutic protein, NsG33, in particular for the treatment of disorders of the nervous system. NsG33 is a nerve survival and growth factor with antiapoptotic effects on a cell line with neuronal potential and with neuroprotective and/or neurogenesis effects on a neural precursor cell line and on primary striatal cultures. The invention also relates to novel bioactive NsG33 polypeptide fragments and the corresponding encoding DNA sequences.
摘要翻译：本发明涉及蛋白质，基因和细胞的治疗用途领域。更具体地，本发明涉及基于分泌的治疗性蛋白质NsG33的生物学功能的治疗，特别是用于治疗神经系统疾病。 NsG33是神经存活和生长因子，对具有神经元潜力的细胞系具有抗细胞凋亡作用，并且对神经前体细胞系和原始纹状体培养物具有神经保护和/或神经发生作用。本发明还涉及新的生物活性NsG33多肽片段和相应的编码DNA序列。

4. 发明申请

WO2005051992A8 USE OF NEUBLASMIN AS A MAKER FOR TESTIS CANCER 审中-公开
标题翻译： NEUBLASMIN作为睾丸癌的制造商
公开(公告)号：WO2005051992A8
公开(公告)日：2005-07-21
申请号：PCT/EP2004053101
申请日：2004-11-25
申请人： NSGENE AS , GROENBORG METTE , BLOM NIKOLAJ
发明人： GROENBORG METTE , BLOM NIKOLAJ
IPC分类号： C07K14/475
CPC分类号： C07K14/475
摘要： The present invention relates to the field of diagnostic and therapeutic use of proteins and genes, in particular to the diagnostic and therapeutic use of a secreted human hormone/growth factor, Neublasmin, and use of the gene coding for Neublasmin in the diagnosis and treatment of testicular disorders, in particular diagnosis and treatment of germ cell tumours and infertility. The invention also relates to use of Neublasmin in the treatment of CNS disorders. Neublasmin is expressed at high levels in human adult testicles and in developing mouse testicles from pn 22 and onwards. Expression of Neublasmin is strongly up-regulated in carcinoma in situ. Expression is also seen in foetal and adult brain.
摘要翻译：本发明涉及蛋白质和基因的诊断和治疗用途领域，特别涉及分泌的人类激素/生长因子Neublasmin的诊断和治疗用途以及编码Neublasmin的基因在诊断和治疗睾丸疾病，特别是生殖细胞肿瘤和不育症的诊断和治疗。本发明还涉及Neublasmin在治疗CNS疾病中的用途。 Neublasmin在人类成年睾丸中高水平表达，并且在来自pn22及以上的小鼠睾丸发育中表达。 Neublasmin的表达在原位癌中强烈上调。在胎儿和成人大脑中也可见到表达。

5. 发明申请

WO2004108760A3 IMPROVED SECRETION OF NEUBLASTIN 审中-公开
标题翻译：改善的分泌物
公开(公告)号：WO2004108760A3
公开(公告)日：2005-04-07
申请号：PCT/DK2004000411
申请日：2004-06-10
申请人： NSGENE AS , BIOGEN IDEC INC , WAHLBERG LARS U , GROENBORG METTE , KUSK PHILIP , TORNOEE JENS , PEDERSON NELS E , SISK WILLIAM P
发明人： WAHLBERG LARS U , GROENBORG METTE , KUSK PHILIP , TORNOEE JENS , PEDERSON NELS E , SISK WILLIAM P
IPC分类号： A61K9/00 , A61K48/00 , A61P25/28 , C07K14/475 , C12N15/867 , C12N5/10 , C12N15/62
CPC分类号： C12N15/86 , A01K2217/05 , A61K9/0051 , A61K9/0085 , A61K48/0075 , C07K14/4756 , C12N2740/15043 , C12N2740/15052
摘要： The present invention concerns methods and compositions for producing a neublastin polypeptide as well as local delivery of neublastin to specific regions of the nervous system including the central nervous system and the eye for example by gene therapy. The biologically active neublastin polypeptide is produced from a construct not encoding naturally occurring neublastin pro-region, i.e. a construct comprising a nucleic acid with a promoter sequence operably linked to a nucleotide sequence encoding a signal peptide and a neublastin polypeptide, wherein said nucleotide sequence does not encode a neublastin pro-region.
摘要翻译：本发明涉及用于产生新斯的斯多肽多肽的方法和组合物，以及例如通过基因治疗将神经系统局部递送至包括中枢神经系统和眼睛在内的神经系统的特定区域。生物活性的新斯的斯多肽由不编码天然存在的新斯普派斯汀前区的构建体产生，即构建体包含具有可操作地连接于编码信号肽和新伯斯特蛋白多肽的核苷酸序列的启动子序列的核酸，其中所述核苷酸序列不编码新伯斯坦原始地区。

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