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1. 发明申请

WO2010088394A1 COMPOUNDS 审中-公开
标题翻译：化合物
公开(公告)号：WO2010088394A1
公开(公告)日：2010-08-05
申请号：PCT/US2010/022414
申请日：2010-01-28
申请人： GLAXOSMITHKLINE LLC , COOPER, Joel P , DUAN, Maosheng , GRIMES, Richard Martin , KAZMIERSKI, Wieslaw Mieczyslaw , TALLANT, Matthew D
发明人： COOPER, Joel P , DUAN, Maosheng , GRIMES, Richard Martin , KAZMIERSKI, Wieslaw Mieczyslaw , TALLANT, Matthew D
IPC分类号： A61K31/519 , A61K31/44
CPC分类号： A61K31/44 , A61K31/519 , A61K45/06 , C07D487/04 , A61K2300/00
摘要： The present invention features compounds of Formula (I) and (Ia), pharmaceutical compositions and use in the treatment of viral disease.
摘要翻译：本发明的特征在于式（I）和（Ia）的化合物，药物组合物和用于治疗病毒性疾病的用途。

2. 发明申请

WO2007147794A1 FURAN DERIVATIVES AND THEIR USE AS ANTIVIRAL AGENTS 审中-公开
标题翻译： FURAN衍生物及其作为抗病毒剂的用途
公开(公告)号：WO2007147794A1
公开(公告)日：2007-12-27
申请号：PCT/EP2007/055991
申请日：2007-06-18
申请人： SMITHKLINE BEECHAM CORPORATION , GRIMES, Richard, Martin , SHAH, Pritom
发明人： GRIMES, Richard, Martin , SHAH, Pritom
IPC分类号： C07D307/68 , A61K31/341 , C07D471/04 , C07D493/04 , A61P31/00 , C07D413/10 , C07D498/04 , C07D513/04 , A61K31/4355 , A61K31/437 , A61K31/421 , A61K31/429
CPC分类号： C07D307/68 , C07D413/10 , C07D471/04 , C07D487/04 , C07D491/04 , C07D491/048 , C07D498/04 , C07D513/04
摘要： Anti-viral agents of compounds of Formula (Ia) : wherein A, R 1 , R 2 and R 3 are as defined in the specification, processes for their preparation and their use in HCV treatment are provided.
摘要翻译：式（Ia）化合物的抗病毒剂：其中A，R 1，R 2和R 3如本说明书中所定义提供其制备方法及其在HCV治疗中的应用。

3. 发明申请

WO2013022810A1 CHEMICAL COMPOUNDS 审中-公开
标题翻译：化学化合物
公开(公告)号：WO2013022810A1
公开(公告)日：2013-02-14
申请号：PCT/US2012/049681
申请日：2012-08-06
申请人： GLAXOSMITHKLINE LLC , BASKARAN, Subramanian , GRIMES, Richard, Martin , KAZMIERSKI, Wieslaw, Miieczyslaw , LEIVERS, Martin, Robert
发明人： BASKARAN, Subramanian , GRIMES, Richard, Martin , KAZMIERSKI, Wieslaw, Miieczyslaw , LEIVERS, Martin, Robert
IPC分类号： A61K31/4178 , C07D403/14
CPC分类号： C07D403/14 , C07D405/14 , C07D409/14
摘要： Disclosed are compounds of Formula I, Formula II, and Formula III. Also disclosed are salts of the compounds, pharmaceutical composition comprising the compounds or salts, and methods for treating HCV infection by administration of the compounds or salts. In another aspect, the present invention discloses pharmaceutical compositions comprising a compound of Formula I or a pharmaceutically acceptable salt thereof. In another aspect, the present invention discloses pharmaceutically acceptable salts of the compounds of Formula II or Formula III. In another aspect, the present invention discloses pharmaceutical compositions comprising a compound of Formula II or Formula III or a pharmaceutically acceptable salt thereof. In another aspect, the present invention discloses a method for treating a viral infection, for example infection with HCV, in a human, comprising administration of a pharmaceutical composition of the invention.
摘要翻译：公开了式I，式II和式III的化合物。还公开了化合物的盐，包含化合物或盐的药物组合物，以及通过施用化合物或盐治疗HCV感染的方法。另一方面，本发明公开了包含式I化合物或其药学上可接受的盐的药物组合物。另一方面，本发明公开了式II或式III化合物的药学上可接受的盐。另一方面，本发明公开了包含式II或式III化合物或其可药用盐的药物组合物。另一方面，本发明公开了一种用于治疗病毒感染（例如HCV感染）的方法，包括给予本发明的药物组合物。

4. 发明申请

WO2011054844A1 CONDENSED AZEPINE DERIVATIVES AS BROMODOMAIN INHIBITORS 审中-公开
标题翻译：浓缩的衍生物作为BROMODOMAIN抑制剂
公开(公告)号：WO2011054844A1
公开(公告)日：2011-05-12
申请号：PCT/EP2010/066696
申请日：2010-11-03
申请人： GLAXOSMITHKLINE LLC , CROWE, Miriam , DAUGAN, Alain, Claude-Marie , GOSMINI, Romain, Luc, Marie , GRIMES, Richard, Martin , MIRGUET, Olivier , MORDAUNT, Jacqueline, Elizabeth
发明人： CROWE, Miriam , DAUGAN, Alain, Claude-Marie , GOSMINI, Romain, Luc, Marie , GRIMES, Richard, Martin , MIRGUET, Olivier , MORDAUNT, Jacqueline, Elizabeth
IPC分类号： C07D487/04 , C07D495/14 , C07D491/147 , A61P35/00 , A61P29/00 , A61K31/5517
CPC分类号： C07D487/04 , C07D491/147 , C07D495/14
摘要： Benzodiazepine compounds of formula (I) and salts thereof, pharmaceutical compositions containing such compounds and their use in therapy.
摘要翻译：式（I）的苯并二氮杂化合物及其盐，含有这些化合物的药物组合物及其在治疗中的用途。

5. 发明申请

WO2011028596A1 CHEMICAL COMPOUNDS 审中-公开
标题翻译：化学化合物
公开(公告)号：WO2011028596A1
公开(公告)日：2011-03-10
申请号：PCT/US2010/046782
申请日：2010-08-26
申请人： GLAXOSMITHKLINE LLC , CHEN, Pingyun , COUCH, Ricky , DUAN, Maosheng , GRIMES, Richard, Martin , KAZMIERSKI, Wieslaw, Mieczyslaw , NORTON, Beth, Adams , TALLANT, Matthew
发明人： CHEN, Pingyun , COUCH, Ricky , DUAN, Maosheng , GRIMES, Richard, Martin , KAZMIERSKI, Wieslaw, Mieczyslaw , NORTON, Beth, Adams , TALLANT, Matthew
IPC分类号： A01N57/00 , C07C403/00
CPC分类号： A61K31/4178 , A61K31/435 , A61K31/7056 , A61K38/21 , C07D403/12 , C07D403/14 , C07D471/10 , C07D487/10 , C07D487/20 , C07D491/10 , C07D491/107 , C07D491/113 , C07D495/10 , C07D519/00
摘要： Disclosed are compounds of Formula III. Also disclosed are salts of the compounds, pharmaceutical composition comprising the compounds or salts, and methods for treating HCV infection by administration of the compounds or salts.
摘要翻译：公开了式III的化合物。还公开了化合物的盐，包含化合物或盐的药物组合物，以及通过施用化合物或盐治疗HCV感染的方法。

6. 发明申请

WO2007071434A1 ANTIVIRAL 2-CARBOXY-THIOPHENE COMPOUNDS 审中-公开
标题翻译：有害的2-羧基 - 噻吩化合物
公开(公告)号：WO2007071434A1
公开(公告)日：2007-06-28
申请号：PCT/EP2006/012442
申请日：2006-12-20
申请人： SMITHKLINE BEECHAM CORPORATION , CORFIELD, John, Andrew , GRIMES, Richard, Martin , HARRISON, David , HARTLEY, Charles, David , HOWES, Peter, David , LE, Joelle , MEESON, Malcolm, Lees , MORDAUNT, Jacqueline, Elizabeth , SHAH, Pritom , SLATER, Martin, John , WHITE, Gemma, Victoria
发明人： CORFIELD, John, Andrew , GRIMES, Richard, Martin , HARRISON, David , HARTLEY, Charles, David , HOWES, Peter, David , LE, Joelle , MEESON, Malcolm, Lees , MORDAUNT, Jacqueline, Elizabeth , SHAH, Pritom , SLATER, Martin, John , WHITE, Gemma, Victoria
IPC分类号： C07D409/10 , C07D413/10 , C07D413/14 , C07D471/04 , C07D487/04 , C07D491/04 , C07D498/04 , C07D513/04 , A61K31/423 , A61K31/429 , A61K31/4184 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/4355
CPC分类号： C07D409/10 , C07D333/70 , C07D413/10 , C07D413/14 , C07D471/04 , C07D487/04 , C07D491/04 , C07D513/04
摘要： Anti-viral agents of compounds of Formula (I) : wherein A, R 1 , R 2 and R 3 are as defined in the specification, processes for their preparation and their use in HCV treatment are provided.
摘要翻译：式（I）化合物的抗病毒剂：其中A，R 1，R 2和R 3如本说明书中所定义提供其制备方法及其在HCV治疗中的应用。

7. 发明申请

WO2008059042A1 2-CARBOXY THIOPHENE DERIVATIVES AS ANTI VIRAL AGENTS 审中-公开
标题翻译： 2-羧基噻吩衍生物作为反病毒剂
公开(公告)号：WO2008059042A1
公开(公告)日：2008-05-22
申请号：PCT/EP2007/062431
申请日：2007-11-15
申请人： SMITHKLINE BEECHAM CORPORATION , GRIMES, Richard Martin , HARTLEY, Charles David , MORDAUNT, Jacqueline Elizabeth , SHAH, Pritom , SLATER, Martin John , WHITE, Gemma Victoria
发明人： GRIMES, Richard Martin , HARTLEY, Charles David , MORDAUNT, Jacqueline Elizabeth , SHAH, Pritom , SLATER, Martin John , WHITE, Gemma Victoria
IPC分类号： C07D409/04 , C07D409/10 , C07D409/12
CPC分类号： C07D417/12 , C07D333/38 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/14
摘要： Anti-viral agents of compounds of Formula (I): wherein A, R 1 , R 2 and R 3 are as defined in the specification, processes for their preparation and their use in HCV treatment are provided.
摘要翻译：式（I）化合物的抗病毒剂：其中A，R 1，R 2和R 3如本说明书中所定义提供其制备方法及其在HCV治疗中的应用。

8. 发明申请

WO2006100106A1 3-CARBOXY PYRROLES AS ANTI-VIRAL AGENTS 审中-公开
标题翻译： 3-羧基吡咯烷作为反病毒剂
公开(公告)号：WO2006100106A1
公开(公告)日：2006-09-28
申请号：PCT/EP2006/002833
申请日：2006-03-20
申请人： SMITHKLINE BEECHAM CORPORATION , GRIMES, Richard, Martin , SHAH, Pritom
发明人： GRIMES, Richard, Martin , SHAH, Pritom
IPC分类号： A61K31/40 , C07D405/12 , C07D207/34 , A61K31/4025 , A61P31/12
CPC分类号： C07D405/12 , C07D207/34
摘要： Novel antiviral compounds of Formula (I) : wherein: A represents hydroxy; R 4 represents hydrogen and the other substituents are as defined in the claims; and salts, solvates and esters thereof; processes for their preparation, pharmaceutical compositions comprising them, and their use in HCV treatment are provided. .
摘要翻译：式（I）的新型抗病毒化合物：其中：A表示羟基; R 4表示氢，其它取代基如权利要求中所定义; 及其盐，溶剂化物和酯; 提供其制备方法，包含它们的药物组合物及其在HCV治疗中的用途。。

9. 发明申请

WO2004096210A1 ACYLATED INDOLINE AND TETRAHYDROQUINOLINE DERIVATIVES AS HCV INHIBITORS 审中-公开
标题翻译：作为HCV抑制剂的ACYLATED INDOLINE ANDTETRAHYDROQUINOLINE DERIVITIVES
公开(公告)号：WO2004096210A1
公开(公告)日：2004-11-11
申请号：PCT/EP2004/004663
申请日：2004-04-29
申请人： GLAXO GROUP LIMITED , BRAVI, Gianpaolo , GRIMES, Richard, Martin , GUIDETTI, Rossella , HAIGH, David , HARTLEY, Charles, David , MORDAUNT, Jacqueline, Elizabeth , SHAH, Pritom , SLATER, Martin, John
发明人： BRAVI, Gianpaolo , GRIMES, Richard, Martin , GUIDETTI, Rossella , HAIGH, David , HARTLEY, Charles, David , MORDAUNT, Jacqueline, Elizabeth , SHAH, Pritom , SLATER, Martin, John
IPC分类号： A61K31/404
CPC分类号： C07D401/04 , C07D209/42 , C07D215/48 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/12 , C07D413/06 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/12
摘要： Use of a compound of Formula (I) : wherein: R 1 represents hydroxy or NR B R C ; R 2 represents C 1-6 alkyl, heterocyclylalkyl, arylalkyl or heteroarylalkyl; R 3 represents aryl or heteroaryl; R 4 represents one or two substituents independently selected from hydrogen, C 1-6 alkyl, halo, OR A , C(O)NR B R C , C(O)R D , CO 2 H , CO 2 R D , NR B R C , NR E C(O)R D , NR E CO 2 R D , NR E C(O)NR F R G , NR E SO 2 R D , SO 2 NR F R G , SO 2 R D , nitro, cyano, heterocyclyl, heteroaryl, aryl, arylalkyl heteroarylalkyl or CF 3 ; R 5 and R 6 independently represent hydrogen, C 1-6 alkyl, aryl, heteroaryl, arylalkyl, or heteroarylalkyl; R 7 and R 8 independently represent hydrogen, C 1-6 alkyl, aryl, heteroaryl, arylalkyl, or heteroarylalkyl; n represents 0 or 1; R A represents hydrogen, C 1-6 alkyl, arylalkyl, heteroarylalkyl, aryl or heteroaryl; R B and R C independently represent hydrogen, C 1-6 alkyl, aryl or heteroaryl; or R B and R C together with the nitrogen atom to which they are attached form a 5 or 6 membered saturated cyclic group; R D is selected from the group consisting of C 1-6 alkyl, aryl, heteroaryl, arylalkyl, and heteroarylalkyl; R E represents hydrogen or C 1-6 alkyl; R F and R G are independently selected from the group consisting of hydrogen, C 1-6 alkyl, aryl, heteroaryl, arylalkyl, and heteroarylalkyl; or R F and R G together with the nitrogen atom to which they are attached form a 5 or 6 membered saturated cyclic group; and salts, solvates and esters thereof; provided that when R 1 is esterified to form -OR where R is selected from straight or branched chain alkyl, aralkyl, aryloxyalkyl, or aryl, then R is other than tert -butyl; in the manufacture of a medicament for the treatment of viral infection is provided. Also provided are certain novel compounds of Formula (I) represented by Formula (Ib). Further provided are processes for the preparation of compounds of Formula (I), pharmaceutical compositions comprising them, and methods of using them in HCV treatment.
摘要翻译：式（I）化合物的用途：其中：R 1表示羟基或NR B; R 2表示C 1-6烷基，杂环基烷基，芳烷基或杂芳基烷基; R 3表示芳基或杂芳基; R 4表示一个或两个独立地选自氢，C 1-6烷基，卤素，OR A，C（O）NR B，C（O）R D，CO 2 H，CO 2 R NR（R）R C，NR C（O）R D，NR E 2 CO 2 R D，NR C（O）NR F SO 2 R D，SO 2 R R，SO 2 R 6，硝基，氰基，杂环基，杂芳基，芳基，芳基烷基杂芳基烷基或CF 3; R 5和R 6独立地表示氢，C 1-6烷基，芳基，杂芳基，芳烷基或杂芳基烷基; R 7和R 8独立地表示氢，C 1-6烷基，芳基，杂芳基，芳烷基或杂芳基烷基; n表示0或1; R A表示氢，C 1-6烷基，芳基烷基，杂芳基烷基，芳基或杂芳基; R B和R C独立地表示氢，C 1-6烷基，芳基或杂芳基; 或R B和R C与它们所连接的氮原子一起形成5或6元饱和的环状基团; R D选自C 1-6烷基，芳基，杂芳基，芳基烷基和杂芳基烷基; R E表示氢或C 1-6烷基; R F和R G独立地选自氢，C 1-6烷基，芳基，杂芳基，芳基烷基和杂芳基烷基; 或R F和R G与它们所连接的氮原子一起形成5或6元饱和的环状基团; 及其盐，溶剂化物和酯; 条件是当R 1被酯化形成-OR时，其中R选自直链或支链烷基，芳烷基，芳氧基烷基或芳基，则R不是叔丁基; 在制备用于治疗病毒感染的药物中。还提供某些由式（Ib）表示的式（I）的新化合物。还提供了制备式（I）化合物，包含它们的药物组合物的方法和在HCV治疗中使用它们的方法。

10. 发明申请

WO2007039146A1 4-CARBOXY PYRAZOLE DERIVATIVES AS ANTI-VIRAL AGENTS 审中-公开
标题翻译： 4-羧基吡唑衍生物作为反病毒剂
公开(公告)号：WO2007039146A1
公开(公告)日：2007-04-12
申请号：PCT/EP2006/009238
申请日：2006-09-21
申请人： SMITHKLINE BEECHAM CORPORATION , BRAVI, Gianpaolo , CHEASTY, Anne Goretti , CORFIELD, John Andrew , GRIMES, Richard Martin , HARRISON, David , HARTLEY, Charles David , HOWES, Peter David , MEDHURST, Katrina Jane , MEESON, Malcolm Lees , MORDAUNT, Jacqueline Elizabeth , SHAH, Pritom , SLATER, Martin John , WHITE, Gemma Victoria
发明人： BRAVI, Gianpaolo , CHEASTY, Anne Goretti , CORFIELD, John Andrew , GRIMES, Richard Martin , HARRISON, David , HARTLEY, Charles David , HOWES, Peter David , MEDHURST, Katrina Jane , MEESON, Malcolm Lees , MORDAUNT, Jacqueline Elizabeth , SHAH, Pritom , SLATER, Martin John , WHITE, Gemma Victoria
IPC分类号： C07D401/10 , C07D403/10 , C07D413/10 , C07D417/10 , A61K31/41 , A61P31/12
CPC分类号： C07D401/10 , C07D401/14 , C07D403/10 , C07D403/14 , C07D405/10 , C07D405/14 , C07D409/10 , C07D413/10 , C07D413/14 , C07D417/10 , C07D471/04 , C07D487/04 , C07D493/04 , C07D513/04
摘要： Anti-viral agents of compounds of Formula (I): wherein A, R 1 , R 2 , R 3 and R 4 are as defined in the specification, processes for their preparation and their use in HCV treatment are provided.
摘要翻译：式（I）化合物的抗病毒剂：其中A，R 1，R 2，R 3和R 4 本说明书中定义，其制备方法及其在HCV治疗中的应用。

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