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1. 发明专利

GB9207235D0 ARRANGEMENT FOR IMMOBILISING A VEHICLE 未知
公开(公告)号：GB9207235D0
公开(公告)日：1992-05-13
申请号：GB9207235
申请日：1992-04-02
申请人： GREEN NEIL R , LEECH ALAN
IPC分类号： B60R25/08

2. 发明专利

GB9306930D0 VEHICLE IMMOBILISATION APPARATUS 未知
公开(公告)号：GB9306930D0
公开(公告)日：1993-05-26
申请号：GB9306930
申请日：1993-04-02
申请人： GREEN NEIL R , LEECH ALAN
IPC分类号： B60R25/08

3. 发明专利

AU2015101678A4 Fence 未知
公开(公告)号：AU2015101678A4
公开(公告)日：2015-12-24
申请号：AU2015101678
申请日：2015-11-17
申请人： GREEN NEIL JAMES
发明人： GREEN NEIL JAMES
IPC分类号： E04H17/14
摘要： -15 Abstract A fencing assembly (14) for forming a fence panel (12) in an assembled condition, the fencing assembly (14) including posts (16), at least two rails (18) arranged to extend between the posts (16) and a releasable coupling (20) arranged to couple a coupling one of the at least two rails (18) with the posts (14). The at least two rails (18) and posts (16) are arranged to allow the at least two rails (18) to be removably locatable between the posts (16) such that, in the assembled condition, engagement of the releasable coupling (20) between the coupling one (18b) of the at least two rails (18) and the posts (16) secures the coupling one of the at least two rails (18) and the other of the at least two rails (18) between the posts (16), and wherein, in a disassembled condition, the releasable coupling (20) is disengaged such that the at least two rails (18) and the posts (14) are dislocated and thereby storable alongside one another. A fencing system (10) and a method of assembling a fence panel (12) are also disclosed. ]2 1 2 Fig.]I

4. 发明专利

GB2265679A Vehicle immobilisation apparatus 未知
公开(公告)号：GB2265679A
公开(公告)日：1993-10-06
申请号：GB9306930
申请日：1993-04-02
申请人： GREEN NEIL ROBERT , LEECH ALAN
发明人： GREEN NEIL ROBERT
IPC分类号： B60R25/08
摘要： Apparatus for immobilising a vehicle which has a pneumatic braking system, for example a commercial vehicle, operates by preventing the supply of compressed air to the vehicle's hand-brake release mechanism. As illustrated, the apparatus includes a multiple-position switch (14) which in a first position de-energises a solenoid valve (24) to prevent that compressed air supply and in a second position also cuts off via a solenoid switch (26) the supply of electricity to at least the engine starting system, and via a solenoid valve (34) the fuel supply to the engine.

5. 发明申请

WO1998013473A1 GENETICALLY ENGINEERED YEAST WITH MODIFIED SIGNAL PEPTIDASE COMPLEX 审中-公开
标题翻译：具有修饰信号肽复合物的遗传工程YEAST
公开(公告)号：WO1998013473A1
公开(公告)日：1998-04-02
申请号：PCT/US1997017597
申请日：1997-09-25
申请人： VANDERBILT UNIVERSITY , FANG, Hong , GREEN, Neil , VAN KAER, Luc
发明人： VANDERBILT UNIVERSITY
IPC分类号： C12N01/15
CPC分类号： C12N9/52 , C12N15/81
摘要： The present invention provides a yeast cell comprising a nucleic acid functionally encoding a eukaryotic (e.g., mammalian) protein homologue of a subunit (Sec11p, Spc1p, Spc2p and/or Spc3p) of the yeast signal peptidase complex. The yeast cell of this invention can be, for example, of the genus Saccharomyces, Schizosaccharomyces, Pichia, Hansenula, Kluyveromyces and/or Yarrowia. Furthermore, the yeast cell can lack one or more functional subunits (Sec11p, Spc1p, Spc2p and/or Spc3p) of the yeast signal peptidase complex. The present invention further provides a method for producing a protein heterologous to a yeast cell comprising expressing, in the yeast cell of this invention, a nucleic acid functionally encoding the heterologous protein under conditions which permit the expression of the nucleic acid as a precursor protein having a signal peptide and processing of the precursor protein to a signal peptide-cleaved form of the protein. A method is also provided for obtaining increased production of a protein heterologous to a yeast cell comprising expressing, in the yeast cell of this invention, a nucleic acid functionally encoding the heterologous protein under conditions which permit the expression of the nucleic acid as a precursor protein having a signal peptide and processing of the precursor protein to a signal peptide-cleaved form of the protein. Additionally provided is a method for producing a yeast cell capable of increased production of a protein heterologous to the yeast cell, comprising introducing into the yeast cell (with or without one or more functional SPC subunits) a nucleic acid which functionally encodes one or more eukaryotic protein homologues of the signal peptidase complex under conditions permitting the expression of the nucleic acid as the protein homologues.
摘要翻译：本发明提供了酵母细胞，其包含功能性编码酵母信号肽酶复合物的亚基（Sec11p，Spc1p，Spc2p和/或Spc3p）的真核（例如哺乳动物）蛋白质同源物的核酸。本发明的酵母细胞可以是例如酵母属，裂殖酵母属，毕赤酵母，汉逊酵母，克鲁维酵母属和/或耶氏酵母属。此外，酵母细胞可以缺乏酵母信号肽酶复合物的一个或多个功能性亚基（Sec11p，Spc1p，Spc2p和/或Spc3p）。本发明还提供了一种用于生产与酵母细胞异源的蛋白质的方法，包括在本发明的酵母细胞中表达在允许表达核酸作为前体蛋白的条件下功能性编码异源蛋白质的核酸，信号肽和前体蛋白与信号肽切割形式的蛋白质的加工。还提供了用于获得增加对酵母细胞异源的蛋白质产生的方法，包括在本发明的酵母细胞中表达在允许核酸作为前体蛋白表达的条件下功能编码异源蛋白质的核酸具有信号肽和将前体蛋白加工成信号肽切割形式的蛋白质。另外提供了一种用于生产能够增加与酵母细胞异源的蛋白质产生的酵母细胞的方法，包括向功能上编码一种或多种真核生物的核酸引入酵母细胞（具有或不具有一个或多个功能性SPC亚基）在允许核酸作为蛋白质同系物表达的条件下，信号肽酶复合物的蛋白质同系物。

6. 发明申请

WO2005024051A1 CELL-BASED ASSAY FOR IDENTIFYING PEPTIDASE INHIBITORS 审中-公开
标题翻译：用于鉴定肽酶抑制剂的基于细胞的测定
公开(公告)号：WO2005024051A1
公开(公告)日：2005-03-17
申请号：PCT/US2004/014586
申请日：2004-05-11
申请人： VANDERBILT UNIVERSITY , FANG, Hong , GREEN, Neil
IPC分类号： C12Q1/37
CPC分类号： C12N9/6489 , C12Q1/02 , C12Q1/37 , G01N2333/39
摘要： The present invention provides assays for the identification of inhibitors of endopeptidase toxins. The assays utilize genetically engineered yeast cells that contain a conditionally expressed endopeptidase toxin. When conditions for expression of the toxin are met, the toxin cleaves a yeast (natural or engineered) peptide product that is required for yeast survival. If the yeast is grown in the presence of a candidate substance that is an inhibitor of the toxin, the yeast survives, thereby providing a rapid and sensitive identification of the inhibitor.
摘要翻译：本发明提供了鉴定内肽酶毒素抑制剂的测定法。该测定法利用含有条件表达的内肽酶毒素的遗传工程酵母细胞。当满足毒素表达条件时，毒素切割酵母存活所需的酵母（天然或工程化）肽产物。如果酵母在存在作为毒素抑制剂的候选物质的情况下生长，则酵母存活，从而提供抑制剂的快速且敏感的鉴定。

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