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1. 发明专利

GB2137880A IMMUNOGENIC COMPOSITIONS 未知
公开(公告)号：GB2137880A
公开(公告)日：1984-10-17
申请号：GB8407684
申请日：1984-03-23
申请人： CRIGHTON DAVID BARRY , GRAHAM NEIL BONNETTE , HOWELLS ROBERT ELWYN , KEELING BEVERLEY JANE , THEAKSTON ROBERT DAVID GEOFFRE
发明人： CRIGHTON DAVID BARRY , GRAHAM NEIL BONNETTE , HOWELLS ROBERT ELWYN , KEELING BEVERLEY JANE , THEAKSTON ROBERT DAVID GEOFFRE
IPC分类号： A23K1/16 , A61D7/00 , A61K39/00 , A61K39/385 , A61K39/39 , C07K7/23 , C07K16/18 , C07K16/26
摘要： An immunogenic composition which comprises: (i) an immunogen containing, an active principle, an antigen; and (ii) an adjuvant which comprises a monomeric adduct formable by adding: (a) at least one monomeric, substituted or unsubstituted, saturated or unsaturated, mono-, di- or poly-acid, neutral or amphoteric active hydrogen atom-containing organic compound to the, or at least one of the, ring double bonds of (b) at least one mono-, di- or poly-unsaturated cyclic (thio)ether.

2. 发明专利

DK148284A 未知
公开(公告)号：DK148284A
公开(公告)日：1984-09-03
申请号：DK148284
申请日：1984-02-29
申请人： GRAHAM NEIL BONNETTE
发明人： GRAHAM NEIL BONNETTE
IPC分类号： A61L29/00 , A61F13/00 , A61K9/00 , A61K9/20 , A61K9/22 , C02F1/26 , C08G18/48 , C08G18/66 , A61K , C02F
摘要： An envelope having flexible water-permeable or porous walls contains a quantity of particulate water-insoluble hydrogel. The quantity of hydrogel in the envelope is such that, when the hydrogel is fully swollen at 20°C, its volume is at least 66%, preferably at least 100%, of the maximum non-stretched intemal volume ofthe envelope. Thus, the envelope according to the invention is limp and floppy under dry conditions but in a wet environment the hydrogel absorbs water and swells accordingly causing the envelope to swell and take on a more rigid configuration. The envelope is particularly useful for the administration of sustained release pharmaceutically or veterinarily active ingredients. Thus the limp dry envelope may for example be rolled up for introduction through the throat but will swell up and therefore be retained in the stomach for sustained release of the active ingredient therein.

3. 发明专利

GB2144051B HYDROGEL-CONTAINING ENVELOPES 未知
公开(公告)号：GB2144051B
公开(公告)日：1986-10-15
申请号：GB8405405
申请日：1984-03-01
申请人： GRAHAM NEIL BONNETTE
发明人： GRAHAM NEIL BONNETTE
IPC分类号： A61L29/00 , A61F13/00 , A61K9/00 , A61K9/20 , A61K9/22 , C02F1/26 , C08G18/48 , C08G18/66 , B01D13/00
摘要： An envelope having flexible water-permeable or porous walls contains a quantity of particulate water-insoluble hydrogel. The quantity of hydrogel in the envelope is such that, when the hydrogel is fully swollen at 20°C, its volume is at least 66%, preferably at least 100%, of the maximum non-stretched intemal volume ofthe envelope. Thus, the envelope according to the invention is limp and floppy under dry conditions but in a wet environment the hydrogel absorbs water and swells accordingly causing the envelope to swell and take on a more rigid configuration. The envelope is particularly useful for the administration of sustained release pharmaceutically or veterinarily active ingredients. Thus the limp dry envelope may for example be rolled up for introduction through the throat but will swell up and therefore be retained in the stomach for sustained release of the active ingredient therein.

4. 发明专利

GB2144051A HYDROGEL-CONTAINING ENVELOPES 未知
公开(公告)号：GB2144051A
公开(公告)日：1985-02-27
申请号：GB8405405
申请日：1984-03-01
申请人： GRAHAM NEIL BONNETTE
发明人： GRAHAM NEIL BONNETTE
IPC分类号： A61L29/00 , A61F13/00 , A61K9/00 , A61K9/20 , A61K9/22 , C02F1/26 , C08G18/48 , C08G18/66 , B01D13/00
摘要： An envelope having flexible water-permeable or porous walls contains a quantity of particulate water-insoluble hydrogel. The quantity of hydrogel in the envelope is such that, when the hydrogel is fully swollen at 20°C, its volume is at least 66%, preferably at least 100%, of the maximum non-stretched intemal volume ofthe envelope. Thus, the envelope according to the invention is limp and floppy under dry conditions but in a wet environment the hydrogel absorbs water and swells accordingly causing the envelope to swell and take on a more rigid configuration. The envelope is particularly useful for the administration of sustained release pharmaceutically or veterinarily active ingredients. Thus the limp dry envelope may for example be rolled up for introduction through the throat but will swell up and therefore be retained in the stomach for sustained release of the active ingredient therein.

5. 发明专利

GB2137880B IMMUNOGENIC COMPOSITIONS 未知
公开(公告)号：GB2137880B
公开(公告)日：1987-07-29
申请号：GB8407684
申请日：1984-03-23
申请人： CRIGHTON DAVID BARRY , GRAHAM NEIL BONNETTE , HOWELLS ROBERT ELWYN , KEELING BEVERLEY JANE , THEAKSTON ROBERT DAVID GEOFFRE
发明人： CRIGHTON DAVID BARRY , GRAHAM NEIL BONNETTE , HOWELLS ROBERT ELWYN , KEELING BEVERLEY JANE , THEAKSTON ROBERT DAVID GEOFFRE
IPC分类号： A23K1/16 , A61D7/00 , A61K39/00 , A61K39/385 , A61K39/39 , C07K7/23 , C07K16/18 , C07K16/26

6. 发明专利

DK148284D0 未知
公开(公告)号：DK148284D0
公开(公告)日：1984-02-29
申请号：DK148284
申请日：1984-02-29
申请人： GRAHAM NEIL BONNETTE
发明人： GRAHAM NEIL BONNETTE
IPC分类号： A61L29/00 , A61F13/00 , A61K9/00 , A61K9/20 , A61K9/22 , C02F1/26 , C08G18/48 , C08G18/66 , A61K
摘要： An envelope having flexible water-permeable or porous walls contains a quantity of particulate water-insoluble hydrogel. The quantity of hydrogel in the envelope is such that, when the hydrogel is fully swollen at 20°C, its volume is at least 66%, preferably at least 100%, of the maximum non-stretched intemal volume ofthe envelope. Thus, the envelope according to the invention is limp and floppy under dry conditions but in a wet environment the hydrogel absorbs water and swells accordingly causing the envelope to swell and take on a more rigid configuration. The envelope is particularly useful for the administration of sustained release pharmaceutically or veterinarily active ingredients. Thus the limp dry envelope may for example be rolled up for introduction through the throat but will swell up and therefore be retained in the stomach for sustained release of the active ingredient therein.

7. 发明申请

WO2011051689A3 POLYMERS FOR CONTACT LENSES 审中-公开
标题翻译：用于隐形眼镜的聚合物
公开(公告)号：WO2011051689A3
公开(公告)日：2011-06-23
申请号：PCT/GB2010002018
申请日：2010-11-02
申请人： OCUTEC LTD , RASHID ABDUL , BOWERS RODERICK WILLIAM JONATHAN , TIPTON WADE , GRAHAM NEIL BONNETTE
发明人： RASHID ABDUL , BOWERS RODERICK WILLIAM JONATHAN , TIPTON WADE , GRAHAM NEIL BONNETTE
IPC分类号： C08G18/48 , C08G18/61 , C08K5/00 , G02B1/04
CPC分类号： C08G71/04 , C08G18/4825 , C08G18/4829 , C08G18/4833 , C08G18/61 , C08G2101/0091 , C08G2210/00 , G02B1/043 , C08L69/00
摘要： The present invention relates to a polyurethane polymer composition comprising polyethyleneglycol dialkyl ether. There is also provided a process for preparing a polyurethane. The invention also relates to a process for preparing a polyurethane xerogel in the form of a molded article, said process comprising the steps of: i. preparing a mixture of a. at least one polyethylene glycol or at least one polyol of formula (I), wherein at least three Of X1, X2, X3, X4 and X5 are each independently an OH-terminated group, and the remainder of X1, X2, X3, X4 and X5 are each independently H or absent, and Z is a central linking unit, a. at least one di- or poly-isocyanate, b. optionally at least one OH-terminated chain extender, and c. at least one polyethyleneglycol dialkyl ether; ii. dispensing the reaction mixture formed in step i) into a mold; iii. allowing the reaction mixture to react and cure; iv. removing the molded article from the mold; and v. hydrating the molded article.
摘要翻译：本发明涉及包含聚乙二醇二烷基醚的聚氨酯聚合物组合物。还提供了一种制备聚氨酯的方法。本发明还涉及制备模制品形式的聚氨酯干凝胶的方法，所述方法包括以下步骤：i。准备一种混合物。至少一种聚乙二醇或至少一种式（I）的多元醇，其中X 1，X 2，X 3，X 4和X 5中的至少三个各自独立地为OH-封端的基团，且X 1，X 2，X 3，X 4的剩余部分和X 5各自独立地为H或不存在，且Z为中心连接单元，a。至少一种二异氰酸酯或多异氰酸酯，b。任选至少一种OH-封端的增链剂，和c。至少一种聚乙二醇二烷基醚; II。将步骤i）中形成的反应混合物分配到模具中; III。使反应混合物反应并固化; IV。从模具中取出模制品; 和v。使模制品水合。

8. 发明申请

WO9740822A3 DELIVERY DEVICE 审中-公开
标题翻译：交货设备
公开(公告)号：WO9740822A3
公开(公告)日：1998-02-19
申请号：PCT/GB9701192
申请日：1997-04-30
申请人： UNIV STRATHCLYDE , GRAHAM NEIL BONNETTE
发明人： GRAHAM NEIL BONNETTE
IPC分类号： A61K9/00 , A61K9/52 , A61K9/22
CPC分类号： A61K9/0004
摘要： A delivery device under osmotic control when in contact with a liquid comprising an enclosure having an enclosure wall and at least an aperture through the wall, wherein the osmotically active material is present within the enclosure, and the apertures being sized such that when the device is in contact with liquid, osmotically controlled flow of solution from the enclosure through the aperture occurs.

9. 发明申请

WO2011055110A8 POLYMERS FOR CONTACT LENSES 审中-公开
标题翻译：聚合物用于接触镜片
公开(公告)号：WO2011055110A8
公开(公告)日：2012-05-31
申请号：PCT/GB2010002026
申请日：2010-11-02
申请人： OCUTEC LTD , RASHID ABDUL , BOWERS RODERICK WILLIAM JONATHAN , TIPTON WADE , GRAHAM NEIL BONNETTE
发明人： RASHID ABDUL , BOWERS RODERICK WILLIAM JONATHAN , TIPTON WADE , GRAHAM NEIL BONNETTE
IPC分类号： C08G18/48 , C08G18/66 , G02B1/04
CPC分类号： C08G18/4833 , C08G18/6674 , C08G2220/00 , G02B1/043 , C08L75/08
摘要： The present invention relates to a thermoplastic polyurethane contact lens prepared from a mixture comprising: (a) at least one polyethylene glycol; (b) at least one di-isocyanate; and (c) at least one diol of formula (I): wherein n is an integer from 1 to 25; wherein the polyethylene glycol, di-isocyanate and diol are reacted under substantially anhydrous conditions. Further aspects of the invention relate to a process for preparing a contact lens. The invention also relates to a process for preparing a polyurethane xerogel in the form of a molded article, said process comprising the steps of: (i) preparing a reaction mixture comprising at least one polyethylene glycol, at least one di-isocyanate and at least one diol of formula I as described above; (ii) reacting the reaction mixture formed in step (i) under substantially anhydrous conditions to form a polyurethane xerogel; (iii) injection molding the polyurethane xerogel to form a molded article, (iv) hydrating the xerogel molded article to form a contact lens.
摘要翻译：本发明涉及由以下混合物制备的热塑性聚氨酯隐形眼镜：（a）至少一种聚乙二醇; （b）至少一种二异氰酸酯; 和（c）至少一种式（I）的二醇：其中n是1至25的整数; 其中聚乙二醇，二异氰酸酯和二醇在基本无水条件下反应。本发明的其它方面涉及一种制备隐形眼镜的方法。本发明还涉及一种制备模制品形式的聚氨酯干凝胶的方法，所述方法包括以下步骤：（i）制备包含至少一种聚乙二醇，至少一种二异氰酸酯和至少一种二异氰酸酯的反应混合物如上所述的一种式I的二醇; （ii）在基本上无水条件下使步骤（i）中形成的反应混合物反应形成聚氨酯干凝胶; （iii）注射成型聚氨酯干凝胶以形成模塑制品，（iv）将干凝胶模塑制品保湿以形成隐形眼镜。

10. 发明申请

WO2011055108A1 POLYMERS FOR CONTACT LENSES 审中-公开
标题翻译：聚合物用于接触镜片
公开(公告)号：WO2011055108A1
公开(公告)日：2011-05-12
申请号：PCT/GB2010/002020
申请日：2010-11-02
申请人： OCUTEC LIMITED , RASHID, Abdul , BOWERS, Roderick, WIlliam, Jonathan , TIPTON, Wade , GRAHAM, Neil, Bonnette
发明人： RASHID, Abdul , BOWERS, Roderick, WIlliam, Jonathan , TIPTON, Wade , GRAHAM, Neil, Bonnette
IPC分类号： C08G18/48 , C08G18/61 , C08G18/66 , G02B1/04
CPC分类号： C08G18/61 , C08G18/4833 , C08G18/6674 , C08G2101/0091 , G02B1/043 , C08L75/04 , C08L83/04
摘要： The present invention relates to a polyurethane prepared from a mixture comprising: (a) at least one polyethylene glycol; (b) at least one di-isocyanate; (c) at least one polydialkyl siloxane diol; and (d) at least one diol of formula (I) wherein n is an integer from 1 to 25; wherein the polyethylene glycol, di-isocyanate, polydialkyl siloxane diol and diol are reacted under substantially anhydrous conditions. Further aspects of the invention relate to a process for preparing a polyurethane. The invention also relates to a process for preparing a polyurethane xerogel in the form of a molded article, said process comprising the steps of: (i) preparing a reaction mixture comprising at least one polyethylene glycol, at least one di-isocyanate, at least one polydialkyl siloxane diol and at least one diol of formula I as described above; (ii) reacting the reaction mixture formed in step (i) under substantially anhydrous conditions to form a polyurethane xerogel; and (iii) injection molding the polyurethane xerogel to form a molded article.
摘要翻译：本发明涉及由以下混合物制备的聚氨酯：（a）至少一种聚乙二醇; （b）至少一种二异氰酸酯; （c）至少一种聚二烷基硅氧烷二醇; 和（d）至少一种式（I）的二醇，其中n是1至25的整数; 其中聚乙二醇，二异氰酸酯，聚二烷基硅氧烷二醇和二醇在基本无水条件下反应。本发明的其它方面涉及一种制备聚氨酯的方法。本发明还涉及一种制备模制品形式的聚氨酯干凝胶的方法，所述方法包括以下步骤：（i）制备包含至少一种聚乙二醇，至少一种二异氰酸酯的反应混合物，至少一种一种聚二烷基硅氧烷二醇和至少一种如上所述的式I的二醇; （ii）在基本上无水条件下使步骤（i）中形成的反应混合物反应形成聚氨酯干凝胶; 和（iii）注射成型聚氨酯干凝胶以形成模塑制品。

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