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1. 发明申请

WO0237106A3 METHODS FOR COMPARITIVE ANALYSIS OF CARBOHYDRATE POLYMERS 审中-公开
标题翻译：碳水化合物聚合物的比较分析方法
公开(公告)号：WO0237106A3
公开(公告)日：2002-11-21
申请号：PCT/US0147064
申请日：2001-11-05
申请人： GLYCODATA LTD , MARKMAN OFER , ROTHMAN CHANA , AMOR YEHUDIT , ORON ASSAF , OR EINAT
发明人： MARKMAN OFER , ROTHMAN CHANA , AMOR YEHUDIT , ORON ASSAF , OR EINAT
IPC分类号： C12Q1/02 , C12Q1/34 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/566 , G01N33/58
CPC分类号： G01N33/5308 , C12Q1/34
摘要： Disclosed is a method for characterizing a carbohydrate polymer by identifying at least two binding agents that bind to the carbohydrate polymer. Binding is preferably determined by contacting the carbohydrate polymer with substrate that contains a plurality of first saccharide-binding agents affixed at predetermined locations on the substrate. The carbohydrate polymer is allowed to contact the substrate under conditions that allow for formation of a first complex between the first saccharide-binding agent and the carbohydrate polymer. A second saccharide-binding agent, which preferably includes a label, is also contacted with the carbohydrate polymer under conditions that allow for formation of a second complex between the second binding agent and the first complex. Identification of the first and second binding agent allows for characterization of the polysaccharide.
摘要翻译：公开了通过鉴定结合至碳水化合物聚合物的至少两种结合剂来表征碳水化合物聚合物的方法。优选通过使碳水化合物聚合物与含有固定在基材上预定位置的多个第一糖结合剂的底物接触来确定结合。允许碳水化合物聚合物在允许在第一糖结合剂和碳水化合物聚合物之间形成第一配合物的条件下接触底物。优选包括标签的第二糖结合剂在允许在第二结合剂和第一配合物之间形成第二配合物的条件下也与碳水化合物聚合物接触。鉴定第一和第二结合剂允许表征多糖。

2. 发明专利

CA2373119C POLYSACCHARIDE STRUCTURE AND SEQUENCE DETERMINATION 未知
公开(公告)号：CA2373119C
公开(公告)日：2011-07-19
申请号：CA2373119
申请日：2000-05-04
申请人： GLYCODATA LTD
发明人： MARKMAN OFER
IPC分类号： G01N33/53 , C12M1/40 , C12Q1/34 , C12Q1/48 , G01N33/02 , G01N33/15 , G01N33/50 , G01N33/543 , G01N33/66
摘要： The invention provides a method for the structural analysis of a saccharide, comprising: a) providing on a surface a plurality of essentially sequence-and/or site-specific binding agents; b) contacting said surface with a saccharide to be analyzed, or with a mixture comprising a plurality of fragments of said saccharide; c) washing or otherwise removing unbound saccharide or saccharide fragments; d) adding to the surface obtained in step c) an essentially sequence- and/or site-specific marker, or a mixture of essentially sequence- and/or site-specific markers; e) acquiring one or more images of the markers that are bound to said surface; and f) deriving information related to the identity of the saccharide being analyzed from said image.

3. 发明专利

NZ515375A Polysaccharide structure and sequence determination 未知
公开(公告)号：NZ515375A
公开(公告)日：2004-05-28
申请号：NZ51537500
申请日：2000-05-04
申请人： GLYCODATA LTD
发明人： MARKMAN OFER
IPC分类号： C12M1/40 , C12Q1/34 , C12Q1/48 , G01N33/02 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/543 , G01N33/66
摘要： A method for obtaining structure-related data of saccharides comprising in any order: a) reacting the saccharide with a number of essentially sequence-specific agents capable of cleaving the saccharide chain, wherein said sequence specific agents are immobilized the same substrate; b) reacting the saccharide with an essentially sequence-specific agent capable of binding to the saccharide; c) introducing a label into the saccharide, either directly or indirectly including the use of a labeled essentially sequence-specific agent capable of binding the saccharide; d) detecting the presence of the label in reactions where the cleabage agent was present and in reactions where the cleavage agent was not present. Also covered is a method for at least partially sequencing a saccharide and a substrate comprising: a) a plurality of essentially sequence specific and or site specific saccharide binding agents on a surface of said substrate, wherein a number of the agents are immobilized on the same surface of said substrate. b) saccharide or saccharide fragments bound to said binding agents; and c) one or more essentially sequence and or site specific markers, or a mixture of markers bound to said saccharide or saccharide fragments.

4. 发明专利

AU4160402A System and method for integrated analysis of data for characterizing carbohydrate polymers 未知
公开(公告)号：AU4160402A
公开(公告)日：2002-06-11
申请号：AU4160402
申请日：2001-11-05
申请人： GLYCODATA LTD
发明人： ORON ASSAF , OR EINAT , MARKMAN OFER , SHVARTSER LEONID , ZAARUR NAVA
IPC分类号： C12Q1/02 , C12Q1/34 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/566 , G01N33/58 , G01N33/00

5. 发明专利

CA2407272A1 METHOD AND COMPOSITION FOR ANALYZING A CARBOHYDRATE POLYMER 未知
公开(公告)号：CA2407272A1
公开(公告)日：2001-11-08
申请号：CA2407272
申请日：2000-11-03
申请人： GLYCODATA LTD
发明人： MARKMAN OFER , ORON ASSAF PERETZ , ROTHMAN CHANA
IPC分类号： C12Q1/34 , G01N33/53 , G01N33/566 , G01N33/58
摘要： Disclosed is a method for characterizing a carbohydrate polymer by identifyi ng at least two binding agents that bind to the carbohydrate polymer. Binding i s preferably determined by contacting the carbohydrate polymer with substrate that contains a plurality of first saccharide-binding agents affixed at predetermined locations on the substrate. The carbohydrate polymer is allowe d to contact the substrate under conditions that allow for formation of a firs t complex between the first saccharide-binding agent and the carbohydrate polymer. A second saccharide-binding agent, which preferably includes a labe l, is also contacted with the carbohydrate polymer under conditions that allow for formation of a second complex between the second binding agent and the first complex. Identification of the first and second binding agent allows f or characterization of the polysaccharide.

6. 发明公开

EP1179177A1 POLYSACCHARIDE STRUCTURE AND SEQUENCE DETERMINATION 有权
标题翻译：多糖的结构和序列测定
公开(公告)号：EP1179177A1
公开(公告)日：2002-02-13
申请号：EP00922830.5
申请日：2000-05-04
申请人： Glycodata Ltd.
发明人： MARKMAN, Ofer
IPC分类号： G01N33/53 , C12Q1/34
CPC分类号： G01N33/66 , C12Q1/34 , G01N33/5308 , G01N2333/42 , G01N2333/924 , G01N2400/00 , G01N2400/02 , G01N2400/10 , Y10T436/143333
摘要： The invention provides a method for the structural analysis of a saccharide, comprising: a) providing on a surface a plurality of essentially sequence- and/or site-specific binding agents; b) contacting said surface with a saccharide to be analyzed, or with a mixture comprising a plurality of fragments of said saccharide; c) washing or otherwise removing unbound saccharide or saccharide fragments; d) adding to the surface obtained in step c) an essentially sequence- and/or site-specific marker, or a mixture of essentially sequence- and/or site-specific markers; e) acquiring one or more images of the markers that are bound to said surface; and f) deriving information related to the identity of the saccharide being analyzed from said image.

7. 发明专利

AU779812B2 Polysaccharide structure and sequence determination 未知
公开(公告)号：AU779812B2
公开(公告)日：2005-02-10
申请号：AU4310700
申请日：2000-05-04
申请人： GLYCODATA LTD
发明人： MARKMAN OFER
IPC分类号： C12M1/40 , C12Q1/34 , C12Q1/48 , G01N33/02 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/543 , G01N33/66
摘要： A method for the structural analysis of a saccharide is disclosed, comprising: a) providing on a surface a plurality of essentially sequence- and/or site-specific binding agents; b) contacting said surface with a saccharide to be analyzed, or with a mixture comprising a plurality of fragments of said saccharide; c) washing or otherwise removing unbound saccharide or saccharide fragments; d) adding to the surface obtained in step c) an essentially sequence- and/or site-specific marker, or a mixture of essentially sequence- and/or site-specific markers; e) acquiring one or more images of the markers that are bound to said surface; and f) deriving information related to the identity of the saccharide being analyzed from said image. The invention further provides a solid support comprising in a pre-defined order a plurality of visual or otherwise detectable markers representative of a saccharide or saccharide sequence or fragment, as well as methods and software for choosing a set of essentially sequence-specific markers for use in the method of the invention, methods for obtaining structure-related data of saccharides, and methods and apparatus for analyzing the structure of a saccharide by sequential digestion using a glycosidase or an equivalent thereof.

8. 发明专利

DE1179177T1 未知
公开(公告)号：DE1179177T1
公开(公告)日：2003-11-27
申请号：DE00922830
申请日：2000-05-04
申请人： GLYCODATA LTD
发明人： MARKMAN OFER
IPC分类号： C12M1/40 , C12Q1/34 , C12Q1/48 , G01N33/02 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/543 , G01N33/66
摘要： A method for the structural analysis of a saccharide is disclosed, comprising: a) providing on a surface a plurality of essentially sequence- and/or site-specific binding agents; b) contacting said surface with a saccharide to be analyzed, or with a mixture comprising a plurality of fragments of said saccharide; c) washing or otherwise removing unbound saccharide or saccharide fragments; d) adding to the surface obtained in step c) an essentially sequence- and/or site-specific marker, or a mixture of essentially sequence- and/or site-specific markers; e) acquiring one or more images of the markers that are bound to said surface; and f) deriving information related to the identity of the saccharide being analyzed from said image. The invention further provides a solid support comprising in a pre-defined order a plurality of visual or otherwise detectable markers representative of a saccharide or saccharide sequence or fragment, as well as methods and software for choosing a set of essentially sequence-specific markers for use in the method of the invention, methods for obtaining structure-related data of saccharides, and methods and apparatus for analyzing the structure of a saccharide by sequential digestion using a glycosidase or an equivalent thereof.

9. 发明专利

IL146327D0 POLYSACCHARIDE STRUCTURE AND SEQUENCE DETERMINATION 未知
公开(公告)号：IL146327D0
公开(公告)日：2002-07-25
申请号：IL14632700
申请日：2000-05-04
申请人： GLYCODATA LTD
IPC分类号： G01N20060101 , G01N

10. 发明专利

AU2599202A Methods for comparitive analysis of carbohydrate polymers and carbohydrate polymers identified using same 未知
公开(公告)号：AU2599202A
公开(公告)日：2002-05-15
申请号：AU2599202
申请日：2001-11-05
申请人： GLYCODATA LTD
发明人： MARKMAN OFER , ROTHMAN CHANA , AMOR YEHUDIT , ORON ASSAF , OR EINAT
IPC分类号： C12Q1/02 , C12Q1/34 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/566 , G01N33/58

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