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1. 发明申请

WO1996020927A1 DIBENZ[cd,f]INDOLE DERIVATIVES 审中-公开
标题翻译： DIBENZ [cd，f] INDOLE DERIVATIVES
公开(公告)号：WO1996020927A1
公开(公告)日：1996-07-11
申请号：PCT/EP1995005167
申请日：1995-12-29
申请人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. , GIGER, Rudolf, Karl, Andreas
发明人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H.
IPC分类号： C07D209/56
CPC分类号： C07D209/80
摘要： 1-Alkyl-9,10-dihydroxy-4,5,5a,6-tetrahydro-dibenz[cd,f]indoles of formula (I) may be used in the treatment of Morbus Parkinson, alcohol abuse and drug dependency. In said formula, R1, R2 and R3 are independently (C1-4)alkyl, in free or acid addition salt form.
摘要翻译：式（I）的1-烷基-9,10-二羟基-4,5,5a，6-四氢 - 二苯并[cd，f]吲哚可用于治疗Morbus帕金森氏症，酒精滥用和药物依赖性。在所述式中，R 1，R 2和R 3独立地为（C 1-4）烷基，为游离或酸加成盐形式。

2. 发明申请

WO2005074926A1 ORGANIC COMPOUNDS 审中-公开
标题翻译：有机化合物
公开(公告)号：WO2005074926A1
公开(公告)日：2005-08-18
申请号：PCT/US2005/003427
申请日：2005-01-28
申请人： NOVARTIS AG , OTTLECZ, Anna , GIGER, Rudolf, Karl, Andreas , ALVAREZ, Carlos
发明人： OTTLECZ, Anna , GIGER, Rudolf, Karl, Andreas , ALVAREZ, Carlos
IPC分类号： A61K31/44
CPC分类号： A61K31/44
摘要： The present invention provides methods and uses of imidazolylalkyl-pyridines in the treatment of ocular disorders. A first aspect of the invention provides a method of treating ocular neovascularization comprising administering to a subject in need of such treatment a therapeutically effective amount of a compound having the formula (I) in free base or physiologically acceptable acid addition salt form, wherein R 1 .is hydrogen, lower alkyl, halogen with an atomic number of 9 to 35 or amino optionally mono- or disubstituted by lower alkyl, R 2 . and R 3 . independently of one another are hydrogen or lower alkyl, R 4 . is hydrogen, hydroxy, lower alkyl, lower alkoxy or halogen with an atomic number of 9 to 35, and the bridge between the pyridine and the imidazole, illustrated as methylene, is methylene or ethylene.
摘要翻译：本发明提供咪唑烷基 - 吡啶类治疗眼部疾病的方法和用途。本发明的第一方面提供了一种治疗眼新生血管形成的方法，包括向需要这种治疗的受试者施用治疗有效量的游离碱或生理学上可接受的酸加成盐形式的式（I）化合物，其中R1。是氢，低级烷基，原子数为9至35的卤素或任选被低级烷基R2单取代或二取代的氨基。和R3。独立地是氢或低级烷基，R4。是氢原子，羟基，低级烷基，低级烷氧基或卤素，原子序数为9至35，吡啶和咪唑之间的桥接，亚甲基是亚甲基或亚乙基。

3. 发明专利

CA2078700C IMIDAZOLYLMETHYL-PYRIDINES 未知
公开(公告)号：CA2078700C
公开(公告)日：2005-09-13
申请号：CA2078700
申请日：1992-09-21
申请人： GIGER RUDOLF KARL ANDREAS
发明人： GIGER RUDOLF KARL ANDREAS
IPC分类号： A61K31/44 , A61K31/4155 , A61K31/4427 , A61P25/28 , C07D401/06 , C07D521/00
摘要： Compounds of formula I, (see formula I) wherein R1 to R4 possess the significances given in the description, may be used in the treatment of senile dementia, Alzheimer's disease and depression.

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