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1. 发明专利

IL176649D0 POLYMERIC IMPLANTS, PREFERABLY CONTAINING A MIXTURE OF PEG AND PLG, FOR CONTROLLED RELEASE OF ACTIVE AGENTS, PREFERABLY A GNRH 未知
公开(公告)号：IL176649D0
公开(公告)日：2006-10-31
申请号：IL17664906
申请日：2006-06-29
申请人： DURECT CORP , GIBSON JOHN W , TIPTON ARTHUR J
IPC分类号： A61K20100101 , A61K9/00 , A61K9/16 , A61K9/20 , A61K38/09 , A61K38/24

2. 发明专利

AU2003299659A1 ORAL DRUG DELIVERY SYSTEM 未知
公开(公告)号：AU2003299659A1
公开(公告)日：2004-07-09
申请号：AU2003299659
申请日：2003-12-15
申请人： SCHOENHARD GRANT , TIPTON ARTHUR J , GIBSON JOHN W , MIDDLETON JOHN C , DURECT CORP , YUM SU IL
发明人： SCHOENHARD GRANT , TIPTON ARTHUR J , GIBSON JOHN W , MIDDLETON JOHN C , YUM SU IL
IPC分类号： A61K9/48 , A61K9/52 , A61K31/485 , A61K9/00

3. 发明专利

IL176649A POLYMERIC IMPLANTS, PREFERABLY CONTAINING A MIXTURE OF PEG AND PLG, FOR CONTROLLED RELEASE OF ACTIVE AGENTS, PREFERABLY A GNRH 未知
公开(公告)号：IL176649A
公开(公告)日：2011-12-29
申请号：IL17664906
申请日：2006-06-29
申请人： DURECT CORP , GIBSON JOHN W , TIPTON ARTHUR J
发明人： GIBSON JOHN W , TIPTON ARTHUR J
IPC分类号： A61K9/00 , A61K9/16 , A61K9/20 , A61K38/09 , A61K38/24

4. 发明专利

GB0517016D0 Electric powered vehicle 未知
公开(公告)号：GB0517016D0
公开(公告)日：2005-09-28
申请号：GB0517016
申请日：2005-08-19
申请人： GIBSON JOHN W
IPC分类号： B62K5/05 , B62M6/40

5. 发明专利

AU2003299659A8 Oral drug delivery system comprising high viscosity liquid carrier materials 未知
公开(公告)号：AU2003299659A8
公开(公告)日：2004-07-09
申请号：AU2003299659
申请日：2003-12-15
申请人： GIBSON JOHN W , YUM SU IL , DURECT CORP , MIDDLETON JOHN C , TIPTON ARTHUR J , SCHOENHARD GRANT
发明人： SCHOENHARD GRANT , MIDDLETON JOHN C , GIBSON JOHN W , TIPTON ARTHUR J , YUM SU IL
IPC分类号： A61K9/48 , A61K9/52 , A61K31/485

6. 发明专利

AU2003297848A1 HIGH VISCOSITY LIQUID CONTROLLED DELIVERY SYSTEM AND MEDICAL OR SURGICAL DEVICE 未知
公开(公告)号：AU2003297848A1
公开(公告)日：2004-06-30
申请号：AU2003297848
申请日：2003-12-10
申请人： GIBSON JOHN W , MILLER STACEY S , DURECT CORP
发明人： MILLER STACEY S , MIDDLETON JOHN C , TIPTON ARTHUR J , GIBSON JOHN W
IPC分类号： A61K8/60 , A61K9/00 , A61K9/14 , A61K9/16 , A61K9/48 , A61K9/70 , A61K47/14 , A61K47/26 , A61K47/34 , A61L15/20 , A61L15/44 , A61L24/00 , A61L26/00 , A61L27/54 , A61L31/16 , A61Q11/00
摘要： The present invention relates to novel nonpolymeric compounds and compositions that form liquid high viscosity materials suitable for the delivery of biologically active substances in a controlled fashion, and for use as medical or surgical devices. The materials can optionally be diluted with a solvent to form a material of lower viscosity, rendering the material easy to administer. This solvent may be water insoluble or water soluble, where the water soluble solvent rapidly diffuses or migrates away from the material in vivo, leaving a higher viscosity liquid material.

7. 发明申请

WO2008143992A3 IMPROVED DEPOT FORMULATIONS 审中-公开
标题翻译：改进的DEPOT制剂
公开(公告)号：WO2008143992A3
公开(公告)日：2009-09-24
申请号：PCT/US2008006320
申请日：2008-05-16
申请人： DURECT CORP , WRIGHT JEREMY C , THEEUWES FELIX , GIBSON JOHN W , BRANHAM KEITH E , SJOBECK STEFANIA
发明人： WRIGHT JEREMY C , THEEUWES FELIX , GIBSON JOHN W , BRANHAM KEITH E , SJOBECK STEFANIA
IPC分类号： A61K9/08 , A61K9/10 , A61K31/519 , A61K47/06 , A61K47/34
CPC分类号： A61K31/519 , A61K9/0019 , A61K9/0024 , A61K9/08 , A61K9/10 , A61K47/22 , A61K47/26 , A61K47/34
摘要： Disclosed are formulations and related methods that comprise a non- polymeric, non-water soluble high viscosity liquid carrier material having a viscosity of at least 5,000 cP at 37°C that does not crystallize neat under ambient or physiological conditions; a specified linear polymer comprising lactide repeat units; and one or more solvents that have a solvent capacity. Preferably the formulations contain sucrose acetate isobutyrate (SAIB), poly(lactide-c glycolide) (PLGA) and a suitable solvent, being preferably NMP. Exemplified drugs ar risperidone and naltrexone.
摘要翻译：公开了包含非常优选的非水溶性高粘度液体载体材料的制剂和相关方法，其在37℃下的粘度至少为5,000cP，在环境或生理条件下不结晶; 包含丙交酯重复单元的指定线性聚合物; 和一种或多种具有溶剂能力的溶剂。优选地，制剂含有蔗糖乙酸异丁酸酯（SAIB），聚（丙交酯 - 乙交酯）（PLGA）和合适的溶剂，优选为NMP。示例药物为利培酮和纳曲酮。

8. 发明申请

WO2008143992A2 IMPROVED DEPOT FORMULATIONS 审中-公开
标题翻译：改进的DEPOT制剂
公开(公告)号：WO2008143992A2
公开(公告)日：2008-11-27
申请号：PCT/US2008/006320
申请日：2008-05-16
申请人： DURECT CORPORATION , WRIGHT, Jeremy, C. , THEEUWES, Felix , GIBSON, John, W. , BRANHAM, Keith, E. , SJOBECK, Stefania
发明人： WRIGHT, Jeremy, C. , THEEUWES, Felix , GIBSON, John, W. , BRANHAM, Keith, E. , SJOBECK, Stefania
IPC分类号： A61K9/10
CPC分类号： A61K31/519 , A61K9/0019 , A61K9/0024 , A61K9/08 , A61K9/10 , A61K47/22 , A61K47/26 , A61K47/34
摘要： Disclosed are formulations and related methods that comprise a non- polymeric, non-water soluble high viscosity liquid carrier material having a viscosity of at least 5,000 cP at 37°C that does not crystallize neat under ambient or physiological conditions; a specified linear polymer comprising lactide repeat units; and one or more solvents that have a solvent capacity.
摘要翻译：公开了包含非常优选的非水溶性高粘度液体载体材料的制剂和相关方法，其在37℃下的粘度至少为5,000cP，在环境或生理条件下不结晶; 包含丙交酯重复单元的指定线性聚合物; 和一种或多种具有溶剂能力的溶剂。

9. 发明申请

WO2006071208A1 POLYMERIC IMPLANTS, PREFERABLY CONTAINING A MIXTURE OF PEG AND PLG, FOR CONTROLLED RELEASE OF A GNRH 审中-公开
标题翻译：聚合物植入物，含有PEG和PLG的混合物，用于控制释放的GNRH
公开(公告)号：WO2006071208A1
公开(公告)日：2006-07-06
申请号：PCT/US2004/043079
申请日：2004-12-23
申请人： DURECT CORPORATION , BROWN, James, E. , GIBSON, John, W.
发明人： BROWN, James, E. , GIBSON, John, W.
IPC分类号： A61K9/00 , A61K38/00 , A61K9/16
CPC分类号： A61K9/1647 , A61K9/0024 , A61K9/1635
摘要： Controlled release compositions for controlling release of a GnRH molecule or a GnRH analog are provided. The compositions include a GnRH molecule or GnRH analog as an active agent, and a controlled release component for controlling release of the GnRH molecule or GnRH analog from the composition. The compositions provide a sustained mean steady state plasma concentration (Css) of the active agent of at least about 1.5 ng/mL for a period of at least about 48 hours when the composition is administered to a subject. In addition, the use of a controlled release component in the manufacture of a composition for the controlled release of a GnRH molecule or GnRH analog is provided. The controlled release component'is capable of providing a sustained mean steady state plasma concentration (C 38 ) of the active agent of at. least about 1.5 ng/mL for a period of at least about 48 hours when the manufactured composition is administered to a subject. The controlled release component can include a polymeric material and/or a non-polymeric material. When the compositions are administered to a subject, for example when implanted, the compositions release the active agent in a controlled fashion. Methods for producing the compositions are also provided, as are methods of using the compositions to provide for controlled release of the GnRH molecule or GnRH analog in a subject. Preferred polymeric material is PLG or a copolymer of PLG and a PEG derivative such as methoxy PEG. Preferred non-polymeric material can be SAIB.
摘要翻译：提供了用于控制GnRH分子或GnRH类似物释放的控制释放组合物。组合物包括GnRH分子或GnRH类似物作为活性剂，以及用于控制组合物中GnRH分子或GnRH类似物释放的控释组分。当组合物施用于受试者时，组合物提供至少约1.5ng / mL的持续的平均稳态血浆浓度（Css）至少约48小时的时间。此外，提供了控制释放组分在制备用于控制释放GnRH分子或GnRH类似物的组合物中的用途。控制释放组分“能够提供at的活性剂的持续平均稳态血浆浓度（C 38 S 38）。至少约1.5ng / mL至少约48小时的时间。控制释放组分可以包括聚合物材料和/或非聚合材料。当将组合物施用于受试者时，例如当植入时，组合物以受控的方式释放活性剂。还提供了用于制备组合物的方法，以及使用该组合物提供受试者中GnRH分子或GnRH类似物的受控释放的方法。优选的聚合物材料是PLG或PLG和PEG衍生物如甲氧基PEG的共聚物。优选的非聚合物材料可以是SAIB。

10. 发明申请

WO0228366A9 DEVICES AND METHODS FOR MANAGEMENT OF INFLAMMATION 审中-公开
标题翻译：用于管理炎症的装置和方法
公开(公告)号：WO0228366A9
公开(公告)日：2003-02-13
申请号：PCT/US0131652
申请日：2001-10-09
申请人： DURECT CORP , CHAN TAI WAH , JOHNSON RANDOLPH M , MIKSZTAL ANDREW R , TIPTON ARTHUR J , GIBSON JOHN W , MEADOR STACEY K
发明人： CHAN TAI WAH , JOHNSON RANDOLPH M , MIKSZTAL ANDREW R , TIPTON ARTHUR J , GIBSON JOHN W , MEADOR STACEY K
IPC分类号： A61K9/00 , A61K9/22 , A61K31/352 , A61K31/37
CPC分类号： A61K9/0024 , A61K31/352
摘要： Devices and methods for the sustained release into a subject of an inhibitor of mast cell-mediated inflammation, specifically sustained-release of sodium cromoglycate as a prophylactic to prevent acute asthma attacks.
摘要翻译：用于持续释放到肥大细胞介导的炎症抑制剂的受试者的装置和方法，特别是缓释色甘酸钠作为预防性急性哮喘发作的预防剂。

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