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1. 发明授权

US08530624B2 Osteoprotegerin variant proteins 失效
标题翻译：骨保护素变体蛋白
公开(公告)号：US08530624B2
公开(公告)日：2013-09-10
申请号：US12584802
申请日：2009-09-11
申请人： Anthony Roberts , George Kopsidas , Gregory Coia , Merilyn Sleigh , Vincent Batori
发明人： Anthony Roberts , George Kopsidas , Gregory Coia , Merilyn Sleigh , Vincent Batori
IPC分类号： C07K14/00 , C07K14/435 , C07K14/46 , C07K14/47 , C07K14/475
CPC分类号： C07K14/70578
摘要： The present invention relates to novel osteoprotegerin variant proteins (GYPs) that demonstrate reduced binding affinity for their ligand TRAIL when compared to wild-type osteoprotegerin. Nucleic acids which encode these GYPs are also provided. Recombinant vectors and host cells expressing these GYPs are also encompassed as are methods of producing recombinant GYPs. The present invention also relates to compositions comprising these GYPs, and to methods of treating bone diseases characterised by increased bone turnover and/or loss. The GYPs of the invention are useful for preventing bone resorption and may be used to treat any condition resulting in abnormal bone turnover or bone loss such as osteoporosis, hypercalcemia, Paget's disease of bone, multiple myeloma, bone cancer and bone loss due to rheumatoid arthritis or osteomyelitis, and the like.
摘要翻译：本发明涉及当与野生型骨保护素相比时，其表现出对其配体TRAIL的结合亲和力降低的新型骨保护蛋白变体蛋白（GYP）。还提供了编码这些GYP的核酸。重组载体和表达这些GYP的宿主细胞也包括在生产重组GYP的方法中。本发明还涉及包含这些GYP的组合物，以及治疗以增加的骨转换和/或损失为特征的骨疾病的方法。本发明的GYP可用于预防骨吸收，并且可用于治疗导致异常骨周转或骨丢失的任何病症，例如骨质疏松症，高钙血症，骨的佩吉特氏病，多发性骨髓瘤，骨癌和类风湿性关节炎引起的骨丢失或骨髓炎等。

2. 发明申请

US20100221260A1 IMMUNOGLOBULINS 有权
标题翻译：免疫球蛋白
公开(公告)号：US20100221260A1
公开(公告)日：2010-09-02
申请号：US12097279
申请日：2006-12-14
申请人： Stephanie Jane Clegg , Jonathan Henry Ellis , Volker Germaschewski , Paul Andrew Hamblin , George Kopsidas , Ruth McAdam , Rabinder Kumar Prinjha
发明人： Stephanie Jane Clegg , Jonathan Henry Ellis , Volker Germaschewski , Paul Andrew Hamblin , George Kopsidas , Ruth McAdam , Rabinder Kumar Prinjha
IPC分类号： A61K39/395 , C07K16/00 , C07H21/04 , C07K16/18 , A61P9/10
CPC分类号： C07K16/18 , A61K2039/505 , C07K16/22 , C07K16/465 , C07K2317/24 , C07K2317/56 , C07K2317/565
摘要： The present invention relates to antibodies to NOGO, pharmaceutical formulations containing them and to the use of such antibodies in the treatment and/or prophylaxis of neurological diseases/disorder.
摘要翻译：本发明涉及NOGO的抗体，含有它们的药物制剂以及这些抗体在治疗和/或预防神经疾病/病症中的用途。

3. 发明申请

US20100144600A1 Osteoprotegerin variant proteins 失效
标题翻译：骨保护素变体蛋白
公开(公告)号：US20100144600A1
公开(公告)日：2010-06-10
申请号：US12584802
申请日：2009-09-11
申请人： Anthony Roberts , George Kopsidas , Gregory Coia , Merilyn Sleigh , Vincent Batori
发明人： Anthony Roberts , George Kopsidas , Gregory Coia , Merilyn Sleigh , Vincent Batori
IPC分类号： A61K38/19 , A61P19/02 , A61P3/10 , A61P19/10 , A61P35/04 , C07K14/52 , C07H21/04
CPC分类号： C07K14/70578
摘要： The present invention relates to novel osteoprotegerin variant proteins (OVPs) that demonstrate reduce binding affinity for their ligand TRAIL when compared to wild-type osteoprotegerin. Nucleic acids which encode these OVPs are also provided. Recombinant vectors and host cells expressing these OVPs are also encompassed as are methods of producing recombinant OVPs. The present invention also relates to compositions comprising these OVPs, and to methods of treating bone diseases characterised by increased bone turnover and/or loss. The OVPs of the invention are useful for preventing bone resorption and may be used to treat any condition resulting in abnormal bone turnover or bone loss such as osteoporosis, hypercalcemia, Paget's disease of bone, multiple myeloma, bone cancer and bone loss due to rheumatoid arthritis or osteomyelitis, and the like.
摘要翻译：本发明涉及当与野生型骨保护素相比时，其表现出降低其配体TRAIL的结合亲和力的新型骨保护蛋白变体蛋白（OVP）。还提供了编码这些OVP的核酸。重组载体和表达这些OVP的宿主细胞也包括在生产重组OVP的方法中。本发明还涉及包含这些OVP的组合物，以及治疗以增加的骨转换和/或损失为特征的骨疾病的方法。本发明的OVP可用于预防骨吸收，并且可用于治疗导致异常骨转换或骨丢失的任何病症，例如骨质疏松症，高钙血症，骨多普勒骨髓瘤，骨癌和由类风湿性关节炎引起的骨丢失或骨髓炎等。

4. 发明授权

US08563697B2 Anti-IL-12/IL-23 antibodies 有权
标题翻译：抗IL-12 / IL-23抗体
公开(公告)号：US08563697B2
公开(公告)日：2013-10-22
申请号：US13058914
申请日：2009-08-14
申请人： Adam William Clarke , Anthony Gerard Doyle , Philip Anthony Jennings , Lynn Dorothy Poulton , Bernadette Wai , Andrew James Pow , George Kopsidas
发明人： Adam William Clarke , Anthony Gerard Doyle , Philip Anthony Jennings , Lynn Dorothy Poulton , Bernadette Wai , Andrew James Pow , George Kopsidas
IPC分类号： C07K16/24 , C12P21/08
CPC分类号： C07K16/244 , A61K2039/505 , C07K14/5434 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/76 , C07K2317/92
摘要： The present invention provides an antibody comprising an antigen binding domain which binds to human IL-12 and human IL-23. The antibody binds human IL-12p40 existing as a monomer (human IL-12p40) and as a homodimer (human IL-12p80) and the antibody inhibits the binding of human IL-12 to human IL-12R β2 and human IL-23 to human IL-23R but does not inhibit the binding of human IL-12 or human IL-23 or human IL-12p40 or human IL-12p80 to human IL-12Rβ1.
摘要翻译：本发明提供了包含结合人IL-12和人IL-23的抗原结合域的抗体。抗体结合作为单体存在的人IL-12p40（人IL-12p40）和作为同二聚体（人IL-12p80）存在，并且抗体抑制人IL-12与人IL-12Rβ2和人IL-23的结合至人IL-23R但不抑制人IL-12或人IL-23或人IL-12p40或人IL-12p80与人IL-12Rβ1的结合。

5. 发明授权

US08362208B2 Immunoglobulins 有权
标题翻译：免疫球蛋白
公开(公告)号：US08362208B2
公开(公告)日：2013-01-29
申请号：US12097279
申请日：2006-12-14
申请人： Stephanie Jane Clegg , Jonathan Henry Ellis , Volker Germaschewski , Paul Andrew Hamblin , George Kopsidas , Ruth McAdam , Rabinder Kumar Prinjha
发明人： Stephanie Jane Clegg , Jonathan Henry Ellis , Volker Germaschewski , Paul Andrew Hamblin , George Kopsidas , Ruth McAdam , Rabinder Kumar Prinjha
IPC分类号： C07K16/00 , C12P21/08 , A61K39/395 , A61K39/40 , C07K17/00
CPC分类号： C07K16/18 , A61K2039/505 , C07K16/22 , C07K16/465 , C07K2317/24 , C07K2317/56 , C07K2317/565
摘要： The present invention relates to antibodies to NOGO, pharmaceutical formulations containing them and to the use of such antibodies in the treatment and/or prophylaxis of neurological diseases/disorder.
摘要翻译：本发明涉及NOGO的抗体，含有它们的药物制剂以及这些抗体在治疗和/或预防神经疾病/病症中的用途。

6. 发明专利

IL231975D0 Antibodies to cd1d 未知
公开(公告)号：IL231975D0
公开(公告)日：2014-05-28
申请号：IL23197514
申请日：2014-04-07
申请人： TEVA PHARMACEUTICALS AUSTRALIA PTY LTD , POULTON LYNN DOROTHY , JONATHAN KANNAN NAMBIAR , ADAM CLARKE , ANDREW JAMES POW , DEBRA TAMVAKIS , GEORGE KOPSIDAS , ANTHONY GERARD DOYLE , NATTHEW POLLARD , HUSEYIN MUSTAFA
IPC分类号： A61K20060101

7. 发明申请

US20120093811A1 ANTI-VEGF-D ANTIBODIES 审中-公开
标题翻译：抗VEGF-D抗体
公开(公告)号：US20120093811A1
公开(公告)日：2012-04-19
申请号：US13262487
申请日：2010-04-01
申请人： Jason W. Simmonds , Andrew J. Pow , Vincent Emil W. Batori , Irene Koukoulas , George Kopsidas
发明人： Jason W. Simmonds , Andrew J. Pow , Vincent Emil W. Batori , Irene Koukoulas , George Kopsidas
IPC分类号： A61K39/395 , C12N15/13 , C12N1/21 , A61P17/06 , C12N1/19 , C12N5/10 , A61P35/00 , A61P29/00 , C07K16/22 , C12N1/15
CPC分类号： C07K16/2863 , A61K2039/505 , C07K16/22 , C07K2317/24 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/73 , C07K2317/92
摘要： The invention relates to an isolated antibody that specifically binds vascular endothelial growth factor-D (VEGF-D) and to a humanized antibody that specifically binds VEGF-D.
摘要翻译：本发明涉及特异性结合血管内皮生长因子-D（VEGF-D）和特异性结合VEGF-D的人源化抗体的分离抗体。

8. 发明申请

US20090311710A1 MUTAGENESIS METHODS USING RIBAVIRIN AND/OR RNA REPLICASES 审中-公开
标题翻译：使用RIBAVIRIN和/或RNA替代的诱变方法
公开(公告)号：US20090311710A1
公开(公告)日：2009-12-17
申请号：US12503539
申请日：2009-07-15
申请人： Gregory COIA , George Kopsidas , Merilyn Sleigh
发明人： Gregory COIA , George Kopsidas , Merilyn Sleigh
IPC分类号： C12Q1/68
CPC分类号： C07D405/04 , C12N15/102
摘要： The use of RNA-replicases for introducing mutations into and selecting for improved RNA molecules is described. The use of ribavirin, or a derivative/analogue thereof, in methods for introducing one or more mutations during replication or transcription of a target nucleic acid molecule is also described. These methods can be used to screen for nucleic acids, or proteins encoded thereby, with altered or new activity. Also provided are kits comprising ribavirin, or a derivative/analogue thereof, for use in mutagenesis procedures.
摘要翻译：描述了使用RNA复制酶将突变引入并选择改良的RNA分子。还描述了利巴韦林或其衍生物/类似物在用于在靶核酸分子的复制或转录过程中引入一个或多个突变的方法中的用途。这些方法可用于筛选具有改变或新活性的核酸或由其编码的蛋白质。还提供了包含用于诱变程序的利巴韦林或其衍生物/类似物的试剂盒。

9. 发明申请

US20090123479A1 IMMUNOGLOBULINS 审中-公开
标题翻译：免疫球蛋白
公开(公告)号：US20090123479A1
公开(公告)日：2009-05-14
申请号：US12245426
申请日：2008-10-03
申请人： Gary Peter Bembridge , Jane Elizabeth Clarkson , Jonathan Henry Ellis , Paul Andrew Hamblin , George Kopsidas , Alan Peter Lewis , Ruth McAdam
发明人： Gary Peter Bembridge , Jane Elizabeth Clarkson , Jonathan Henry Ellis , Paul Andrew Hamblin , George Kopsidas , Alan Peter Lewis , Ruth McAdam
IPC分类号： A61K39/395 , C07K16/00 , A61P29/00 , A61P37/00 , C12N5/00
CPC分类号： C07K16/244 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to antigen binding proteins to human IL-23, pharmaceutical formulations containing them and to the use of such antigen binding proteins in the treatment and/or prophylaxis of inflammatory diseases such as Rheumatoid Arthritis (RA).
摘要翻译：本发明涉及到人IL-23的抗原结合蛋白，含有它们的药物制剂以及这种抗原结合蛋白在治疗和/或预防炎性疾病如类风湿性关节炎（RA）中的用途。

10. 发明申请

US20110206686A1 IL-23 ANTIBODIES 审中-公开
标题翻译： IL-23抗体
公开(公告)号：US20110206686A1
公开(公告)日：2011-08-25
申请号：US12681413
申请日：2008-10-03
申请人： Gary Peter Bembridge , Jane Elizabeth Clarkson , Jonathan Henry Ellis , Paul Andrew Hamblin , George Kopsidas , Alan Peter Lewis , Ruth Mcadam
发明人： Gary Peter Bembridge , Jane Elizabeth Clarkson , Jonathan Henry Ellis , Paul Andrew Hamblin , George Kopsidas , Alan Peter Lewis , Ruth Mcadam
IPC分类号： A61K39/395 , C07K16/24 , C12N1/00 , C12N5/10 , A61P29/00 , A61P17/06 , A61P19/02 , A61P25/00 , A61P11/00 , A61P3/10 , A61P11/06 , A61P37/08 , A61P37/06
CPC分类号： C07K16/244 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to antigen binding proteins to human IL-23, pharmaceutical formulations containing them and to the use of such antigen binding proteins in the treatment and/or prophylaxis of inflammatory diseases such as Rheumatoid Arthritis (RA).
摘要翻译：本发明涉及到人IL-23的抗原结合蛋白，含有它们的药物制剂以及这种抗原结合蛋白在治疗和/或预防炎性疾病如类风湿关节炎（RA）中的用途。

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