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1. 发明专利

GB565986A Improvements in or relating to the treatment of anaemias and similar conditions 未知
公开(公告)号：GB565986A
公开(公告)日：1944-12-07
申请号：GB192143
申请日：1943-02-05
申请人： EVANS SONS LESCHER & WEBB LTD , DOUGLAS RIDING , GEORGE EDWARD SHAW , HAROLD ALEXANDER MITCHELL
IPC分类号： A61K31/00
摘要： A liver preparation for the treatment of an mias is obtained by digesting mammalian liver with papain at a pH value of 5.5 at 60 DEG C. for three hours, and then rapidly raising the temperature to 100 DEG C. and boiling, say, for five minutes, to destroy the activity of the enzyme without destruction of the active principles of the liver. The product may be filtered and concentrated to half its volume, again filtered through sterile kieselguhr, the filtrate &c. passed through a Seitz filter, and a solid product be obtained from the final filtrate by spray drying or removal of water at a low temperature under reduced pressure. According to the Provisional Specification, other enzymes such as pepsin, trypsin, or bromelin may be used in the process, and their destruction effected by means other than heat; and the digestion may take place at a pH value of 5-5.5.

2. 发明专利

GB696712A Temperature control of air supply systems 未知
公开(公告)号：GB696712A
公开(公告)日：1953-09-09
申请号：GB1205551
申请日：1951-05-23
申请人： GEORGE EDWARD SHAW
IPC分类号： B64D13/08 , F24F11/02 , F24F11/08
摘要： 696,712. Ventilating aircraft and other enclosures. SHAW, G. E. May 23. 1951 [June 22, 1950], No. 12055/51. Class 137 In a ventilating system, especially for an aircraft, a compressor feeds air to a choke valve which can be positioned to throttle the compressor outlet duct and cause the air to become heated by the additional compression, the valve also serving to apportion the flow of air between two ducts, one of which contains a cooler whilst the other forms a bypass which joins the outlet duct from the cooler to form a single duct leading to the space to be ventilated. In the apparatus shown, a compressor 10 is connected by a duct 12 to a combined selector and choke valve 11, which has two outlet ducts 13 and 14, the former containing a refrigerator unit 17, the ducts combining at 15 into a duct 16 leading to the aircraft cabin &c. The valve 11, Fig. 2, comprises a cylinder 19 in which pivots a shutter 22 which can be moved from a position wherein it nearly covers the inlet port 24 to one wherein it covers the outlet 26 into the duct 14. In operation, with the shutter 22 in the " neutral" position shown, air from the compressor passes to the carbin almost wholly via duct 14 since the unit 17 in duct 13 presents a comparatively large resistance to the flow of air therethrough. If the air temperature rises above the level set on a thermostat 27 mounted in the duct 16, a reversible motor 28 moves the shutter to close the duct 14 thus diverting more air through the cooler 17. If the temperature falls below the required level, the shutter is moved to close off the inlet duct 12 and so produce more heating of the air by additional compression.

3. 发明专利

GB595111A Improvements in or relating to the manufacture of liver extracts 未知
公开(公告)号：GB595111A
公开(公告)日：1947-11-26
申请号：GB1710545
申请日：1945-07-04
申请人： EVANS SONS LESCHER & WEBB LTD , DOUGLAS RIDING , GEORGE EDWARD SHAW
IPC分类号： A61K31/00
摘要： An anti-an mia liver preparation is obtained by subjecting to the action of Papain an aqueous solution prepared from liver, said solution containing the water-soluble constituents of liver, but being free from the water-insoluble constituents. Preferably, minced liver is mixed with cold water acidified to a pH of 5.6, the mixture is heated to coagulate heat-coagulatable material, the aqueous extract is separated and is treated with Papain at a temperature of 60 DEG C. for, say, two hours, and the extract is then boiled to destroy the Papain. The Papain employed may be previously activated with sodium sulphide. The resulting preparation may be dried or concentrated (e.g. in vacuo) or fractionated by the following procedures: (1) precipitation with Reinecke acid and subsequent decomposition of the precipitate; (2) adsorption on charcoal followed by subsequent extraction of the adsorbate with 50-60 per cent alcohol; (3) precipitation by ammonium sulphate; (4) solution in 70-80 per cent alcohol; (5) solution in phenolic solvents such as cresylic acid; (6) rejection of the precipitate produced by the addition of lead acetate; (7) precipitation by phosphotungstic acid and subsequent regeneration of the precipitate. The product as well as the anti-an mia factor contains vitamin B1, nicotinic acid, pyridoxin, pantothenic acid and folic acid. Specification 565,986 is referred to.

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