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1. 发明申请

WO1996032960A1 PREVENTIVE AND/OR REMEDY FOR ISCHEMIC DISEASES 审中-公开
标题翻译：预防和/或补救疾病
公开(公告)号：WO1996032960A1
公开(公告)日：1996-10-24
申请号：PCT/JP1996001065
申请日：1996-04-19
申请人： MITSUBISHI CHEMICAL CORPORATION , GEMBA, Munekazu , YONEHANA, Tsutomu
发明人： MITSUBISHI CHEMICAL CORPORATION
IPC分类号： A61K38/18
CPC分类号： A61K38/1833
摘要： A preventive and/or remedy for ischemic diseases containing as the active ingredient a hepatic parenchymal cell growth factor, for example, a proteinous factor with the following physicochemical properties: 1) having a molecular weight deduced from SDS-PAGE of about 76 to 92 kD; 2) having the activity of proliferating hepatic parenchymal cells; 3) this activity being lost by heating at 80 DEG C for 10 minutes; 4) this activity being lost by digesting with trypsin or chymotrypsin; 5) having a high affinity for heparin; etc. HGF employed as the active ingredient exerts the effect of suppressing cytotoxicyty in an ischemic model and, therefore, is efficacious as a preventive and/or remedy for ischemic diseases.
摘要翻译：含有作为活性成分的肝实质细胞生长因子，例如具有以下物理化学性质的蛋白质因子的缺血性疾病的预防和/或补救措施：1）从SDS-PAGE推导的分子量为约76至92kD ; 2）具有增殖性肝实质细胞活性; 3）此活动在80℃下加热10分钟; 4）通过用胰蛋白酶或胰凝乳蛋白酶消化而损失该活性; 5）对肝素具有高亲和力; 作为活性成分的HGF在缺血模型中发挥抑制细胞毒素作用，因此作为缺血性疾病的预防和/或补救有效。

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