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1. 发明申请

WO2003102225A1 DESTRUCTIBLE SURFACTANTS AND USES THEREOF 审中-公开
标题翻译：可破坏的表面活性剂及其用途
公开(公告)号：WO2003102225A1
公开(公告)日：2003-12-11
申请号：PCT/US2003/016820
申请日：2003-05-30
申请人： WATERS INVESTMENTS LIMITED , BOUVIER, Edouard, S., P. , COPTON, Bruce, John , GEBLER, John, C. , GILAR, Martin , YU, Ying-Qing , LEE, Peter, Jeng, Jong , BROWN, Elizabeth, K.
发明人： BOUVIER, Edouard, S., P. , COPTON, Bruce, John , GEBLER, John, C. , GILAR, Martin , YU, Ying-Qing , LEE, Peter, Jeng, Jong , BROWN, Elizabeth, K.
IPC分类号： C12Q1/37
CPC分类号： C12Q1/37 , C12P21/06 , G01N27/44726 , G01N27/44747 , G01N33/5306
摘要： The present invention provides methods for enhancing chemical reactions of molecules, e.g. , biomolecules, with destructible surfactants. The chemical reactions may involve and/or be associate with analysis, e.g. , solubilizing, separating, purifying and/or characterizing the molecules. In one aspect, the anionic surfactants of the present invention may be selectively broken up at relatively low pH. The resulting breakdown products of the surfactants may be removed from the molecule/sample with relative ease. The invention has applicability in a variety of analytical techniques.
摘要翻译：本发明提供了增强具有可破坏表面活性剂的分子（例如生物分子）的化学反应的方法。化学反应可能涉及和/或与分析有关，例如增溶，分离，纯化和/或表征分子。在一个方面，本发明的阴离子表面活性剂可以在相对低的pH下选择性地分解。可以相对容易地从分子/样品中除去所得表面活性剂的分解产物。本发明适用于各种分析技术。

2. 发明申请

WO2006116064A2 APPARATUS AND METHODS FOR MASS-SPECTROMETRIC DIRECTED PURIFICATION OF BIOPOLYMERS 审中-公开
标题翻译：用于生物聚合物的质谱定向纯化的装置和方法
公开(公告)号：WO2006116064A2
公开(公告)日：2006-11-02
申请号：PCT/US2006/015060
申请日：2006-04-21
申请人： WATERS INVESTMENTS LIMITED , GILAR, Martin , GEBLER, John, C. , XIA, Fang
发明人： GILAR, Martin , GEBLER, John, C. , XIA, Fang
IPC分类号： A45C11/02
CPC分类号： G01N30/34
摘要： A method for extracting at least one target compound from a sample includes injecting an overloaded amount of the sample into a chromatographic conduit, and flowing a solvent having a time-varying composition through the conduit. An apparatus for extracting at least one target compound from a sample includes a chromatography module, a mass-spectrometry module in fluid communication with the chromatography module to receive a portion of an eluent from the chromatography module, and a control unit in communication with the chromatography module and the mass-spectrometry module.
摘要翻译：从样品中提取至少一种目标化合物的方法包括将过量的样品注入色谱管道中，并使具有时变组成的溶剂流经导管。用于从样品中提取至少一种目标化合物的装置包括色谱模块，与色谱模块流体连通以从色谱模块接收一部分洗脱液的质谱模块，以及与色谱法连通的控制单元模块和质谱模块。

3. 发明申请

WO2004092707A2 AROMATIC PHOSPHONIUM SALTS AND THEIR USE AS LABELING REAGENTS MASS SPECTROMETRY ANALYSIS 审中-公开
标题翻译：芳香族磷酸盐钠盐及其作为标签试剂的大分子量分析
公开(公告)号：WO2004092707A2
公开(公告)日：2004-10-28
申请号：PCT/US2004/011426
申请日：2004-04-14
申请人： WATERS INVESTMENTS LIMITED , GEBLER, John, C. , LEE, Peter, J,. J. , CHEN, Weibin
发明人： GEBLER, John, C. , LEE, Peter, J,. J. , CHEN, Weibin
IPC分类号： G01N
CPC分类号： G01N33/6848 , C07F9/5407 , C07F9/5442 , G01N33/6842 , G01N2458/15 , H01J49/164 , Y10T436/24
摘要： This invention relates to methods and reagents for the assay, detection, quantification, location, or analysis of each of a plurality of substances of interest ("analytes") in a sample in which each substance is labeled with a cationic triarylphosphonium group. The present invention also provides MALDI mass spectrometry techniques in which the analysis of samples containing low molecule weight analytes is not obscured by matrix components. The invention also provides labeling reagents for use in labeling analytes prior to MS analysis in which the labeled analytes have a molecular weight above the useful detection threshold of MALDI techniques. In some aspects, the invention provides methods of quantitative MS analysis of components of a sample. Methods of the present invention include sensitive techniques for desorption/ionization of molecules at the picomole, femtomole, and attomole amounts. Another benefit of the present invention is that measurement of m/Z values is not complicated by the low-mass interference that a matrix normally offers, and therefore the invention provides methods of MALDI MS analysis of low molecular weight samples as well as mixtures of high and low molecular weight samples.
摘要翻译：本发明涉及用于将每种物质用阳离子三芳基鏻基团标记的样品中的多种感兴趣物质（“分析物”）中的每一种的测定，检测，定量，定位或分析的方法和试剂。本发明还提供MALDI质谱技术，其中含有低分子量分析物的样品的分析不被基质组分遮蔽。本发明还提供用于在MS分析之前标记分析物的标记试剂，其中标记的分析物的分子量高于MALDI技术的有用检测阈值。在一些方面，本发明提供了样品组分的定量MS分析方法。本发明的方法包括在吡索莫斯，飞甲和阿托莫尔量下解吸/电离分子的敏感技术。本发明的另一个好处是，通过基质通常提供的低质量干扰，m / Z值的测量并不复杂，因此本发明提供了低分子量样品的MALDI MS分析方法以及高分子量混合物和低分子量样品。

4. 发明申请

WO2004092707A3 AROMATIC PHOSPHONIUM SALTS AND THEIR USE AS LABELING REAGENTS MASS SPECTROMETRY ANALYSIS 审中-公开
标题翻译：芳香族磷酸盐钠盐及其作为标签试剂的大分子量分析
公开(公告)号：WO2004092707A3
公开(公告)日：2006-01-05
申请号：PCT/US2004011426
申请日：2004-04-14
申请人： WATERS INVESTMENTS LTD , GEBLER JOHN C , LEE PETER J J , CHEN WEIBIN
发明人： GEBLER JOHN C , LEE PETER J J , CHEN WEIBIN
IPC分类号： C07F9/54 , G01N20060101 , G01N33/68 , G01N24/00 , G01N33/00
CPC分类号： G01N33/6848 , C07F9/5407 , C07F9/5442 , G01N33/6842 , G01N2458/15 , H01J49/164 , Y10T436/24
摘要： This invention relates to methods and reagents for the assay, detection, quantification, location, or analysis of each of a plurality of substances of interest ("analytes") in a sample in which each substance is labeled with a cationic triarylphosphonium group. The present invention also provides MALDI mass spectrometry techniques in which the analysis of samples containing low molecule weight analytes is not obscured by matrix components. The invention also provides labeling reagents for use in labeling analytes prior to MS analysis in which the labeled analytes have a molecular weight above the useful detection threshold of MALDI techniques. In some aspects, the invention provides methods of quantitative MS analysis of components of a sample. Methods of the present invention include sensitive techniques for desorption/ionization of molecules at the picomole, femtomole, and attomole amounts. Another benefit of the present invention is that measurement of m/Z values is not complicated by the low-mass interference that a matrix normally offers, and therefore the invention provides methods of MALDI MS analysis of low molecular weight samples as well as mixtures of high and low molecular weight samples.
摘要翻译：本发明涉及用于将每种物质用阳离子三芳基鏻基团标记的样品中的多种感兴趣物质（“分析物”）中的每一种的测定，检测，定量，定位或分析的方法和试剂。本发明还提供MALDI质谱技术，其中含有低分子量分析物的样品的分析不被基质组分遮蔽。本发明还提供用于在MS分析之前标记分析物的标记试剂，其中标记的分析物的分子量高于MALDI技术的有用检测阈值。在一些方面，本发明提供了样品组分的定量MS分析方法。本发明的方法包括在吡索莫斯，飞甲和阿托莫尔量下解吸/电离分子的敏感技术。本发明的另一个好处是，通过基质通常提供的低质量干扰，m / Z值的测量并不复杂，因此本发明提供了低分子量样品的MALDI MS分析方法以及高分子量混合物和低分子量样品。

5. 发明申请

WO2004072616A3 A SAMPLE PREPARATION PLATE FOR MASS SPECTROMETRY 审中-公开
标题翻译：用于质谱的样品制备板
公开(公告)号：WO2004072616A3
公开(公告)日：2005-06-02
申请号：PCT/US2004003890
申请日：2004-02-10
申请人： WATERS INVESTMENTS LTD , FINCH JEFFREY W , GEBLER JOHN C , VAZQUEZ SANTIAGO
发明人： FINCH JEFFREY W , GEBLER JOHN C , VAZQUEZ SANTIAGO
IPC分类号： G01N1/40 , G01N35/04 , H01J49/16 , H01J49/26 , B01D59/44
CPC分类号： H01J49/0418 , G01N1/40 , G01N35/028 , G01N2001/4027 , H01J49/0413
摘要： A sample preparation plate for a mass spectrometer having a monolithic substrate (20) and a plurality of well structures (12) where the wells comprise a hydrophilic central region (18) and hydrophobic suurrounding regions (16).
摘要翻译：一种用于质谱仪的样品制备板，其具有整体式基底（20）和多个孔结构（12），其中所述孔包括亲水中心区域（18）和疏水性周边区域（16）。

6. 发明申请

WO2004072616A2 A SAMPLE PREPARATION PLATE FOR MASS SPECTROMETRY 审中-公开
标题翻译：用于质谱的样品制备板
公开(公告)号：WO2004072616A2
公开(公告)日：2004-08-26
申请号：PCT/US2004/003890
申请日：2004-02-10
申请人： WATERS INVESTMENTS LIMITED , FINCH,, Jeffrey W. , GEBLER,, John C. , VAZQUEZ,, Santiago
发明人： FINCH,, Jeffrey W. , GEBLER,, John C. , VAZQUEZ,, Santiago
IPC分类号： G01N
CPC分类号： H01J49/0418 , G01N1/40 , G01N35/028 , G01N2001/4027 , H01J49/0413
摘要： ABSTRACT Disclosed herein is a sample preparation plate used to prepare a sample for mass spectrometry. In particular, a sample plate used to concentrate a sample as well as remove contaminants from the sample while providing easy manipulation of small liquid droplets on a surface with minimal sample loss.
摘要翻译：摘要本发明公开了一种用于制备质谱样品的样品制备板。特别地，用于浓缩样品以及从样品中除去污染物的样品板，同时以最小的样品损失容易地操纵表面上的小液滴。

7. 发明申请

WO2006116064A3 APPARATUS AND METHODS FOR MASS-SPECTROMETRIC DIRECTED PURIFICATION OF BIOPOLYMERS 审中-公开
标题翻译：用于生物聚合物的质谱定向纯化的装置和方法
公开(公告)号：WO2006116064A3
公开(公告)日：2007-08-09
申请号：PCT/US2006015060
申请日：2006-04-21
申请人： WATERS INVESTMENTS LTD , GILAR MARTIN , GEBLER JOHN C , XIA FANG
发明人： GILAR MARTIN , GEBLER JOHN C , XIA FANG
IPC分类号： B01D15/08
CPC分类号： G01N30/34
摘要： A method for extracting at least one target compound from a sample includes injecting an overloaded amount of the sample into a chromatographic conduit (110), and flowing a solvent having a time- varying composition through the conduit (110). An apparatus for extracting at least one target compound from a sample includes a chromatography module, a mass-spectrometry module in fluid communication with the chromatography module to receive a portion of an eluent from the chromatography module, and a control unit in communication with the chromatography module and the mass-spectrometry module.
摘要翻译：从样品中提取至少一种目标化合物的方法包括将过量的样品注入色谱管道（110）中，并使具有时变组成的溶剂流经导管（110）。用于从样品中提取至少一种目标化合物的装置包括色谱模块，与色谱模块流体连通以从色谱模块接收一部分洗脱液的质谱模块，以及与色谱法连通的控制单元模块和质谱模块。

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