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    • 7. 发明申请
    • METHOD AND APPARATUS ASSESSING VENTRICULAR CONTRACTILE STATUS
    • 方法和装置评估心室收缩状态
    • WO2004098381A2
    • 2004-11-18
    • PCT/US2004013085
    • 2004-04-28
    • MEDTRONIC INCMULLIGAN LAWRENCE JGEBHARDT URSULA
    • MULLIGAN LAWRENCE JGEBHARDT URSULA
    • A61N1/362A61B
    • A61N1/3627
    • Methods and devices for improving ventricular contractile status of a patient suitably exploit changes in ventricular pressure and/or dP/dtmax to provide and/or optimize a response to a patient. The ventricular pressure may be appropriately correlated to intracellular calcium regulation, which is indicative of contractile status. To assess ventricular contractile status, the device suitably observes a cardiac perturbation of the patient and measures force interval potentiation following the perturbation. The contractile potentiation can then be stored and/or quantified in the implantable medical device to determine the ventricular contractile status of the patient, and an appropriate response may be provided to the patient as a function of the ventricular contractile status. Examples of responses may include administration of drug or neuro therapies, modification of a pacing rate, or the like. Force interval potentiation may also be used to optimize or improve a parameter for a response provided by the implantable medical device.
    • 用于改善患者的心室收缩状态的方法和装置适当地利用心室压力和/或dP / dtmax的变化,以提供和/或优化对患者的反应。 心室压力可以适当地与细胞内钙调节相关,细胞内钙调节指示收缩状态。 为了评估心室收缩状态,该装置适当地观察患者的心脏摄动,并测量扰动后的力间隔增强作用。 收缩增强能随后在可植入的医疗装置中被储存和/或定量,以确定患者的心室收缩状态,并且作为心室收缩状态的函数可以向患者提供适当的响应。 反应的实例可包括药物或神经疗法的施用,起搏速率的改变等。 力间隔增强也可用于优化或改善由可植入医疗装置提供的响应的参数。