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1. 发明公开

EP1179007A1 SELF-ASSEMBLING BIOMOLECULAR STRUCTURES 审中-公开
标题翻译：自组装生物分子STRUKTURE
公开(公告)号：EP1179007A1
公开(公告)日：2002-02-13
申请号：EP00929708.6
申请日：2000-05-15
申请人： Affibody Technology Sweden AB , Gardner, Rebecca
发明人： NYGREN, Per- ke , UHL N, Mathias
IPC分类号： C07K1/22 , C07K14/00 , C07K1/04 , C12N15/10 , C07K14/31 , G01N33/68 , A61K38/04
CPC分类号： C40B40/02 , A61K38/00 , B82Y5/00 , B82Y30/00 , C07K1/047 , C07K1/22 , C07K14/001 , C07K14/31 , C12N15/1037 , C12N15/66
摘要： The present invention relates to a self-assembled biomolecular structure comprising affinity modules, said affinity modules each having at least two affinity domains which may be the same or different, at least one affinity domain within each affinity module having specific and exclusive affinity for an affinity domain within another affinity module, said affinity modules capable of biospecific interaction to form an assembled structure; affinity modules for use in said structures, methods of producing the structures and uses of the structures.

2. 发明公开

EP1251843A1 COMPOSITIONS FOR DELIVERY OF A CORTISOL ANTAGONIST 有权
标题翻译：组合物用于递送皮质醇拮抗剂
公开(公告)号：EP1251843A1
公开(公告)日：2002-10-30
申请号：EP01901275.6
申请日：2001-01-19
申请人： Cortendo AB , Gardner, Rebecca
发明人： MÄRIN, Per , LANDH, Tomas , ÖSTHOLM, Ivan
IPC分类号： A61K31/19 , A61K31/4168 , A61K31/569 , A61K31/496 , A61K31/451 , A61K31/4545 , A61K31/4174 , A61K31/03 , A61K31/58 , A61K31/245 , A61K31/375 , A61K31/4164 , A61K31/167 , A61K31/00 , A61K9/22 , A61K9/20
CPC分类号： A61K47/24 , A61K9/2013 , A61K9/4858 , A61K31/00 , A61K31/03 , A61K31/167 , A61K31/19 , A61K31/245 , A61K31/375 , A61K31/4164 , A61K31/4166 , A61K31/4168 , A61K31/444 , A61K31/451 , A61K31/496 , A61K31/567 , A61K31/58 , A61K47/14
摘要： The present invention relates to compositions for controlled release of a cortisol antagonist comprising at least one release rate controlling substance together with said cortisol antagonist and methods of preventing or treating metabolic syndrome, diabetes mellitis type II or symptoms or complications thereof in a mammal, which method comprises administering such a composition to said mammal in an amount effective to treat one or more of the clinical manifestations of metabolic syndrome or diabetes mellitis type II as well as complications thereof.

3. 发明公开

EP1147217A1 A METHOD OF DNA SEQUENCING 有权
标题翻译：方法DNA测序
公开(公告)号：EP1147217A1
公开(公告)日：2001-10-24
申请号：EP00900717.0
申请日：2000-01-20
申请人： Pyrosequencing AB , Gardner, Rebecca
发明人： RONAGHI, Mostafa,Stanford DNA Seq. & Techn. Ctr.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6869 , C12Q2565/301 , C12Q2535/125 , C12Q2522/10
摘要： The present invention relates to a method of identifying a base at a target position in a sample nucleic acid sequence wherein a primer, which hybridises to the sample nucleic acid immediately adjacent to the target position, is provided and the sample nucleic acid and primer are subjected to a polymerase reaction in the presence of a nucleotide whereby the nucleotide will only become incorporated if it is complementary to the base in the target positon, and said incorporation is detected, characterised in that, a single-stranded nucleic acid binding protein is included in the polymerase reaction step.

4. 发明公开

EP1123389A1 A METHOD OF AFFINITY SEPARATION AND LIGANDS FOR USE THEREIN 有权
标题翻译：亲和分离方法和使用相关的配体
公开(公告)号：EP1123389A1
公开(公告)日：2001-08-16
申请号：EP99950942.5
申请日：1999-10-21
申请人： Affibody Technology Sweden AB , Gardner, Rebecca
发明人： UHL N, Mathias , HOBER, Sophia
IPC分类号： C12N15/10 , C07K1/22 , C07K14/31
CPC分类号： C07K14/31 , C07K1/047 , C07K1/22 , C07K2319/00 , C12N15/1037 , C40B40/02
摘要： The present invention relates to methods of affinity separation wherein the affinity ligand is an immobilised proteinaceous ligand wherein one or more of its asparagine (Asn) residues has been modified. Methods of making a stabilised combinatorial protein comprising the steps of: a) modification of Asn residues within a protein molecule to increase stability of the protein in alkaline conditions; and b) randomisation of the protein molecule to modify its binding characteristics and combinatorial proteins wherein in a step separate from the randomisation step, the stability of the protein in alkaline conditions has been increased by modifying one or more of its Asn residues are also described.

5. 发明公开

EP1317308A2 REDUCTION OF THE ELECTROCARDIOGRAPHIC OT INTERVAL 审中-公开
标题翻译：还原心电图QT间期
公开(公告)号：EP1317308A2
公开(公告)日：2003-06-11
申请号：EP01965451.6
申请日：2001-09-12
申请人： Creative Peptides Sweden AB , Gardner, Rebecca
发明人： WAHREN, John , JOHANSSON, Bo-Lennart , BIANCHINE, Joseph,Schwarz BioSciences, Inc.
IPC分类号： A61P9/00
CPC分类号： A61K38/28
摘要： The present invention relates to the use of proinsulin C-peptide or a variant, derivative or fragment thereof in the manufacture of a medicament for reducing the OTc interval and the use of proinsulin C-peptide or a variant, derivative or fragment thereof in the manufacture of a medicament for reducing the risk of sudden death or 'dead in bed' syndrome; particularly in patients suffering from IDDM.

6. 发明公开

EP1109831A2 CYCTOTOXIC PEPTIDES MODIFIED BY BULKY OR LIPOPHILIC MOIETIES 有权
标题翻译：随着大量或亲脂性基团改性，细胞毒性肽
公开(公告)号：EP1109831A2
公开(公告)日：2001-06-27
申请号：EP99941773.6
申请日：1999-08-31
申请人： ALPHARMA AS , Gardner, Rebecca
发明人： SVENDSEN, John, Sigurd , REKDAL, Oystein , SVEINBJORNSSON Baldur,Dept. of Experimental Path. , VORLAND, Lars,Dept. of Medical Microbiology
IPC分类号： C07K14/79 , C07K14/46 , A61K38/16 , A61K38/17 , A61P31/00 , A61P35/00
CPC分类号： C07K14/46 , A61K38/00 , C07K14/79
摘要： The present invention provides a cytotoxic 7 to 25 mer peptide with three or more cationic residues which has one or more non-genetic bulky and lipophilic amino acids, as well as esters, amides, salts and cyclic derivatives thereof as well as methods of preparing the peptides, pharmaceutical compositions containing them and their use as medicaments, particularly as antibacterions or antitumoural agents.

7. 发明公开

EP1109827A2 BIOACTIVE PEPTIDES 有权
标题翻译：生物活性肽
公开(公告)号：EP1109827A2
公开(公告)日：2001-06-27
申请号：EP99941774.4
申请日：1999-08-31
申请人： ALPHARMA AS , Gardner, Rebecca
发明人： SVENDSEN, John Sigurd,Dept. of Chemistry , REKDAL,Oystein,Biochemistry Dept. , SVEINBJORNSSON, Baldur , VORLAND, Lars,Dept. of Medical Microbiology
IPC分类号： C07K14/00
CPC分类号： C07K14/46 , A61K38/00 , C07K14/79
摘要： The present invention provides a modified lactoferrin peptide which is cytotoxic, 7 to 25 amino acids in length, with three or more cationic residues and which has one or more extra bulky and lipophilic amino acids as compared to the native lactoferrin sequence, as well as esters, amides, salts and cyclic derivatives thereof as well as methods of preparing such peptides, pharmaceutical compositions containing such peptides and use of the peptides as medicaments, particularly as antibacterials or anti-tumoural agents.

8. 发明专利

AU9398701A Shrimp alkaline phosphatase 未知
公开(公告)号：AU9398701A
公开(公告)日：2002-04-22
申请号：AU9398701
申请日：2001-10-10
申请人： NORWEGIAN INST OF FISHERIES AN , GARDNER REBECCA
发明人： GARDNER REBECCA , NILSEN INGE , OVERBO KERSTI
IPC分类号： A01K67/027 , A01K67/033 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/16 , C12N15/09 , C12N15/52
摘要： The present invention relates to a nucleic acid molecule comprising a nucleotide sequence as set forth in SEQ ID Nos. 1 or 20 or having at least 55% sequence identify therewith and/or capable of hybridising under medium stringency conditions to the complementary sequence of SEQ ID Nos. 1 or 20, or the complementary sequence of said sequences, wherein said nucleotide sequence encodes or is complementary to a sequence which encodes a heat labile alkaline phosphatase and to a recombinant heat labile alkaline comprising: (a) all or a significant part of an amino acid sequence as shown in SEQ ID No. 2; or (b) all or a significant part of an amino acid sequence which has at least 60% sequence identify with SEQ ID No. 2 as well as methods for the manufacture thereof. 1 k AYWNKDAQDALDKQLGIKLREKQAKNVIFFLGDGMSLSTVTAARIYKGG 5ReRP6:17 51 LTGKFEREKISWEEFDFAALSKTYNTDKQ AYLTGVKTNQGV Active site 101 IGLDANTVRTNCSYQLDESLFTYSIAHWFQEAGRSTGVVTSTRVTHATPA 151 GTYAHVADRDWENDSDVVHDREDPEICDDIAEQLVFREPGKNFK VIMGGG 5ReRP6:26 201 RRGFFPEEALDIEDGIPGEREDGK HLITDWLDDKASQGATASYVWNRDDL H23:30 251 LAVDIRNTDYLMGLFSYTHLDTVLTRDAEMDPTLPEMTKVAIEMLTKDEN 301 GFFLLVEGGRIDHMHHANQIRQSLAETLDMEEAVSMALSMTDPEETIILV 351 TADHGHTLTITGYADRNTDILDFAGISDLDDRRYTILDYGSGPGYHITED 401 GKRYEPTEEDLK DINFRYASAAPKHSVTHDGTDVGIWVNGPFAHLFTGVY H23:18 451 EENYIPHALAYAACVGTGRTFCDEK *

9. 发明专利

AU2003205830A1 Molecular libraries 未知
公开(公告)号：AU2003205830A1
公开(公告)日：2003-09-02
申请号：AU2003205830
申请日：2003-01-23
申请人： EL GEWELY MOHAMED RAAFAT , GARDNER REBECCA KATHERINE
发明人： EL-GEWELY MOHAMED RAAFAT
IPC分类号： A61K38/00 , C07K7/06 , C12N15/10 , C40B30/04 , G01N33/68
摘要： The present invention provides a peptide having 2 to 10 amino acids or a derivative thereof which is able to restore wild type function of human p53, for use in therapy; and a method of screening a library of molecules for the ability of members of that library to restore or modify the function of a target protein in an intra-cellular environment, which method comprises introducing the library into host cells which have a reporter system which allows the identification of those cells in which the function of the target protein has been restored or modified.

10. 发明申请

WO2013104897A1 THERAPEUTIC BORON-CONTAINING COMPOUNDS 审中-公开
标题翻译：含治疗含硼的化合物
公开(公告)号：WO2013104897A1
公开(公告)日：2013-07-18
申请号：PCT/GB2013/050020
申请日：2013-01-08
申请人： UNIVERSITY OF TROMSØ , GARDNER, Rebecca
发明人： LEJON, Tore , SVENDSEN, John Sigurd , GOROVOY, Alexey , GOZHINA, Olga
IPC分类号： C07F5/02 , A61K31/69 , A61P31/06 , A61P31/10
CPC分类号： C07F5/04 , C07F5/02 , C07F5/025
摘要： The present invention relates to compounds of Formula (I) wherein R 1 and R 3 are hydrogen; R 2 and R 4 , which may be the same or different, are hydrogen, a C 1-6 alkyl group optionally substituted by an aryl group which may itself be substituted, the substituent group including an alkyl group or an -OR group in which R is a C 1-3 alkyl group, with one or more hydrogen atoms optionally replaced with a halogen atom; or an aryl group which may be substituted, the substituent group including an alkyl group or an -OR group in which R is a C 1-3 alkyl group, with one or more hydrogen atoms optionally replaced with a halogen atom; with the proviso that R 2 and R 4 are not both hydrogen; the atom of R 4 which is attached to C β is either a saturated carbon atom or an atom which is part of a 1 substituted aromatic ring; (AA) 0-5 is an amino acid, amino acid derivative, peptide of up to 5 amino acids or a peptidomimetic thereof which optionally incorporates an N-terminal capping group, when the group is (AA) 0 an N-terminal capping group is present, covalently attached to the nitrogen atom shown in Formula (I) and the capping group comprises at least 5 non-hydrogen atoms; R 5 is hydrogen or a C 1-3 20 alkyl group, when AA=0, R 5 may form a cyclic group with the N-terminal capping group; R 6 and R 7 independently of one another denote hydrogen or a C 1-6 alkyl group; or together with the boron atom and the oxygen atoms, form a mono-, bi- or tricyclic, saturated or partly unsaturated, mono-, di-, tri- or tetra- C 1-6 alkylated or phenylated ring system having 5-18 ring members; and salt forms and stereoisomers thereof. The invention further relates to pharmaceutical formulations containing these compounds and the use of these compounds in therapy, particularly as antimicrobial agents, more particularly as an agent effective in treating a Mycobacterium tuberculosis infection or a Candida albicans infection. (I)
摘要翻译：本发明涉及其中R 1和R 3为氢的式（I）化合物; R 2和R 4可以相同或不同，为氢，任选被本身可被取代的芳基取代的C 1-6烷基，包括烷基或-OR基团的取代基，其中R为具有一个或多个氢原子任选被卤素原子取代的C 1-3烷基; 或可被取代的芳基，所述取代基包括烷基或-OR基团，其中R为C 1-3烷基，一个或多个氢原子任选被卤素原子取代; 条件是R2和R4不同时为氢; 与Cbeta连接的R4的原子是饱和碳原子或作为1取代芳环的一部分的原子; （AA）0-5是氨基酸，氨基酸衍生物，最多5个氨基酸的肽或其肽模拟物，其任选地包含N-末端封端基团，当基团为（AA）0时，N-末端封端基团共价连接到式（I）所示的氮原子上，封端基包含至少5个非氢原子; R5为氢或C1-320烷基，当AA = 0时，R5可与N-末端封端基形成环状基团; R 6和R 7彼此独立地表示氢或C 1-6烷基; 或与硼原子和氧原子一起形成具有5-18个环的单 - ，二 - 或三环饱和或部分不饱和的单 - ，二 - ，三 - 或四-C 1-6烷基化或苯基环系成员; 及其盐形式和立体异构体。本发明还涉及含有这些化合物的药物制剂以及这些化合物在治疗中的用途，特别是作为抗微生物剂，特别是作为有效治疗结核分枝杆菌感染或白色念珠菌感染的药剂。（一世）

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