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    • 4. 发明申请
    • HIGH RATE SCREENING METHOD AND DEVICE FOR OPTICALLY DETECTING SAMPLES
    • 用于样品的光学检测高通量筛选方法和装置
    • WO0140769A3
    • 2001-12-13
    • PCT/EP0012126
    • 2000-12-02
    • EVOTEC BIOSYSTEMS AGGARBOW NORBERT
    • GARBOW NORBERT
    • G01N21/64
    • G01N21/6408
    • The invention relates to a high rate screening method according to which a first electromagnetic radiation is generated by at least one radiation generating device (31) and this radiation is simultaneously guided in a multitude of first optical fibers (34) to at least one beam splitting device (36) from which the first electromagnetic radiation is simultaneously guided in a multitude of second optical fibers (48) to focussing optics (56). Said focussing optics (56) are used to simultaneously focus the first electromagnetic radiation into a multitude of foci (60), which are located inside the measurement volumes of the sample that are to be detected. The second electromagnetic radiation emitted by the measurement volumes of the sample is guided by means of the multitude of second optical fibers (48) from the focussing optics (56) to the at least one beam splitting device (36) from which the second electromagnetic radiation is routed to separate detector regions (70) of at least one detector device (72). Said detector regions are arranged outside of the beam path, which extends from the at least one radiation generating device (31) via the at least one beam splitting device (36) and up to the focussing optics (56), and they detect the second electromagnetic radiation. The measured data which is generated on the basis of the detected second electromagnetic radiation is processed.
    • 用于高通量筛选,具有至少一个辐射生成设备(31)的第一电磁辐射中产生,并且这同时在多个从起点通过第一光纤(34)的至少一个分束器装置(36)的,同时第一电磁辐射成多个 第二光纤(48)的聚焦透镜(56)被传递。 所述第一电磁辐射由聚焦光学系统(56),同时聚焦成多个焦点(60),其将被检测体的测定体积内检测到。 从上述检体测定体积的第二电磁辐射被所述多个聚焦光学系统(56)的第二光纤(48)的被引导至从起点的所述至少一个分束器装置(36),所述第二电磁辐射,以单独的探测器区域(70)至少一个检测器装置发射 (72)经由所述至少一个分束装置(36)通过,该外延伸到所述至少一个辐射生成设备(31)的聚焦光学器件(56)光束路径被布置,并且检测所述第二电磁辐射。 被检测的第二电磁辐射的基础上产生的测量数据进行处理。