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1. 发明授权

US08309712B2 Industrial process for the preparation of 17-hydroxy-6beta,7beta;15beta, 16beta-bismethylene-3-oxo-17alpha-pregn-4-ene-21-carboxylic acid y-lactone and key intermediates for this process 有权
标题翻译：用于制备17-羟基-6β，7beta; 15beta，16beta-双亚甲基-3-氧代-17α-孕-4-烯-21-羧酸γ-内酯和该方法的关键中间体的工业方法
公开(公告)号：US08309712B2
公开(公告)日：2012-11-13
申请号：US11719333
申请日：2005-10-11
申请人： Béla Sörös , Judit Horváth , György Gálik , József Bódi , Zoltán Tuba , Sándor Mahó , Gábor Balogh , Antal Aranyi
发明人： Béla Sörös , Judit Horváth , György Gálik , József Bódi , Zoltán Tuba , Sándor Mahó , Gábor Balogh , Antal Aranyi
IPC分类号： C07J53/00
CPC分类号： C07J53/008
摘要： The invention relates to an industrial process for the preparation of 17-hydroxy-6β,7β;15β,16β-bismethylene-3-oxo-17α-pregn-4-ene-21-carboxylic acid γ-lactone of formula (I), and to the key-intermediates for this process.
摘要翻译：本发明涉及制备式17的17-羟基-6α，17β，16β-二亚甲基-3-氧代-17α-孕烷-4-烯-21-羧酸γ-内酯的工业方法（I），以及此过程的关键中间体。

2. 发明申请

US20100311719A1 Prevention of Obesity in Antipsychotic, Antidepressant and Antiepileptic Medication 审中-公开
标题翻译：预防精神病，抗抑郁药和抗癫痫药物中的肥胖
公开(公告)号：US20100311719A1
公开(公告)日：2010-12-09
申请号：US12858299
申请日：2010-08-17
申请人： Péter Literáti Nagy , Jesse Roth , Zoltán Szilvássy , Kálmán Tory , Mike Brownstein , Kálmán Takács , László Vígh , József Mandl , Balázs Sümegi , Sándor Bernáth , Attila Kolonics , Gábor Balogh , János Egri
发明人： Péter Literáti Nagy , Jesse Roth , Zoltán Szilvássy , Kálmán Tory , Mike Brownstein , Kálmán Takács , László Vígh , József Mandl , Balázs Sümegi , Sándor Bernáth , Attila Kolonics , Gábor Balogh , János Egri
IPC分类号： A61K31/554 , A61K31/4545 , A61K31/5513 , A61K31/519 , A61P3/04 , A61P25/24
CPC分类号： A61K31/4545 , A61K31/19 , A61K31/40 , A61K31/519 , A61K31/551 , A61K31/5513 , A61K31/554 , A61K45/06 , A61K2300/00
摘要： O-(3-piperidino-2-hydroxypropyl)-nicotinic amidoxime or a pharmaceutically suitable acid addition salt thereof (BGP-15) can be used for the prevention or reduction of weight gain or obesity in a patient treated with an antipsychotic drug or an antidepressant drug or an antiepileptic drug.
摘要翻译： O-（3-哌啶子基-2-羟丙基） - 烟酰胺肟或其药学上合适的酸加成盐（BGP-15）可以用于预防或减轻用抗精神病药物治疗的患者体重增加或肥胖，抗抑郁药或抗癫痫药。

3. 发明授权

US07148239B2 Method of enhancing cellular production of molecular chaperon, hydroxylamine derivatives useful for enhancing the chaperon production and the preparation thereof 有权
标题翻译：促进分子伴侣的细胞产生的方法，用于增强伴侣生产的羟胺衍生物及其制备方法
公开(公告)号：US07148239B2
公开(公告)日：2006-12-12
申请号：US10618157
申请日：2003-07-10
申请人： László Vígh , Péter Literáti Nagy , Jenó Szilbereky , László Ürögdi , Andrea Jednákovits , László Jaszlits , Katalin Bíró , Ede Márványos , Mihály Barabás , Erzsébet Hegedüs , László Korányi , Mária Kürthy , Gábor Balogh , Ibolya Horváth , Zsolt Török , Éva Udvardy , György Dormán , Dénes Medzihradszky , Bea Mézes , Eszter Kovács , Ernó Duda , Beatrix Farkas , Attila Glatz
发明人： László Vígh , Péter Literáti Nagy , Jenó Szilbereky , László Ürögdi , Andrea Jednákovits , László Jaszlits , Katalin Bíró , Ede Márványos , Mihály Barabás , Erzsébet Hegedüs , László Korányi , Mária Kürthy , Gábor Balogh , Ibolya Horváth , Zsolt Török , Éva Udvardy , György Dormán , Dénes Medzihradszky , Bea Mézes , Eszter Kovács , Ernó Duda , Beatrix Farkas , Attila Glatz
IPC分类号： H63K31/44 , C07C259/02 , C07D213/78
CPC分类号： C07D213/78 , C07C259/02 , C07C259/18 , C07C275/64 , C07C279/18 , C07C2601/14 , C07D213/89 , C07D215/54 , C07D217/26 , C07D295/088 , C07D307/68 , C07D333/38 , C07D409/12 , C07D413/04
摘要： A method of increasing expression of a molecular chaperon by a cell and/or enhancing the activity of a molecular chaperon in cells is provided. The method comprises treating a cell that is exposed to a physiological stress which induces expression of a molecular chaperon by the cell with an effective amount of a certain hydroxylamine derivative to increase the stress. Alternatively, an hydroxylamine derivative can be administrated to a cell before it is exposed to a physiological stress which induces expression of a molecular chaperon by the cell. Preferably, the cell to which an hydroxylamine derivative is administered is an eukaryotic cell. The hydroxylamine derivative corresponds to the formulae (I) or (II).The invention also provides novel hydroxylamine derivatives falling within the scope of the formulae (I) and (II) as well as pharmaceutical and/or cosmetical compositions comprising the said compounds.
摘要翻译：提供了增加细胞分子伴侣表达和/或提高细胞中分子伴侣活性的方法。所述方法包括用有效量的某种羟胺衍生物处理暴露于生理应激的细胞，所述生理应激诱导细胞表达分子伴侣以增加应激。或者，可以在细胞暴露于诱导细胞分子伴侣表达的生理应激之前向细胞施用羟胺衍生物。优选地，施用羟胺衍生物的细胞是真核细胞。羟胺衍生物对应于式（I）或（II）。本发明还提供了落入式（I）和（II）范围内的新型羟胺衍生物以及包含所述化合物的药物和/或化妆品组合物。

4. 发明授权

US06653326B1 Hydroxylamine derivatives useful for enhancing the molecular chaperon production and the preparation thereof 有权
标题翻译：用于增强分子伴侣生产的羟胺衍生物及其制备方法
公开(公告)号：US06653326B1
公开(公告)日：2003-11-25
申请号：US08860582
申请日：1999-12-07
申请人： László Vígh , Péter Literáti Nagy , Jenó Szilbereky , László Ürögdi , Andrea Jednákovits , László Jaszlits , Katalin Bíró , Ede Màrvànyos , Mihály Barabás , Erzsébet Hegedüs , László Korányi , Mária Kürthy , Gábor Balogh , Ibolya Horváth , Zsolt Török , Éva Udvardy , György Dormán , Dénes Medzihradszky , Bea Mézes , Eszter Kovács , Ernö Duda , Beatrix Farkas , Attila Glatz
发明人： László Vígh , Péter Literáti Nagy , Jenó Szilbereky , László Ürögdi , Andrea Jednákovits , László Jaszlits , Katalin Bíró , Ede Màrvànyos , Mihály Barabás , Erzsébet Hegedüs , László Korányi , Mária Kürthy , Gábor Balogh , Ibolya Horváth , Zsolt Török , Éva Udvardy , György Dormán , Dénes Medzihradszky , Bea Mézes , Eszter Kovács , Ernö Duda , Beatrix Farkas , Attila Glatz
IPC分类号： H61K3144
CPC分类号： C07D213/78 , C07C259/02 , C07C259/18 , C07C275/64 , C07C279/18 , C07C2601/14 , C07D213/89 , C07D215/54 , C07D217/26 , C07D295/088 , C07D307/68 , C07D333/38 , C07D409/12 , C07D413/04
摘要： A method of increasing expression of a molecular chaperon by a cell and/or enhancing the activity of a molecular chaperon in cells is provided. The method comprises treating a cell that is exposed to a physiological stress which induces expression of a molecular chaperon by the cell with an effective amount of a certain hydroxylamine derivative to increase the stress. Alternatively; an hydroxylamine derivative can be administrated to a cell before it is exposed to a physiological stress which induces expression of a molecular chaperon by the cell. Preferably, the cell to which an hydroxylamine derivative is administered is an eukaryotic cell. The hydroxylamine derivative corresponds to the formulae (I) or (II). The invention also provides novel hydroxyl amine derivatives falling within the scope of the formulae (I) and (II) as well as pharmaceutical and/or cosmetical compositions comprising the said compounds.
摘要翻译：提供了增加细胞分子伴侣表达和/或提高细胞中分子伴侣活性的方法。所述方法包括用有效量的某种羟胺衍生物处理暴露于生理应激的细胞，所述生理应激诱导细胞表达分子伴侣以增加应激。或者; 在将细胞暴露于诱导细胞分子伴侣表达的生理应激之前，可以向细胞施用羟胺衍生物。优选地，施用羟胺衍生物的细胞是真核细胞。羟胺衍生物对应于式（I）或（II）。本发明还提供了落入式（I）和（II）范围内的新型羟胺衍生物以及包含所述化合物的药物和/或化妆品组合物。

5. 发明授权

US06500651B1 Metabolic controlled fermentation procedure for the manufacture of lovastatin hydroxy acid 失效
标题翻译：用于制造洛伐他汀羟基酸的代谢控制发酵程序
公开(公告)号：US06500651B1
公开(公告)日：2002-12-31
申请号：US09424131
申请日：2000-04-05
申请人： Péter Seress , Gábor Balogh , Antal Oláh , László Cséke
发明人： Péter Seress , Gábor Balogh , Antal Oláh , László Cséke
IPC分类号： C12P1706
CPC分类号： C12P7/42 , C12P7/62 , C12P17/06
摘要： A method for producing mevinolin by a microorganism in a fermentation process having a seed culture stage and a main fermentation stage, including a) cultivating a microorganism biomass in the seed culture stage to produce an inoculum; b) transferring the inoculum into a fermentation medium in the main fermentation stage; and, c) maintaining steady stage conditions in the main fermentation stage, thereby producing a fermentation broth containing mevinolin. Preferably, the steady state conditions are maintained in the main fermentation stage by one or more of feeding of organic carbon sources; controlling glucose and/or total reducing sugar content; feeding of organic nitrogen sources; controlling pH; controlling foam level; controlling the mass of the fermentation broth by withdrawals and feedings; and, controlling the dissolved oxygen level.
摘要翻译：一种在具有种子培养阶段和主发酵阶段的发酵过程中通过微生物生产美维林的方法，包括a）在种子培养阶段培养微生物生产物以产生接种物; b）将接种物转移到发酵培养基中主发酵阶段和c）在主发酵阶段维持稳定状态，从而生产含有维林林素的发酵液。优选地，在主发酵阶段通过一次或多次进料有机碳源维持稳态条件; 控制葡萄糖和/或总还原糖含量; 有机氮源的喂养; 控制pH值; 控制泡沫水平; 通过提取和喂食控制发酵液的质量; 并控制溶解氧水平。

6. 发明授权

US08183402B2 Industrial method for the synthesis of 17-acetoxy-11β[4-(dimethylamino)-phenyl]-21-methoxy-19-norpregna-4,9-dien-3,20-dione and the key intermediates of the process 有权
标题翻译：合成17-乙酰氧基-11β-[4-（二甲基氨基） - 苯基] -21-甲氧基-19-去甲基-4,9-二烯-3,20-二酮的工业方法和该方法的关键中间体
公开(公告)号：US08183402B2
公开(公告)日：2012-05-22
申请号：US12598163
申请日：2008-06-19
申请人： József Bódi , György Visky , János Széles , Sándor Mahó , Csaba Sánta , János Csörgei , Zoltán Tuba , László Terdy , Csaba Molnár , Antal Aranyi , Zoltán Horváth , Gábor Balogh
发明人： József Bódi , György Visky , János Széles , Sándor Mahó , Csaba Sánta , János Csörgei , Zoltán Tuba , László Terdy , Csaba Molnár , Antal Aranyi , Zoltán Horváth , Gábor Balogh
IPC分类号： C07J5/00 , C07J3/00
CPC分类号： C07J41/0083 , C07J21/006 , C07J41/0094 , C07J51/00 , Y02P20/55
摘要： The present invention relates to a process for the synthesis of the 17-acetoxy-11β-[4-(dimethylamino)-phenyl]-21-methoxy-19-norpregna-4,9-dien-3,20-dione of formula (I): from 3,3-[1,2-etandiyl-bis(oxy)]-oestr-5(10),9(11)-dien-17-one of formula (II):
摘要翻译：本发明涉及合成式17-乙酰氧基-11β-（4-（二甲基氨基） - 苯基] -21-甲氧基-19-去甲基-4,9-二烯-3,20-二酮的方法（I）：由式（II）的3,3- [1,2-二（二乙基 - 双（氧基）） - 雌 - 5（10），9（11） - 二 -

7. 发明授权

US07745465B2 Method of enhancing cellular production of molecular chaperone, hydroxylamine derivatives useful for enhancing the chaperone production and the preparation thereof 有权
标题翻译：增强分子伴侣的细胞生产的方法，可用于增强伴侣生产的羟胺衍生物及其制备方法
公开(公告)号：US07745465B2
公开(公告)日：2010-06-29
申请号：US10618162
申请日：2003-07-10
申请人： László Vígh , Péter Literáti Nagy , Jenö Szilbereky , László Ürögdi , Andrea Jednákovits , László Jaszlits , Katalin Bíró , Ede Márványos , Mihály Barabás , Erzsébet Hegedüs , László Korányi , Mária Kürthy , Gábor Balogh , Ibolya Horváth , Zsolt Török , Éva Udvardy , György Dormán , Dénes Medzihradszky , Bea Mézes , Eszter Kovács , Ernö Duda , Beatrix Farkas , Attila Glatz
发明人： László Vígh , Péter Literáti Nagy , Jenö Szilbereky , László Ürögdi , Andrea Jednákovits , László Jaszlits , Katalin Bíró , Ede Márványos , Mihály Barabás , Erzsébet Hegedüs , László Korányi , Mária Kürthy , Gábor Balogh , Ibolya Horváth , Zsolt Török , Éva Udvardy , György Dormán , Dénes Medzihradszky , Bea Mézes , Eszter Kovács , Ernö Duda , Beatrix Farkas , Attila Glatz
IPC分类号： A61K31/445 , A61K31/44 , A01N37/00
CPC分类号： C07D213/78 , C07C259/02 , C07C259/18 , C07C275/64 , C07C279/18 , C07C2601/14 , C07D213/89 , C07D215/54 , C07D217/26 , C07D295/088 , C07D307/68 , C07D333/38 , C07D409/12 , C07D413/04
摘要： A method of increasing expression of a molecular chaperon by a cell and/or enhancing the activity of a molecular chaperon in cells is provided. The method comprises treating a cell that is exposed to a physiological stress which induces expression of a molecular chaperon by the cell with an effective amount of a certain hydroxylamine derivative to increase the stress. Alternatively, an hydroxylamine derivative can be administrated to a cell before it is exposed to a physiological stress which induces expression of a molecular chaperon by the cell. Preferably, the cell to which an hydroxylamine derivative is administered is an eukaryotic cell. The hydroxylamine derivative corresponds to the formulae (I) or (II).The invention also provides novel hydroxylamine derivatives falling within the scope of the formulae (I) and (II) as well as pharmaceutical and/or cosmetical compositions comprising the said compounds.
摘要翻译：提供了增加细胞分子伴侣表达和/或提高细胞中分子伴侣活性的方法。所述方法包括用有效量的某种羟胺衍生物处理暴露于生理应激的细胞，所述生理应激诱导细胞表达分子伴侣以增加应激。或者，可以在细胞暴露于诱导细胞分子伴侣表达的生理应激之前向细胞施用羟胺衍生物。优选地，施用羟胺衍生物的细胞是真核细胞。羟胺衍生物对应于式（I）或（II）。本发明还提供了落入式（I）和（II）范围内的新型羟胺衍生物以及包含所述化合物的药物和/或化妆品组合物。

8. 发明申请

US20090312299A1 Isolated Isomers of Norelgestromin and Methods of Making and Using the Same 审中-公开
标题翻译：分离的异头孢菌素的异构体及其制备和使用方法
公开(公告)号：US20090312299A1
公开(公告)日：2009-12-17
申请号：US12500375
申请日：2009-07-09
申请人： Zoltán TUBA , Sándor MAHÓ , György KESERÜ , József KOZMA , János HORVÁTH , Gábor BALOGH
发明人： Zoltán TUBA , Sándor MAHÓ , György KESERÜ , József KOZMA , János HORVÁTH , Gábor BALOGH
IPC分类号： C07J41/00 , A61K31/56 , A61P15/00
CPC分类号： C07J41/0016 , A61K31/567
摘要： The invention is directed to a process of preparing substantially pure d-(17α)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene-20-yn-3-one-3E- and -3Z-oxime isomers, as well as a process for the synthesis of the mixture of isomers and the pure isomers. The invention also relates to substantially pure d-(17α)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene20-yn-3-one-3E-oxime and substantially pure d-(17α)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene-20-yn-3-one-3Z-oxime isomer. Further aspects of the invention include a composition comprising substantially pure d-(17α)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene20-yn-3-one-3E-oxime or substantially pure d-(17α)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene-20-yn-3-one-3Z-oxime isomer, and methods of treatment using said compositions.
摘要翻译：本发明涉及一种制备基本上纯的d-（17α）-13-乙基-17-羟基-18,19-二孕酮-4-烯-20-炔-3-酮-3E-和-3Z-肟的方法异构体，以及合成异构体和纯异构体混合物的方法。本发明还涉及基本上纯的d-（17α）-13-乙基-17-羟基-18,19-二孕酮-4-烯-20-炔-3-酮-3E-肟和基本上纯的d-（17α）-13 - 乙基-17-羟基-18,19-二孕酮-4-烯-20-炔-3-酮-3Z-肟异构体。本发明的其它方面包括包含基本上纯的d-（17α）-13-乙基-17-羟基-18,19-二孕酮-4-烯-20-炔-3-酮-3E-肟或基本上纯的d-（ 17α）-13-乙基-17-羟基-18,19-二孕酮-4-烯-20-炔-3-酮-3Z-肟异构体，以及使用所述组合物处理的方法。

9. 发明申请

US20100137622A1 INDUSTRIAL METHOD FOR THE SYNTHESIS OF 17-ACETOXY-11beta-[4-(DIMETHYLAMINO)-PHENYL]-21-METHOXY-19-NORPREGNA-4,9-DIEN-3,20-DIONE AND THE KEY INTERMEDIATES OF THE PROCESS 有权
标题翻译：合成17-乙酰氧基-11β-[4-（二甲基氨基） - 苯基] -2-甲氧基-19-壬基-4,9-二烯-3,20-二酮的工业方法及该方法的主要中间体
公开(公告)号：US20100137622A1
公开(公告)日：2010-06-03
申请号：US12598163
申请日：2008-06-19
申请人： József Bódi , György Visky , János Széles , Sándor Mahó , Csaba Sánta , János Csörgei , Zoltán Tuba , László Terdy , Csaba Molnár , Antal Aranyi , Zoltán Horváth , Gábor Balogh
发明人： József Bódi , György Visky , János Széles , Sándor Mahó , Csaba Sánta , János Csörgei , Zoltán Tuba , László Terdy , Csaba Molnár , Antal Aranyi , Zoltán Horváth , Gábor Balogh
IPC分类号： C07J9/00
CPC分类号： C07J41/0083 , C07J21/006 , C07J41/0094 , C07J51/00 , Y02P20/55
摘要： The present invention relates to a process for the synthesis of the known 17-acetoxy-11-β-[4-(dimethyl amino)-phenyl]-21-methoxy-19-norpregna-4,9-dien-3,20-dione (further on CDB-4124) of formula (I) from 3,3-[1,2-ethandiyl-bis(oxy)]-oestr-5(10),9(11)-dien-17-one of formula (II). Compound CDB-4124 belongs to the group of anti-hormones. The process has the following steps: i) formation of an epoxide; ii) addition of hydrogen cyanide; iii) silylation of a hydroxyl group; iv) reaction with 4-(dimethylamino)-phenyl magnesium bromide Grignard reagent in the presence of CuCl (Teutsch reaction); v) silylation of a hydroxyl group with trimethyl chlorosilane; vi) reaction with diisobutyl aluminum hydride and after addition of acid to the reaction mixture; vii) methoxy-methylation with methoxy-methyl Grignard reagent formed in situ, while hydrolyzing the trimethylsilyl protective groups; viii) oxidation of a hydroxyl group with dicyclohexyl carbodiimide in the presence of dimethyl sulfoxide and a strong organic acid (Swern oxidation), and in given case after purification by chromatography; ix) acetylation of a hydroxyl group with acetic anhydride in the presence of perchloric acid, and in given case, purification by chromatography. The invention also relates to new intermediates of the process.
摘要翻译：本发明涉及合成已知的17-乙酰氧基-11-二 - [4-（二甲基氨基） - 苯基] -2-甲氧基-19-去甲基-4,9-二烯-3,20 （I）的3,3- [1,2-乙二基 - 双（氧基）] - 甲酯-5（10），9（11） - 二烯-17-酮（另外在CDB-4124上）式（II）。化合物CDB-4124属于抗激素类。该方法具有以下步骤：i）形成环氧化物; ii）加入氰化氢; iii）羟基的甲硅烷基化; iv）在CuCl（Teutsch反应）存在下与4-（二甲基氨基） - 苯基溴化镁格氏试剂反应; v）用三甲基氯硅烷甲硅烷基化羟基; vi）与二异丁基氢化铝反应并向反应混合物中加入酸; vii）甲氧基甲基化与甲氧基甲基格氏试剂原位形成，同时水解三甲基甲硅烷基保护基; viii）在二甲基亚砜和强有机酸（Swern氧化）存在下，用二环己基碳二亚胺氧化羟基，在给定的情况下，通过色谱法纯化; ix）在高氯酸存在下用乙酸酐乙酰化羟基，在给定的情况下，通过色谱法纯化。本发明还涉及该方法的新中间体。

10. 发明授权

US07576226B2 Process of making isomers of norelgestromin and methods using the same 失效
标题翻译：制备炔诺孕酮异构体的方法及使用其的方法
公开(公告)号：US07576226B2
公开(公告)日：2009-08-18
申请号：US10879710
申请日：2004-06-30
申请人： Zoltán Tuba , Sándor Mahó , György Keserü , József Kozma , János Horváth , Gábor Balogh
发明人： Zoltán Tuba , Sándor Mahó , György Keserü , József Kozma , János Horváth , Gábor Balogh
IPC分类号： C07J41/00
CPC分类号： C07J41/0016 , A61K31/567
摘要： The invention is directed to a process of preparing substantially pure d-(17α)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene-20-yn-3-one-3E- and -3Z-oxime isomers, as well as a process for the synthesis of the mixture of isomers and the pure isomers. The invention also relates to substantially pure d-(17α)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene20-yn-3-one-3E-oxime and substantially pure d-(17α)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene-20-yn-3-one-3Z-oxime isomer. Further aspects of the invention include a composition comprising substantially pure d-(17α)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene20-yn-3-one-3E-oxime or substantially pure d-(17α)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene-20-yn-3-one-3Z-oxime isomer, and methods of treatment using said compositions.
摘要翻译：本发明涉及一种制备基本上纯的d-（17α）-13-乙基-17-羟基-18,19-二孕酮-4-烯-20-炔-3-酮-3E-和-3Z-肟的方法异构体，以及合成异构体和纯异构体混合物的方法。本发明还涉及基本上纯的d-（17α）-13-乙基-17-羟基-18,19-二孕酮-4-烯-20-炔-3-酮-3E-肟和基本上纯的d-（17α）-13 - 乙基-17-羟基-18,19-二孕酮-4-烯-20-炔-3-酮-3Z-肟异构体。本发明的其它方面包括包含基本上纯的d-（17α）-13-乙基-17-羟基-18,19-二孕酮-4-烯-20-炔-3-酮-3E-肟或基本上纯的d-（ 17α）-13-乙基-17-羟基-18,19-二孕酮-4-烯-20-炔-3-酮-3Z-肟异构体，以及使用所述组合物处理的方法。

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