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1. 发明专利

JP2010070463A Nutrition-supplementing beverage 审中-公开
标题翻译：营养补充饮料
公开(公告)号：JP2010070463A
公开(公告)日：2010-04-02
申请号：JP2008236787
申请日：2008-09-16
申请人： Fukumi Morishige , 福美森重
发明人： MORISHIGE FUKUMI
IPC分类号： A61K31/7105 , A23L1/30 , A23L1/304 , A23L1/305 , A61K9/08 , A61K31/198 , A61K31/375 , A61K31/7052 , A61K35/60 , A61K36/06 , A61P3/02 , A61P25/00 , A61P25/02 , A61P29/00
摘要： PROBLEM TO BE SOLVED: To provide a nutrition-supplementing beverage inhibiting Maillard reaction (browning) caused by L-arginine with L-ascorbic acid, and also reducing the astringent taste and astringent feeling of the L-arginine. SOLUTION: This nutrition-supplementing beverage is provided by containing (a) 0.03 to 3 mass%≥1 kind of a compound selected from the group consisting of an RNA, a ribonucleotide and a ribonucleoside, (b) 0.5 to 9 mass% L-arginine, (c) 0.1 to 10 mass% L-ascorbic acid and (d) 0 to 6 mass% pH-adjusting agent, based on the total mass of the beverage, and having pH 3 to 4. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：待解决的问题：提供营养补充饮料，其抑制由L-精氨酸与L-抗坏血酸引起的美拉德反应（褐变），并且还降低L-精氨酸的收敛味和收敛感。解决方案：该营养补充饮料通过含有（a）0.03〜3质量％≥1种选自由RNA，核糖核苷酸和核糖核苷组成的组的化合物，（b）0.5〜9质量％％L-精氨酸，（c）0.1〜10质量％的L-抗坏血酸和（d）0〜6质量％的pH调节剂，基于饮料的总质量，pH为3〜4。版权所有（C）2010，JPO＆INPIT

2. 发明专利

JP2010047519A Agent for treating fibromyalgia syndrome, and agent for treating pain caused by muscle spasm 有权
标题翻译：治疗纤维瘤综合征的药剂，以及用于治疗由肌肉SPASM引起的疼痛的药剂
公开(公告)号：JP2010047519A
公开(公告)日：2010-03-04
申请号：JP2008213345
申请日：2008-08-21
申请人： Fukumi Morishige , 福美森重
发明人： MORISHIGE FUKUMI
IPC分类号： A61K31/7105 , A61K31/198 , A61K31/375 , A61K35/60 , A61K36/06 , A61P9/00 , A61P21/00 , A61P29/00
CPC分类号： A61K31/375 , A61K9/14 , A61K31/198 , A61K36/064 , A61K2300/00
摘要： PROBLEM TO BE SOLVED: To provide a treating agent of fibromyalgia syndrome and an agent for treating pain caused by vascular smooth muscle spasm. SOLUTION: The treating agent of fibromyalgia syndrome and the agent for treating pain caused by vascular smooth muscle spasm are provided by containing (a) ≥1 compound selected from the group consisting of an RNA, a ribonucleotide and a ribonucleoside, (b) ≥1 compound selected from the group consisting of L-arginine, L-citrullin and L-ornithine, and (c) L-ascorbic acid, and having (1:0.2 to 20) mass ratio of the component (b) to the component (c). COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：待解决的问题：提供纤维肌痛综合征的治疗剂和用于治疗由血管平滑肌痉挛引起的疼痛的药剂。解决方案：通过含有（a）选自RNA，核糖核苷酸和核糖核苷酸的≥1种化合物（b），提供纤维肌痛综合征的治疗剂和治疗由血管平滑肌痉挛引起的疼痛的药剂）≥1种选自L-精氨酸，L-瓜氨酸和L-鸟氨酸的化合物和（c）L-抗坏血酸，并且组分（b）与（b）的质量比（1:0.2至20）组分（c）。版权所有（C）2010，JPO＆INPIT

3. 发明专利

JP2003335664A Nutritional preparation for cerebrospinal nerve containing arginine and rna 有权
标题翻译：含有ARGININE和RNA的骨髓神经营养制剂
公开(公告)号：JP2003335664A
公开(公告)日：2003-11-25
申请号：JP2002140390
申请日：2002-05-15
申请人： Kimoto Sachiko , Fukumi Morishige , 木本幸子 , 福美森重
发明人： KIMOTO EIJI , MORISHIGE FUKUMI
IPC分类号： A23L1/30 , A61K31/198 , A61K31/375 , A61K31/7052 , A61K31/7088 , A61K31/7105 , A61K35/60 , A61K47/26 , A61P25/00
摘要： PROBLEM TO BE SOLVED: To provide a nutritional preparation for cerebrospinal nerve for promoting RNA nutritional effect. SOLUTION: This nutritional preparation for cerebrospinal nerve is used also as a nutritional supplement food product and comprising RNA, ribonucleotide and/or ribonucleoside (hereafter, referred to as RNA, and/or the like) in the form of powder, L-arginine powder, and L-ascorbic acid powder at 0.2-20 wt. time(s) the L-arginine powder. Incorporation of the L-arginine powder promotes the nutritional effect by the RNA, and/or the like. The incorporation of the L-ascorbic acid eliminates the harsh taste inherent in L-arginine, mitigates the harsh feeling of the stomach (heartburn, nausea, vomiting, or the like) and has the preventing effect on cytotoxicity that may be caused by intake of a large amount of L-arginine. Further, by making the form of the three components, i.e., the RNA, and/or the like, L-arginine and L-ascorbic acid, into dry powder, this nutritional preparation can avoid its getting brownish due to long-term storage. COPYRIGHT: (C)2004,JPO
摘要翻译：要解决的问题：提供脑脊髓营养制剂，以促进RNA的营养作用。解决方案：这种脑脊髓营养制剂也用作营养补充食品，并且包含粉末形式的RNA，核糖核苷酸和/或核糖核苷（以下称为RNA等），L 精氨酸粉末和L-抗坏血酸粉末，重量比为0.2-20重量％。时间（L）精氨酸粉末。 L-精氨酸粉末的掺入促进RNA的营养效果和/或类似物质。 L-抗坏血酸的结合消除了L-精氨酸固有的恶劣味道，减轻了胃的刺激感（胃灼热，恶心，呕吐等），并且具有防止由于摄入引起的细胞毒性的作用大量的L-精氨酸。此外，通过将三种成分，即RNA等的形式，L-精氨酸和L-抗坏血酸的形式制成干粉，该营养制剂可以避免由于长期储存而变得褐色。版权所有（C）2004，JPO

4. 发明专利

JP2004089004A Arginine and rna-containing nutritional supplement for complementary therapy 审中-公开
公开(公告)号：JP2004089004A
公开(公告)日：2004-03-25
申请号：JP2002250574
申请日：2002-08-29
申请人： Kimoto Sachiko , Fukumi Morishige , 木本幸子 , 森重福美
发明人： KIMOTO EIJI , MORISHIGE FUKUMI
IPC分类号： A23L1/30 , A23L1/305 , A61K9/14 , A61K31/198 , A61K31/375 , A61K31/7105 , A61K35/60 , A61K36/06 , A61P3/02 , A61K35/72
摘要： PROBLEM TO BE SOLVED: To facilitate nutritional effect of an RNA. SOLUTION: This nutritional supplement for complementary therapy comprises the RNA, powder of ribonureotide and/or ribonucleoside (hereafter, referred to as RNA, and/or the like), L-arginine powder, and L-ascorbic acid powder at 0.2-20 wt. time(s) the L-arginine powder. Incorporation of the L-arginine powder promotes the nutritional effect by the RNA, and/or the like. The incorporation of the L-ascorbic acid eliminates the harsh taste inherent in L-arginine and mitigates the harsh feeling of the stomach (heartburn, nausea, vomiting, or the like) and has the preventing effect on cytotoxicity that may be caused by the intake of a large amount of L-arginine. Further, by making the form of the three components, i.e., the RNA, and/or the like, L-arginine and L-ascorbic acid, into dry powder, this nutritional supplement can avoid its getting brownish due to long-term storage. COPYRIGHT: (C)2004,JPO

5. 发明申请

US20100113578A1 Prevention of and countermeasures against mitochondrial disease 审中-公开
标题翻译：预防和对抗线粒体疾病
公开(公告)号：US20100113578A1
公开(公告)日：2010-05-06
申请号：US12654963
申请日：2010-01-11
申请人： Fukumi Morishige
发明人： Fukumi Morishige
IPC分类号： A61K31/375 , A61K31/7088 , A61K31/706
CPC分类号： A61K31/198 , A61K31/375 , A61K2300/00
摘要： The present invention relates to an agent containing L-arginine, 0.2 to 20 parts by weight of L-ascorbic acid per 1 part by weight of L-arginine, and, if desired, at least one selected from the group consisting of ribonucleic acids, ribonucleotides and ribonucleosides. The agent can treat mitochondrial disease which shows a variety of symptoms caused by dysfunction of mitochondria in cells. L-arginine contained in the agent for treating mitochondrial disease of the present invention increases an NO radical level to thereby dilate the arteries. L-ascorbic acid serves to mitigate a harsh taste and acrid feeling accompanied with the intake of L-arginine and eliminate excessive NO radicals.
摘要翻译：本发明涉及含有L-精氨酸的试剂，每1重量份L-精氨酸0.2〜20重量份的L-抗坏血酸，如果需要，可以使用选自核糖核酸，核糖核苷酸和核糖核苷。该药物可以治疗线粒体疾病，其显示由细胞中线粒体功能障碍引起的各种症状。本发明的用于治疗线粒体疾病的药物中所含的L-精氨酸增加了NO自由基水平从而使动脉扩张。 L-抗坏血酸用于减轻伴随摄入L-精氨酸的苛刻味道和刺激感，并消除过量的NO自由基。

6. 发明申请

US20090209640A1 Prevention of and countermeasures against viral infection 审中-公开
标题翻译：预防和对抗病毒感染
公开(公告)号：US20090209640A1
公开(公告)日：2009-08-20
申请号：US12385667
申请日：2009-04-15
申请人： Fukumi Morishige
发明人： Fukumi Morishige
IPC分类号： A61K31/375 , A61P31/12
CPC分类号： A61K31/198 , A61K31/375 , A61K2300/00
摘要： The present invention relates to a method for treating viral infection, which includes administering arginine and a high dose of vitamin C. It also relates to an agent for treating viral infection, which includes arginine and coated vitamin C.
摘要翻译：本发明涉及治疗病毒感染的方法，其包括给予精氨酸和高剂量的维生素C.它还涉及用于治疗病毒感染的药物，其包括精氨酸和包被的维生素C.

7. 发明申请

US20050256186A1 Prevention of and countermeasures against mitochondrial disease 审中-公开
标题翻译：预防和对抗线粒体疾病
公开(公告)号：US20050256186A1
公开(公告)日：2005-11-17
申请号：US10518768
申请日：2004-03-05
申请人： Fukumi Morishige
发明人： Fukumi Morishige
IPC分类号： A61K31/198 , A61K31/375 , A61P43/00
CPC分类号： A61K31/198 , A61K31/375 , A61K2300/00
摘要： The present invention relates to an agent containing L-arginine, 0.2 to 20 parts by weight of L-ascorbic acid per 1 part by weight of L-arginine, and, if desired, at least one selected from the group consisting of ribonucleic acids, ribonucleotides and ribonucleosides. The agent can treat mitochondrial disease which shows a variety of symptoms caused by dysfunction of mitochondria in cells. L-arginine contained in the agent for treating mitochondrial disease of the present invention increases an NO radical level to thereby dilate the arteries. L-ascorbic acid serves to mitigate a harsh taste and acrid feeling accompanied with the intake of L-arginine and eliminate excessive NO radicals.
摘要翻译：本发明涉及含有L-精氨酸的试剂，每1重量份L-精氨酸0.2〜20重量份的L-抗坏血酸，如果需要，可以使用选自核糖核酸，核糖核苷酸和核糖核苷。该药物可以治疗线粒体疾病，其显示由细胞中线粒体功能障碍引起的各种症状。本发明的用于治疗线粒体疾病的药物中所含的L-精氨酸增加了NO自由基水平从而使动脉扩张。 L-抗坏血酸用于减轻伴随摄入L-精氨酸的苛刻味道和刺激感，并消除过量的NO自由基。

8. 发明申请

US20030073739A1 Novel arginine/ascorbic acid mixed powder as an oral supplement 失效
公开(公告)号：US20030073739A1
公开(公告)日：2003-04-17
申请号：US10294862
申请日：2002-11-15
申请人： Fukumi Morishige
发明人： Eiji Kimoto , Fukumi Morishige
IPC分类号： A61K031/375 , A61K031/198
CPC分类号： A61K45/06 , A61K31/198 , A61K31/375 , A61K2300/00
摘要： A mixture obtained by mixing ascorbic acid powder with arginine powder in a weight ratio (ascorbic acid/arginine) of 1/5 to 20, especially 1/5 to 1/4; and a supplement such as a nutrient preparation and a health-care food containing the mixture. Mixing of arginine powder and ascorbic acid powder in the weight ratios eliminates stringent taste specific to arginine and alleviates stringent feeling in the stomach (heartburn, nausea or vomiting) after oral intake thereof. The mixture prevents also peroxidative injuries of cells caused by an administration of a great amount of arginine alone. Further, mixing of arginine powder with ascorbic acid powder prevents browning of the mixture after long-term storage.

9. 发明授权

US06552074B2 Arginine/ascorbic acid mixed powder as an oral supplement 失效
标题翻译：精氨酸/抗坏血酸混合粉末作为口服补充剂
公开(公告)号：US06552074B2
公开(公告)日：2003-04-22
申请号：US09987179
申请日：2001-11-13
申请人： Eiji Kimoto , Fukumi Morishige
发明人： Eiji Kimoto , Fukumi Morishige
IPC分类号： A61K3134
CPC分类号： A61K45/06 , A61K31/198 , A61K31/375 , A61K2300/00
摘要： A mixture obtained by mixing ascorbic acid powder with arginine powder in a weight ratio (ascorbic acid/arginine) of ⅕ to 20, especially ⅕ to ¼; and a supplement such as a nutrient preparation and a health-care food containing the mixture. Mixing of arginine powder and ascorbic acid powder in the weight ratios eliminates stringent taste specific to arginine and alleviates stringent feeling in the stomach (heartburn, nausea or vomiting) after oral intake thereof. The mixture prevents also peroxidative injuries of cells caused by an administration of a great amount of arginine alone. Further, mixing of arginine powder with ascorbic acid powder prevents browning of the mixture after long-term storage.
摘要翻译：将抗坏血酸粉末与精氨酸粉末（抗坏血酸/精氨酸）的重量比（1/5至20，特别是1/5至1/4）混合，以及补充剂，例如营养制剂和含有该混合物的保健食品。混合精氨酸粉末和抗坏血酸粉末的重量比消除了对精氨酸特异性的严格味道，并减轻了口服摄入后胃中的严重感觉（胃灼热，恶心或呕吐）。该混合物还防止单独施用大量精氨酸引起的细胞的过氧化损伤。此外，精氨酸粉末与抗坏血酸粉末的混合可以防止长期储存后混合物的褐变。

10. 发明授权

US07214709B2 Arginine/ascorbic acid mixed powder as an oral supplement 失效
标题翻译：精氨酸/抗坏血酸混合粉末作为口服补充剂
公开(公告)号：US07214709B2
公开(公告)日：2007-05-08
申请号：US10294862
申请日：2002-11-15
申请人： Eiji Kimoto , Fukumi Morishige
发明人： Eiji Kimoto , Fukumi Morishige
IPC分类号： A61K31/34 , A61K31/195
CPC分类号： A61K45/06 , A61K31/198 , A61K31/375 , A61K2300/00
摘要： A mixture obtained by mixing ascorbic acid powder with arginine powder in a weight ratio (ascorbic acid/arginine) of 1/5 to 20, especially 1/5 to 1/4; and a supplement such as a nutrient preparation and a health-care food containing the mixture. Mixing of arginine powder and ascorbic acid powder in the weight ratios eliminates stringent taste specific to arginine and alleviates stringent feeling in the stomach (heartburn, nausea or vomiting) after oral intake thereof. The mixture prevents also peroxidative injuries of cells caused by an administration of a great amount of arginine alone. Further, mixing of arginine powder with ascorbic acid powder prevents browning of the mixture after long-term storage.
摘要翻译：将抗坏血酸粉末与精氨酸粉末（抗坏血酸/精氨酸）的重量比为1/5至20，特别是1/5至1/4的混合物; 以及补充剂，例如营养制剂和含有该混合物的保健食品。混合精氨酸粉末和抗坏血酸粉末的重量比消除了对精氨酸特异性的严格味道，并减轻了口服摄入后胃中的严重感觉（胃灼热，恶心或呕吐）。该混合物还防止单独施用大量精氨酸引起的细胞的过氧化损伤。此外，精氨酸粉末与抗坏血酸粉末的混合可以防止长期储存后混合物的褐变。

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