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1. 发明申请

US20110142842A1 POLYPEPTIDES 审中-公开
公开(公告)号：US20110142842A1
公开(公告)日：2011-06-16
申请号：US12741573
申请日：2008-11-05
申请人： Johanna Petra Olweus , Fridtjof Lund-Johansen , Philippe Sebastien Walchli , Erlend Stronen , Jorunn Johansen
发明人： Johanna Petra Olweus , Fridtjof Lund-Johansen , Philippe Sebastien Walchli , Erlend Stronen , Jorunn Johansen
IPC分类号： A61K39/395 , A61K31/7088 , A61K35/12 , A61P35/00
CPC分类号： C07K14/7051 , A61K35/17 , A61K38/00 , A61K39/0011 , A61K2039/5158
摘要： There is disclosed a polypeptide consisting of between 7 and 100 amino acids and comprising: the sequence of the peptide of any one of SEQ. ID NOS: 1 to 145. There is also disclosed a T-cell receptor, or a peptide-binding fragment thereof, wherein the CDR3 region of the beta chain of the T-cell receptor comprises a glycine residue at position 5 from the N-terminus. The T-cell receptor is capable of binding a peptide consisting of the sequence of SEQ. ID NO. 18, when the peptide is presented on an HLA molecule of a first HLA allele.
摘要翻译：公开了由7至100个氨基酸组成的多肽，其包含：SEQ ID NO：还公开了一种T细胞受体或其肽结合片段，其中T细胞受体的β链的CDR3区域包含位于第5位的N-末端的甘氨酸残基，终点。 T细胞受体能够结合SEQ ID NO：证件号码。 18，当肽存在于第一HLA等位基因的HLA分子上时。

2. 发明授权

US06555324B1 Method to distinguish hematopoietic progenitor cells 失效
标题翻译：区分造血祖细胞的方法
公开(公告)号：US06555324B1
公开(公告)日：2003-04-29
申请号：US08147707
申请日：1993-11-04
申请人： Johanna Olweus , Fridtjof Lund-Johansen , Leon Wmm Terstappen
发明人： Johanna Olweus , Fridtjof Lund-Johansen , Leon Wmm Terstappen
IPC分类号： G01N33566
CPC分类号： C12N5/0647 , G01N33/56977
摘要： The expression of various cell adhesion molecules and growth factor receptor was examined on human progenitor cells (i.e., CD34+/CD38+). Certain changes in the expression if one or more of these molecules and receptors correlates with the progression of cell from non-lineage committed to commitment to a specific lineage. Using one or more markers for these molecules and/or receptors in combination with markers for CD34 and CD38 will enable one to identify and isolate each of the different progenitor cell populations.
摘要翻译：在人祖细胞（即CD34 + / CD38 +）上检查各种细胞粘附分子和生长因子受体的表达。如果这些分子和受体中的一种或多种与从承诺到特定谱系的非谱系的细胞进展相关联，则表达的某些变化。将这些分子和/或受体结合用于CD34和CD38的标记物使用一种或多种标记将使得能够鉴别和分离每种不同的祖细胞群体。

3. 发明授权

US06294381B1 CD123+ dendritic cells in blood and lymphoid tissues 有权
标题翻译： CD123 +血液和淋巴组织中的树突状细胞
公开(公告)号：US06294381B1
公开(公告)日：2001-09-25
申请号：US09391946
申请日：1999-09-08
申请人： Johanna Olweus , Fridtjof Lund-Johansen
发明人： Johanna Olweus , Fridtjof Lund-Johansen
IPC分类号： C12N506
CPC分类号： G01N33/56972 , C07K16/2866 , C12N5/0639 , C12N2501/22 , C12N2501/25 , G01N33/56966 , Y10S436/824
摘要： Dendritic cells (DCs) are the primary antigen presenting cells during the initiation of T cell-dependent immune responses. The cells originate from the bone marrow and have been suggested to represent a distinct cell lineage. However, distinct DC precursors have not been identified in bone marrow, and mature monocytes can also give rise to DCs. The instant invention presents a distinct DC precursor among bone marrow CD34+ cells. The cells express high levels of the interleukin-3 receptor &agr; chain and CD4 and can be uniquely identified also in blood and lymphoid tissues by this phenotype.
摘要翻译：树突状细胞（DCs）是T细胞依赖性免疫应答开始期间的主要抗原呈递细胞。细胞起源于骨髓，并被认为是代表不同的细胞谱系。然而，在骨髓中尚未发现不同的DC前体，而成熟的单核细胞也可能引起DCs。本发明在骨髓CD34 +细胞中呈现明显的DC前体。细胞表达高水平的白细胞介素-3受体α链和CD4，并且可以通过该表型在血液和淋巴组织中独特地鉴定。

4. 发明授权

US6008004A Identification of a CD34+ bone marrow precursor for dendritic cells in blood and lymphoid tissues 失效
标题翻译：鉴定血液和淋巴组织中树突状细胞的CD34 +骨髓前体
公开(公告)号：US6008004A
公开(公告)日：1999-12-28
申请号：US939545
申请日：1997-09-29
申请人： Johanna Olweus , Fridtjof Lund-Johansen
发明人： Johanna Olweus , Fridtjof Lund-Johansen
IPC分类号： C07K16/28 , C12N5/0784 , G01N33/569 , G01N33/53 , C12N5/08
CPC分类号： G01N33/56972 , C07K16/2866 , C12N5/0639 , G01N33/56966 , C12N2501/22 , C12N2501/25 , Y10S436/824
摘要： Dendritic cells (DCs) are the primary antigen presenting cells during the initiation of T cell-dependent immune responses. The cells originate from the bone marrow and have been suggested to represent a distinct cell lineage. However, distinct DC precursors have not been identified in bone marrow, and mature monocytes can also give rise to DCs. The instant invention presents a distinct DC precursor among bone marrow CD34+ cells. The cells express high levels of the interleukin-3 receptor a chain and CD4 and can be uniquely identified also in blood and lymphoid tissues by this phenotype.
摘要翻译：树突状细胞（DCs）是T细胞依赖性免疫应答开始期间的主要抗原呈递细胞。细胞起源于骨髓，并被认为是代表不同的细胞谱系。然而，在骨髓中尚未发现不同的DC前体，而成熟的单核细胞也可能引起DCs。本发明在骨髓CD34 +细胞中呈现明显的DC前体。细胞表达高水平的白细胞介素-3受体a链和CD4，并且可以通过该表型在血液和淋巴组织中独特地鉴定。

5. 发明申请

US20110135929A1 MULTICOLORED PARTICLES 审中-公开
标题翻译：混合颗粒
公开(公告)号：US20110135929A1
公开(公告)日：2011-06-09
申请号：US12961811
申请日：2010-12-07
申请人： Fridtjof Lund-Johansen
发明人： Fridtjof Lund-Johansen
IPC分类号： C08G83/00
CPC分类号： G01N33/533 , B82Y5/00 , B82Y10/00 , Y10T428/2982
摘要： The present invention relates to a set of polymer particles stained with at least two fluorescent dyes, wherein at least 16 subsets of particles can be resolved on the basis of variable emission from the at least two fluorescent dyes wherein emission from at least one dye derives from a fluorescent dye covalently attached to the particle surface, and wherein all particles in said set of polymer particles can bind a uniform amount of a capture reagent. The invention also relates to a method for the preparation of said set of polymer particles as well as a kit comprising said set of polymer particles. The invention further relates to methods and uses of said set of polymer particles.
摘要翻译：本发明涉及用至少两种荧光染料染色的一组聚合物颗粒，其中可以基于来自至少两种荧光染料的可变发射来分辨至少16个亚类的颗粒，其中至少一种染料的发射来源于共价连接到颗粒表面的荧光染料，并且其中所述聚合物颗粒组中的所有颗粒可以结合均匀量的捕获试剂。本发明还涉及制备所述聚合物颗粒组的方法以及包含所述聚合物颗粒组的试剂盒。本发明还涉及所述聚合物颗粒组的方法和用途。

6. 发明授权

US07897407B2 Multicolored particles 失效
标题翻译：多彩的颗粒
公开(公告)号：US07897407B2
公开(公告)日：2011-03-01
申请号：US11995418
申请日：2006-07-10
申请人： Fridtjof Lund-Johansen
发明人： Fridtjof Lund-Johansen
IPC分类号： G01N21/77 , C12Q1/00
CPC分类号： G01N33/533 , B82Y5/00 , B82Y10/00 , Y10T428/2982
摘要： A set of polymer particles stained with at least two fluorescent dyes is presented. At least 16 subsets of particles can be resolved on the basis of variable emission from the at least two fluorescent dyes where emission from at least one dye derives from a fluorescent dye covalently attached to the particle surface. All particles in the set of polymer particles can bind a uniform amount of a capture reagent. A method for the preparation of the set of polymer particles as well as a kit including the set of polymer particles is also presented as well as methods and uses of the set of polymer particles.
摘要翻译：提出了一组用至少两种荧光染料染色的聚合物颗粒。可以基于来自至少两种荧光染料的可变发射来解析至少16个颗粒子集，其中来自至少一种染料的发射源自共价连接到颗粒表面的荧光染料。聚合物颗粒组中的所有颗粒可以结合均匀量的捕获试剂。还提出了制备该组聚合物颗粒的方法以及包含该组聚合物颗粒的试剂盒以及该组聚合物颗粒的方法和用途。

7. 发明授权

US5840580A Phenotypic characterization of the hematopoietic stem cell 失效
标题翻译：造血干细胞的表型表征
公开(公告)号：US5840580A
公开(公告)日：1998-11-24
申请号：US856406
申请日：1997-05-14
申请人： Leon W. Terstappen , Michael R. Loken , Shiang Huang , Johanna Olweus , Fridtjof Lund-Johansen
发明人： Leon W. Terstappen , Michael R. Loken , Shiang Huang , Johanna Olweus , Fridtjof Lund-Johansen
IPC分类号： A61K35/14 , A61K35/28 , A61K48/00 , C12N5/0789 , A01N63/00 , C12N5/06 , C12N5/08
CPC分类号： C12N5/0647 , A61K35/28 , A61K48/00
摘要： One or more population of cells enriched for human hematopoietic stem cells is disclosed. HSC in this population of cells are capable of limited self-renewal and are capable of differentiating into all elements of the hematopoietic system. This population of cells has the phenotype of CD34.sup.+ /CD38.sup.- and more preferably CD34.sup.+ /CD38.sup.- /HLA-DR.sup.+. Cells within this population have been found to express CD13, CD33 and CD71. Hematopoietic stem cells can be used in a number of therapies, including autologous transplantation and in gene therapy.
摘要翻译：公开了一种或多种富含人造血干细胞的细胞群。 HSC在这个细胞群中能够有限的自我更新，并能够区分成造血系统的所有元素。这种细胞群具有CD34 + / CD38-，更优选CD34 + / CD38- / HLA-DR +的表型。已经发现该群体内的细胞表达CD13，CD33和CD71。造血干细胞可用于许多疗法，包括自体移植和基因治疗。

8. 发明申请

US20100273677A1 PROTEIN ANALYSIS 审中-公开
标题翻译：蛋白质分析
公开(公告)号：US20100273677A1
公开(公告)日：2010-10-28
申请号：US12809879
申请日：2008-12-19
申请人： Fridtjof Lund-Johansen
发明人： Fridtjof Lund-Johansen
IPC分类号： C40B30/04 , C40B40/10 , C40B40/06
CPC分类号： G01N33/6842 , G01N15/1459 , G01N33/573 , G01N33/582
摘要： A method of analysing the interaction between a mixture of molecular components and a group of binding agents includes the following steps. (i) Separating the molecular components in the mixture into a plurality of fractions on the basis of a physical parameter. (ii) Providing a plurality of different binding agents. (iii) Contacting the binding agents with at least two of the fractions and detecting the binding of the molecular components in each fraction to the binding agents. (iv) Detecting the presence of a plurality of the molecular components by the binding of the molecular components to the binding agents.
摘要翻译：分析分子组分和一组结合剂的混合物之间的相互作用的方法包括以下步骤。（i）基于物理参数将混合物中的分子组分分离成多个级分。（ii）提供多种不同的粘合剂。（iii）将结合剂与至少两个级分接触并检测每个级分中的分子组分与结合剂的结合。（iv）通过分子组分与结合剂的结合来检测多个分子组分的存在。

9. 发明申请

US20090137060A1 MULTICOLORED PARTICLES 失效
标题翻译：混合颗粒
公开(公告)号：US20090137060A1
公开(公告)日：2009-05-28
申请号：US11995418
申请日：2006-07-10
申请人： Fridtjof Lund-Johansen
发明人： Fridtjof Lund-Johansen
IPC分类号： G01N21/76 , C08F289/00
CPC分类号： G01N33/533 , B82Y5/00 , B82Y10/00 , Y10T428/2982
摘要： A set of polymer particles stained with at least two fluorescent dyes is presented. At least 16 subsets of particles can be resolved on the basis of variable emission from the at least two fluorescent dyes where emission from at least one dye derives from a fluorescent dye covalently attached to the particle surface. All particles in the set of polymer particles can bind a uniform amount of a capture reagent. A method for the preparation of the set of polymer particles as well as a kit including the set of polymer particles is also presented as well as methods and uses of the set of polymer particles.
摘要翻译：提出了一组用至少两种荧光染料染色的聚合物颗粒。可以基于来自至少两种荧光染料的可变发射来解析至少16个颗粒子集，其中来自至少一种染料的发射源自共价连接到颗粒表面的荧光染料。聚合物颗粒组中的所有颗粒可以结合均匀量的捕获试剂。还提出了制备该组聚合物颗粒的方法以及包含该组聚合物颗粒的试剂盒以及该组聚合物颗粒的方法和用途。

10. 发明授权

US6096540A Differentiation of granulocytic and monocytic progenitor cells 失效
标题翻译：粒细胞和单核细胞祖细胞的分化
公开(公告)号：US6096540A
公开(公告)日：2000-08-01
申请号：US724725
申请日：1996-09-30
申请人： Johanna Olweus , Fridtjof Lund-Johansen , Peter Thompson
发明人： Johanna Olweus , Fridtjof Lund-Johansen , Peter Thompson
IPC分类号： C12N5/0786 , C12N5/0787 , G01N33/569 , C12N5/00 , C12N5/06 , C12N5/08
CPC分类号： C12N5/0645 , C12N5/0642 , G01N33/56972 , C12N2501/125 , C12N2501/14 , C12N2501/22 , C12N2501/23
摘要： The present invention demonstrates that M-CSF responsiveness and the M-CSFR expression can be used to discriminate monocytic and granulocytic cells within a population of cells which strongly expresses the CD34 antigen (CD34.sup.hi). Briefly, the method comprises isolating phenotypically and functionally defined CD34.sup.+ subsets, and staining with anti-M-CSFR monoclonal antibodies to measure expression on these primitive progenitors and cells committed to the granulocytic and monocytic lineages, based upon expression of M-CSFR. CD34.sup.hi M-CSFR.sup.hi cells are highly clonogenic and approximately 70% of the colonies are CFU-M (monocytic), whereas less than 20% were CFU-G (granulocytic). In contrast, CD34.sup.hi cells that were positive for the granulo-monocytic marker CD64 and negative for the M-CSFR contained high frequencies of 91% pure CFU-Gs. After 60 h in culture, CD34.sup.hi M-CSFR.sup.hi cells developed into distinct populations of M-CSFR.sup.hi and M-CSFR.sup.lo cells. These two populations gave rise almost exclusively to monocytes and granulocytes, respectively. This result demonstrates that M-CSF target specificity among human hematopoietic progenitor cells is determined by lineage-specific regulation of the M-CSFR and demonstrate that M-CSFR is a useful marker to discriminate CFU-Ms from CFU-Gs.
摘要翻译：本发明证明M-CSF反应性和M-CSFR表达可用于区分强烈表达CD34抗原（CD34hi）的细胞群体内的单核细胞和粒细胞。简而言之，该方法包括分离表型和功能定义的CD34 +亚群，并用抗M-CSFR单克隆抗体染色，以测量基于M-CSFR表达的这些原始祖细胞和致粒细胞和单核细胞谱系的细胞的表达。 CD34hiM-CSFRhi细胞高度克隆，大约70％的菌落是CFU-M（单核细胞），而小于20％是CFU-G（粒细胞）。相比之下，对于粒细胞单核细胞标志物CD64阳性且M-CSFR阴性的CD34hi细胞含有91％纯CFU-Gs的高频率。培养60 h后，CD34hiM-CSFRhi细胞发育成不同种群的M-CSFRhi和M-CSFRlo细胞。这两个群体几乎分别产生单核细胞和粒细胞。该结果表明，通过M-CSFR的谱系特异性调节来确定人造血祖细胞中的M-CSF靶特异性，并证明M-CSFR是鉴别CFU-Ms与CFU-Gs的有用标记。

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