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1. 发明申请

US20140147883A1 FILTER SUPPORT WITH A PHASE-CHANGING MEDIUM 有权
标题翻译：过滤器支持与相位变化中
公开(公告)号：US20140147883A1
公开(公告)日：2014-05-29
申请号：US14131757
申请日：2012-07-04
申请人： Menno Willem Jose Prins , Mikhail Mikhaylovich Ovsyanko , Freek Van Hemert , Arie Rombertus Van Doorn
发明人： Menno Willem Jose Prins , Mikhail Mikhaylovich Ovsyanko , Freek Van Hemert , Arie Rombertus Van Doorn
IPC分类号： G01N1/30
CPC分类号： G01N1/30 , G01N1/2813 , G01N1/36 , G01N33/48 , G01N33/569 , G02B21/34
摘要： The present invention relates to a method for processing isolated cells, in particular rare cells such as circulating tumor cells, to render them suitable for optical imaging, comprising the steps of (a) depositing filter material comprising captured cells on a phase-change medium; (b) melting said phase-change medium until the medium is spread out below said filter material; and (c) lowering the temperature of said phase-change medium until the medium solidifies, resulting in an optically flat filter comprising said cells at a fixed position. The method may additionally comprise an initial step of capturing a cell on a filter material. The phase-change medium, preferably paraffin wax, may comprise a porous, or mesh-like structure allowing the passage of a fluid through the medium. The phase-change medium may further be mounted on a carrier such as a glass carrier or a polymer material carrier. The present invention further relates to processed filter material comprising isolated cells suitable for optical imaging, which is obtainable by the method; the use of such filter material for diagnostic, histological, microbiological, biochemical, oncologic, or hematologic analysis, as well as a device for isolating cells or processing cells to render them suitable for optical imaging.
摘要翻译：本发明涉及一种用于处理分离的细胞，特别是稀有细胞例如循环肿瘤细胞以使其适合于光学成像的方法，包括以下步骤：（a）将包含捕获的细胞的过滤材料沉积在相变介质上; （b）熔化所述相变介质，直到介质在所述过滤材料之下展开; 和（c）降低所述相变介质的温度，直到介质凝固，得到包含所述电池在固定位置的光学平面滤光器。该方法可以另外包括在过滤材料上捕获细胞的初始步骤。相变介质，优选石蜡，可以包括允许流体通过介质的多孔或网状结构。相变介质还可以安装在诸如玻璃载体或聚合物材料载体的载体上。本发明还涉及包含可通过该方法获得的适于光学成像的分离的细胞的经处理的过滤材料; 使用这种过滤材料进行诊断，组织学，微生物学，生物化学，肿瘤学或血液学分析，以及用于分离细胞或处理细胞以使其适合于光学成像的装置。

2. 发明授权

US09291533B2 Filter support with a phase-changing medium 有权
标题翻译：过滤器支持与相变介质
公开(公告)号：US09291533B2
公开(公告)日：2016-03-22
申请号：US14131757
申请日：2012-07-04
申请人： Menno Willem Jose Prins , Mikhail Mikhaylovich Ovsyanko , Freek Van Hemert , Arie Rombertus Van Doorn
发明人： Menno Willem Jose Prins , Mikhail Mikhaylovich Ovsyanko , Freek Van Hemert , Arie Rombertus Van Doorn
IPC分类号： G02B21/34 , G01N1/28 , G01N1/30 , G01N1/36 , G01N33/569 , G01N33/48
CPC分类号： G01N1/30 , G01N1/2813 , G01N1/36 , G01N33/48 , G01N33/569 , G02B21/34
摘要： The present invention relates to a method for processing isolated cells, in particular rare cells such as circulating tumor cells, to render them suitable for optical imaging, comprising the steps of (a) depositing filter material comprising captured cells on a phase-change medium; (b) melting said phase-change medium until the medium is spread out below said filter material; and (c) lowering the temperature of said phase-change medium until the medium solidifies, resulting in an optically flat filter comprising said cells at a fixed position. The method may additionally comprise an initial step of capturing a cell on a filter material. The phase-change medium, preferably paraffin wax, may comprise a porous, or mesh-like structure allowing the passage of a fluid through the medium. The phase-change medium may further be mounted on a carrier such as a glass carrier or a polymer material carrier. The present invention further relates to processed filter material comprising isolated cells suitable for optical imaging, which is obtainable by the method; the use of such filter material for diagnostic, histological, microbiological, biochemical, oncologic, or hematologic analysis, as well as a device for isolating cells or processing cells to render them suitable for optical imaging.
摘要翻译：本发明涉及一种用于处理分离的细胞，特别是稀有细胞例如循环肿瘤细胞以使其适合于光学成像的方法，包括以下步骤：（a）将包含捕获的细胞的过滤材料沉积在相变介质上; （b）熔化所述相变介质，直到介质在所述过滤材料之下展开; 和（c）降低所述相变介质的温度，直到介质凝固，得到包含所述电池在固定位置的光学平面滤光器。该方法可以另外包括在过滤材料上捕获细胞的初始步骤。相变介质，优选石蜡，可以包括允许流体通过介质的多孔或网状结构。相变介质还可以安装在诸如玻璃载体或聚合物材料载体的载体上。本发明还涉及包含可通过该方法获得的适于光学成像的分离的细胞的经处理的过滤材料; 使用这种过滤材料进行诊断，组织学，微生物学，生物化学，肿瘤学或血液学分析，以及用于分离细胞或处理细胞以使其适合于光学成像的装置。

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