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1. 发明申请

US20150238958A1 MICROFLUIDIC DEVICE FOR BIOLOGICAL SAMPLE PREPARATION 审中-公开
标题翻译：用于生物样品制备的微流体装置
公开(公告)号：US20150238958A1
公开(公告)日：2015-08-27
申请号：US14428218
申请日：2013-09-13
申请人： Frederic ZENHAUSERN , Matthew ESTES , Jianing YANG , ARIZONA BOARD OF REGENTS FOR THE UNIVERSITY OF ARIZONA
发明人： Frederic Zenhausern , Matthew Estes , Jianing Yang
IPC分类号： B01L3/00 , C12Q1/68 , C12N15/10
CPC分类号： B01L3/502707 , B01L3/5027 , B01L7/52 , B01L2200/10 , B01L2300/0816 , B01L2300/0867 , B01L2300/087 , B01L2300/123 , B01L2400/0415 , B01L2400/0421 , B01L2400/0481 , B01L2400/0487 , B01L2400/0655 , C12N15/1003 , C12Q1/6806 , G01N1/4055 , G01N2001/4061 , G01N2035/00158
摘要： The present invention provides a microfluidic device for preparing or extracting a biological sample from a solid material and methods for using the same. The microfluidic device of the invention automates the biological sample extraction from a solid material, thereby significantly reducing the possibility of contamination, human error and a potential variability of the sample that is obtained by different technicians.
摘要翻译：本发明提供一种用于从固体材料制备或提取生物样品的微流体装置及其使用方法。本发明的微流体装置使固体材料的生物样品提取自动化，从而显着降低由不同技术人员获得的样品的污染可能性，人为错误和潜在的变异性。

2. 发明申请

US20120034601A1 Porous Materials for Biological Sample Collection 有权
标题翻译：用于生物样品收集的多孔材料
公开(公告)号：US20120034601A1
公开(公告)日：2012-02-09
申请号：US13121031
申请日：2009-08-14
申请人： Frederic Zenhausern , Ralf Lenigk , James Kinder , Jianing Yang
发明人： Frederic Zenhausern , Ralf Lenigk , James Kinder , Jianing Yang
IPC分类号： C12Q1/68 , C08F283/12 , B01D15/08 , G01N33/50 , C12M1/00
CPC分类号： G01N1/12 , Y10T436/143333 , Y10T436/25 , Y10T436/25375 , Y10T436/255
摘要： Methods, apparatuses, and systems for collecting samples using hybrid porous materials that include an organic material and an inorganic material. A method for sample collection includes contacting a hybrid porous material and a biological sample to the porous material. The hybrid porous material includes an inorganic material and an organic material. The method includes placing the porous material with the attached sample in a liquid medium, wherein the sample is separated from the porous material in the liquid medium to form a separated sample, and collecting the separated sample in the medium.
摘要翻译：用于使用包括有机材料和无机材料的混合多孔材料收集样品的方法，装置和系统。用于样品收集的方法包括将杂化多孔材料和生物样品接触到多孔材料。混合多孔材料包括无机材料和有机材料。该方法包括将附着的样品的多孔材料放置在液体介质中，其中将样品与液体介质中的多孔材料分离以形成分离的样品，并将分离的样品收集在培养基中。

3. 发明申请

US20100241358A1 ANALYSIS 审中-公开
标题翻译：分析
公开(公告)号：US20100241358A1
公开(公告)日：2010-09-23
申请号：US12558244
申请日：2009-09-11
申请人： Frederic Zenhausern , Ralf Lenigk , Andrew Hopwood , Pieris Koumi
发明人： Frederic Zenhausern , Ralf Lenigk , Andrew Hopwood , Pieris Koumi
IPC分类号： G06F19/00 , G01N33/48
CPC分类号： G01N1/28 , B01L3/502753 , B01L2300/024 , C12Q1/68 , C12Q1/6876 , C12Q2600/166 , G01D21/00 , G01N27/44791 , G01N33/487 , G01N33/6803 , G01N2030/045 , G06F17/00
摘要： A method of verifying the performance of a size standard, formed of a plurality of size standard elements, used in a nucleic acid analysis method is provided. The verification is achieved by introducing the size standard to an analysis stage and performing a size based separation on the size standard. The size based separation defines an experimental position for each size standard element. A comparison is made as to whether or not the experimental position for the size standard element corresponds with expected position. The comparison allows a decision to be made on whether or not to use the size standard, which is dependent upon whether or not the experimental position of the size standard element corresponds with the expected position.
摘要翻译：提供了一种验证在核酸分析方法中使用的由多个尺寸标准元素形成的尺寸标准的性能的方法。通过将尺寸标准引入分析阶段并根据尺寸标准执行基于尺寸的分离来实现验证。基于尺寸的分离定义了每个尺寸标准元素的实验位置。比较尺寸标准元件的实验位置是否对应于预期位置。该比较允许决定是否使用尺寸标准，这取决于尺寸标准件的实验位置是否与预期位置相对应。

4. 发明授权

US07097973B1 Method for monitoring molecular species within a medium 有权
标题翻译：监测介质中分子物种的方法
公开(公告)号：US07097973B1
公开(公告)日：2006-08-29
申请号：US09332659
申请日：1999-06-14
申请人： Frederic Zenhausern
发明人： Frederic Zenhausern
IPC分类号： C12Q1/68 , G01N33/53 , G01N33/567 , G01N21/00 , C12M1/34
CPC分类号： G01N21/6486 , C12Q1/686 , G06F19/24 , Y10S977/924 , C12Q2561/113
摘要： Apparatus and methods for monitoring, analyzing, and/or discriminating molecular species, preferably a biomolecule, within a medium using a multisensor array (MSA) and multivariate processing. Biological compounds such as nucleotides and polynucleotides can be detected and analyzed. A reaction process such as an accumulation cycle of nucleic acids can be monitored, analyzed, and controlled using a multisensor array (MSA) and multivariate processing. Monitoring a biomolecule includes interrogating the medium, and preferably its gas phase, by coupling a sensor responsive to any changes of the medium and or biomolecule and its secondary products when, for example, an amplification reaction is proceeded. It is also a scope of the present invention to use direct detection and monitoring of biomolecular reactions in real-time without radioactive or fluorescent labeling. A preferred application is real-time polymerase chain reaction (PCR) detection.
摘要翻译：使用多传感器阵列（MSA）和多变量处理在介质内监测，分析和/或区分分子种类，优选生物分子的装置和方法。可以检测和分析生物化合物如核苷酸和多核苷酸。可以使用多传感器阵列（MSA）和多变量处理来监测，分析和控制反应过程，例如核酸的累积循环。监测生物分子包括当例如进行扩增反应时，响应于介质和/或生物分子及其次级产物的任何变化而耦合传感器来询问介质，优选其气相。本发明的范围也是实时地直接检测和监测生物分子反应而没有放射性或荧光标记。优选的应用是实时聚合酶链反应（PCR）检测。

5. 发明授权

US06989235B2 Single molecule detection of bio-agents using the F1-ATPase biomolecular motor 有权
标题翻译：使用F1-ATPase生物分子运动的单分子检测生物试剂
公开(公告)号：US06989235B2
公开(公告)日：2006-01-24
申请号：US10365378
申请日：2003-02-11
申请人： Lars Chapsky , Wayne D. Frasch , Chia Fu Chou , Frederic Zenhausern , Herbert Goronkin
发明人： Lars Chapsky , Wayne D. Frasch , Chia Fu Chou , Frederic Zenhausern , Herbert Goronkin
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： B82Y5/00 , C12Q1/6825 , C12Q2563/155
摘要： An exemplary system and method of employing DNA hybridization for the detection of bio-agents is disclosed as comprising inter alia a biomolecular rotary motor (150); a capture probe DNA fragment (140) effectively attached to said biomolecular motor (150); a target DNA fragment (130) suitably adapted for hybridization with said capture probe DNA (140); a signal probe DNA fragment (120) suitably adapted for hybridization with said target DNA (130); and a fluorescent bead (100) attached to said signal probe DNA (120). Disclosed features and specifications may be variously controlled, adapted or otherwise optionally modified to improve certain device fabrication parameters and/or performance metrics.
摘要翻译：公开了使用DNA杂交来检测生物试剂的示例性系统和方法，其特别包括生物分子旋转马达（150）; 有效连接到所述生物分子马达（150）的捕获探针DNA片段（140）; 适于与所述捕获探针DNA（140）杂交的靶DNA片段（130）; 适于与所述靶DNA（130）杂交的信号探针DNA片段（120）; 和连接到所述信号探针DNA（120）上的荧光珠（100）。公开的特征和规范可以被不同地控制，适应或以其他方式任意地修改以改进某些设备制造参数和/或性能度量。

6. 发明授权

US5623339A Interferometric measuring method based on multi-pole sensing 失效
标题翻译：基于多极感测的干涉测量方法
公开(公告)号：US5623339A
公开(公告)日：1997-04-22
申请号：US511579
申请日：1995-08-04
申请人： Hemantha K. Wickramasinghe , Frederic Zenhausern , Martin P. O'Boyle
发明人： Hemantha K. Wickramasinghe , Frederic Zenhausern , Martin P. O'Boyle
IPC分类号： G01R33/12 , G01N37/00 , G01Q60/18 , G01Q80/00 , G01B9/02
CPC分类号： G01Q60/22 , B82Y20/00 , B82Y35/00
摘要： A method for deriving physical properties of a workpiece. The method comprises the steps of sampling an electromagnetic wave packet representative of workpiece properties and comprising encoded scattered wave information derivable from a multi-pole interactive coupling between a probe tip and the workpiece; decoding said electromagnetic wave packet by interrogating at least one of its phase and amplitude information; and, correlating this information to referent physical-chemical properties of the workpiece.
摘要翻译：用于导出工件的物理性质的方法。该方法包括以下步骤：对表示工件属性的电磁波包进行采样，并包括可从探针尖端和工件之间的多极交互耦合导出的编码散射波信息; 通过询问其相位和幅度信息中的至少一个来解码所述电磁波分组; 并将该信息与工件的物理化学特性相关联。

7. 发明申请

US20150221048A1 Method and system for matching a gear and travel storage for processing a transaction in an on-demand service system 审中-公开
标题翻译：用于匹配齿轮和行驶存储器以处理按需服务系统中的交易的方法和系统
公开(公告)号：US20150221048A1
公开(公告)日：2015-08-06
申请号：US14174018
申请日：2014-02-06
申请人： Frederic Zenhausern , Ryan Stephen Zenhausern , Alissia Marguerite Zenhausern , Nicole Michele Zenhausern
发明人： Frederic Zenhausern , Ryan Stephen Zenhausern , Alissia Marguerite Zenhausern , Nicole Michele Zenhausern
IPC分类号： G06Q50/14 , G06Q50/30 , G06Q30/06
CPC分类号： G06Q50/14 , G06Q30/0621 , G06Q50/30
摘要： A matching of a traveler's gear and vehicle when engaging into an electronic transaction of on demand services, preferably for transportation. In a preferred embodiment, the present method and apparatus is suitable for assessing remotely from a digital image, the physical properties of a travel gear, for example its shape, size and weight dimensions or texture, in order to match the geometric parameters of the container storage of a vehicle, for example the trunk of an automobile, listed in a database of an electronic transportation service, in order to optimize the conditions of transportation, such as cost reduction and energy fuel efficiency, for improving the quality of the traveler's experience.
摘要翻译：在进行按需服务的电子交易时，最好搭配旅行者的装备和车辆，以便运输。在优选实施例中，本方法和装置适用于从数字图像远程评估行星齿轮的物理特性，例如其形状，尺寸和重量尺寸或纹理，以便匹配容器的几何参数车辆的存储，例如列在电子运输服务的数据库中的汽车的行李箱，以便优化诸如成本降低和能量燃料效率的运输条件，以提高旅行者体验的质量。

8. 发明授权

US08759075B2 Biologic sample collection devices and methods of production and use thereof 失效
标题翻译：生物样品采集装置及其生产和使用方法
公开(公告)号：US08759075B2
公开(公告)日：2014-06-24
申请号：US13548643
申请日：2012-07-13
申请人： Thomas J Kindt , Franco A Ferrari , Frederic Zenhausern , Vasana Maneeratana , Deirdre Morhet
发明人： Jeff Morhet , Thomas J Kindt , Franco A Ferrari , Frederic Zenhausern , Vasana Maneeratana
IPC分类号： C12M1/00 , C12Q1/68 , C12M1/34 , C12M3/00
CPC分类号： C12N15/1006 , B01L3/5029 , G01N2001/007 , G01N2001/027 , Y10T428/24802
摘要： Collection devices and kits for biological sample collection include a biologic sample collection device having a hydrophilic swab matrix that includes a modified polycaprolactone (PCL). Methods of production and use thereof are also described herein. The biologic sample collection devices, kits and methods described herein are used to collect a biologic sample (e.g., blood, buccal cells, etc.) and to enable extraction of nucleic acids (e.g., DNA) from that biologic sample so that the nucleic acids can be analyzed (e.g., sequencing and subsequent analysis of DNA).
摘要翻译：用于生物样品收集的收集装置和试剂盒包括具有包含改性聚己内酯（PCL）的亲水拭子基质的生物样品收集装置。本文还描述了生产方法和使用方法。本文描述的生物样品采集装置，试剂盒和方法用于收集生物样品（例如，血液，颊细胞等）并且能够从该生物样品中提取核酸（例如DNA），使得核酸可以进行分析（例如DNA的测序和随后的分析）。

9. 发明申请

US20110287524A1 METHODS AND SYSTEMS FOR PREDICTIVE DESIGN OF STRUCTURES BASED ON ORGANIC MODELS 审中-公开
标题翻译：基于有机模型的结构预测设计方法与系统
公开(公告)号：US20110287524A1
公开(公告)日：2011-11-24
申请号：US13097030
申请日：2011-04-28
申请人： Frederic Zenhausern
发明人： Frederic Zenhausern
IPC分类号： C12N1/12 , C08G77/00 , G06F17/50
CPC分类号： G16B20/00 , G16B25/00 , G16B40/00
摘要： A method and system to predict a design of an article of manufacture, which can include the steps of introducing a biological organism into a test environment to activate at least one molecular component of the biological organism representing at least one set of genetic characters of the biological organism; monitoring for change in at least one expression phenomenon pattern in response to the test environment; translating the monitored change in the at least one expression phenomenon pattern into a molecular data profile; interrogating the molecular data profile against a stored database to generate an information pattern of a phenotype correlated to the molecular data profile; and translating the information pattern of the phenotype into a correlated design component of the article of manufacture.
摘要翻译：一种用于预测制品的设计的方法和系统，其可以包括以下步骤：将生物体引入到测试环境中以激活生物生物体的至少一个分子成分，代表生物体的至少一组遗传特征生物; 监测响应于测试环境的至少一种表情现象模式的变化; 将所述至少一种表达现象模式中所监测的变化转化为分子数据谱; 对存储的数据库询问分子数据概况，以产生与分子数据轮廓相关的表型的信息模式; 以及将所述表型的信息模式转换成所述制品的相关设计组件。

10. 发明申请

US20100221726A1 RELATING TO DEVICES 审中-公开
标题翻译：相关设备
公开(公告)号：US20100221726A1
公开(公告)日：2010-09-02
申请号：US12703046
申请日：2010-02-09
申请人： Frederic Zenhausern , Alan Nordquist , Ralf Lenigk , Cedric Hurth , Jianing Yang , Xiaojia Chen , Matthew Estes , John Lee-Edghill , Nina Moran , Andrew Hopwood , Pieris Koumi
发明人： Frederic Zenhausern , Alan Nordquist , Ralf Lenigk , Cedric Hurth , Jianing Yang , Xiaojia Chen , Matthew Estes , John Lee-Edghill , Nina Moran , Andrew Hopwood , Pieris Koumi
IPC分类号： C12Q1/68 , C12M1/34 , B01D57/02
CPC分类号： B01L3/502761 , B01L3/502715 , B01L3/502738 , B01L7/52 , B01L7/525 , C12Q1/6806 , C25B9/00 , G01N1/10 , G01N21/01 , G01N21/6428 , G01N21/645 , G01N27/44721 , G01N27/44791 , G01N2021/6484 , G01N2201/062 , G01N2201/0846 , Y10T436/143333
摘要： A method of analysis, instrument for analysis and device for use in such an instrument are provided, which perform a number of processes need to reach a useful result in the context of a wide variety of samples. The sequence of those processes being optimised. A device, instrument using the device and method of use are also provided which offer reliable performance of a heating based process, with minimal condensation and/or sample loss issues.
摘要翻译：提供了一种分析方法，用于分析仪器和用于这种仪器的设备，其执行许多过程需要在各种样品的上下文中获得有用的结果。这些过程的顺序被优化。还提供了使用该装置和使用方法的装置，仪器，其具有基于加热的工艺的可靠性能，具有最小的冷凝和/或样品损失问题。

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