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1. 发明申请

US20090253659A1 Cycloalkylidene Compounds As Modulators of Estrogen Receptor 失效
标题翻译：环亚烷基化合物作为雌激素受体的调节剂
公开(公告)号：US20090253659A1
公开(公告)日：2009-10-08
申请号：US12480097
申请日：2009-06-08
申请人： Jing Fang , Dennis Heyer , Aaron Bayne Miller , Frank Navas, III , Terrence Lee Smalley, JR. , William J. Zuercher , Subba Reddy Katamreddy
发明人： Jing Fang , Dennis Heyer , Aaron Bayne Miller , Frank Navas, III , Terrence Lee Smalley, JR. , William J. Zuercher , Subba Reddy Katamreddy
IPC分类号： A61K31/66 , A61K31/19 , A61P15/00
CPC分类号： C07D207/333 , C07C39/23 , C07C39/42 , C07C43/23 , C07C45/45 , C07C45/46 , C07C45/59 , C07C45/62 , C07C45/673 , C07C45/71 , C07C47/57 , C07C49/403 , C07C49/83 , C07C49/835 , C07C49/84 , C07C59/54 , C07C59/56 , C07C65/19 , C07C233/25 , C07C235/34 , C07C235/42 , C07C255/13 , C07C255/53 , C07C311/08 , C07C311/21 , C07C317/22 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07D207/16 , C07D211/60 , C07D211/62 , C07D213/30 , C07D239/26 , C07D261/08 , C07D263/32 , C07D295/096 , C07D307/42 , C07D309/20 , C07D309/22 , C07D335/02 , C07F9/4015
摘要： The present invention relates to novel compounds with a variety of therapeutic uses, more particularly novel substituted cyclic alkylidene compounds that are particularly useful for selective estrogen receptor modulation.
摘要翻译：本发明涉及具有多种治疗用途的新化合物，更特别地涉及特别适用于选择性雌激素受体调节的新型取代的环亚烷基化合物。

2. 发明申请

US20100249179A1 Farnesoid X Receptor Agonists 审中-公开
标题翻译：法呢型X受体激动剂
公开(公告)号：US20100249179A1
公开(公告)日：2010-09-30
申请号：US12663722
申请日：2008-06-13
申请人： David Norman Deaton , Frank Navas, III , Paul Kenneth Spearing
发明人： David Norman Deaton , Frank Navas, III , Paul Kenneth Spearing
IPC分类号： A61K31/4365 , C07D497/04 , A61P1/16 , C07D413/12 , A61K31/422 , C07D413/14 , A61K31/4439 , A61K31/423
CPC分类号： C07D413/12 , C07D261/08 , C07D413/14 , C07D495/04
摘要： The present invention provides novel isoxazole compounds, pharmaceutical compositions, therapeutic uses and processes for preparing the same.
摘要翻译：本发明提供新的异恶唑化合物，药物组合物，治疗用途及其制备方法。

3. 发明申请

US20070123548A1 Pth agonists 审中-公开
公开(公告)号：US20070123548A1
公开(公告)日：2007-05-31
申请号：US10597858
申请日：2005-02-03
申请人： David Cowan , Frank Navas III , Jeffrey Oplinger
发明人： David Cowan , Frank Navas III , Jeffrey Oplinger
IPC分类号： A61K31/515 , C07D239/60
CPC分类号： C07D239/557 , C07D239/60 , C07D401/04 , C07D405/04 , C07D413/04
摘要： This invention relates to compounds of formula (I) or (II) wherein, in either formula, independently; R1 and R2 are the same or are different and are C1-8 alkyl, C2-8 alkylene, C3-8 cycloalkyl, aryl, heteroaryl, heterocycloalkyl, C3-6 cycloalkylaryl, or heterocycloaryl; wherein said alkyl, alkylene, cycloalkyl, aryl, heteroaryl, heterocyclyl, cycloalkylaryl, or heterocycloaryl are unsubstituted or substituted by one or more groups selected from the group consisting of halogen, C1-8 alkyl, C1-8alkoxy, C1-8thioalkoxy, cycloalkyl, aryl, heteroaryl, heterocycloalkyl, CF3, SCF3, NHC(O)nR5, S(O)mR5, S(O)2NR5R6, C(S)NR5R6, CONR5R6, C(O)nR5; n is 0, 1 or 2; m is 0, 1 or 2; R5 is hydrogen, alkyl, aryl, alkylaryl, heterocycloalkyl, or heteroaryl and is unsubstituted or substituted by one or more groups selected from the group consisting of alkyl, C1-8alkoxy, aryl, heteroaryl, halogen, NO2, CN, N3, SCF3, and CF3; R6 is hydrogen, alkyl, aryl, alkylaryl, heterocycloalkyl, or heteroaryl and is unsubstituted or substituted by one or more groups selected from the group consisting of alkyl, C1-8alkoxy, aryl, heteroaryl, halogen, NO2, CN, N3, SCF3, and CF3, or when R1 and/or R2 contains S(O)2NR5R6, CONR5R6, or C(S)NR5R6, then R5R6 together with the nitrogen may form a heterocyclic ring; or a pharmaceutically acceptable salt or solvate thereof.

4. 发明授权

US07569601B2 Cycloalkylidene compounds as modulators of estrogen receptor 失效
公开(公告)号：US07569601B2
公开(公告)日：2009-08-04
申请号：US11748096
申请日：2007-05-14
申请人： Jing Fang , Dennis Heyer , Aaron Bayne Miller , Frank Navas, III , Terrence Lee Smalley, Jr. , William J. Zuercher , Subba Reddy Katamreddy
发明人： Jing Fang , Dennis Heyer , Aaron Bayne Miller , Frank Navas, III , Terrence Lee Smalley, Jr. , William J. Zuercher , Subba Reddy Katamreddy
IPC分类号： A61K31/351 , C07D315/00
CPC分类号： C07D207/333 , C07C39/23 , C07C39/42 , C07C43/23 , C07C45/45 , C07C45/46 , C07C45/59 , C07C45/62 , C07C45/673 , C07C45/71 , C07C47/57 , C07C49/403 , C07C49/83 , C07C49/835 , C07C49/84 , C07C59/54 , C07C59/56 , C07C65/19 , C07C233/25 , C07C235/34 , C07C235/42 , C07C255/13 , C07C255/53 , C07C311/08 , C07C311/21 , C07C317/22 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07D207/16 , C07D211/60 , C07D211/62 , C07D213/30 , C07D239/26 , C07D261/08 , C07D263/32 , C07D295/096 , C07D307/42 , C07D309/20 , C07D309/22 , C07D335/02 , C07F9/4015
摘要： The present invention relates to novel compounds with a variety of therapeutic uses, more particularly novel substituted cyclic alkylidene compounds that are particularly useful for selective estrogen receptor modulation.

5. 发明申请

US20080096921A1 FARNESOID X RECEPTOR AGONISTS 有权
公开(公告)号：US20080096921A1
公开(公告)日：2008-04-24
申请号：US11876906
申请日：2007-10-23
申请人： Frank NAVAS , Paul Spearing
发明人： Frank NAVAS , Paul Spearing
IPC分类号： A61K31/4725 , A61P3/10 , C07D413/02
CPC分类号： C07D413/14 , C07D413/12
摘要： The present invention provides novel substituted isoxazole compounds, pharmaceutical compositions, therapeutic uses and processes for preparing the same.

6. 发明申请

US20070155839A1 Cycloalkylidene compounds as modulators of estrogen receptor 失效
标题翻译：环亚烷基化合物作为雌激素受体的调节剂
公开(公告)号：US20070155839A1
公开(公告)日：2007-07-05
申请号：US10565296
申请日：2004-07-27
申请人： Jonathan Britton , Jing Fang , Dennis Heyer , Aaron Miller , Frank Navas , Terrence Smalley , William Zuercher , Subba Katamreddy
发明人： Jonathan Britton , Jing Fang , Dennis Heyer , Aaron Miller , Frank Navas , Terrence Smalley , William Zuercher , Subba Katamreddy
IPC分类号： A61K31/192 , C07C62/30
CPC分类号： C07D207/333 , C07C39/23 , C07C39/42 , C07C43/23 , C07C45/45 , C07C45/46 , C07C45/59 , C07C45/62 , C07C45/673 , C07C45/71 , C07C47/57 , C07C49/403 , C07C49/83 , C07C49/835 , C07C49/84 , C07C59/54 , C07C59/56 , C07C65/19 , C07C233/25 , C07C235/34 , C07C235/42 , C07C255/13 , C07C255/53 , C07C311/08 , C07C311/21 , C07C317/22 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07D207/16 , C07D211/60 , C07D211/62 , C07D213/30 , C07D239/26 , C07D261/08 , C07D263/32 , C07D295/096 , C07D307/42 , C07D309/20 , C07D309/22 , C07D335/02 , C07F9/4015
摘要： The present invention relates to novel compounds with a variety of therapeutic uses, more particularly novel substituted cyclic alkylidene compounds that are particularly useful for selective estrogen receptor modulation.
摘要翻译：本发明涉及具有多种治疗用途的新化合物，更特别地涉及特别适用于选择性雌激素受体调节的新型取代的环亚烷基化合物。

7. 发明授权

US07960552B2 Farnesoid X receptor agonists 有权
标题翻译：法呢甾X受体激动剂
公开(公告)号：US07960552B2
公开(公告)日：2011-06-14
申请号：US11876906
申请日：2007-10-23
申请人： Jonathan York Bass, III , Justin Caravella , David Norman Deaton , Robert Blount McFadyen , Frank Navas, III , Paul Kenneth Spearing
发明人： Jonathan York Bass, III , Justin Caravella , David Norman Deaton , Robert Blount McFadyen , Frank Navas, III , Paul Kenneth Spearing
IPC分类号： C07D401/00
CPC分类号： C07D413/14 , C07D413/12
摘要： The present invention provides novel substituted isoxazole compounds, pharmaceutical compositions, therapeutic uses and processes for preparing the same.
摘要翻译：本发明提供了新的取代的异恶唑化合物，药物组合物，治疗用途及其制备方法。

8. 发明授权

US07799828B2 Cycloalkylidene compounds as modulators of estrogen receptor 失效
标题翻译：环亚烷基化合物作为雌激素受体的调节剂
公开(公告)号：US07799828B2
公开(公告)日：2010-09-21
申请号：US12480097
申请日：2009-06-08
申请人： Jing Fang , Dennis Heyer , Aaron Bayne Miller , Frank Navas, III , Terrence Lee Smalley, Jr. , William J. Zuercher , Subba Reddy Katamreddy
发明人： Jing Fang , Dennis Heyer , Aaron Bayne Miller , Frank Navas, III , Terrence Lee Smalley, Jr. , William J. Zuercher , Subba Reddy Katamreddy
IPC分类号： A61K31/351
CPC分类号： C07D207/333 , C07C39/23 , C07C39/42 , C07C43/23 , C07C45/45 , C07C45/46 , C07C45/59 , C07C45/62 , C07C45/673 , C07C45/71 , C07C47/57 , C07C49/403 , C07C49/83 , C07C49/835 , C07C49/84 , C07C59/54 , C07C59/56 , C07C65/19 , C07C233/25 , C07C235/34 , C07C235/42 , C07C255/13 , C07C255/53 , C07C311/08 , C07C311/21 , C07C317/22 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07D207/16 , C07D211/60 , C07D211/62 , C07D213/30 , C07D239/26 , C07D261/08 , C07D263/32 , C07D295/096 , C07D307/42 , C07D309/20 , C07D309/22 , C07D335/02 , C07F9/4015
摘要： The present invention relates to novel compounds with a variety of therapeutic uses, more particularly novel substituted cyclic alkylidene compounds that are particularly useful for selective estrogen receptor modulation.
摘要翻译：本发明涉及具有多种治疗用途的新化合物，更特别地涉及特别适用于选择性雌激素受体调节的新型取代的环亚烷基化合物。

9. 发明授权

US07705028B2 Farnesoid X receptor agonists 有权
标题翻译：法呢甾X受体激动剂
公开(公告)号：US07705028B2
公开(公告)日：2010-04-27
申请号：US11609914
申请日：2006-12-13
申请人： Richard Caldwell , David Norman Deaton , Robert Blout McFayden , Frank Navas, III , Paul Kenneth Spearing
发明人： Richard Caldwell , David Norman Deaton , Robert Blout McFayden , Frank Navas, III , Paul Kenneth Spearing
IPC分类号： A61K31/42 , C07D261/06
CPC分类号： C07D413/12 , C07D261/08
摘要： The present invention provides novel substituted isoxazole compounds, pharmaceutical compositions, therapeutic uses and processes for preparing the same.
摘要翻译：本发明提供了新的取代的异恶唑化合物，药物组合物，治疗用途及其制备方法。

10. 发明授权

US07649093B2 Naphthalene compounds as selective estrogen receptor modulators 失效
标题翻译：萘化合物作为选择性雌激素受体调节剂
公开(公告)号：US07649093B2
公开(公告)日：2010-01-19
申请号：US11570838
申请日：2005-06-21
申请人： Dennis Heyer , Jing Fang , Frank Navas, III , Subba Reddy Katamreddy , Jennifer Poole Peckham , Philip Stewart Turnbull , Aaron Bayne Miller , Adwoa Akwabi-Ameyaw
发明人： Dennis Heyer , Jing Fang , Frank Navas, III , Subba Reddy Katamreddy , Jennifer Poole Peckham , Philip Stewart Turnbull , Aaron Bayne Miller , Adwoa Akwabi-Ameyaw
IPC分类号： C07D471/00 , C07D295/00 , A61K31/445
CPC分类号： C07D213/30 , C07C43/295 , C07C59/68 , C07C59/70 , C07C59/72 , C07C65/24 , C07C69/92 , C07C233/25 , C07C235/34 , C07C235/46 , C07C255/54 , C07C311/08 , C07C311/09 , C07C311/21 , C07C2601/02 , C07D211/62 , C07D295/108 , C07D295/185 , C07D307/42 , C07D333/16 , C07F9/3826 , C07F9/4006
摘要： The present invention relates to cycloalkylidene compounds with a variety of therapeutic uses, more particularly novel naphthalene compounds that are particularly useful for selective estrogen receptor modulation.
摘要翻译：本发明涉及具有多种治疗用途的环亚烷基化合物，更特别地涉及特别可用于选择性雌激素受体调节的新型萘化合物。

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