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1. 发明申请

US20140056500A1 Generating Attenuation Correction Maps for Combined Modality Imaging Studies and Improving Generated Attenuation Correction Maps Using MLAA and DCC Algorithms 有权
标题翻译：使用MLAA和DCC算法生成组合模态成像研究和改进生成的衰减校正图的衰减校正图
公开(公告)号：US20140056500A1
公开(公告)日：2014-02-27
申请号：US13970753
申请日：2013-08-20
申请人： Girish Bal , Frank Kehren , Vladimir Y. Panin , Christian J. Michel , Johan Nuyts
发明人： Girish Bal , Frank Kehren , Vladimir Y. Panin , Christian J. Michel , Johan Nuyts
IPC分类号： G06T11/00
CPC分类号： G06T11/005
摘要： The DCC (Data Consistency Condition) algorithm is used in combination with MLAA (Maximum Likelihood reconstruction of Attenuation and Activity) to generate extended attenuation correction maps for nuclear medicine imaging studies. MLAA and DCC are complementary algorithms that can be used to determine the accuracy of the mu-map based on PET data. MLAA helps to estimate the mu-values based on the biodistribution of the tracer while DCC checks if the consistency conditions are met for a given mu-map. These methods are combined to get a better estimation of the mu-values. In gated MR/PET cardiac studies, the PET data is framed into multiple gates and a series of MR based mu-maps corresponding to each gate is generated. The PET data from all gates is combined. Once the extended mu-map is generated the central region is replaced with the MR based mu-map corresponding to that particular gate. On the other hand, in dynamic PET studies the uptake in the patient's arms reaches a steady state only after the tracer distributes throughout the body. Hence, for dynamic scans, the projection data of all frames is summed and used to generate the MLAA based extended mu-map for all frames.
摘要翻译： DCC（数据一致条件）算法与MLAA（衰减和活动的最大似然重构）结合使用，以产生用于核医学成像研究的扩展衰减校正图。 MLAA和DCC是可以用于基于PET数据确定mu-map精度的互补算法。 MLAA有助于根据示踪剂的生物分布估计μ值，而DCC检查是否满足给定mu-map的一致性条件。将这些方法组合起来，以便更好地估计μ值。在门控MR / PET心脏研究中，PET数据被框架成多个门，并且生成与每个门对应的一系列基于MR的mu图。来自所有门的PET数据被组合。一旦生成了扩展的mu-map，就将中心区域替换为与该特定门对应的基于MR的mu-map。另一方面，在动态PET研究中，仅在跟踪器分布在整个身体之后，患者的手臂中的摄取才达到稳定状态。因此，对于动态扫描，将所有帧的投影数据求和并用于为所有帧生成基于MLAA的扩展mu-map。

2. 发明授权

US07876941B2 Incorporation of axial system response in iterative reconstruction from axially compressed data of cylindrical scanner using on-the-fly computing 有权
标题翻译：在圆柱形扫描仪的轴向压缩数据的迭代重建中使用飞行计算结合轴向系统响应
公开(公告)号：US07876941B2
公开(公告)日：2011-01-25
申请号：US11716358
申请日：2007-03-09
申请人： Vladimir Panin , Frank Kehren , Michael E. Casey
发明人： Vladimir Panin , Frank Kehren , Michael E. Casey
IPC分类号： G06K9/00
CPC分类号： G01T1/1644
摘要： A method and system for reconstructing PET image data from a cylindrical PET scanner by incorporation of axial system response. The method includes the steps of: assuming the decomposition of axial components into individual line-of-response (LOR) contributions, approximating each LOR spreading in image space as depth-independent, implementing each LOR response, combining the LORs to produce large span projection data, implementing the back projector as a transposed matrix, and assembling the LOR projections and spans for each azimuthal angle.
摘要翻译：一种用于通过结合轴向系统响应从圆柱形PET扫描仪重建PET图像数据的方法和系统。该方法包括以下步骤：假设将轴向分量分解为单独的响应响应（LOR）贡献，将图像空间中的每个LOR扩展近似为深度独立，实现每个LOR响应，组合LOR以产生大的跨距投影数据，将背投影机实现为转置矩阵，并为每个方位角组装LOR投影和跨距。

3. 发明授权

US09053569B2 Generating attenuation correction maps for combined modality imaging studies and improving generated attenuation correction maps using MLAA and DCC algorithms 有权
标题翻译：生成用于组合模态成像研究的衰减校正图，并使用MLAA和DCC算法改进生成的衰减校正图
公开(公告)号：US09053569B2
公开(公告)日：2015-06-09
申请号：US13970753
申请日：2013-08-20
申请人： Girish Bal , Frank Kehren , Vladimir Y. Panin , Christian J. Michel , Johan Nuyts
发明人： Girish Bal , Frank Kehren , Vladimir Y. Panin , Christian J. Michel , Johan Nuyts
IPC分类号： G06K9/00 , G06T11/00
CPC分类号： G06T11/005
摘要： The DCC (Data Consistency Condition) algorithm is used in combination with MLAA (Maximum Likelihood reconstruction of Attenuation and Activity) to generate extended attenuation correction maps for nuclear medicine imaging studies. MLAA and DCC are complementary algorithms that can be used to determine the accuracy of the mu-map based on PET data. MLAA helps to estimate the mu-values based on the biodistribution of the tracer while DCC checks if the consistency conditions are met for a given mu-map. These methods are combined to get a better estimation of the mu-values. In gated MR/PET cardiac studies, the PET data is framed into multiple gates and a series of MR based mu-maps corresponding to each gate is generated. The PET data from all gates is combined. Once the extended mu-map is generated the central region is replaced with the MR based mu-map corresponding to that particular gate. On the other hand, in dynamic PET studies the uptake in the patient's arms reaches a steady state only after the tracer distributes throughout the body. Hence, for dynamic scans, the projection data of all frames is summed and used to generate the MLAA based extended mu-map for all frames.
摘要翻译： DCC（数据一致条件）算法与MLAA（衰减和活动的最大似然重构）结合使用，以产生用于核医学成像研究的扩展衰减校正图。 MLAA和DCC是可以用于基于PET数据确定mu-map精度的互补算法。 MLAA有助于根据示踪剂的生物分布估计μ值，而DCC检查是否满足给定mu-map的一致性条件。将这些方法组合起来，以便更好地估计μ值。在门控MR / PET心脏研究中，PET数据被框架成多个门，并且生成与每个门对应的一系列基于MR的mu图。来自所有门的PET数据被组合。一旦生成了扩展的mu-map，就将中心区域替换为与该特定门对应的基于MR的mu-map。另一方面，在动态PET研究中，仅在跟踪器分布在整个身体之后，患者的手臂中的摄取才达到稳定状态。因此，对于动态扫描，将所有帧的投影数据求和并用于为所有帧生成基于MLAA的扩展mu-map。

4. 发明授权

US07856129B2 Acceleration of Joseph's method for full 3D reconstruction of nuclear medical images from projection data 有权
标题翻译：加速约瑟夫从投影数据全面3D重建核医学图像的方法
公开(公告)号：US07856129B2
公开(公告)日：2010-12-21
申请号：US11716359
申请日：2007-03-09
申请人： Vladimir Panin , Frank Kehren , Christian J. Michel
发明人： Vladimir Panin , Frank Kehren , Christian J. Michel
IPC分类号： G06K9/00
CPC分类号： G06T11/005 , A61B6/037
摘要： A method for interpolating at least one oblique line of response ray representing nuclear image projection data through a rectangular volume and a system for using the method. The method consists of steps of interpolating all the direct rays in a rectangular volume, making a projected ray by projecting the oblique ray onto a surface of the rectangular volume, matching the projected ray to a coinciding interpolated direct ray, shearing the rectangular volume to match the projected ray, and interpolating the oblique ray in the sheared volume.
摘要翻译：一种用于内插通过矩形体积表示核图像投影数据的响应光线的至少一条斜线和用于使用该方法的系统的方法。该方法包括将所有直射光线插入矩形体积中的步骤，通过将倾斜射线投射到矩形体积的表面上，将投射光线匹配成符合插值的直接射线，将矩形体积剪切成匹配投射光线，并将剪切光线插入剪切体积。

5. 发明申请

US20080217540A1 Incorporation of axial system response in iterative reconstruction from axially compressed data of cylindrical scanner using on-the-fly computing 有权
标题翻译：在圆柱形扫描仪的轴向压缩数据的迭代重建中使用飞行计算结合轴向系统响应
公开(公告)号：US20080217540A1
公开(公告)日：2008-09-11
申请号：US11716358
申请日：2007-03-09
申请人： Vladimir Panin , Frank Kehren , Michael E. Casey
发明人： Vladimir Panin , Frank Kehren , Michael E. Casey
IPC分类号： G01T1/164
CPC分类号： G01T1/1644
摘要： A method and system for reconstructing PET image data from a cylindrical PET scanner by incorporation of axial system response. The method includes the steps of: assuming the decomposition of axial components into individual line-of-response (LOR) contributions, approximating each LOR spreading in image space as depth-independent, implementing each LOR response, combining the LORs to produce large span projection data, implementing the back projector as a transposed matrix, and assembling the LOR projections and spans for each azimuthal angle.
摘要翻译：一种用于通过结合轴向系统响应从圆柱形PET扫描仪重建PET图像数据的方法和系统。该方法包括以下步骤：假设将轴向分量分解为单独的响应响应（LOR）贡献，将图像空间中的每个LOR扩展近似为深度独立，实现每个LOR响应，组合LOR以产生大的跨距投影数据，将背投影机实现为转置矩阵，并为每个方位角组装LOR投影和跨距。

6. 发明申请

US20080219525A1 Acceleration of Joseph's method for full 3D reconstruction of nuclear medical images from projection data 有权
标题翻译：加速约瑟夫从投影数据全面3D重建核医学图像的方法
公开(公告)号：US20080219525A1
公开(公告)日：2008-09-11
申请号：US11716359
申请日：2007-03-09
申请人： Vladimir Panin , Frank Kehren , Christian J. Michel
发明人： Vladimir Panin , Frank Kehren , Christian J. Michel
IPC分类号： G06K9/00 , A61B6/00 , A61B6/03
CPC分类号： G06T11/005 , A61B6/037
摘要： A method for interpolating at least one oblique line of response ray representing nuclear image projection data through a rectangular volume and a system for using the method. The method consists of steps of interpolating all the direct rays in a rectangular volume, making a projected ray by projecting the oblique ray onto a surface of the rectangular volume, matching the projected ray to a coinciding interpolated direct ray, shearing the rectangular volume to match the projected ray, and interpolating the oblique ray in the sheared volume.
摘要翻译：一种用于内插通过矩形体积表示核图像投影数据的响应光线的至少一条斜线和用于使用该方法的系统的方法。该方法包括将所有直射光线插入矩形体积中的步骤，通过将倾斜射线投射到矩形体积的表面上，将投射光线匹配成符合插值的直接射线，将矩形体积剪切成匹配投射光线，并将剪切光线插入剪切体积。

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