专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US5922589A Preparation of lactams from aliphatic .alpha.,.omega.-Dinitiles 失效
标题翻译：从脂肪族α，ω-二核苷酸制备内酰胺
公开(公告)号：US5922589A
公开(公告)日：1999-07-13
申请号：US108729
申请日：1998-07-01
申请人： Robert Di Cosimo , Robert Donald Fallon , John Edward Gavagan , Frank Edward Herkes
发明人： Robert Di Cosimo , Robert Donald Fallon , John Edward Gavagan , Frank Edward Herkes
IPC分类号： C07C255/19 , C07C255/23 , C07D201/08 , C07D207/26 , C07D211/76 , C07D223/10 , C12N9/78 , C12N9/88 , C12P13/00 , C12P17/10 , C12N1/20 , C12P17/12
CPC分类号： C07D211/76 , C07C255/19 , C07C255/23 , C07D201/08 , C07D207/26 , C07D223/10 , C12N9/78 , C12N9/88 , C12P13/002 , C12P13/02 , C12P17/10 , C12R1/01 , Y02P20/52
摘要： A process for the preparation of five-membered or six-membered ring lactams from aliphatic .alpha., .omega.-dinitriles has been developed. In the process an aliphatic .alpha.,.omega.-dinitrile is first converted to an ammonium salt of an .omega.-nitrilecarboxylic acid in aqueous solution using a catalyst having an aliphatic nitrilase (EC 3.5.5.7) activity, or a combination of nitrile hydratase (EC 4.2.1.84) and amidase (EC 3.5.1.4) activities. The ammonium salt of the .omega.-nitrilecarboxylic acid is then converted directly to the corresponding lactam by hydrogenation in aqueous solution, without isolation of the intermediate .omega.-nitrilecarboxylic acid or .omega.-aminocarboxylic acid. When the aliphatic .alpha.,.omega.-dinitrile is also unsymmetrically substituted at the .alpha.-carbon atom, the nitrilase produces the .omega.-nitrilecarboxylic acid ammonium salt resulting from hydrolysis of the .omega.-nitrile group with greater than 98% regioselectivity, thereby producing only one of the two possible lactam products during the subsequent hydrogenation. A heat-treatment process to select for desirable regioselective nitrilase or nitrile hydratase activities while destroying undesirable activities is also provided.
摘要翻译：已经开发了从脂肪族α，ω-二腈制备五元或六元环内酰胺的方法。在该方法中，使用具有脂族腈水解酶（EC 3.5.5.7）活性的催化剂或腈水合酶（EC 4.2）的组合，首先将脂族α，ω-二腈转化为ω-二硝基甲酸的铵盐 .1.84）和酰胺酶（EC 3.5.1.4）活性。然后通过在水溶液中氢化将ω-二硝基羧酸的铵盐直接转化成相应的内酰胺，而不分离中间体ω-二硝基甲酸或ω-氨基羧酸。当脂肪族α，ω-二腈在α-碳原子处也不对称取代时，腈水解酶产生由ω-腈基水解产生的ω-亚硝基羧酸铵盐，其具有大于98％的区域选择性，从而仅产生在随后氢化期间两种可能的内酰胺产物。还提供了在破坏不期望的活性的同时选择期望的区域选择性腈水解酶或腈水合酶活性的热处理方法。

2. 发明授权

US5858736A Preparation of lactams from aliphatic .alpha.,.omega.-dinitriles 失效
标题翻译：从脂肪族α，ω-二腈制备内酰胺
公开(公告)号：US5858736A
公开(公告)日：1999-01-12
申请号：US650073
申请日：1996-05-17
申请人： Robert Di Cosimo , Robert Donald Fallon , John Edward Gavagan , Frank Edward Herkes
发明人： Robert Di Cosimo , Robert Donald Fallon , John Edward Gavagan , Frank Edward Herkes
IPC分类号： C07C255/19 , C07C255/23 , C07D201/08 , C07D207/26 , C07D211/76 , C07D223/10 , C12N9/78 , C12N9/88 , C12P13/00 , C12P17/10 , C12P17/12
CPC分类号： C07D211/76 , C07C255/19 , C07C255/23 , C07D201/08 , C07D207/26 , C07D223/10 , C12N9/78 , C12N9/88 , C12P13/002 , C12P13/02 , C12P17/10 , C12R1/01 , Y02P20/52
摘要： A process for the preparation of five-membered or six-membered ring lactams from aliphatic .alpha.,.omega.-dinitriles has been developed. In the process an aliphatic .alpha.,.omega.-dinitrile is first converted to an ammonium salt of an .omega.-nitrilecarboxylic acid in aqueous solution using a catalyst having an aliphatic nitrilase (EC 3.5.5.7) activity, or a combination of nitrile hydratase (EC 4.2.1.84) and amidase (EC 3.5.1.4) activities. The aimnonium salt of the .omega.-nitrilecarboxylic acid is then converted directly to the corresponding lactam by hydrogenation in aqueous solution, without isolation of the intermediate .omega.-nitrilecarboxylic acid or .omega.-monocarboxylic acid. When the aliphatic .alpha.,.omega.-dinitrile is also unsymmetrically substituted at the .alpha.-carbon atom, the nitrilase produces the .omega.-nitrilecarboxylic acid ammonium salt resulting from hydrolysis of the .omega.-nitrile group with greater than 98% regioselectivity, thereby producing only one of the two possible lactam products during the subsequent hydrogenation. A heat-treatment process to select for desirable regioselective nitrilase or nitrile hydratase activities while destroying undesirable activities is also provided.
摘要翻译：已经开发了从脂肪族α，ω-二腈制备五元或六元环内酰胺的方法。在该方法中，使用具有脂族腈水解酶（EC 3.5.5.7）活性的催化剂或腈水合酶（EC 4.2）的组合，首先将脂族α，ω-二腈转化为ω-二硝基甲酸的铵盐 .1.84）和酰胺酶（EC 3.5.1.4）活性。然后通过在水溶液中氢化将ω-二硝基甲酸的目的盐直接转化成相应的内酰胺，而不分离中间体ω-二硝基甲酸或ω-单羧酸。当脂肪族α，ω-二腈在α-碳原子处也不对称取代时，腈水解酶产生由ω-腈基水解产生的ω-亚硝基羧酸铵盐，其具有大于98％的区域选择性，从而仅产生在随后氢化期间两种可能的内酰胺产物。还提供了在破坏不期望的活性的同时选择期望的区域选择性腈水解酶或腈水合酶活性的热处理方法。

3. 发明授权

US5814508A Preparation of lactams from aliphatic .alpha.,.omega.-dinitriles 失效
标题翻译：从脂肪族α，ω-二腈制备内酰胺
公开(公告)号：US5814508A
公开(公告)日：1998-09-29
申请号：US910260
申请日：1997-08-13
申请人： Robert Di Cosimo , Robert Donald Fallon , John Edward Gavagan , Frank Edward Herkes
发明人： Robert Di Cosimo , Robert Donald Fallon , John Edward Gavagan , Frank Edward Herkes
IPC分类号： C07C255/19 , C07C255/23 , C07D201/08 , C07D207/26 , C07D211/76 , C07D223/10 , C12N9/78 , C12N9/88 , C12P13/00 , C12P17/10 , C12P17/12
CPC分类号： C07D211/76 , C07C255/19 , C07C255/23 , C07D201/08 , C07D207/26 , C07D223/10 , C12N9/78 , C12N9/88 , C12P13/002 , C12P13/02 , C12P17/10 , C12R1/01 , Y02P20/52
摘要： A process for the preparation of five-membered or six-membered ring lactams from aliphatic .alpha.,.omega.-dinitriles has been developed. In the process an aliphatic .alpha.,.omega.-dinitrile is first converted to an ammonium salt of an .omega.-nitrile-carboxylic acid in aqueous solution using a catalyst having an aliphatic nitrilase (EC 3.5.5.7) activity, or a combination of nitrile hydratase (EC 4.2.1.84) and amidase (EC 3.5.1.4) activities. The ammonium salt of the .omega.-nitrilecarboxylic acid is then converted directly to the corresponding lactam by hydrogenation in aqueous solution, without isolation of the intermediate .omega.-nitrilecarboxylic acid or .omega.-aminocarboxylic acid. When the aliphatic .alpha.,.omega.-dinitrile is also unsymmetrically substituted at the .alpha.-carbon atom, the nitrilase produces the .omega.-nitrilecarboxylic acid ammonium salt resulting from hydrolysis of the .omega.-nitrile group with greater than 98% regioselectivity, thereby producing only one of the two possible lactam products during the subsequent hydrogenation. A heat-treatment process to select for desirable regioselective nitrilase or nitrile hydratase activities while destroying undesirable activities is also provided.
摘要翻译：已经开发了从脂肪族α，ω-二腈制备五元或六元环内酰胺的方法。在该方法中，首先使用具有脂族腈水解酶（EC 3.5.5.7）活性的催化剂或腈水合酶的组合（在水溶液中将ω-腈 - 羧酸的铵盐转化为ω-腈 - 羧酸的铵盐， EC 4.2.1.84）和酰胺酶（EC 3.5.1.4）活动。然后通过在水溶液中氢化将ω-二硝基羧酸的铵盐直接转化成相应的内酰胺，而不分离中间体ω-二硝基甲酸或ω-氨基羧酸。当脂肪族α，ω-二腈在α-碳原子处也不对称取代时，腈水解酶产生由ω-腈基水解产生的ω-亚硝基羧酸铵盐，其具有大于98％的区域选择性，从而仅产生在随后氢化期间两种可能的内酰胺产物。还提供了在破坏不期望的活性的同时选择期望的区域选择性腈水解酶或腈水合酶活性的热处理方法。

4. 发明授权

US6077955A Preparation of lactams from aliphatic .alpha..omega.-dinitriles 失效
标题翻译：从脂肪族αω-二腈制备内酰胺
公开(公告)号：US6077955A
公开(公告)日：2000-06-20
申请号：US108728
申请日：1998-07-01
申请人： Robert Di Cosimo , Robert Donald Fallon , John Edward Gavagan , Frank Edward Herkes
发明人： Robert Di Cosimo , Robert Donald Fallon , John Edward Gavagan , Frank Edward Herkes
IPC分类号： C07C255/19 , C07C255/23 , C07D201/08 , C07D207/26 , C07D211/76 , C07D223/10 , C12N9/78 , C12N9/88 , C12P13/00 , C12P17/10 , C07D211/60 , C07D207/00
CPC分类号： C07D211/76 , C07C255/19 , C07C255/23 , C07D201/08 , C07D207/26 , C07D223/10 , C12N9/78 , C12N9/88 , C12P13/002 , C12P13/02 , C12P17/10 , C12R1/01 , Y02P20/52
摘要： A process for the preparation of five-membered or six-membered ring lactams from aliphatic .alpha.,.omega.-dinitriles has been developed. In the process an aliphatic .alpha.,.omega.-dinitrile is first converted to an ammonium salt of an .omega.-nitrilecarboxylic acid in aqueous solution using a catalyst having an aliphatic nitrilase (EC 3.5.5.7) activity, or a combination of nitrile hydratase (EC 4.2.1.84) and amidase (EC 3.5.1.4) activities. The ammonium salt of the .omega.-nitrilecarboxylic acid is then converted directly to the corresponding lactam by hydrogenation in aqueous solution, without isolation of the intermediate .omega.-nitrilecarboxylic acid or .omega.-aminocarboxylic acid. When the aliphatic .alpha.,.omega.-dinitrile is also unsymmetrically substituted at the .alpha.-carbon atom, the nitrilase produces the .omega.-nitrilecarboxylic acid ammonium salt resulting from hydrolysis of the .omega.-nitrile group with greater than 98% regioselectivity, thereby producing only one of the two possible lactam products during the subsequent hydrogenation. A heat-treatment process to select for desirable regioselective nitrilase or nitrile hydratase activities while destroying undesirable activities is also provided.
摘要翻译：已经开发了从脂肪族α，ω-二腈制备五元或六元环内酰胺的方法。在该方法中，使用具有脂族腈水解酶（EC 3.5.5.7）活性的催化剂或腈水合酶（EC 4.2）的组合，首先将脂族α，ω-二腈转化为ω-二硝基甲酸的铵盐 .1.84）和酰胺酶（EC 3.5.1.4）活性。然后通过在水溶液中氢化将ω-二硝基羧酸的铵盐直接转化成相应的内酰胺，而不分离中间体ω-二硝基甲酸或ω-氨基羧酸。当脂肪族α，ω-二腈在α-碳原子处也不对称取代时，腈水解酶产生由ω-腈基水解产生的ω-亚硝基羧酸铵盐，其具有大于98％的区域选择性，从而仅产生在随后氢化期间两种可能的内酰胺产物。还提供了在破坏不期望的活性的同时选择期望的区域选择性腈水解酶或腈水合酶活性的热处理方法。

5. 发明授权

US5908954A Preparation of lactams from aliphatic .alpha., .omega.-dinitriles 失效
标题翻译：从脂肪族α，ω-二腈制备内酰胺
公开(公告)号：US5908954A
公开(公告)日：1999-06-01
申请号：US108445
申请日：1998-07-01
申请人： Robert Di Cosimo , Robert Donald Fallon , John Edward Gavagan , Frank Edward Herkes
发明人： Robert Di Cosimo , Robert Donald Fallon , John Edward Gavagan , Frank Edward Herkes
IPC分类号： C07C255/19 , C07C255/23 , C07D201/08 , C07D207/26 , C07D211/76 , C07D223/10 , C12N9/78 , C12N9/88 , C12P13/00 , C12P17/10 , C07C255/03 , C12P17/12
CPC分类号： C07D211/76 , C07C255/19 , C07C255/23 , C07D201/08 , C07D207/26 , C07D223/10 , C12N9/78 , C12N9/88 , C12P13/002 , C12P13/02 , C12P17/10 , C12R1/01 , Y02P20/52
摘要： A process for the preparation of five-membered or six-membered ring lactams from aliphatic .alpha.,.omega.-dinitriles has been developed. In the process an aliphatic .alpha.,.omega.-dinitrile is first converted to an ammonium salt of an .omega.-nitrile-carboxylic acid in aqueous solution using a catalyst having an aliphatic nitrilase (EC 3.5.5.7) activity, or a combination of nitrile hydratase (EC 4.2.1.84) and arnidase (EC 3.5.1.4) activities. The ammonium salt of the .omega.-nitrilecarboxylic acid is then converted directly to the corresponding lactam by hydrogenation in aqueous solution, without isolation of the intermediate .omega.-nitrilecarboxylic acid or .omega.-aminocarboxylic acid. When the aliphatic .alpha.,.omega.-dinitrile is also unsymmetrically substituted at the .alpha.-carbon atom, the nitrilase produces the .omega.-nitrilecarboxylic acid ammonium salt resulting from hydrolysis of the .omega.-nitrile group with greater than 98% regioselectivity, thereby producing only one of the two possible lactam products during the subsequent hydrogenation. A heat-treatment process to select for desirable regioselective nitrilase or nitrile hydratase activities while destroying undesirable activities is also provided.
摘要翻译：已经开发了从脂肪族α，ω-二腈制备五元或六元环内酰胺的方法。在该方法中，首先使用具有脂族腈水解酶（EC 3.5.5.7）活性的催化剂或腈水合酶的组合（在水溶液中将ω-腈 - 羧酸的铵盐转化为ω-腈 - 羧酸的铵盐， EC 4.2.1.84）和arnidase（EC 3.5.1.4）活动。然后通过在水溶液中氢化将ω-二硝基羧酸的铵盐直接转化成相应的内酰胺，而不分离中间体ω-二硝基甲酸或ω-氨基羧酸。当脂肪族α，ω-二腈在α-碳原子处也不对称取代时，腈水解酶产生由ω-腈基水解产生的ω-亚硝基羧酸铵盐，其具有大于98％的区域选择性，从而仅产生在随后氢化期间两种可能的内酰胺产物。还提供了在破坏不期望的活性的同时选择期望的区域选择性腈水解酶或腈水合酶活性的热处理方法。

6. 发明授权

US5834617A Selective dimerization of pentenenitrile 失效
标题翻译：戊烯腈的选择性二聚
公开(公告)号：US5834617A
公开(公告)日：1998-11-10
申请号：US993970
申请日：1997-12-18
申请人： William Allen Beck , Frank Edward Herkes , David Page Higley
发明人： William Allen Beck , Frank Edward Herkes , David Page Higley
IPC分类号： C07C253/30 , C07C255/09 , C07C255/00
CPC分类号： C07C253/30
摘要： The present invention relates to a process for selective dimerization of 2-pentenenitrile or mixtures of 2- and 3-pentenenitrile in the presence of a strong base to form 1,3-dicyano-2-ethyl-3-hexene.
摘要翻译：本发明涉及在强碱存在下2-戊烯腈或2-和3-戊烯腈的混合物的选择性二聚作用以形成1,3-二氰基-2-乙基-3-己烯的方法。

7. 发明授权

US5808078A Process for preparation of 1-alkyl-3-methylpiperidone-2 and 1-alkyl-5-methylpiperidone-2 失效
标题翻译： 1-烷基-3-甲基哌啶酮-2和1-烷基-5-甲基哌啶酮-2的制备方法
公开(公告)号：US5808078A
公开(公告)日：1998-09-15
申请号：US853182
申请日：1997-05-08
申请人： Frank Edward Herkes
发明人： Frank Edward Herkes
IPC分类号： C07D211/76 , C07D211/36
CPC分类号： C07D211/76
摘要： This invention relates to an improved process for the preparation of 1-alkyl-3-methylpiperidone-2 and 1-alkyl-5-methylpiperidone-2 from 2-methylglutaronitrile wherein the selectivity of the process to bis-1,5-(methylamido)-3-methylpentane is less than 8%.
摘要翻译：本发明涉及从2-甲基戊二腈制备1-烷基-3-甲基哌啶酮-2和1-烷基-5-甲基哌啶酮-22的改进方法，其中该方法对双-1,5-（甲基酰氨基） -3-甲基戊烷小于8％。

8. 发明授权

US4020051A Control of nitrogen oxide reactions in off-gases from the diazotization/coupling of aromatic amines 失效
标题翻译：控制芳香胺的重氮化/偶联废气中的氮氧化物反应
公开(公告)号：US4020051A
公开(公告)日：1977-04-26
申请号：US635058
申请日：1975-11-25
申请人： Frank Edward Herkes
发明人： Frank Edward Herkes
IPC分类号： B01J8/00 , C01B21/00 , C07D20060101 , C07C115/00 , C07C113/00
摘要： The deposition of an aromatic diazonium nitrate on the walls of a pipeline through which is conducted a residual gas produced in the diazotization of a primary aromatic monoamine is prevented by heating the walls of the pipeline, limiting the residence time of the gas in the pipeline, or providing for the absence of nitrogen dioxide in the gas. Nitrogen dioxide can form in the pipeline when nitric oxide and molecular oxygen are present, but the deposition of the diazonium nitrate, formed from the nitrogen dioxide via a reaction with the monoamine, is prevented by the hot pipeline walls and/or short residence time.
摘要翻译：通过加热管道壁，限制气体在管道中的停留时间，可以防止在管道的壁上沉积芳族重氮硝酸盐，在管壁的壁上进行在芳族芳族单胺的重氮化中产生的残余气体，或提供气体中不存在二氧化氮。当一氧化氮和分子氧存在时，二氧化氮可以在管道中形成，但是通过与单胺的反应由二氧化氮形成的硝酸重氮盐的沉积被热管道壁和/或较短的停留时间阻止。

9. 发明授权

US5936114A Preparation of lactams from aliphatic .alpha., .omega.-dinitriles 失效
标题翻译：从脂肪族α，ω-二腈制备内酰胺
公开(公告)号：US5936114A
公开(公告)日：1999-08-10
申请号：US108631
申请日：1998-07-01
申请人： Robert Di Cosimo , Robert Donald Fallon , John Edward Gavagan , Frank Edward Herkes
发明人： Robert Di Cosimo , Robert Donald Fallon , John Edward Gavagan , Frank Edward Herkes
IPC分类号： C07C255/19 , C07C255/23 , C07D201/08 , C07D207/26 , C07D211/76 , C07D223/10 , C12N9/78 , C12N9/88 , C12P13/00 , C12P17/10 , C07C255/29
CPC分类号： C07D211/76 , C07C255/19 , C07C255/23 , C07D201/08 , C07D207/26 , C07D223/10 , C12N9/78 , C12N9/88 , C12P13/002 , C12P13/02 , C12P17/10 , C12R1/01 , Y02P20/52
摘要： A process for the preparation of five-membered or six-membered ring lactams from aliphatic .alpha.,.omega.-dinitriles has been developed. In the process an aliphatic .alpha.,.omega.-dinitrile is first converted to an ammonium salt of an .omega.-nitrilecarboxylic acid in aqueous solution using a catalyst having an aliphatic nitrilase (EC 3.5.5.7) activity, or a combination of nitrile hydratase (EC 4.2.1.84) and amidase (EC 3.5.1.4) activities. The ammonium salt of the .omega.-nitrilecarboxylic acid is then converted directly to the corresponding lactam by hydrogenation in aqueous solution, without isolation of the intermediate .omega.-nitrilecarboxylic acid or .omega.-aminocarboxylic acid. When the aliphatic .alpha.,.omega.-dinitrile is also unsymmetrically substituted at the .alpha.-carbon atom, the nitrilase produces the .omega.-nitrilecarboxylic acid ammonium salt resulting from hydrolysis of the .omega.-nitrile group with greater than 98% regioselectivity, thereby producing only one of the two possible lactam products during the subsequent hydrogenation. A heat-treatment process to select for desirable regioselective nitrilase or nitrile hydratase activities while destroying undesirable activities is also provided.
摘要翻译：已经开发了从脂肪族α，ω-二腈制备五元或六元环内酰胺的方法。在该方法中，使用具有脂族腈水解酶（EC 3.5.5.7）活性的催化剂或腈水合酶（EC 4.2）的组合，首先将脂族α，ω-二腈转化为ω-二硝基甲酸的铵盐 .1.84）和酰胺酶（EC 3.5.1.4）活性。然后通过在水溶液中氢化将ω-二硝基羧酸的铵盐直接转化成相应的内酰胺，而不分离中间体ω-二硝基甲酸或ω-氨基羧酸。当脂肪族α，ω-二腈在α-碳原子处也不对称取代时，腈水解酶产生由ω-腈基水解产生的ω-亚硝基羧酸铵盐，其具有大于98％的区域选择性，从而仅产生在随后氢化期间两种可能的内酰胺产物。还提供了在破坏不期望的活性的同时选择期望的区域选择性腈水解酶或腈水合酶活性的热处理方法。

10. 发明授权

US6066490A Nitrilase-producing acidovorax facilis 失效
标题翻译：生产硝酸酯的酸酵母
公开(公告)号：US6066490A
公开(公告)日：2000-05-23
申请号：US987938
申请日：1997-12-10
申请人： Robert Di Cosimo , Robert Donald Fallon , John Edward Gavagan , Frank Edward Herkes
发明人： Robert Di Cosimo , Robert Donald Fallon , John Edward Gavagan , Frank Edward Herkes
IPC分类号： C07C255/19 , C07C255/23 , C07D201/08 , C07D207/26 , C07D211/76 , C07D223/10 , C12N9/78 , C12N9/88 , C12P13/00 , C12P17/10 , C12N1/12
CPC分类号： C07D211/76 , C07C255/19 , C07C255/23 , C07D201/08 , C07D207/26 , C07D223/10 , C12N9/78 , C12N9/88 , C12P13/002 , C12P13/02 , C12P17/10 , C12R1/01 , Y02P20/52
摘要： A process for the preparation of five-membered or six-membered ring lactams from aliphatic .alpha.,.omega.-dinitriles has been developed. In the process an aliphatic .alpha.,.omega.-dinitrile is first converted to an ammonium salt of an .omega.-nitrilecarboxylic acid in aqueous solution using a catalyst having an aliphatic nitrilase (EC 3.5.5.7) activity, or a combination of nitrile hydratase (EC 4.2.1.84) and amidase (EC 3.5.1.4) activities. The ammonium salt of the .omega.-nitrilecarboxylic acid is then converted directly to the corresponding lactam by hydrogenation in aqueous solution, without isolation of the intermediate .omega.-nitrilecarboxylic acid or .omega.-aminocarboxylic acid. When the aliphatic .alpha.,.omega.-dinitrile is also unsymmetrically substituted at the .alpha.-carbon atom, the nitrilase produces the .omega.-nitrilecarboxylic acid ammonium salt resulting from hydrolysis of the .omega.-nitrile group with greater than 98% regioselectivity, thereby producing only one of the two possible lactam products during the subsequent hydrogenation. A heat-treatment process to select for desirable regioselective nitrilase or nitrile hydratase activities while destroying undesirable activities is also provided.
摘要翻译：已经开发了从脂肪族α，ω-二腈制备五元或六元环内酰胺的方法。在该方法中，使用具有脂族腈水解酶（EC 3.5.5.7）活性的催化剂或腈水合酶（EC 4.2）的组合，首先将脂族α，ω-二腈转化为ω-二硝基甲酸的铵盐 .1.84）和酰胺酶（EC 3.5.1.4）活性。然后通过在水溶液中氢化将ω-二硝基羧酸的铵盐直接转化成相应的内酰胺，而不分离中间体ω-二硝基甲酸或ω-氨基羧酸。当脂肪族α，ω-二腈在α-碳原子处也不对称取代时，腈水解酶产生由ω-腈基水解产生的ω-亚硝基羧酸铵盐，其具有大于98％的区域选择性，从而仅产生在随后氢化期间两种可能的内酰胺产物。还提供了在破坏不期望的活性的同时选择期望的区域选择性腈水解酶或腈水合酶活性的热处理方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式