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1. 发明授权

US09717451B2 Device for withdrawing or administering a substance and method of manufacturing a device 有权
公开(公告)号：US09717451B2
公开(公告)日：2017-08-01
申请号：US13442933
申请日：2012-04-10
申请人： James Down , Noel G. Harvey , Frank E. Martin , Ronald J. Pettis , Alexander G. Lastovich
发明人： James Down , Noel G. Harvey , Frank E. Martin , Ronald J. Pettis , Alexander G. Lastovich
IPC分类号： B32B37/00 , A61B5/15 , A61M37/00 , A61M5/32 , B29C65/08 , B29L31/00
CPC分类号： A61B5/150282 , A61M5/3298 , A61M37/0015 , A61M2037/0046 , A61M2037/0053 , A61M2207/00 , B29C65/08 , B29L2031/7544 , Y10T29/49826 , Y10T156/10
摘要： A device includes a plurality of skin penetrating devices for delivering or withdrawing a substance through the skin of a patient. The device has a support formed with a top and bottom end and a plurality of channels extending axially through the support. A plurality of the skin penetrating members is positioned in the channels with a tip extending from the bottom end of the support. A coupling member is attached to the support for coupling with a fluid supply and directing the fluid to the skin penetrating members. The skin penetrating members have a length of about 100 microns to about 2000 microns and are about 30 to 50 gauge.

2. 发明申请

US20130263997A1 Device for Withdrawing or Administering a Substance and Method of Manufacturing a Device 有权
标题翻译：取出或管理物质的装置和制造装置的方法
公开(公告)号：US20130263997A1
公开(公告)日：2013-10-10
申请号：US13442933
申请日：2012-04-10
申请人： James Down , Noel G. Harvey , Frank E. Martin , Ronald J. Pettis , Alexander G. Lastovich
发明人： James Down , Noel G. Harvey , Frank E. Martin , Ronald J. Pettis , Alexander G. Lastovich
IPC分类号： B32B37/06 , B32B37/12 , B23P17/04
CPC分类号： A61B5/150282 , A61M5/3298 , A61M37/0015 , A61M2037/0046 , A61M2037/0053 , A61M2207/00 , B29C65/08 , B29L2031/7544 , Y10T29/49826 , Y10T156/10
摘要： A device includes a plurality of skin penetrating devices for delivering or withdrawing a substance through the skin of a patient. The device has a support formed with a top and bottom end and a plurality of channels extending axially through the support. A plurality of the skin penetrating members is positioned in the channels with a tip extending from the bottom end of the support. A coupling member is attached to the support for coupling with a fluid supply and directing the fluid to the skin penetrating members. The skin penetrating members have a length of about 100 microns to about 2000 microns and are about 30 to 50 gauge.
摘要翻译：一种装置包括用于通过患者皮肤递送或取出物质的多个皮肤穿透装置。该装置具有形成有顶端和底端以及轴向延伸穿过支撑件的多个通道的支撑件。多个皮肤穿透构件定位在通道中，其顶端从支撑件的底端延伸。联接构件附接到支撑件以与流体供应件联接并将流体引导到皮肤穿透构件。皮肤穿透构件具有约100微米至约2000微米的长度，并且为约30至50度。

3. 发明申请

US20110071494A1 Intradermal Delivery Device 有权
标题翻译：皮内输送装置
公开(公告)号：US20110071494A1
公开(公告)日：2011-03-24
申请号：US12955554
申请日：2010-11-29
申请人： Richard P. Clarke , M. Lehag Haider , Richard J. Klug , Frank E. Martin
发明人： Richard P. Clarke , M. Lehag Haider , Richard J. Klug , Frank E. Martin
IPC分类号： A61M5/46
CPC分类号： A61M5/158 , A61M5/3287 , A61M5/46 , A61M5/488 , A61M2005/1581
摘要： A system and method is provided for an injectable substance delivery device comprising a limiter, shoulder or post, that controls how deep the needle is inserted into the tissue. The limiter is sized in proportions that control the maximum insertion depth of the needle into the tissue without excessively restricting the complete insertion of the needle. The system and method further comprises an normalization or stabilizer ring that prevents distortion of the tissue in the vicinity of the infusion, so that the needle length is the major determining factor as to how deep the infusion is delivered.
摘要翻译：提供了一种用于可控制物质递送装置的系统和方法，所述注射物质递送装置包括限制器，肩部或柱，其控制针被插入到组织中的深度。限制器的大小按比例控制针头进入组织的最大插入深度，而不会过度地限制针的完全插入。该系统和方法还包括防止输注附近组织变形的归一化或稳定环，使得针头长度是输送输送深度的主要决定因素。

4. 发明授权

US07842008B2 Intradermal delivery device 有权
标题翻译：皮内输送装置
公开(公告)号：US07842008B2
公开(公告)日：2010-11-30
申请号：US11282591
申请日：2005-11-21
申请人： Richard P. Clarke , M. Ishaq Haider , Richard J. Klug , Frank E. Martin
发明人： Richard P. Clarke , M. Ishaq Haider , Richard J. Klug , Frank E. Martin
IPC分类号： A61M5/00
CPC分类号： A61M5/158 , A61M5/3287 , A61M5/46 , A61M5/488 , A61M2005/1581
摘要： A system and method is provided for an injectable substance delivery device comprising a limiter, shoulder or post, that controls how deep the needle is inserted into the tissue. The limiter is sized in proportions that control the maximum insertion depth of the needle into the tissue without excessively restricting the complete insertion of the needle. The system and method further comprises an normalization or stabilizer ring that prevents distortion of the tissue in the vicinity of the infusion, so that the needle length is the major determining factor as to how deep the infusion is delivered.
摘要翻译：提供了一种用于可控制物质递送装置的系统和方法，所述注射物质递送装置包括限制器，肩部或柱，其控制针被插入到组织中的深度。限制器的大小按比例控制针头进入组织的最大插入深度，而不会过度地限制针的完全插入。该系统和方法还包括防止输注附近组织变形的归一化或稳定环，使得针头长度是输送输送深度的主要决定因素。

5. 发明申请

US20100292648A1 Device and method for delivering or withdrawing a substance through the skin 审中-公开
标题翻译：通过皮肤递送或取出物质的装置和方法
公开(公告)号：US20100292648A1
公开(公告)日：2010-11-18
申请号：US12845373
申请日：2010-07-28
申请人： Alexander G. Lastovich , James K. Fentress , Julia Griggs , Ronald J. Pettis , Diane Sutter , Frank E. Martin , M. Ishaq Haider
发明人： Alexander G. Lastovich , James K. Fentress , Julia Griggs , Ronald J. Pettis , Diane Sutter , Frank E. Martin , M. Ishaq Haider
IPC分类号： A61M5/00
CPC分类号： A61M5/425 , A61M5/14244 , A61M5/3007 , A61M5/46 , A61M37/0015
摘要： An apparatus for delivering or withdrawing a fluid through at least one layer of the skin is provided. A device includes a body having a top face, a bottom face, a side edge and at least one channel. The bottom face includes a first surface area and a second surface area adjacent to and recessed at a first distance from the first surface area. The bottom face further includes at least one raised protrusion disposed on the second surface area. The protrusion has a height from the first surface greater than the first distance. At least one dermal-access member is provided in the protrusion and is in fluid communication with the channel to deliver or withdraw the fluid.
摘要翻译：提供了一种用于通过至少一层皮肤递送或取出流体的装置。一种装置包括具有顶面，底面，侧缘和至少一个通道的主体。底面包括与第一表面区域相邻并且与第一表面区域第一距离凹陷的第一表面区域和第二表面区域。底面还包括设置在第二表面区域上的至少一个凸起突起。突起具有从第一表面的高度大于第一距离。在突起中提供至少一个真皮进入构件，并且与通道流体连通以输送或抽出流体。

6. 发明授权

US07556615B2 Microneedle-based pen device for drug delivery and method for using same 有权
标题翻译：用于药物递送的基于微针的笔式装置及其使用方法
公开(公告)号：US07556615B2
公开(公告)日：2009-07-07
申请号：US10238958
申请日：2002-09-11
申请人： Ronald J. Pettis , Frank E. Martin , Scott A. Kaestner
发明人： Ronald J. Pettis , Frank E. Martin , Scott A. Kaestner
IPC分类号： A61M5/00
CPC分类号： A61M37/0015 , A61M5/20 , A61M5/28 , A61M5/288 , A61M5/31548 , A61M5/31568 , A61M5/31593 , A61M5/32 , A61M5/3298 , A61M5/425 , A61M5/46 , A61M2037/0023 , A61M2037/003
摘要： A system and method is provided for an injectable substance delivery pen comprising a microneedle hub assembly removably engaged with a pen device body which includes a cartridge, a plunger, and a drive mechanism. The hub assembly includes at least one microneedle for intradermal or shallow subcutaneous injection of the contents of the cartridge. The cartridge, plunger and drive mechanism components of the pen body are fabricated of non-compliant and non-compressible materials to allow effective communication of the cartridge contents via the microneedle patient interface.
摘要翻译：提供了一种用于可注射物质输送笔的系统和方法，其包括可拆卸地与包括药筒，柱塞和驱动机构的笔装置主体接合的微针毂组件。轮毂组件包括用于皮内或浅皮下注射筒的内容物的至少一个微针。笔体的盒，柱塞和驱动机构部件由非顺应性和不可压缩材料制成，以允许经由微针患者界面有效地连通药筒内容物。

7. 发明申请

US20090112181A1 Device and method for delivering or withdrawing a substance through the skin 审中-公开
标题翻译：通过皮肤递送或取出物质的装置和方法
公开(公告)号：US20090112181A1
公开(公告)日：2009-04-30
申请号：US12341589
申请日：2008-12-22
申请人： Alexander G. Lastovich , James K. Fentress , Julia Griggs , Ronald J. Pettis , Diane Sutter , Frank E. Martin , M. Ishaq Haider
发明人： Alexander G. Lastovich , James K. Fentress , Julia Griggs , Ronald J. Pettis , Diane Sutter , Frank E. Martin , M. Ishaq Haider
IPC分类号： A61M5/32
CPC分类号： A61M5/425 , A61M5/14244 , A61M5/3007 , A61M5/46 , A61M37/0015
摘要： An apparatus for delivering or withdrawing a fluid through at least one layer of the skin is provided. A device includes a body having a top face, a bottom face, a side edge and at least one channel. The bottom face includes a first surface area and a second surface area adjacent to and recessed at a first distance from the first surface area. The bottom face further includes at least one raised protrusion disposed on the second surface area. The protrusion has a height from the first surface greater than the first distance. At least one dermal-access member is provided in the protrusion and is in fluid communication with the channel to deliver or withdraw the fluid.
摘要翻译：提供了一种用于通过至少一层皮肤递送或取出流体的装置。一种装置包括具有顶面，底面，侧缘和至少一个通道的主体。底面包括与第一表面区域相邻并且与第一表面区域第一距离凹陷的第一表面区域和第二表面区域。底面还包括设置在第二表面区域上的至少一个凸起突起。突起具有从第一表面的高度大于第一距离。在突起中提供至少一个真皮进入构件，并且与通道流体连通以输送或抽出流体。

8. 发明申请

US20080161759A1 Device and Method for Delivering or Withdrawing a Substance through the Skin 审中-公开
标题翻译：通过皮肤递送或提取物质的装置和方法
公开(公告)号：US20080161759A1
公开(公告)日：2008-07-03
申请号：US12045861
申请日：2008-03-11
申请人： Alexander G. Lastovich , James K. Fentress , Julia Griggs , Ronald J. Pettis , Diane Sutter , Frank E. Martin , M. Ishaq Haider
发明人： Alexander G. Lastovich , James K. Fentress , Julia Griggs , Ronald J. Pettis , Diane Sutter , Frank E. Martin , M. Ishaq Haider
IPC分类号： A61M37/00
CPC分类号： A61M5/425 , A61M5/14244 , A61M5/3007 , A61M5/46 , A61M37/0015
摘要： An apparatus for delivering or withdrawing a fluid through at least one layer of the skin is provided. A device includes a body having a top face, a bottom face, a side edge and at least one channel. The bottom face includes a first surface area and a second surface area adjacent to and recessed at a first distance from the first surface area. The bottom face further includes at least one raised protrusion disposed on the second surface area. The protrusion has a height from the first surface greater than the first distance. At least one dermal-access member is provided in the protrusion and is in fluid communication with the channel to deliver or withdraw the fluid.
摘要翻译：提供了一种用于通过至少一层皮肤递送或取出流体的装置。一种装置包括具有顶面，底面，侧缘和至少一个通道的主体。底面包括与第一表面区域相邻并且与第一表面区域第一距离凹陷的第一表面区域和第二表面区域。底面还包括设置在第二表面区域上的至少一个凸起突起。突起具有从第一表面的高度大于第一距离。在突起中提供至少一个真皮进入构件，并且与通道流体连通以输送或抽出流体。

9. 发明授权

US07086266B2 Method of producing tapered or pointed cannula 有权
标题翻译：生产锥形或尖头套管的方法
公开(公告)号：US07086266B2
公开(公告)日：2006-08-08
申请号：US10912439
申请日：2004-08-05
申请人： Marcelino Munoz , Frank E. Martin , M. Ishaq Haider
发明人： Marcelino Munoz , Frank E. Martin , M. Ishaq Haider
IPC分类号： B21D37/16
CPC分类号： B21C37/18 , B21C5/00 , B21G1/006 , B21G1/08 , Y10T225/12
摘要： A method of producing a tubular device is provided. The method comprises providing a tubular stock having an axial passage, heating the tubular stock at a first heating location to form a softened section, the softened section separating a workpiece portion of the tubular stock from a remaining portion of the tubular stock, and drawing the workpiece portion away from the remaining portion to elongate the softened section and separate the workpiece portion from the remaining portion to form the tubular device. The drawing is performed at a rate such that the tubular device has an axial passage having a substantially uniform inside diameter, and an end of the tubular device formed from the elongated softened section is tapered.
摘要翻译：提供一种制造管状装置的方法。该方法包括提供具有轴向通道的管状坯料，在第一加热位置加热管状坯料以形成软化部分，软化部分将管状坯料的工件部分与管状坯料的剩余部分分开，工件部分远离其余部分以伸长软化部分并将工件部分与其余部分分开以形成管状装置。以使得管状装置具有基本上均匀的内径的轴向通道的速度进行拉伸，并且由细长的软化部分形成的管状装置的端部是锥形的。

10. 发明授权

US5961911A Process for manufacture of closure assembly 失效
标题翻译：封闭组件的制造工艺
公开(公告)号：US5961911A
公开(公告)日：1999-10-05
申请号：US985955
申请日：1997-12-05
申请人： Chorng-Fure Robin Hwang , Frank E. Martin , Tim M. Sullivan , Joel L. Williams
发明人： Chorng-Fure Robin Hwang , Frank E. Martin , Tim M. Sullivan , Joel L. Williams
IPC分类号： A61J1/00 , A61J1/05 , A61J1/14 , B29C33/36 , B29C35/02 , B29C43/18 , B29C70/80 , B29K21/00 , B29L31/56 , B65D51/00 , B29C45/14
CPC分类号： B29C43/146 , B29C43/18 , B29C70/80 , B65D51/002 , A61J1/1406 , A61M2207/00 , B29C33/36 , B29K2009/06 , B29K2023/16 , B29L2031/565
摘要： A process for making a closure assembly includes placing a closure cap portion in a compression mold, introducing a melt of elastomer, pressing the melt into a septum against the cap and applying a foil barrier against the septum. The process may be performed in a rotary compression molding apparatus.
摘要翻译：一种用于制造闭合组件的方法，包括将封盖盖部分放置在压缩模具中，引入弹性体熔体，将熔体压入抵靠盖的隔膜中，并将箔阻挡件抵靠隔膜。该方法可以在旋转压缩成型设备中进行。

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