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1. 发明申请

US20100209505A1 Controlled release pharmaceutical formulations of nitazoxanide 有权
标题翻译：硝唑尼特的控释药物制剂
公开(公告)号：US20100209505A1
公开(公告)日：2010-08-19
申请号：US12656704
申请日：2010-02-12
申请人： Jean-Francois Rossignol , Marc Ayers
发明人： Jean-Francois Rossignol , Marc Ayers
IPC分类号： A61K9/28 , A61K31/426 , A61K9/20 , A61P1/16 , A61K38/21 , A61K31/7056
CPC分类号： A61K31/426 , A61K9/2086 , A61K9/209 , A61K9/28 , A61K9/284 , A61K9/2853 , A61K9/4808 , A61K31/7056 , A61K38/21 , A61K2300/00
摘要： Solid dosage formulations of nitazoxanide or a nitazoxanide analogue are provided that comprise a controlled release portion and an immediate release portion. The pharmaceutical composition is typically in the form of a bilayer solid oral dosage form comprising (a) a first layer comprising a first quantity of nitazoxanide or analogue thereof in a controlled release formulation; and (b) a second layer comprising a second quantity of nitazoxanide or analogue thereof in an immediate release formulation. Method of using the formulations in the treatment of hepatitis C are also provided.
摘要翻译：提供硝唑尼特或硝唑尼特类似物的固体剂量制剂，其包含受控释放部分和速释部分。药物组合物通常为双层固体口服剂型的形式，其包含（a）在控制释放制剂中包含第一量的硝唑尼特或其类似物的第一层; 和（b）在立即释放制剂中包含第二量的硝唑尼特或其类似物的第二层。还提供了用于治疗丙型肝炎的方法。

2. 发明申请

US20100071665A1 INJECTOR WITH AXIAL-PRESSURE COMPENSATED CONTROL VALVE 有权
标题翻译：注射器带轴压补偿控制阀
公开(公告)号：US20100071665A1
公开(公告)日：2010-03-25
申请号：US12447322
申请日：2007-08-29
申请人： Francois Rossignol , Stephan Amelang , Friedrich Howey , Olivier Charvet , Tony Dumont
发明人： Francois Rossignol , Stephan Amelang , Friedrich Howey , Olivier Charvet , Tony Dumont
IPC分类号： F02M69/46 , F02M43/00 , F02M51/00
CPC分类号： F02M63/0015 , F02M47/027 , F02M55/002 , F02M63/0026 , F02M63/0031 , F02M63/004 , F02M63/0043
摘要： The invention relates to an injector for injecting fuel into combustion chambers. According to the invention, a valve piston of a control valve is provided with low pressure on both faces thereof. The valve piston is arranged in a valve chamber hydraulically connected to a control chamber and is guided inside a sleeve received in the valve chamber. The valve chamber contains a spring supported on one end against the sleeve and on the other end on the valve piston such that the spring presses the valve piston onto a valve seat and the sleeve onto an opposing bottom surface. The valve piston diameter inside the sleeve corresponds to the effective valve piston diameter at the valve seat.
摘要翻译：本发明涉及一种用于将燃料喷射到燃烧室中的喷射器。根据本发明，控制阀的阀活塞在其两个面上设置有低压。阀活塞设置在液压连接到控制室的阀室中，并被引导到容纳在阀室中的套筒内。阀室包含一个弹簧，该弹簧支撑在一端抵靠套筒上，另一端支撑在阀活塞上，使得弹簧将阀活塞压到阀座上并将套筒压到相对的底表面上。套管内的阀活塞直径对应于阀座处的有效阀活塞直径。

3. 发明授权

US07644700B2 Fuel injection system for an internal combustion engine 失效
标题翻译：内燃机燃油喷射系统
公开(公告)号：US07644700B2
公开(公告)日：2010-01-12
申请号：US11721233
申请日：2005-11-22
申请人： Francois Rossignol , Olivier Charvet
发明人： Francois Rossignol , Olivier Charvet
IPC分类号： B05B15/06 , F02M59/20 , F02M59/48
CPC分类号： F02M57/023 , F02M45/00 , F02M47/027 , F02M51/005 , F02M51/0603 , F02M51/061 , F02M59/366 , F02M63/0015
摘要： The fuel injection system has at least two electrically actuated control valves for controlling the fuel injection; the control valves are each connected via electric lines to an electric control unit. In the fuel injection system, terminal elements for connection of the electric lines are provided. For a first of the control valves, a structural element is provided, on which the terminal elements for all the control valves are disposed, and which can be secured to a housing part of the fuel injection system. At least one electric connecting line from the terminal elements to the second control valve disposed inside a housing part of the fuel injection system is integrated with the structural element.
摘要翻译：燃料喷射系统具有用于控制燃料喷射的至少两个电动控制阀; 控制阀各自经由电线连接到电气控制单元。在燃料喷射系统中，提供用于连接电线的端子元件。对于第一控制阀，设置有用于所有控制阀的端子元件设置在其上并可固定到燃料喷射系统的壳体部分的结构元件。设置在燃料喷射系统的壳体部分内的从端子元件到第二控制阀的至少一条电连接线与结构元件集成。

4. 发明申请

US20070167504A1 Viral hepatitis treatment 有权
标题翻译：病毒性肝炎治疗
公开(公告)号：US20070167504A1
公开(公告)日：2007-07-19
申请号：US11651672
申请日：2007-01-09
申请人： Jean-Francois Rossignol
发明人： Jean-Francois Rossignol
IPC分类号： A61K31/426 , A61K38/21
CPC分类号： A61K31/426 , A61K31/7068 , A61K38/21 , A61K38/212 , A61K45/06 , A61K2300/00
摘要： The present disclosure relates to methods for treating viral hepatitis, compounds useful in the treatment of viral hepatitis, and pharmaceutical compositions comprising such compounds. In one embodiment, pharmaceutical compositions comprising nitazoxanide, tizoxanide, or derivatives and/or mixtures thereof are provided, as well as methods of treating hepatitis C using such compositions.
摘要翻译：本公开涉及治疗病毒性肝炎的方法，可用于治疗病毒性肝炎的化合物和包含这些化合物的药物组合物。在一个实施方案中，提供了包含硝唑尼特，替佐昔奈或其衍生物和/或其混合物的药物组合物，以及使用这些组合物治疗丙型肝炎的方法。

5. 发明授权

US5856348A Method for treatment of trematodes with pharmaceutical compositions of tizoxanide and nitazoxanide 失效
标题翻译：用噻唑尼特和硝唑尼特的药物组合物治疗吸虫的方法
公开(公告)号：US5856348A
公开(公告)日：1999-01-05
申请号：US887810
申请日：1997-07-03
申请人： Jean-Francois Rossignol
发明人： Jean-Francois Rossignol
IPC分类号： A61K31/425 , A61K31/426 , C07D277/58
CPC分类号： C07D277/58 , A61K31/425 , A61K31/426
摘要： Methods for treatment of a parasitic infection of a trematode selected from the group consisting of Schistosoma such as Schistosoma mansoni, Schistosoma haematobium, Schistosoma mekongi, Schistosoma japonicum, and Schistosoma intercalatum, Fasciola such as Fasciola hepatica and Fasciola gigantica, Fasciolopsis buski, Dicrocoelium dendriticun, Heterophyes heterophyes, and Metagonimus yokogawa, the methods comprising administration of a pharmaceutical composition containing as active agent at least one compound selected the group consisting of a compound of formula I: ##STR1## and a compound of formula II: ##STR2##
摘要翻译：用于治疗寄生虫感染的方法，其选自血吸虫例如血吸虫血吸虫，血吸虫，日本血吸虫，日本血吸虫，血吸虫，Fasciola hepatica和Fasciola gigantica，Fasciolopsis buski，Dicrocoelium dendriticun，异嗜异嗜性嗜异性嗜异性嗜异性嗜异性嗜异性嗜血杆菌和横氏马鞭霉的方法，包括施用含有作为活性剂的药物组合物的方法，所述药物组合物含有至少一种选自式I化合物：式（I）化合物和式II化合物的化合物：（二）

6. 发明授权

US5360164A Fuel filter in a fuel injection apparatus for internal combustion engines 失效
标题翻译：用于内燃机的燃料喷射装置中的燃料过滤器
公开(公告)号：US5360164A
公开(公告)日：1994-11-01
申请号：US127029
申请日：1993-09-24
申请人： Werner Pape , Francois Rossignol
发明人： Werner Pape , Francois Rossignol
IPC分类号： F02M57/02 , F02M59/36 , F02M59/44 , F02M57/00 , F02M51/00
CPC分类号： F02M59/366 , F02M57/02 , Y10S239/23
摘要： A fuel injection apparatus for internal combustion engines, having a pump piston, axially guided in a cylinder bore of a pump housing, driven in a reciprocating manner by a cam drive; the pump piston defines a pump work chamber with its face end. The pump work chamber communicates with an injection valve via a pressure conduit and fuel from a reservoir is fed in and removed via a fuel line that has a feed pump; the triggering of the supply onset and end of supply of the unit fuel injector is achieved by means of a magnet valve inserted in the feed line in the region of the pump housing. In order to prevent the deposit of dirt particles in the pump, the unit fuel injector has a fuel filter in the pump housing, which is inserted in a diversion chamber below the magnet valve, and upstream of which a baffle plate is provided in the direction of the magnet valve to protect the filter from the intense diversion stream.
摘要翻译：一种用于内燃机的燃料喷射装置，具有在泵壳体的气缸孔中轴向引导的泵活塞，所述泵活塞通过凸轮驱动以往复方式驱动; 泵活塞限定了具有其端面的泵工作室。泵工作室通过压力管道与注射阀连通，并且来自储存器的燃料通过具有进料泵的燃料管线进入和移出; 单元燃料喷射器的供应开始和供应结束的触发通过插入在泵壳体的区域中的供给管线中的磁体阀来实现。为了防止污垢颗粒沉积在泵中，单元燃料喷射器在泵壳体中具有燃料过滤器，其被插入在磁阀下面的转向室中，并且在其上游设置有挡板的磁阀，以保护过滤器免受强力转向流。

7. 发明授权

US4669659A Electrically controlled unit fuel injector for fuel injection in diesel engines 失效
标题翻译：用于柴油发动机燃料喷射的电控单元燃油喷射器
公开(公告)号：US4669659A
公开(公告)日：1987-06-02
申请号：US775866
申请日：1985-09-13
申请人： Jean Leblanc , Jean Pigeroulet , Francois Rossignol
发明人： Jean Leblanc , Jean Pigeroulet , Francois Rossignol
IPC分类号： F02M57/02 , F02M59/36 , F02M59/44 , F02M55/00
CPC分类号： F02M59/44 , F02M57/02 , F02M57/023 , F02M59/366
摘要： The unit fuel injector has a pump piston driven at a constant stroke length, which pumps fuel at injection pressure to an injection nozzle as long as an electrically actuated overflow valve blocks the flow of the fuel flowing from the pump work chamber to a low-pressure chamber via an overflow conduit. The overflow valve is inserted between a first section which communicates continuously with the pump work chamber and a second section leading to the low-pressure chamber of the overflow conduit and is secured to a housing part laterally projecting from the pump housing. The first section of the overflow conduit comprises a connecting bore leading away from the pump work chamber, a control conduit controlled by the overflow valve, and a transverse conduit connecting these two. The transverse conduit extends from the housing side remote from the projecting housing part to the control conduit, crossing through the cylinder bore and in every stroke position of the pump piston is sealed off, without additional sealing means, by the jacket face of the pump piston. The unit fuel injector is particularly suitable for high-pressure injection in Diesel engines.
摘要翻译：单元燃料喷射器具有以恒定的行程长度驱动的泵活塞，其将注射压力的燃料泵送到喷射喷嘴，只要电致动的溢流阀阻止从泵工作室流动的燃料的流动到低压通过溢流管道。溢流阀插入在与泵工作室连续连通的第一部分和通向溢流导管的低压室的第二部分之间，并且固定到从泵壳侧向突出的壳体部分。溢流管道的第一部分包括远离泵工作室的连接孔，由溢流阀控制的控制管道和连接这两个的横向管道。横向导管从壳体侧远离突出壳体部分延伸到控制管道，穿过气缸孔，并且在泵活塞的每个行程位置中，泵活塞的护套面没有额外的密封装置而被密封。单元燃油喷射器特别适用于柴油发动机的高压喷射。

8. 发明授权

US4452574A Fuel injection pump 失效
标题翻译：燃油喷射泵
公开(公告)号：US4452574A
公开(公告)日：1984-06-05
申请号：US421176
申请日：1982-09-22
申请人： Jean Leblanc , Francois Rossignol , Jean Pierre Cigolotti
发明人： Jean Leblanc , Francois Rossignol , Jean Pierre Cigolotti
IPC分类号： F02M57/02 , F02M59/10 , F02M59/36 , F02M59/44
CPC分类号： F02M59/102 , F02M57/023 , F02M59/365 , F02M59/44 , Y10T74/18296
摘要： The fuel injection pump of this invention proposes at least one cylinder, a piston, a drive rod, a guide sleeve for the drive means, a guide conduit embracing the guide sleeve, a restoring spring for the drive rod and piston, said piston being designed to execute a suction stroke under the influence of the restoring spring. The injection pump also comprises a locking mechanism comprising a bearing which extends into two recesses. The one recess is in the form of an annular groove located in the guide conduit. The other recess is a slot formed in the guide sleeve in its longitudinal direction. The locking mechanism prevents the guide sleeve together with the rod and piston from falling out after the injection pump has been assembled. The locking mechanism is inexpensive and easy to assemble because it requires only a single bearing in addition to already existing components of the injection pump.
摘要翻译：本发明的燃料喷射泵提出了至少一个气缸，活塞，驱动杆，用于驱动装置的导向套筒，包围导向套筒的导向导管，用于驱动杆和活塞的复原弹簧，所述活塞被设计在复原弹簧的影响下执行吸入冲程。注射泵还包括锁定机构，其包括延伸到两个凹部中的轴承。一个凹槽是位于导向管道中的环形凹槽的形式。另一个凹部是在引导套筒中沿其纵向方向形成的槽。在组装注射泵之后，锁定机构防止导向套筒与杆和活塞一起脱落。锁定机构便宜并且容易组装，因为除了注射泵已经存在的部件之外，它仅需要一个轴承。

9. 发明授权

US08633230B2 Viral hepatitis treatment 有权
标题翻译：病毒性肝炎治疗
公开(公告)号：US08633230B2
公开(公告)日：2014-01-21
申请号：US11651672
申请日：2007-01-09
申请人： Jean-Francois Rossignol
发明人： Jean-Francois Rossignol
IPC分类号： A61K31/425 , A61K31/70 , A61K38/00
CPC分类号： A61K31/426 , A61K31/7068 , A61K38/21 , A61K38/212 , A61K45/06 , A61K2300/00
摘要： The present disclosure relates to methods for treating viral hepatitis, compounds useful in the treatment of viral hepatitis, and pharmaceutical compositions comprising such compounds. In one embodiment, pharmaceutical compositions comprising nitazoxanide, tizoxanide, or derivatives and/or mixtures thereof are provided, as well as methods of treating hepatitis C using such compositions.
摘要翻译：本公开涉及治疗病毒性肝炎的方法，可用于治疗病毒性肝炎的化合物和包含这些化合物的药物组合物。在一个实施方案中，提供了包含硝唑尼特，替佐昔奈或其衍生物和/或其混合物的药物组合物，以及使用这些组合物治疗丙型肝炎的方法。

10. 发明授权

US08279345B2 System and method for random noise estimation in a sequence of images 失效
标题翻译：用于图像序列中随机噪声估计的系统和方法
公开(公告)号：US08279345B2
公开(公告)日：2012-10-02
申请号：US12643851
申请日：2009-12-21
申请人： Francois Rossignol , Chon Tam Ledinh
发明人： Francois Rossignol , Chon Tam Ledinh
IPC分类号： H04N5/00
CPC分类号： G06K9/40 , G06T5/002 , G06T5/40 , G06T2207/10016 , G06T2207/20182 , G06T2207/20224 , H04N5/21
摘要： A system and method for estimating random noise in an image frame or a sequence of image frames are presented. In some embodiments, the method includes performing Global Noise Estimation by comparing current and past filtered frames; converting global noise estimates into local noise estimates using estimated noise parameters based on current input image's local mean intensity; and providing local noise estimates to an adapted generic spatio-temporal filter. A parameter-based noise model is applied in the noise calculation.
摘要翻译：提出了一种用于估计图像帧或图像帧序列中的随机噪声的系统和方法。在一些实施例中，该方法包括通过比较当前和过去滤波的帧来执行全局噪声估计; 使用基于当前输入图像的局部平均强度的估计噪声参数将全局噪声估计转换为局部噪声估计; 以及向适应的通用时空滤波器提供局部噪声估计。在噪声计算中应用基于参数的噪声模型。

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