专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明专利

BR1100273A 未知
公开(公告)号：BR1100273A
公开(公告)日：1999-10-13
申请号：BR1100273
申请日：1997-04-16
申请人： JAMES M. BALKOVEC , REGINA M. BLACK , FRANCES AILEEN BOUFFARD
发明人： BALKOVEC JAMES M , BLACK REGINA M , BOUFFARD FRANCES AILEEN
IPC分类号： A61K38/00 , A61K38/08 , A61K38/12 , A61P31/00 , A61P31/04 , A61P31/10 , C07K7/06 , C07K7/54 , C07K7/56 , C07K7/64
摘要： Ceretain aza cyclohexapeptide compounds have been found to have superior antibiotic properties. Novel processes for their preparation are also described.

2. 发明授权

US5741775A Cyclohexapeptidyl aminoalkyl ethers 失效
标题翻译：环己酰基氨基烷基醚
公开(公告)号：US5741775A
公开(公告)日：1998-04-21
申请号：US489976
申请日：1995-06-13
申请人： James M. Balkovec , James F. Dropinski , Frances Aileen Bouffard
发明人： James M. Balkovec , James F. Dropinski , Frances Aileen Bouffard
IPC分类号： A61K38/00 , A61P31/04 , C07K7/06 , C07K7/56 , A61K38/12 , C07K7/64
CPC分类号： C07K7/56 , A61K38/00
摘要： There are disclosed compounds of the general formula ##STR1## wherein all substituents are defined herein. The compounds are useful as antibiotic and antifungal agents.
摘要翻译：公开了通式“IMAGE”的化合物，其中所有取代基均在本文中定义。该化合物可用作抗生素和抗真菌剂。

3. 发明授权

US5914313A 1-�4-hydroxy-5-aminoethyloxy-N.sup.2 -(10,12-dimethyl-1-oxotetradecyl)ornithine!-5-(3-hydroxyglutamine)-6-(3- hydroxyproline)echinocandin B, other aminoalkyl derivatives and salts thereof 失效
标题翻译： 1- [4-羟基-5-氨基乙氧基-N2-（10,12-二甲基-1-氧代十四烷基）鸟氨酸] -5-（3-羟基谷氨酰胺）-6-（3-羟基脯氨酸）棘白菌素B，其它氨基烷基衍生物和盐其中
公开(公告)号：US5914313A
公开(公告)日：1999-06-22
申请号：US5942
申请日：1993-01-15
申请人： Frances Aileen Bouffard , James F. Dropinski
发明人： Frances Aileen Bouffard , James F. Dropinski
IPC分类号： A61K38/00 , C07K7/56 , A61K38/12 , C07K7/50
CPC分类号： C07K7/56 , A61K38/00
摘要： A compound having the formula ##STR1## in which R.sub.1 is an aminoalkyl group and ##STR2## is an acyl group and salts thereof having high antibiotic activity and being substantially free of lytic activity are described.
摘要翻译：描述了具有下式的化合物，其中R 1是氨基烷基并且是酰基，并且其具有高抗生素活性和基本上没有裂解活性的盐。

4. 发明授权

US07863465B2 Antifungal agents 有权
标题翻译：抗真菌剂
公开(公告)号：US07863465B2
公开(公告)日：2011-01-04
申请号：US11727927
申请日：2007-03-29
申请人： James M. Balkovec , Frances Aileen Bouffard , Bruno Tse , James Dropinski , Dongfang Meng , Mark L. Greenlee , Michael Peel , Weiming Fan , Ahmed Mamai , Hao Liu , Keqaing Li
发明人： James M. Balkovec , Frances Aileen Bouffard , Bruno Tse , James Dropinski , Dongfang Meng , Mark L. Greenlee , Michael Peel , Weiming Fan , Ahmed Mamai , Hao Liu , Keqaing Li
IPC分类号： C07D311/00 , C07D315/00
CPC分类号： C07J71/0005
摘要： The present invention relates to novel enfumafungin derivatives of formula I and pharmaceutically acceptable salts thereof, their synthesis, and their use as inhibitors of (1,3)-β-D-glucan synthase. The present compounds and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions comprising the present compounds and pharmaceutically acceptable salts thereof, are useful for treating or preventing antifungal infections and associated diseases and conditions.
摘要翻译：本发明涉及式I的新型烯虫腈衍生物及其药学上可接受的盐，它们的合成及其作为（1,3） - β-葡聚糖合酶抑制剂的用途。本发明化合物及其药学上可接受的盐以及包含本发明化合物及其药学上可接受的盐的药物组合物可用于治疗或预防抗真菌感染和相关疾病和病症。

5. 发明授权

US06268338B1 Cyclohexapeptidyl amine compounds 失效
标题翻译：环己酰胺胺化合物
公开(公告)号：US06268338B1
公开(公告)日：2001-07-31
申请号：US08055996
申请日：1993-04-30
申请人： James M. Balkovec , Frances Aileen Bouffard , James F. Dropinski , Robert A. Zambias
发明人： James M. Balkovec , Frances Aileen Bouffard , James F. Dropinski , Robert A. Zambias
IPC分类号： A61K3800
CPC分类号： C07K7/56 , A61K38/00
摘要： Cyclohexapeptidyl amine compounds are disclosed of the formula: or its acid addition salt, wherein: R1 is H or OH; R2 is H or OH; R3 is QCnH2nNRVRVI, QCnH2nNRVRVIRVII+Y−, or Q(CH2)1-3CRVIIIRIXNHRX. R4 is H or OH; R5 is H, OH or CH3; R6 is H or CH3; RI is wherein Ra is C1-C10 alkyl; or (CH2)qNRbRc wherein Rb and Rc are independently H, C1-C10 alkyl or Rb and Rc taken together are wherein Rd is C1-C16 alkyl, phenyl or benzyl; RII is H, C1-4 alkyl or benzyl; RIII is H, C1-4 alkyl or benzyl; RIV is RII and RIII taken together as —(CH2)4— or —(CH2)5—; RV is H, C1-C4 alkyl or benzyl; RVI is H, C1-C4 alkyl or benzyl or RV and RVI together is —(CH2)4— or —(CH2)5—; RVII is H or C1-C4 alkyl; RVIII is H, (CH2)mH, (CH2)mOH, (CH2)mNH2 or COX wherein X is NH2, OH or O(CH2)mH; RIX is H, (CH2)mH, or together with RVIII is ═O (carbonyl); RX is H (except when RVIII and RIX are H, C(═NH)NH2, C(═NH)CH2)0-3H, CO(CH2)0-3H, CO(CH2)mNH2, (CH2)2-4OH or (CH2)2-4NH2; Q is O or S; Y is an anion of a pharmaceutically acceptable salt each m is independently an integer from 1 to 3, inclusive; n is an integer from 2 to 4, inclusive; p is an integer from 1 to 2, inclusive and q is an integer from 2 to 4, inclusive.
摘要翻译：公开了下式：或其酸加成盐的环己酰胺化合物，其中：R1是H或OH; R2是H或OH; R3是QCnH2nNRVRVI，QCnH2nNRVRVIRVII + Y-或Q（CH2）1-3CRVIIIRIXNHRX.R4是H 或OH; R 5是H，OH或CH 3; R 6是H或CH 3; R 1是其中R a是C 1 -C 10烷基; 或（CH 2）q NR b R c其中R b和R c独立地为H，C 1 -C 10烷基或R b和R c在一起，其中R 1为C 1 -C 16烷基，苯基或苄基; R II为H，C 1-4烷基或苄基; R III为H，Cl -4-烷基或苄基; RIV是RII和RIII，一起作为 - （CH 2）4 - 或 - （CH 2）5 - ; RV是H，C 1 -C 4烷基或苄基; R VI是H，C 1 -C 4烷基或苄基或 RV和RVI一起是 - （CH 2）4 - 或 - （CH 2）5; RVII是H或C 1 -C 4烷基; RVIII是H，（CH 2）m H，（CH 2）m OH，（CH 2）m NH 2或COX，其中X是NH 2 ，OH或O（CH 2）m H; RIX为H，（CH 2）m H或与RVIII一起为=（（羰基））; RX为H（除非当RVIII和RIX为H时，C（= NH）NH 2，C（ = NH）CH 2）0-3H，CO（CH 2）0-3H，CO（CH 2）m NH 2，（CH 2）2-4 OH或（CH 2）2-4 NH 2; Q为O或S; Y为药学上阴离子可接受的salteach m独立地为1〜3的整数，包括0和n; n为2〜4的整数，p为2〜4的整数，q为2〜4的整数。

6. 发明授权

US06030944A Cyclohexapeptidyl bisamine compounds 失效
标题翻译：环己酰肽双胺化合物
公开(公告)号：US06030944A
公开(公告)日：2000-02-29
申请号：US936558
申请日：1992-09-03
申请人： Frances Aileen Bouffard , James F. Dropinski , Robert A. Zambias
发明人： Frances Aileen Bouffard , James F. Dropinski , Robert A. Zambias
IPC分类号： A61K38/00 , A61P31/04 , A61P31/10 , C07K7/56 , C12P21/02 , C12P21/04 , C12R1/01 , C12R1/645 , A61K38/12 , C07K7/54
CPC分类号： C07K7/56 , A61K38/00
摘要： Certain bisamine compounds which have a cyclohexapeptidyl nucleus and which are found to have antibiotic activity with physical properties suitable for direct use in therapeutic compositions are described. A novel process for their preparation is also described.
摘要翻译：描述了具有环己基肽基核并且被发现具有适于直接用于治疗组合物的物理性质的抗生素活性的某些双胺化合物。还描述了其制备的新方法。

7. 发明授权

US5792746A Aza cyclohexapeptide compounds 失效
公开(公告)号：US5792746A
公开(公告)日：1998-08-11
申请号：US741645
申请日：1996-10-28
申请人： James M. Balkovec , Frances Aileen Bouffard , Regina M. Black
发明人： James M. Balkovec , Frances Aileen Bouffard , Regina M. Black
IPC分类号： A61K38/00 , A61K38/08 , A61K38/12 , A61P31/00 , A61P31/04 , A61P31/10 , C07K7/06 , C07K7/54 , C07K7/56 , C07K7/64 , C07K7/52
CPC分类号： C07K7/56 , A61K38/00 , Y10S930/27
摘要： Ceretain aza cyclohexapeptide compounds have been found to have superior antibiotic properties. Novel processes for their preparation are also described.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式