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1. 发明授权

US06893876B2 Enhancing surface-generated fluorescence signal emitted by a sample 失效
标题翻译：增强样品发出的表面产生的荧光信号
公开(公告)号：US06893876B2
公开(公告)日：2005-05-17
申请号：US10129948
申请日：2000-12-01
申请人： François Perraut , Patrick Chaton , Patrick Pouteau
发明人： François Perraut , Patrick Chaton , Patrick Pouteau
IPC分类号： G01N21/55 , G01N21/64 , G01N33/543
CPC分类号： G01N21/6452
摘要： A device and process for the amplification of fluorescence emitted by an areal sample. The device includes a support transmitting all or part of a fluorescence signal and configured to support the areal sample and a thin layer interposed between the support and the areal sample. The thin layer has a refractive index greater than the refractive index of the support and than the refractive index of a medium flooding the areal sample during a fluorescence measurement. The thickness of the thin layer is chosen so that the thin layer transmits all or part of the fluorescence signal which is measured after passing through the support.
摘要翻译：用于扩增由面状样品发射的荧光的装置和方法。该装置包括透射全部或部分荧光信号并被配置为支撑面状样品的支撑体和介于载体和面状样品之间的薄层。薄层的折射率大于支撑体的折射率，而不是在荧光测量期间填充面状样品的介质的折射率。选择薄层的厚度，使得薄层透过在通过载体之后测量的全部或部分荧光信号。

2. 发明授权

US08034226B2 Device for dielectrophoretic separation of particles contained in a fluid 失效
标题翻译：包含在流体中的颗粒的介电电泳分离的装置
公开(公告)号：US08034226B2
公开(公告)日：2011-10-11
申请号：US11576211
申请日：2005-09-15
申请人： Pascale Pham , François Perraut , Adrien Plecis
发明人： Pascale Pham , François Perraut , Adrien Plecis
IPC分类号： G01N27/26 , G01N27/447
CPC分类号： B03C5/026
摘要： A device for dielectrophoretic separation of particles contained in a fluid, includes two sets of electrodes, each of the two sets of electrodes being brought to a different potential, so as to generate an electric field inside said fluid. The two sets of electrodes are positioned inside a chamber, itself provided with a particle collecting surface. Each of the two sets of electrodes is immersed in the fluid inside the chamber and is located in a plane different from the plane of the particle collecting surface. The two sets of electrodes are supplied with electrical current in phase opposition. The potential of each of the two sets of electrodes have a gradient based on the distance along a direction perpendicular to the plane of the particle collecting surface.
摘要翻译：包含在流体中的颗粒的介电电泳分离的装置包括两组电极，两组电极中的每一组被带到不同的电位，以便在所述流体内产生电场。两组电极位于室内，本身设有颗粒收集表面。两组电极中的每一个浸入室内的流体中，并且位于与颗粒收集表面的平面不同的平面中。两组电极被提供相位相反的电流。两组电极中的每一组的电位具有基于垂直于颗粒收集表面平面的方向的距离的梯度。

3. 发明授权

US07064893B2 Optical microscope with modifiable lighting and operating process of such a microscope 失效
标题翻译：具有可修改照明的光学显微镜和这种显微镜的操作过程
公开(公告)号：US07064893B2
公开(公告)日：2006-06-20
申请号：US10724613
申请日：2003-12-02
申请人： Jérõme Boutet , François Perraut , Philippe Peltié , Philippe Rizo
发明人： Jérõme Boutet , François Perraut , Philippe Peltié , Philippe Rizo
IPC分类号： G02B21/06
CPC分类号： G02B21/06
摘要： An optical microscope is adapted for observation of several spots of an object by a modifiable optical transmission screen placed on the path of the optical beam and able to generate in the object plane a screen image coinciding substantially with the spots of the object. The modifiable optical transmission screen can comprise a matrix of mirrors, each of the mirrors presenting a first position enabling the light beam to be reflected to the object along the optical path and a second position enabling the light beam to be diverted from the optical path. Alternatively, the modifiable optical transmission screen can comprise a matrix of liquid crystal elements, each of the liquid crystal elements presenting a first transparent state, a second opaque state and, possibly, a third polarising state. The light source can be a light-emitting diode array.
摘要翻译：光学显微镜适于通过放置在光束路径上的可修改的光学传输屏幕观察物体的几个点，并且能够在物体平面中产生与物体的斑点基本上重合的屏幕图像。可修改的光传输屏幕可以包括反射镜矩阵，每个反射镜呈现第一位置，使第一位置能够使光束沿着光路被反射到物体，以及使第二位置能够使光束从光路转向。或者，可修改的光传输屏幕可以包括液晶元件的矩阵，每个液晶元件具有第一透明状态，第二不透明状态和可能的第三偏振状态。光源可以是发光二极管阵列。

4. 发明申请

US20130056620A1 DEVICE FOR LIGHTING AN OBJECT, WITH LIGHT SOURCE PROVIDED WITH A MEMBER FOR SAMPLING A PORTION OF SAID LIGHT, APPLICATION TO THE MEASUREMENT OF FLUX VARIATIONS OF THE SOURCE 有权
标题翻译：用于照亮物体的装置，用光源提供，用于采集一个部分的光，用于测量源的通量变化
公开(公告)号：US20130056620A1
公开(公告)日：2013-03-07
申请号：US13591524
申请日：2012-08-22
申请人： François PERRAUT , Thierry Flahaut
发明人： François PERRAUT , Thierry Flahaut
IPC分类号： G01J1/42
CPC分类号： G01N21/645 , G01N21/78
摘要： A device for lighting an object, with light source provided with a member for sampling a portion of the light, application to the measurement of flux variations of the source. The device includes at least one light source emitting an illuminating light around an illumination axis, for lighting the object, and a photodetector.
摘要翻译：一种用于照明物体的装置，其中光源设置有用于对一部分光进行采样的构件，用于测量源的通量变化。该装置包括发射照明轴周围的照明光，用于照明物体的至少一个光源和光电检测器。

5. 发明申请

US20120113421A1 SYSTEM AND METHOD FOR DETECTING ANALYTES PRESENT IN A GAS SAMPLE 有权
标题翻译：用于检测气体样品中分析物的系统和方法
公开(公告)号：US20120113421A1
公开(公告)日：2012-05-10
申请号：US13218750
申请日：2011-08-26
申请人： Séverine Vignoud , Michael Descamps , François Perraut , Anne Planat-Chretien , Emmanuelle Schultz
发明人： Séverine Vignoud , Michael Descamps , François Perraut , Anne Planat-Chretien , Emmanuelle Schultz
IPC分类号： G01J3/443
CPC分类号： G01N21/783 , G01N21/05 , G01N2021/0346 , G01N2021/7783 , G01N2021/7786
摘要： The invention relates to a system (1) for detecting analytes of interest present in a gas sample. The detection system comprises a layer (30) of porous material positioned along the fluidic flow path for the gas, the material containing probe molecules capable of reacting with the analyte of interest. The detection system also comprises an optical device (50) capable of successively detecting a change in the spectral properties of the probe molecules at different detection areas (32) of the porous material layer (30).
摘要翻译：本发明涉及一种用于检测气体样品中存在的感兴趣分析物的系统（1）。检测系统包括沿着用于气体的流体流动路径定位的多孔材料层（30），所述材料含有能够与感兴趣的分析物反应的探针分子。检测系统还包括能够连续地检测多孔材料层（30）的不同检测区域（32）处的探针分子的光谱特性变化的光学装置（50）。

6. 发明授权

US07396650B2 Method for dosing a biological or chemical sample 有权
标题翻译：计量生物或化学样品的方法
公开(公告)号：US07396650B2
公开(公告)日：2008-07-08
申请号：US10560973
申请日：2004-06-24
申请人： François Perraut , Emmanuelle Schultz
发明人： François Perraut , Emmanuelle Schultz
IPC分类号： G01N33/53
CPC分类号： G01N33/582 , G01N21/645 , G01N33/48
摘要： The invention relates to a method for assaying a biological or chemical sample comprising the following steps: illuminating the sample (10) by means of a light beam (17) from a source (11), producing an image including the image of the beam (18) diffused by the sample (10), analysing the image according to reference criteria, extracting information specific to the light/sample beam interaction, calculating the assay.
摘要翻译：本发明涉及一种用于测定生物或化学样品的方法，包括以下步骤：通过来自源（11）的光束（17）照射样品（10），产生包括束的图像的图像（ 18），根据参考标准分析图像，提取特定于光/样品束相互作用的信息，计算测定。

7. 发明授权

US06537801B1 Biochip and biochip reading device comprising a plurality of zones for molecular recognition 失效
标题翻译：生物芯片和生物芯片读取装置包括用于分子识别的多个区域
公开(公告)号：US06537801B1
公开(公告)日：2003-03-25
申请号：US09787894
申请日：2001-03-28
申请人： Michel Ida , Alain Fargeix , François Perraut , Alexandre Lagrange
发明人： Michel Ida , Alain Fargeix , François Perraut , Alexandre Lagrange
IPC分类号： C12Q168
CPC分类号： G01N21/6452
摘要： A device for reading a biochip including plural molecular recognition areas and plural optical positioning marks, associated with recognition areas. The device includes an optical head capable of projecting excitation light onto the biochip. A device is provided to effectuate relative displacement between the head and the biochip. A first optical analysis system is associated with the optical head to receive any light arriving from recognition areas. A second optical positioning system is associated with the optical head to receive any light from at least one guide track and/or optical positioning mark. A device is further provided for servocontrolling scanning by the optical head. Such a device may find particular application to biological and chemical analysis.
摘要翻译：一种用于读取包括与识别区域相关联的多个分子识别区域和多个光学定位标记的生物芯片的装置。该装置包括能够将激发光投射到生物芯片上的光学头。提供了一种用于实现头部和生物芯片之间的相对位移的装置。第一光学分析系统与光学头相关联以接收从识别区域到达的任何光。第二光学定位系统与光学头相关联以接收来自至少一个导轨和/或光学定位标记的任何光。进一步提供用于由光学头进行伺服控制扫描的装置。这样的装置可以发现特定的生物和化学分析应用。

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