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1. 发明授权

US08492420B2 Use of purine derivatives for the production of medicaments for the treatment of mucoviscidosis and diseases related to protein addressing errors in cells 有权
标题翻译：使用嘌呤衍生物生产用于治疗粘液性疾病的药物和与细胞中的蛋白质寻址错误有关的疾病
公开(公告)号：US08492420B2
公开(公告)日：2013-07-23
申请号：US11786754
申请日：2007-04-12
申请人： Frédéric Becq , Laurent Meijer
发明人： Frédéric Becq , Laurent Meijer
IPC分类号： A01N43/50 , A61K31/415
CPC分类号： A61K31/52
摘要： The invention relates to the use of purine derivatives for the production of medicaments for the treatment of mucoviscidosis and diseases related to protein addressing errors in cells, said derivatives being of formula (I): where R2, R6 and R9, independently=halogen, a R—NH—, R—NH—NH—, NH2—R′—NH or R—NH—R′—NH— group, where R=straight or branched chain saturated or unsaturated alkyl, aryl, cycloalkyl, or heterocyclyl group, R′=straight or branched chain, saturated or unsaturated alkylene, arylene or cycloalkylene, R and R′ each include 1 to 8 carbon atoms optionally substituted with one or more —OH, halogen, amino or alkyl groups, R2 furthermore may be a heterocycle optionally with a straight or branched chain saturated or unsaturated alkyl, aryl or cycloaryl or a heterocycle optionally substituted by one or more —OH, halogen, amino or alkyl groups, R9 furthermore may be a straight or branched chain saturated or unsaturated alkyl, aryl or cycloalkyl and R2 and R9 furthermore may be hydrogen with the exception of 2-(2-hydroxyethylamino)-6-benzylamino-9-methylpurine.
摘要翻译：本发明涉及嘌呤衍生物用于生产药物用于治疗粘液性疾病和与细胞中蛋白质寻址错误相关的疾病的用途，所述衍生物具有式（I）：其中R2，R6和R9独立地为卤素， R-NH-，R-NH-NH-，NH2-R'-NH或R-NH-R'-NH-基，其中R =直链或支链饱和或不饱和的烷基，芳基，环烷基或杂环基， R'=直链或支链，饱和或不饱和的亚烷基，亚芳基或亚环烷基，R和R'各自包含任选被一个或多个-OH，卤素，氨基或烷基取代的1至8个碳原子，此外，R 2也可以是杂环任选地具有直链或支链饱和或不饱和的烷基，芳基或环芳基或任选被一个或多个-OH，卤素，氨基或烷基取代的杂环，R 9还可以是直链或支链饱和或不饱和的烷基，芳基或环烷基，R2和R9另外可以是氢除了2-（2-羟乙基氨基）-6-苄氨基-9-甲基嘌呤外。

2. 发明授权

US08242136B2 Use of glucosidase inhibitors for therapy of mucovisidosis 有权
标题翻译：使用葡萄糖苷酶抑制剂治疗粘膜病变
公开(公告)号：US08242136B2
公开(公告)日：2012-08-14
申请号：US13116482
申请日：2011-05-26
申请人： Frédéric Becq , Caroline Norez
发明人： Frédéric Becq , Caroline Norez
IPC分类号： A61K31/445
CPC分类号： A61K31/352 , A61K31/437 , A61K31/4375 , A61K31/445 , Y10S514/851 , A61K2300/00
摘要： A treatment of cystic fibrosis by administration of a pharmaceutically acceptable amount of the glucosidase inhibitor NB-DMJ (N-butyldeoxy-mannojirimycin).
摘要翻译：通过施用药学上可接受量的葡糖苷酶抑制剂NB-DMJ（N-丁基脱氧 - mannojirimycin）治疗囊性纤维化。

3. 发明授权

US07973054B2 Use of glucosidase inhibitors for therapy of mucovisidosis 有权
标题翻译：使用葡萄糖苷酶抑制剂治疗粘膜病变
公开(公告)号：US07973054B2
公开(公告)日：2011-07-05
申请号：US10578328
申请日：2004-11-05
申请人： Frédéric Becq , Caroline Norez
发明人： Frédéric Becq , Caroline Norez
IPC分类号： A61K31/445
CPC分类号： A61K31/352 , A61K31/437 , A61K31/4375 , A61K31/445 , Y10S514/851 , A61K2300/00
摘要： A method provides for the use of glycosidase inhibitors selected from compounds of general formula (1), wherein R1 represents a CH3 group, or CH2OH, R2 represents H or an alkyl group having 1-5 carbon atoms, or R1 and R2 together form a group having formula (II), with carbon in position (a) and nitrogen of formula (I) mentioned above, for the preparation of a medicament used to treat mucovisidosis. A corresponding product is also described.
摘要翻译：一种方法提供使用选自通式（1）的化合物的糖苷酶抑制剂，其中R 1表示CH 3基团，或CH 2 OH，R 2表示H或具有1-5个碳原子的烷基，或者R 1和R 2一起形成具有式（II）的碳原子，上述式（I）中的碳和式（I）的氮）用于制备用于治疗粘膜病变的药物。还描述了相应的产品。

4. 发明授权

US06630482B1 CFTR channel activator compounds and pharmaceutical compositions containing same 有权
标题翻译： CFTR通道活化剂化合物和含有它们的药物组合物
公开(公告)号：US06630482B1
公开(公告)日：2003-10-07
申请号：US09230747
申请日：1999-03-02
申请人： Frédéric Becq , Yvette Mettey , Jean-Michel Vierfond , Bernard Verrier , Maurice Gola
发明人： Frédéric Becq , Yvette Mettey , Jean-Michel Vierfond , Bernard Verrier , Maurice Gola
IPC分类号： A61K314375
CPC分类号： C07D213/30 , A61K31/4745 , C07D455/04
摘要： CFTR channel activator compounds from the benzo[c]quinolizinium family or families of compounds derived therefrom, as well as pharmaceutical compositions containing said compounds, and the uses thereof, particularly for treating cystic fibrosis, are disclosed.
摘要翻译：公开了来自苯并[c]喹喔啉家族的CFTR通道活化剂化合物或其衍生化合物的家族，以及含有所述化合物的药物组合物及其用途，特别是用于治疗囊性纤维化的用途。

5. 发明授权

US07605153B2 Use of paullone derivatives for the production of medicaments for the treatment of mucoviscidosis and diseases related to protein addressing errors in cells 失效
标题翻译：使用paullone衍生物生产用于治疗粘液性疾病的药物和与细胞中蛋白质寻址错误有关的疾病
公开(公告)号：US07605153B2
公开(公告)日：2009-10-20
申请号：US11786784
申请日：2007-04-12
申请人： Frédéric Becq , Laurent Meijer , Conrad Kunick
发明人： Frédéric Becq , Laurent Meijer , Conrad Kunick
IPC分类号： A61K31/55 , A61P11/00
CPC分类号： A61K31/55
摘要： The invention relates to paullone derivatives for the production of medicaments for the treatment of mucoviscidosis and diseases related to protein addressing errors in cells, said derivatives being of general formula (1): wherein X═C═O, C—S—CH3, C—S, —C—NHOH, Z—C or N, Y— with the adjacent ring, a phenyl or thienyl group, the ring(s) of said derivatives being optionally substituted with one or more halogen atoms, hydroxy, alkylenehydroxy, alkynealkylenehydroxy, alkynehydroxycyclohexyl, alkyl, alkoxy, alkylenealkoxy, or alkylenecyano groups where the alkylene group is either saturated or unsaturated, the groups having a straight or branched chain with C1 to C18, said chain being optionally substituted with one or more hydroxy or amino groups, or one or more trifluoromethyl, —COM, —COOM, or —CH2COOM groups (where M=H, C1 to C18 straight or branched chain alkyl, optionally substituted with one or more hydroxy and/or amino groups) nitroso, or cyano, R5═H, or C1 to C5 alkyl and R12═H, or —C—CO2—(CH3)3 and the physiologically-acceptable salts and derivatives thereof.
摘要翻译：本发明涉及用于生产用于治疗粘液性疾病的药物的paullone衍生物和与细胞中的蛋白质寻址错误有关的疾病，所述衍生物为通式（1）：其中XCO，CS-CH3，CS，-C-NHOH， ZC或N，Y-与相邻的环，苯基或噻吩基，所述衍生物的环任选被一个或多个卤素原子取代，羟基，亚烷基羟基，亚炔基亚烷基羟基，炔羟基环己基，烷基，烷氧基，亚烷基烷氧基或亚烷基基团，其中亚烷基是饱和或不饱和的，该基团具有C1至C18的直链或支链，所述链任选被一个或多个羟基或氨基取代，或一个或多个三氟甲基-COM，-COOM 或-CH 2 COOM基团（其中M = H，C1至C18直链或支链烷基，任选被一个或多个羟基和/或氨基取代）亚硝基或氰基，R 5 -H或C 1至C 5烷基和R 12 - H或 - C-CO 2 - （CH 3）3及其生理学上可接受的盐和衍生物。

6. 发明申请

US20110269795A1 USE OF GLUCOSIDASE INHIBITORS FOR THERAPY OF MUCOVISIDOSIS 有权
标题翻译：用于治疗脑血管病的葡糖苷酶抑制剂
公开(公告)号：US20110269795A1
公开(公告)日：2011-11-03
申请号：US13116482
申请日：2011-05-26
申请人： Frédéric BECQ , Caroline NOREZ
发明人： Frédéric BECQ , Caroline NOREZ
IPC分类号： A61K31/45 , A61P3/00
CPC分类号： A61K31/352 , A61K31/437 , A61K31/4375 , A61K31/445 , Y10S514/851 , A61K2300/00
摘要： A method provides for the use of glycosidase inhibitors selected from compounds of general formula (1), wherein R1 represents a CH3 group, or CH2OH, R2 represents H or an alkyl group having 1-5 carbon atoms, or R1 and R2 together form a group having formula (II), with carbon in position (a) and nitrogen of formula (I) mentioned above, for the preparation of a medicament used to treat mucovisidosis. A corresponding product is also described.
摘要翻译：一种方法提供使用选自通式（1）的化合物的糖苷酶抑制剂，其中R 1表示CH 3基团，或CH 2 OH，R 2表示H或具有1-5个碳原子的烷基，或者R 1和R 2一起形成具有式（II）的碳原子，上述式（I）中的碳和式（I）的氮）用于制备用于治疗粘膜病变的药物。还描述了相应的产品。

7. 发明授权

US07897610B2 Use of benzo[c]quinolizinium derivatives for the treatment of diseases that are linked to smooth muscle cell constriction 失效
标题翻译：苯并[c]喹喔啉衍生物用于治疗与平滑肌细胞收缩相关的疾病的用途
公开(公告)号：US07897610B2
公开(公告)日：2011-03-01
申请号：US10516839
申请日：2003-06-05
申请人： Frédéric Becq , Renaud Robert , Laurence Pignoux , Christian Rogier , Yvette Mettey , Jean Michel Vierfond , Michel Joffre , Cécile Marivingt-Mounir
发明人： Frédéric Becq , Renaud Robert , Laurence Pignoux , Christian Rogier , Yvette Mettey , Jean Michel Vierfond , Michel Joffre , Cécile Marivingt-Mounir
IPC分类号： A61K31/4375 , C07D455/06
CPC分类号： C07D471/14 , A61K31/4375 , C07D455/06
摘要： The invention relates to the use of benzo[c]quinolizinium derivatives for treating diseases that are linked to smooth muscle cell constriction, such as hypertension and asthma.
摘要翻译：本发明涉及苯并[c]喹嗪衍生物用于治疗与平滑肌细胞收缩如高血压和哮喘有关的疾病的用途。

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